71
Views
2
CrossRef citations to date
0
Altmetric
Original Article

Tracing Tissues with N-Nitrosamine-metabolizing Capacity

Pages 273-281 | Published online: 18 Jan 2010

References

  • Althoff J. Simultaneous tumours in the respiratory system and urinary bladder of Syrian golden hamsters. Z. Krebforsch. 1974; 82: 153–158
  • Appel K. E., Ruf H. H., Mahr B., Schwarz M., Rickart R., Kunz W. Binding of nitrosamines to cytochrome P-450 of liver microsomes. Chem.-Biol. Interact. 1979; 28: 17–33
  • Boyd M. R. Evidence for the Clara cells as a site of cytochrome P450-dependent mixed-function oxidase activity in the lungs. Nature 1977; 269: 713–715
  • Brittebo E. B., Löfberg B., Tjälve H. Sites of metabolism of N-nitrosodiethylamine in mice. Chem.-Biol. Interact. 1981; 34: 209–221
  • Brittebo E. B., Löfberg B., Tjälve H. Extrahepatic sites of metabolism of N-nitrosopyrrolidine in mice and rats. Xenobiotica 1981; 11: 619–625
  • Brittebo E. B., Tjälve H. Tissue-specificity of N-nitrosodibutylamine metabolism in Sprague-Dawley rats. Chem.-Biol. Interact. 1982; 38: 231–242
  • Brittebo E. B., Tjälve H. Formation of tissue-bound N′-nitrosonornicotine metabolites by the target tissues of Sprague-Dawley and Fischer rats. Carcinogenesis 1981; 2: 959–963
  • Castonguay A., Tjälve H., Hecht S. S. Tissue distribution of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its metabolites in F344 rats. Cancer Res. 1983; 43: 630–638
  • Dahl A. R., Hadley W. M., Hahn F. F., Benson J. M., McClellan R. O. Cytochrome P-450-dependent monooxygenases in the olfactory epithelium of dogs: possible role in tumorigenicity. Science 1982; 216: 57–59
  • Endou H. Cytochrome P-450 monooxygenase system in the rabbit kidney: Its intranephron localization and its induction. Jpn J. Pharmacol. 1983; 33: 423–430
  • Greenblatt M., Lijinsky W. Failure to induce tumours in Swiss mice after concurrent administration of amino acids and sodium nitrite. J. Natl Cancer Inst. 1972; 48: 1389–1392
  • Griciute L., Castegnaro M., Bereziat J.-C. Influence of ethyl alcohol on carcinogenesis with N-nitrosodimethylamine. Cancer Lett. 1981; 13: 345–352
  • Hecht S. S., Chen C. B., Ohmori T., Hoffmann D. Comparative carcinogenicity in F344 rats of the tobacco-specific nitrosamines, N′-nitrosonornicotine and 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone. Cancer Res. 1980; 40: 298–302
  • Hecht S. S., Adams J. D., Numoto S., Hoffmann D. Induction of respiratory tract tumours in Syrian golden hamsters by a single dose of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and the effect of smoke inhalation. Carcinogenesis 1983; 4: 1287–1290
  • Herrold K. M., Dunham L. J. Induction of tumors in the Syrian hamster with diethylnitrosamine (N-nitrosodiethylamine). Cancer Res. 1963; 23: 773–777
  • Hoffmann D., Rainieri R., Hecht S. S., Maronpot R. R. Effects of N′-nitrosonornicotine and N′-nitrosoanabasine in rats. J. Natl Cancer Inst. 1975; 55: 977–981
  • Hoffmann D., Castonguay A., Rivenson A., Hecht S. S. Comparative carcinogenicity and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N′-nitrosonornicotine in Syrian golden hamsters. Cancer Res. 1981; 41: 2386–2393
  • IARC. Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans. Some N-Nitroso Compounds. IARC, Lyon 1980; Vol. 17
  • Johansson E. B., Tjälve H. The distribution of [14C]dimethylnitrosamine in mice: autoradiographic studies in mice with inhibited and non-inhibited dimethylnitrosamine metabolism and a comparison with the distribution of [14C]formaldehyde. Toxicol. Appl. Pharmacol. 1978; 45: 565–575
