1,078
Views
27
CrossRef citations to date
0
Altmetric
Research Article

Plasma citrulline levels predict intestinal toxicity in patients treated with pelvic radiotherapy

, , , , , & show all
Pages 1167-1174 | Received 23 Mar 2011, Accepted 21 Apr 2011, Published online: 24 Aug 2011

References

  • Atahan IL, Onal C, Ozyar E, Yiliz F, Selek U, Kose F. Long-term outcome and prognostic factors in patients with cervical carcinoma: A retrospective study. Int J Gynecol Cancer 2007;17:833–42.
  • Letschert JG, Lebesque JV, Aleman BM, Bosset JF, Horiot JC, Bartelink H, . The volume effect in radiation-related late small bowel complications: Results of a clinical study of the EORTC Radiotherapy Cooperative Group in patients treated for rectal carcinoma. Radiother Oncol 1994;32: 116–23.
  • Crenn P, Vahedi K, Lavergne-Slove A, Cynober L, Matuchansky C, Messing B. Plasma citrulline: A marker of enterocyte mass in villous atrophy-associated small bowel disease. Gastroenterology 2003;124:1210–9.
  • Lutgens LC, Deutz NE, Gueulette J, Cleutjens JP, Berger MP, Wouters BG, . Citrulline: A physiologic marker enabling quantitation and monitoring of epithelial radiation-induced small bowel damage. Int J Radiat Oncol Biol Phys 2003;57:1067–74.
  • Crenn P, Messing B, Cynober L. Citrulline as a biomarker of intestinal failure due to enterocyte mass reduction. Clin Nutr 2008;27:328–39.
  • Herbers AH, Feuth T, Donnelly JP, Blijlevens NM. Citrulline-based assessment score: First choice for measuring and monitoring intestinal failure after high-dose chemotherapy. Ann Oncol 2010;21:1706–11.
  • Lutgens LC, Blijlevens NM, Deutz NE, Donnelly JP, Lambin P, de Pauw BE. Monitoring myeloablative therapy-induced small bowel toxicity by serum citrulline concentration: A comparison with sugar permeability tests. Cancer 2005;103: 191–9.
  • Packey CD, Ciorba MA. Microbial influences on the small intestinal response to radiation injury. Curr Opin Gastroenterol 2010;26:88–94.
  • Lutgens LC, Deutz N, Granzier-Peeters M, Beets-Tan R, De Ruysscher D, Gueulette J, . Plasma citrulline concentration: A surrogate end point for radiation-induced mucosal atrophy of the small bowel. A feasibility study in 23 patients. Int J Radiat Oncol Biol Phys 2004;60:275–85.
  • Cox JD, Stetz J, Pajak TF. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys 1995;31:1341–6.
  • Onal C, Kayaselcuk F, Topkan E, Yavuz M, Bacanli D, Yavuz A. Protective effects of melatonin and octreotide against radiation-induced intestinal injury. Dig Dis Sci 2011; 56:359–67.
  • Giris M, Erbil Y, Oztezcan S, Olgac V, Barbaros U, Deveci U, . The effect of heme oxygenase-1 induction by glutamine on radiation-induced intestinal damage: The effect of heme oxygenase-1 on radiation enteritis. Am J Surg 2006;191:503–9.
  • Cancer Therapy Evaluation Program. Common Terminology Criteria for Adverse Events v3.0 (CTCAE). Bethesda, MD: National Cancer Institute; 2006.
  • Andreyev HJ. Gastrointestinal problems after pelvic radiotherapy: The past, the present and the future. Clin Oncol (R Coll Radiol) 2007;19:790–9.
  • Sonis ST, Elting LS, Keefe D, Peterson DE, Schubert M, Hauer-Jensen M, . Perspectives on cancer therapy-induced mucosal injury: Pathogenesis, measurement, epidemiology, and consequences for patients. Cancer 2004; 100(9 Suppl):1995–2025.
  • Windmueller HG. Glutamine utilization by the small intestine. Adv Enzymol Relat Areas Mol Biol 1982;53:201–37.
  • Wu G. Synthesis of citrulline and arginine from proline in enterocytes of postnatal pigs. Am J Physiol 1997;272(6 Pt 1): G1382–90.
  • Wakabayashi Y, Yamada E, Yoshida T, Takahashi N. Effect of intestinal resection and arginine-free diet on rat physiology. Am J Physiol 1995;269(2 Pt 1):G313–8.
  • Ioannou HP, Fotoulaki M, Pavlitou A, Efstratiou I, Augoustides-Savvopoulou P. Plasma citrulline levels in paediatric patients with celiac disease and the effect of a gluten-free diet. Eur J Gastroenterol Hepatol 2011;23: 245–9.
  • Gondolesi G, Ghirardo S, Raymond K, Hoppenhauer L, Surillo D, Rumbo C, . The value of plasma citrulline to predict mucosal injury in intestinal allografts. Am J Transplant 2006;6:2786–90.
  • Derikx JP, Blijlevens NM, Donnelly JP, Fujii H, Kanda T, van Bijnen AA, . Loss of enterocyte mass is accompanied by diminished turnover of enterocytes after myeloablative therapy in haematopoietic stem-cell transplant recipients. Ann Oncol 2009;20:337–42.
  • Onal C, Topkan E, Efe E, Yavuz M, Sonmez S, Yavuz A. Comparison of rectal volume definition techniques and their influence on rectal toxicity in patients with prostate cancer treated with 3D conformal radiotherapy: A dose-volume analysis. Radiat Oncol 2009;4:14.
  • Baglan KL, Frazier RC, Yan D, Huang RR, Martinez AA, Robertson JM. The dose-volume relationship of acute small bowel toxicity from concurrent 5-FU-based chemotherapy and radiation therapy for rectal cancer. Int J Radiat Oncol Biol Phys 2002;52:176–83.
  • Gunnlaugsson A, Kjellen E, Nilsson P, Bendahl PO, Willner J, Johnsson A. Dose-volume relationships between enteritis and irradiated bowel volumes during 5-fluorouracil and oxaliplatin based chemoradiotherapy in locally advanced rectal cancer. Acta Oncol 2007;46:937–44.
  • Kim CW, Kim JH, Yu CS, Shin US, Park JS, Jung KY, . Complications after sphincter-saving resection in rectal cancer patients according to whether chemoradiotherapy is performed before or after surgery. Int J Radiat Oncol Biol Phys 2010;78:156–63.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.