221
Views
12
CrossRef citations to date
0
Altmetric
Research Article

The Impact of Porphyromonas gingivalis Lipids on Apoptosis of Primary Human Chondrocytes

, , , , , , , , , , & show all
Pages 327-333 | Received 05 Jul 2011, Accepted 10 Jan 2012, Published online: 13 Feb 2012

References

  • Listgarten, M.A. (1986). Pathogenesis of periodontitis. Clin. Periodontol. 13:418–430.
  • Pischon, N., Heng, N., Bernimoulin, J.P., Kleber, B., Willich, S., and Pischon, T. (2007). Obesity, inflammation, and periodontal disease. J. Dent. Res. 86:400–409.
  • Tonetti, M.S. (2009). Periodontitis and risk for atherosclerosis: An update on intervention trials. J. Clin. Periodontol. 10:15–19.
  • dePablo, P., Chapple, I.L., Buckley, C.D., and Dietrich, T. (2009). Periodontitis in systemic rheumatic diseases. Nat. Rev. Rheumatol. 5:218–224.
  • Pischon, N., Pischon, T., Kröger, J., Gülmez, E., Kleber, B.M., Bernimoulin, J.P., Landau, H., Brinkmann, P.G., Schlattmann, P., Zernicke, J., Buttgereit, F., and Detert, J. (2008). Association among rheumatoid arthritis, oral hygiene, and periodontitis. J. Periodontol. 79:979–986.
  • Pischon, N., Pischon, T., Gülmez, E., Kröger, J., Purucker, P., Kleber, B.M., Landau, H., Jost-Brinkmann, P.G., Schlattmann, P., Zernicke, J., Burmester, G.R., Bernimoulin, J.P., Buttgereit, F., and Detert, J. (2010). Periodontal disease in patients with ankylosing spondylitis. Ann. Rheum. Dis. 69:34–38.
  • de Pablo, P., Dietrich, T., and McAlindon, T.E. (2008). Association of periodontal disease and tooth loss with rheumatoid arthritis in the US population. J. Rheumatol. 35:70–76.
  • Mercado, F.B., Marshall, R.I., Klestov, A.C., and Bartold, P.M. (2001). Relationship between rheumatoid arthritis and periodontitis. J. Periodontol. 72:779–787.
  • Symmons, D.P., Barrett, E.M., Bankhead, C.R., Scott, D.G., and Silman, A.J. (1994). The incidence of rheumatoid arthritis in the United Kingdom: Results from the Norfolk Arthritis register. Br. J. Rheumatol. 33:735–739.
  • Lee, M.L., and Weinblatt., M.E. (2001). Rheumatoid arthritis. Lancet 358:903–911.
  • Cimmino, M.A., Parisi, M., Moggiana, G., Mela, G.S., and Accardo, S. (1998). Prevalence of rheumatoid arthritis in Italy: The Chiavari study. Ann. Rheum. Dis. 57:315–318.
  • Rosenstein, E.D., Greenwald, R.A., Kushner, L.J., and Weissmann, G. (2004). Hypothesis: The humoral immune response to oral bacteria provides a stimulus for the development of rheumatoid arthritis. Inflammation 28:311–318.
  • Moen, K., Brun, J.G., Valen, M., Skartveit, M.L., Ribs Eribe, E.K., Olsen, I., and Jonsson, R. (1996). Synovial inflammation in active rheumatoid arthritis and psoriatic arthritis facilitates trapping of a variety of oral bacterial DNA’s. Clin. Exp. Rheumatol. 24:656–663.
  • Hara, Y., Kaneko, T., Yoshimura, A., and Kato, I. (1996). Serum rheumatoid factor induced by intraperitoneal administration of periodontopathic bacterial lipopolysaccharide in mice. J. Periodont. Res. 31:502–507.
  • Mikuls, T.R., Payne, J.B., Reinhardt, R.A., Thiele, G.M., Maziarz, E., Cannella, A.C., Holers, V.M., Kuhn, K.A., and O’Dell, J.R. (2009). Antibody responses to Porphyromonas gingivalis in subjects with rheumatoid arthritis and periodontitis. Int. Immunopharmacol. 9:38–42.
