Glioblastoma—a moving target

References

• Preusser M, de Ribaupierre S, Wohrer A, Erridge SC, Hegi M, Weller M, Current concepts and management of glioblastoma. Ann Neurol. 2011;70:9–21.
   PubMed Web of Science ®Google Scholar
• Ponten J, Macintyre EH. Long term culture of normal and neoplastic human glia. Acta Pathol Microbiol Scand. 1968;74:465–86.
   PubMedGoogle Scholar
• Westermark B, Ponten J, Hugosson R. Determinants for the establishment of permanent tissue culture lines from human gliomas. Acta Pathol Microbiol Scand A. 1973;81:791–805.
   PubMedGoogle Scholar
• Bigner DD, Bigner SH, Ponten J, Westermark B, Mahaley MS, Ruoslahti E, Heterogeneity of genotypic and phenotypic characteristics of fifteen permanent cell lines derived from human gliomas. J Neuropathol Exp Neurol. 1981;40:201–29.
   PubMed Web of Science ®Google Scholar
• Studer A, de Tribolet N, Diserens AC, Gaide AC, Matthieu JM, Carrel S, Characterization of four human malignant glioma cell lines. Acta Neuropathol. 1985;66:208–17.
   PubMed Web of Science ®Google Scholar
• Rutka JT, Giblin JR, Dougherty DY, Liu HC, McCulloch JR, Bell CW, Establishment and characterization of five cell lines derived from human malignant gliomas. Acta Neuropathol. 1987;75:92–103.
   PubMed Web of Science ®Google Scholar
• Cohen S. Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. J Biol Chem. 1962;237:1555–62.
   PubMed Web of Science ®Google Scholar
• Carpenter G, Lembach KJ, Morrison MM, Cohen S. Characterization of the binding of 125-I-labeled epidermal growth factor to human fibroblasts. J Biol Chem. 1975;250:4297–304.
   PubMed Web of Science ®Google Scholar
• Westermark B, Magnusson A, Heldin CH. Effect of epidermal growth factor on membrane motility and cell locomotion in cultures of human clonal glioma cells. J Neurosci Res. 1982;8:491–507.
   PubMed Web of Science ®Google Scholar
• Libermann TA, Razon N, Bartal AD, Yarden Y, Schlessinger J, Soreq H. Expression of epidermal growth factor receptors in human brain tumors. Cancer Res. 1984;44:753–60.
   PubMed Web of Science ®Google Scholar
• Libermann TA, Nusbaum HR, Razon N, Kris R, Lax I, Soreq H, Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin. Nature. 1985;313:144–7.
   PubMed Web of Science ®Google Scholar
• Bigner SH, Mark J, Burger PC, Mahaley MS Jr, Bullard DE, Muhlbaier LH, Specific chromosomal abnormalities in malignant human gliomas. Cancer Res. 1988;48:405–11.
   PubMed Web of Science ®Google Scholar
• Kinzler KW, Bigner SH, Bigner DD, Trent JM, Law ML, O'Brien SJ, Identification of an amplified, highly expressed gene in a human glioma. Science. 1987;236:70–3.
   PubMed Web of Science ®Google Scholar
• Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science. 1997;275:1943–7.
   PubMed Web of Science ®Google Scholar
• Kamb A, Gruis NA, Weaver-Feldhaus J, Liu Q, Harshman K, Tavtigian SV, A cell cycle regulator potentially involved in genesis of many tumor types. Science. 1994;264:436–40.
   PubMed Web of Science ®Google Scholar
• Westermark B. The deficient density-dependent growth control of human malignant glioma cells and virus-transformed glia-like cells in culture. Int J Cancer. 1973;12:438–51.
   PubMed Web of Science ®Google Scholar
• Ponten J, Westermark B, Hugosson R. Regulation of proliferation and movement of human glialike cells in culture. Exp Cell Res. 1969;58:393–400.
   PubMed Web of Science ®Google Scholar
• Holley RW, Kiernan JA. "Contact inhibition" of cell division in 3T3 cells. Proc Natl Acad Sci USA. 1968;60:300–4.