  • Johansson-Brittebo E., Tjälve H. Studies on the tissue-disposition and fate of N-[14C]ethyl-N-nitrosourea in mice. Toxicology 1979; 13: 275–285
  • Labuc G. E., Archer M. C. Esophageal and hepatic microsomal metabolism of N′-nitrosomethylbenzylamine and N-nitrosodimethylamine in the rat. Cancer Res. 1982; 42: 3181–3186
  • Lai D. Y., Arcos J. C., Argus M. F. Factors influencing the microsomeand mitochondria-catalyzed in vitro binding of diethylnitrosamine and N-nitrosopiperidine to deoxyribonucleic acid. Biochem. Pharmacol. 1979; 28: 3545–3550
  • Lijinsky W., Taylor H. W. The effect of substituents on the carcinogenicity of N-nitrosopyrrolidine in Sprague-Dawley rats. Cancer Res. 1976; 36: 1988–1990
  • Löfberg B., Tjälve H. The disposition and metabolism of N-nitrosodiethylamine in adult, infant and foetal tissues of the Syrian golden hamster. Acta Pharmacol. Toxicol. 1984; 54: 104–114
  • Löfberg B., Tjälve H. Perinatal metabolism of N-nitrosodibutylamine in Syrian golden hamsters. Cancer Lett. 1986; 31: 153–161
  • Löfberg B., Tjälve H. Autoradiography of [14C]N-nitrosodiethanolamine in Sprague-Dawley rats. Cancer Lett. 1985; 26: 129–137
  • Löfberg B., Brittebo E. B., Tjälve H. Localization and binding of N′-nitrosonornicotine metabolites in the nasal region and in some other tissues of Sprague-Dawley rats. Cancer Res. 1982; 42: 2877–2883
  • Löfberg B., Tjälve H. Tracing tissues with chloroform-metabolizing capacity in rats. Toxicology 1986; 39: 13–35
  • Lu A. Y.H., West S. B. Multiplicity of mammalian microsomal cytochromes P-450. Pharmacol. Rev. 1980; 31: 277–295
  • Mohr U., Althoff J., Schmähl D., Krüger F. W. The carcinogenic effect of dibutylnitrosamine in Syrian and Chinese hamsters. Z. Krebsforsch. 1970; 74: 112–113
  • Rao G. S. Drug metabolism in oral soft tissues. Pharm. Int. 1983; 4: 103–107
  • Preussmann R., Habs M., Habs H., Schmähl D. Carcinogenicity of N-nitrosodiethanolamine in rats at five different dose levels. Cancer Res. 1982; 42: 5167–5171
  • Okada M. Comparative metabolism of N-nitrosamines in relation to their organ and species specificity. N-Nitroso Compounds: Occurrence, Biological Effects and Relevance to Human Cancer, I. K. O'Neill, R. C. von Borstel, C. T. Miller, J. Long, H. Bartsch. IARC, Lyon 1984; 401–409, IARC Scientific Publications No. 57
  • Rogers A. E., Sanchez O., Feinsod F. M., Newberne P. M. Dietary enhancement of nitrosamine carcinogenesis. Cancer Res. 1974; 34: 96–99
  • Singer G. M., Taylor H. W. Carcinogenicity of N′-nitrosonornicotine in Sprague-Dawley rats. J. Natl Cancer Inst. 1976; 57: 1275–1276
  • Tjälve H., Castonguay A. The in vivo tissue disposition and in vitro target-tissue metabolism of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in Syrian golden hamsters. Carcinogenesis 1983; 4: 1259–1265
  • Tjälve H., Löfberg B. Extrahepatic sites of metabolism of carbon tetrachloride in rats. Chem.-Biol. Interact. 1983; 46: 299–316
  • Tjälve H., Castonguay A., Rivenson A. Microautoradiographic localization of bound metabolites in the nasal cavities of F344 rats treated with the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3 -pyridyl)-1-butanone. J. Natl Cancer Inst. 1985; 74: 185–189
  • Voigt J. M., Guengerich F. P., Baron J. Localization of a cytochrome P-450 isozyme (cytochrome P-450 PB-B) and NADPH-cytochrome P-450 reductase in rat nasal mucosa. Cancer Lett. 1985; 27: 241–247

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.