  • Ogrendik, M., Hakguder, A., and Keser, N. (2006). Treatment of rheumatoid arthritis with ornidazole. A randomized, double-blind, placebo-controlled study. Rheumatology 45:636–637.
  • Liao, F., Li, Z., Wang, Y., Shi, B., Gong, Z., and Cheng, X. (2009). Porphyromonas gingivalis may play an important role in the pathogenesis of periodontitis-associated rheumatoid arthritis. Med. Hypotheses 72:732–735.
  • Haffajee, A.D., and Socransky, S.S. (1994). Microbial etiological agents of destructive periodontal diseases. Periodontol. 2000 5:78–111.
  • McGraw, W.T., Potempa, J., Farley, D., and Travis, J. (1999). Purification, characterization, and sequence analysis of a potential virulence factor from Porphyromonas gingivalis, peptidylarginine deiminase. Infect Immun. 67:3248–3256.
  • Zahlten, J., Riep, B., Nichols, F.C., Walter, C., Schmeck, B., Bernimoulin, J.P., and Hippenstiel, S. (2007). Porphyromonas gingivalis dihydroceramides induce apoptosis in endothelial cells. J. Dent. Res. 86:635–640.
  • Urnowey, S., Ansai, T., Bitko, V., Nakayama, K., Takehara, T., and Barik, S. (2006). Temporal activation of anti- and pro-apoptotic factors in human gingival fibroblasts infected with the periodontal pathogen, Porphyromonas gingivalis: Potential role of bacterial proteases in host signalling. BMC Microbiol. 6:26.
  • Holt, S.C., Kesavalu, L., Walker, S., and Genco, C.A. (1999). Virulence factors of Porphyromonas gingivalis. Periodontol. 2000 20:168–238.
  • Nichols, F.C., Riep, B., Mun, J., Morton, M.D., Bojarski, M.T., Dewhirst, F.E., and Smith, M.B. (2004). Structures and biological activity of phosphorylated dihydroceramides of Porphyromonas gingivalis. J. Lipid Res. 45:2317–2330.
  • Pischon, N., Röhner, E., Hocke, A., N’Guessan, P., Müller, H.C., Matziolis, G., Kanitz, V., Purucker, P., Kleber, B.M., Bernimoulin, J.P., Burmester, G., Buttgereit, F., and Detert, J. (2009). Effects of Porphyromonas gingivalis on cell cycle progression and apoptosis of primary human chondrocytes. Ann. Rheum. Dis. 68:1902–1907.
  • Röhner, E., Detert, J., Kolar, P., Hocke, A., N’Guessan, P., Matziolis, G., Kanitz, V., Bernimoulin, J.P., Kielbassa, A., Burmester, G.R., Buttgereit, F., and Pischon, N. (2010). Induced apoptosis of chondrocytes by Porphyromonas gingivalis as a possible pathway for cartilage loss in rheumatoid arthritis. Cal. Tiss. Int. 87:333–340.
  • Klamfeldt, A. (1986). Degradation of bovine articular cartilage proteoglycans in vitro. The effect of bacteroides gingivalis. Scand. J. Rheumatol. 15:297–301.
  • Dorn, B.R., Burks, J.N., Seifert, K.N., and Progulske-Fox, A. (2000). Invasion of endothelial and epithelial cells by strains of Porphyromonas gingivalis. FEMS Microbiol. Lett. 187:139–144.
  • Ronnelid, J., Lysholm, J., Engstrom-Laurent, A., Klareskog, L., and Heyman, B. (1994). Local anti-type II collagen antibody production in rheumatoid arthritis synovial fluid. Arthritis Rheum. 37:1023–1029.
  • Gregersen, P.K., Silver, J., and Winchester, R.J. (1987). The shared epitope hypothesis. Arthritis Rheum. 30:1205–1213.
  • Nichols, F.C., Levinbook, H., Shnaydman, M., and Prostaglandin, G.J. (2001). E2 secretion from gingival fibroblasts treated with interleukin-1 beta: Effects of lipid extracts from Porphyromonas gingivalis or calculus. J. Lipid Res. 36:142–152.
