Alternative diagnosis to heparin-induced thrombocytopenia in two critically ill patients despite a positive PF4/heparin-antibody test

References

• Greinacher A, Selleng K. Thrombocytopenia in the intensive care unit patient. Hematology Am Soc Hematol Educ Program. 2010;2010:135–43.
   PubMedGoogle Scholar
• Greinacher A, Eichler P, Lubenow N, Kiefel V. Drug-induced and drug-dependent immune thrombocytopenias. Rev Clin Exp Hematol. 2001;5:166–200.
   PubMedGoogle Scholar
• Greinacher A, Juhl D, Strobel U, Wessel A, Lubenow N, Selleng K, et al. Heparin-induced thrombocytopenia: a prospective study on the incidence, platelet-activating capacity and clinical significance of antiplatelet factor 4/heparin antibodies of the IgG, IgM, and IgA classes. J Thromb Haemost. 2007;5:1666–73.
   PubMed Web of Science ®Google Scholar
• Lo GK, Sigouin CS, Warkentin TE. What is the potential for overdiagnosis of heparin-induced thrombocytopenia? Am J Hematol. 2007;82:1037–43.
   PubMed Web of Science ®Google Scholar
• Selleng S, Malowsky B, Strobel U, Wessel A, Ittermann T, Wollert HG, et al. Early-onset and persisting thrombocytopenia in post-cardiac surgery patients is rarely due to heparin-induced thrombocytopenia, even when antibody tests are positive. J Thromb Haemost. 2010;8:30–6.
   PubMed Web of Science ®Google Scholar
• Lo GK, Juhl D, Warkentin TE, Sigouin CS, Eichler P, Greinacher A. Evaluation of pretest clinical score (4 T's) for the diagnosis of heparin-induced thrombocytopenia in two clinical settings. J Thromb Haemost. 2006;4:759–65.
   PubMed Web of Science ®Google Scholar
• Cuker A, Arepally G, Crowther MA, Rice L, Datko F, Hook K, et al. The HIT Expert Probability (HEP) Score: a novel pre-test probability model for heparin-induced thrombocytopenia based on broad expert opinion. J Thromb Haemost. 2010;8:2642–50.
   PubMed Web of Science ®Google Scholar
• Messmore HL, Fabbrini N, Bird ML, Choudhury AM, Cerejo M, Prechel M, et al. Simple scoring system for early management of heparin-induced thrombocytopenia. Clin Appl Thromb Hemost. 2011;17:197–201.
   PubMed Web of Science ®Google Scholar
• Kiefel V, Santoso S, Weisheit M, Müeller-Eckhardt C. Monoclonal antibody-specific immobilization of platelet antigens (MAIPA): a new tool for the identification of platelet-reactive antibodies. Blood. 1987;70:1722–6.
   PubMed Web of Science ®Google Scholar
• Eichler P, Budde U, Haas S, Kroll H, Loreth RM, Meyer O, et al. First workshop for detection of heparin-induced antibodies: validation of the heparin-induced platelet-activation test (HIPA) in comparison with a PF4/heparin ELISA. Thromb Haemost. 1999;81:625–9.
   PubMed Web of Science ®Google Scholar
• Warkentin TE, Greinacher A, Koster A, Lincoff AM. Treatment and prevention of heparin-induced thrombocytopenia: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. 2008;133:340S–80S.
   PubMed Web of Science ®Google Scholar
• Martel N, Lee J, Wells PS. Risk for heparin-induced thrombocytopenia with unfractionated and low-molecular-weight heparin thromboprophylaxis: a meta-analysis. Blood. 2005;106:2710–15.
   PubMed Web of Science ®Google Scholar
• Yan MT, Chu HY, Chau T, Lin SH. Profound thrombocytopenia associated with piperacillin in a hemodialysis patient. Clin Nephrol. 2009;72:240–3.
   Google Scholar
• Kumar A, Choudhuri G, Aggarwal R. Piperacillin induced bone marrow suppression: a case report. BMC Clin Pharmacol. 2003;3:2.
   Google Scholar
• Lin SY, Huang JC, Shen MC, Chuang SH, Lee MH, Chen HC. Piperacillin-induced thrombocytopenia reversed by high-flux hemodialysis in an uremic patient. Hemodial Int. 2012;16:S50–3.
   Google Scholar
• Perez-Vazquez A, Pastor JM, Riancho JA. Immune thrombocytopenia caused by piperacillin/tazobactam. Clin Infect Dis. 1998;27:650–1.
   PubMed Web of Science ®Google Scholar
• Olivera E, Lakhani P, Watanakunakorn C. Isolated severe thrombocytopenia and bleeding caused by piperacillin. Scand J Infect Dis. 1992;24:815–17.
   PubMed Web of Science ®Google Scholar
• Rousan TA, Aldoss IT, Cowley BD Jr, Curtis BR, Bougie DW, Aster RH, et al. Recurrent acute thrombocytopenia in the hospitalized patient: sepsis, DIC, HIT, or antibiotic-induced thrombocytopenia. Am J Hematol. 2010;85:71–4.
   PubMed Web of Science ®Google Scholar
• Hendrickson JE, Hillyer CD. Noninfectious serious hazards of transfusion. Anesth Analg. 2009;108:759–69.
   PubMed Web of Science ®Google Scholar
• Lubenow N, Eichler P, Albrecht D, Carlsson LE, Kothmann J, Rossocha WR, et al. Very low platelet counts in post-transfusion purpura falsely diagnosed as heparin-induced thrombocytopenia. Report of four cases and review of literature. Thromb Res. 2000;100:115–25.
   Google Scholar
• Hron G, Greinacher A. Advances in the treatment of heparin-induced thrombocytopenia: latest clinical data. Clin Invest. 2011;1:1301–14.
   Google Scholar
• Bakchoul T, Giptner A, Najaoui A, Bein G, Santoso S, Sachs UJ. Prospective evaluation of PF4/heparin immunoassays for the diagnosis of heparin-induced thrombocytopenia. J Thromb Haemost. 2009;7:1260–5.
   PubMed Web of Science ®Google Scholar
• Lindhoff-Last E, Gerdsen F, Ackermann H, Bauersachs R. Determination of heparin-platelet factor 4-IgG antibodies improves diagnosis of heparin-induced thrombocytopenia. Br J Haematol. 2001;113:886–90.
   PubMed Web of Science ®Google Scholar