   PubMed Web of Science ®Google Scholar
• Sporn MB, Todaro GJ. Autocrine secretion and malignant transformation of cells. N Engl J Med. 1980;303:878–80.
   PubMed Web of Science ®Google Scholar
• Heldin CH, Westermark B, Wasteson A. Chemical and biological properties of a growth factor from human-cultured osteosarcoma cells: resemblance with platelet-derived growth factor. J Cell Physiol. 1980;105:235–46.
   PubMed Web of Science ®Google Scholar
• Heldin CH, Johnsson A, Wennergren S, Wernstedt C, Betsholtz C, Westermark B. A human osteosarcoma cell line secretes a growth factor structurally related to a homodimer of PDGF A-chains. Nature. 1986;319:511–14.
   PubMed Web of Science ®Google Scholar
• Nister M, Hammacher A, Mellstrom K, Siegbahn A, Ronnstrand L, Westermark B, A glioma-derived PDGF A chain homodimer has different functional activities from a PDGF AB heterodimer purified from human platelets. Cell. 1988;52:791–9.
   PubMed Web of Science ®Google Scholar
• Hammacher A, Nister M, Westermark B, Heldin CH. A human glioma cell line secretes three structurally and functionally different dimeric forms of platelet-derived growth factor. Eur J Biochem. 1988;176:179–86.
   PubMedGoogle Scholar
• Betsholtz C, Johnsson A, Heldin CH, Westermark B, Lind P, Urdea MS, cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines. Nature. 1986;320:695–9.
   PubMed Web of Science ®Google Scholar
• Hermanson M, Funa K, Hartman M, Claesson-Welsh L, Heldin CH, Westermark B, Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops. Cancer Res. 1992;52:3213–19.
   PubMed Web of Science ®Google Scholar
• Doolittle RF, Hunkapiller MW, Hood LE, Devare SG, Robbins KC, Aaronson SA, Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor. Science. 1983;221:275–7.
   PubMed Web of Science ®Google Scholar
• Waterfield MD, Scrace GT, Whittle N, Stroobant P, Johnsson A, Wasteson A, Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus. Nature. 1983;304:35–9.
   PubMed Web of Science ®Google Scholar
• Heldin CH, Westermark B. Growth factors: mechanism of action and relation to oncogenes. Cell. 1984;37:9–20.
   PubMed Web of Science ®Google Scholar
• Deinhardt F. editor. Biology of primate retroviruses. New York: Raven Press; 1980.
   Google Scholar
• Westermark B, Johnsson A, Betsholtz C, Heldin CH. editors. Biological properties of simian sarcoma virus and its oncogene product. Basel: Karger; 1987.
   Google Scholar
• Uhrbom L, Hesselager G, Nister M, Westermark B. Induction of brain tumors in mice using a recombinant platelet-derived growth factor B-chain retrovirus. Cancer Res. 1998;58:5275–9.
   PubMed Web of Science ®Google Scholar
• Johansson FK, Brodd J, Eklof C, Ferletta M, Hesselager G, Tiger CF, Identification of candidate cancer-causing genes in mouse brain tumors by retroviral tagging. Proc Natl Acad Sci USA. 2004;101:11334–7.
   PubMed Web of Science ®Google Scholar
• Ferletta M, Uhrbom L, Olofsson T, Ponten F, Westermark B. Sox10 has a broad expression pattern in gliomas and enhances platelet-derived growth factor-B–induced gliomagenesis. Mol Cancer Res. 2007;5:891–7.
   PubMed Web of Science ®Google Scholar
• Tchougounova E, Jiang Y, Brasater D, Lindberg N, Kastemar M, Asplund A, Sox5 can suppress platelet-derived growth factor B-induced glioma development in Ink4a-deficient mice through induction of acute cellular senescence. Oncogene. 2009;28:1537–48.
   PubMed Web of Science ®Google Scholar
• Westermark UK, Lindberg N, Roswall P, Brasater D, Helgadottir HR, Hede SM, RAD51 can inhibit PDGF-B-induced gliomagenesis and genomic instability. Neuro Oncol. 2011;13:1277–87.