  • Nichols, F.C. (1994). Distribution of 3-hydroxy iC17:0 in subgingival plaque and gingival tissue samples: Relationship to adult periodontitis. Infect. Immun. 62:3753–3760.
  • Nichols, F.C., and Rojanasomsith, K. (2006). Porphyromonas gingivalis lipids and diseased dental tissues. Oral Microbiol. Immunol. 21:84–92.
  • Huwiler, A., Kolter, T., Pfeilschifter, J., and Sandhoff, K. (2000). Physiology and pathophysiology of sphingolipid metabolism and signaling. Biochim. Biophys. Acta 31:63–99.
  • Hisano, N., Yatomi, Y., Satoh, K., Akimoto, S., Mitsumata, M., Fujino, M.A., and Ozaki, Y. (1999). Induction and suppression of endothelial cell apoptosis by sphingolipids: a possible in vitro model for cell–cell interactions between platelets and endothelial cells. Blood 93:4293–4299.
  • Obeid, L.M., Linardic, C.M., Karolak, L.A., and Hannun, Y.A. (1993). Programmed cell death induced by ceramide. Science 259:1769–1771.
  • Nichols, F.C., Yao, X., Bajrami, B., Downes, J., Finegold, S.M., Knee, E., Gallagher, J.J., Housley, W.J., and Clark, R.B. (2011). Phosphorylated dihydroceramides from common human bacteria are recovered in human tissues. PLoS One 6:e16771.
  • Jasin, H.E. (1983). Bacterial lipopolysaccharides induce in vitro degradation of cartilage matrix through chondrocyte activation. J. Clin. Invest. 72:2014–2019.
  • Forner, L., Larsen, T., Kilian, M., and Holmstrup, P. (2006). Incidence of bacteremia after chewing, tooth brushing and scaling in individuals with periodontal inflammation. J. Clin. Periodontol. 33:401–407.
  • Kim, H.A., and Song, Y.W. (1999). Apoptotic Chondrocyte death in rheumatoid arthritis. Arthritis Rheum. 42:1528–1537.
  • Minamino, M., Sakaguchi, I., Naka, T., Ikeda, N., Kato, Y., Tomiyasu, I., Yano, I., and Kobayashi, K. (2003). Bacterial ceramides and sphingophospholipids induce apoptosis of human leukemic cells. Microbiology. 149:2071–2081.
  • Bühling, K., Lepenies, J., and Witt, K. (2004). Intensivkurs Allgemeine Und Spezielle Pathologie. 3. Auflage. München: Urban und Fischer.
  • Simon, U. (1997). Programmierter Zelltod. Dtsch. Med. Wschr. 122:167–168.
  • Porter, A.G., and Jänicke, R.U. (1999). Emerging roles of caspase-3 in apoptosis. Cell Death Diff. 6:99–104.
  • van Engeland, M., Nieland, L.J., Ramaekers, F.C., Schutte, B., and Reutelingsperger, C.P. (1998). Annexin V-affinity assay: A review on an apoptosis detection system based on phosphatidylserine exposure. Cytometry 31:1–9.
  • Shikata, Y., Birukov, K.G., Birukova, A.A., Verin, A., and Garcia, J.G. (2003). Involvement of site-specific FAK phosphorylation in sphingosine-1 phosphate- and thrombin-induced focal adhesion remodeling: Role of Src and GIT. FASEB J. 17:2240–2249.
  • Wang, Y.H., Jiang, J., Zhu, Q., AlAnezi, A.Z., Clark, R.B., Jiang, X., Rowe, D.W., and Nichols, F.C. (2010). Porphyromonas gingivalis lipids inhibit osteoblastic differentiation and function. Infect. Immun. 78:3726–3735.
  • Walker, N.I., Harmon, B.V., Gobe, G.C., and Kerr, J.V. (1988). Patterns of cell death. Methods Achiev. Exp. Pathol. 13:18–54.
  • Röhner, E., Matzilois, G., Perka, C., Füchtmeier, B., Gaber, T., Burmester, G.R., Buttgereit, F., and Hoff, P. (2011). Inflammatory synovial fluid microenvironment drives primary human chondrocytes to actively take part in inflammatory joint diseases. Immunol. Res. [Epub ahead of print].

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.