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Research Article

Prognostic value of Bcl-2 in two independent populations of estrogen receptor positive breast cancer patients treated with adjuvant endocrine therapy

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Pages 781-789 | Received 10 Oct 2011, Accepted 16 Dec 2012, Published online: 30 Mar 2012

References

  • , Early Breast Cancer Trialists’ Collaborative Group (EBCTCG)Davies C, Godwin J, Gray R, Clarke M, Cutter D, . Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: Patient-level meta- analysis of randomised trials. Lancet 2011;378:771–84.
  • Goldhirsch A, Ingle JN, Gelber RD, Coates AS, Thurlimann B, Senn H-J, . Thresholds for therapies: Highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2009. Ann Oncol 2009;20:1319–29.
  • Schorr K, Li M, Krajewski S, Reed JC, Furth PA. Bcl-2 gene family and related proteins in mammary gland involution and breast cancer. J Mammary Gland Biol Neoplasia 1999;4:153–64.
  • Larsen SS, Heiberg I, Lykkesfeldt AE. Anti-oestrogen resistant human breast cancer cell lines are more sensitive towards treatment with the vitamin D analogue EB1089 than parent MCF-7 cells. Br J Cancer 2001;84:686–90.
  • Callagy GM, Pharoah PD, Pinder SE, Hsu FD, Nielsen TO, Ragaz J, . Bcl-2 is a prognostic marker in breast cancer independently of the Nottingham Prognostic Index. Clin Cancer Res 2006;12:2468–75.
  • Cardoso F, Paesmans M, Larsimont D, Durbecq V, Bernard-Marty C, Rouas G, . Potential predictive value of Bcl-2 for response to tamoxifen in the adjuvant setting of node-positive breast cancer. Clin Breast Cancer 2004;5:364–69.
  • Dawson SJ, Makretsov N, Blows FM, Driver KE, Provenzano E, Le Quesne J, . BCL2 in breast cancer: A favourable prognostic marker across molecular subtypes and independent of adjuvant therapy received. Br J Cancer 2010;103:668–75.
  • Gasparini G, Barbareschi M, Doglioni C, Palma PD, Mauri FA, Boracchi P, . Expression of bcl-2 protein predicts efficacy of adjuvant treatments in operable node-positive breast cancer. Clin Cancer Res 1995;1:189–98.
  • Kim K, Chie EK, Han W, Noh D-Y, Park IA, Oh D-Y, . Prognostic value of p53 and bcl-2 expression in patients treated with breast conservative therapy. J Korean Med Sci 2010;25:235–9.
  • Yang Q, Moran MS, Haffty BG. Bcl-2 expression predicts local relapse for early-stage breast cancer receiving conserving surgery and radiotherapy. Breast Cancer Res Treat 2009;115:343–8.
  • Ihemelandu CU, Dewitty RL, Jr., Leffall LD, Jr., Suryanarayana SM, Frederick WA. Clinical significance of p53 and bcl-2 protein coexpression phenotypes in molecular breast cancer subtypes of pre-menopausal and post- menopausal African-American women. Am Surg 2009;75: 776–84.
  • Daidone MG, Luisi A, Veneroni S, Benini E, Silvestrini R. Clinical studies of Bcl-2 and treatment benefit in breast cancer patients. Endocr Relat Cancer 1999;6:61–8.
  • Moller S, Jensen MB, Ejlertsen B, Bjerre KD, Larsen M, Hansen HB, . The clinical database and the treatment guidelines of the Danish Breast Cancer Cooperative Group (DBCG); its 30-years experience and future promise. Acta Oncol 2008;47:506–24.
  • Mouridsen H, Giobbie-Hurder A, Goldhirsch A, Thurlimann B, Paridaens R, Smith I, . Letrozole therapy alone or in sequence with tamoxifen in women with breast cancer. N Engl J Med 2009;361:766–76.
  • Henriksen KL, Rasmussen BB, Lykkesfeldt AE, Moller S, Ejlertsen B, Mouridsen HT. Semi-quantitative scoring of potentially predictive markers for endocrine treatment of breast cancer: A comparison between whole sections and tissue microarrays. J Clin Pathol 2007;60:397–404.
  • Walter SD, Feinstein AR, Wells CK. Coding ordinal independent variables in multiple regression analyses. Am J Epidemiol 1987;125:319–23.

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