   PubMed Web of Science ®Google Scholar
• Wolf RM, Draghi N, Liang X, Dai C, Uhrbom L, Eklof C, p190RhoGAP can act to inhibit PDGF-induced gliomas in mice: a putative tumor suppressor encoded on human chromosome 19q13.3. Genes Dev. 2003;17:476–87.
   Google Scholar
• Phillips JJ, Huillard E, Robinson AE, Ward A, Lum DH, Polley MY, Heparan sulfate sulfatase SULF2 regulates PDGFRalpha signaling and growth in human and mouse malignant glioma. J Clin Invest. 2012;122:911–22.
   PubMed Web of Science ®Google Scholar
• Fleming TP, Saxena A, Clark WC, Robertson JT, Oldfield EH, Aaronson SA, Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors. Cancer Res. 1992;52:4550–3.
   PubMed Web of Science ®Google Scholar
• Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature. 2008;455:1061–8.
   PubMed Web of Science ®Google Scholar
• Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD, Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell. 2010;17:98–110.
   PubMed Web of Science ®Google Scholar
• Jiang Y, Uhrbom L, On the origin of glioma. Ups J Med Sci. 2012;117:113–21.
   PubMed Web of Science ®Google Scholar
• Lindberg N, Holland EC, PDGF in gliomas: more than just a growth factor? Ups J Med Sci. 2012;117:92–8.
   PubMed Web of Science ®Google Scholar
• Nazarenko I, Hede S-M, He X, Hedrén A, Thompson J, Lindström MS, PDGF and PDGF receptors in glioma Ups J Med Sci. 2012;117:99–112.
   PubMed Web of Science ®Google Scholar
• Keunen O, Johansson M, Oudin A, Sanzey M, Rahim SA, Fack F, Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma. Proc Natl Acad Sci USA. 2011;108:3749–54.
   PubMed Web of Science ®Google Scholar
• Nowell PC. The clonal evolution of tumor cell populations. Science. 1976;194:23–8.
   PubMed Web of Science ®Google Scholar
• Vogelstein B, Fearon ER, Hamilton SR, Kern SE, Preisinger AC, Leppert M, Genetic alterations during colorectal-tumor development. N Engl J Med. 1988;319:525–32.
   PubMed Web of Science ®Google Scholar
• Gupta PB, Chaffer CL, Weinberg RA. Cancer stem cells: mirage or reality? Nat Med. 2009;15:1010–12.
   PubMed Web of Science ®Google Scholar
• Venere M, Fine HA, Dirks PB, Rich JN. Cancer stem cells in gliomas: identifying and understanding the apex cell in cancer's hierarchy. Glia. 2011;59:1148–54.
   PubMed Web of Science ®Google Scholar
• Ikushima H, Todo T, Ino Y, Takahashi M, Miyazawa K, Miyazono K. Autocrine TGF-beta signaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors. Cell Stem Cell. 2009;5:504–14.
   PubMed Web of Science ®Google Scholar
• Ikushima H, Todo T, Ino Y, Takahashi M, Saito N, Miyazawa K, Glioma-initiating cells retain their tumorigenicity through integration of the Sox axis and Oct4 protein. J Biol Chem. 2011;286:41434–41.
   PubMed Web of Science ®Google Scholar
• Piccirillo SG, Reynolds BA, Zanetti N, Lamorte G, Binda E, Broggi G, Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells. Nature. 2006;444:761–5.
   PubMed Web of Science ®Google Scholar
• Ferletta M, Caglayan D, Mokvist L, Jiang Y, Kastemar M, Uhrbom L, Forced expression of Sox21 inhibits Sox2 and induces apoptosis in human glioma cells. Int J Cancer. 2011;129:45–60.
   PubMed Web of Science ®Google Scholar
• Sandberg M, Kallstrom M, Muhr J. Sox21 promotes the progression of vertebrate neurogenesis. Nat Neurosci. 2005;8:995–1001.
   PubMed Web of Science ®Google Scholar
• Herrera B, Inman GJ. A rapid and sensitive bioassay for the simultaneous measurement of multiple bone morphogenetic proteins. Identification and quantification of BMP4, BMP6 and BMP9 in bovine and human serum. BMC Cell Biol. 2009;10:20.
   PubMedGoogle Scholar