Altered sequence of the ETS1 transcription factor may predispose to rheumatoid arthritis susceptibility

References

• Iguchi T, Ziff M. Electron microscopic study of rheumatoid synovial vasculature. Intimate relationship between tall endothelium and lymphoid aggregation. J Clin Invest 1986;77:355–61.
   PubMed Web of Science ®Google Scholar
• FitzGerald O, Soden M, Yanni G, Robinson R, Bresnihan B. Morphometric analysis of blood vessels in synovial membranes obtained from clinically affected and unaffected knee joints of patients with rheumatoid arthritis. Ann Rheum Dis 1991;50:792–6.
   PubMed Web of Science ®Google Scholar
• Dieude P. Rheumatic diseases: environment and genetics. Joint Bone Spine 2009;76:602–7.
   PubMed Web of Science ®Google Scholar
• Deighton CM, Walker DJ, Griffiths ID, Roberts DF. The contribution of HLA to rheumatoid arthritis. Clin Genet 1989;36:178–82.
   PubMed Web of Science ®Google Scholar
• Barton A, Worthington J. Genetic susceptibility to rheumatoid arthritis: an emerging picture. Arthritis Rheum 2009;61:1441–6.
   PubMed Web of Science ®Google Scholar
• He CF, Liu YS, Cheng YL, Gao JP, Pan TM, Han JW, . TNIP1, SLC15A4, ETS1, RasGRP3 and IKZF1 are associated with clinical features of systemic lupus erythematosus in a Chinese Han population. Lupus 2010;19:1181–6.
   PubMed Web of Science ®Google Scholar
• Yang W, Shen N, Ye DQ, Liu Q, Zhang Y, Qian XX, . Asian Lupus Genetics Consortium (ALGC). Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus. PLoS Genet 2010;6:e1000841.
   PubMed Web of Science ®Google Scholar
• Sullivan KE, Piliero LM, Dharia T, Goldman D, Petri MA. 3′ polymorphisms of ETS1 are associated with different clinical phenotypes in SLE. Hum Mutat 2000;16:49–53.
   PubMed Web of Science ®Google Scholar
• Dubois PC, Trynka G, Franke L, Hunt KA, Romanos J, Curtotti A, . Multiple common variants for celiac disease influencing immune gene expression. Nat Genet 2010;42:295–302.
   PubMed Web of Science ®Google Scholar
• Leprince D, Gegonne A, Coll J, de Taisne C, Schneeberger A, Lagrou C, . A putative second cell-derived oncogene of the avian leukaemia retrovirus E26. Nature 1983;306:395–7.
   PubMed Web of Science ®Google Scholar
• Wang CY, Petryniak B, Ho IC, Thompson CB, Leiden JM. Evolutionarily conserved Ets family members display distinct DNA binding specificities. J Exp Med 1992;175:1391–9.
   PubMed Web of Science ®Google Scholar
• Russell L, Garrett-Sinha LA. Transcription factor Ets-1 in cytokine and chemokine gene regulation. Cytokine 2010;51:217–26.
   PubMed Web of Science ®Google Scholar
• Gallant S, Gilkeson G. ETS transcription factors and regulation of immunity. Arch Immunol Ther Exp 2006;54:149–63.
   PubMed Web of Science ®Google Scholar
• Howie BN, Carlson CS, Rieder MJ, Nickerson DA. Efficient selection of tagging single-nucleotide polymorphisms in multiple populations. Hum Genet 2006;120:58–68.
   PubMed Web of Science ®Google Scholar
• Zhernakova A, van Diemen CC, Wijmenga C. Detecting shared pathogenesis from the shared genetics of immune-related genes. Nat Rev Genet 2009;10:43–55.
   PubMed Web of Science ®Google Scholar
• Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, . The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315–24.
   PubMed Web of Science ®Google Scholar
• Coenen MJ, Trynka G, Heskamp S, Franke B, van Diemen CC, Smolonska J, . Common and different genetic background for rheumatoid arthritis and coeliac disease. Hum Mol Genet 2009;18:4195–203.
   PubMed Web of Science ®Google Scholar
• Zhernakova A, Stahl EA, Trynka G, Raychaudhuri S, Festen EA, Franke L, . Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci. PLoS Genet 2011;7:e1002004.
   PubMed Web of Science ®Google Scholar
• Eyre S, Hinks A, Bowes J, Flynn E, Martin P, Wilson AG, . Overlapping genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease. Arthritis Res Ther 2010;12:R175.
   PubMed Web of Science ®Google Scholar
• Han JW, Zheng HF, Cui Y, Sun LD, Ye DQ, Hu Z, . Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat Genet 2009;41:1234–7.
   PubMed Web of Science ®Google Scholar
• Sementchenko VI, Watson DK. Ets target genes: past, present and future. Oncogene 2000;19:6533–48.
   PubMed Web of Science ®Google Scholar
• Redlich K, Kiener HP, Schett G, Tohidast-Akrad M, Selzer E, Radda I, . Overexpression of transcription factor Ets-1 in rheumatoid arthritis synovial membrane. Regulation of expression and activation by interleukin-1 and tumor necrosis factor α. Arthritis Rheum 2001;44:266–74.
   PubMedGoogle Scholar
• Wernert N, Justen HP, Rothe M, Behrens P, Dreschers S, Neuhaus T, . The Ets 1 transcription factor is upregulated during inflammatory angiogenesis in rheumatoid arthritis. J Mol Med 2002;80:258–66.
   PubMed Web of Science ®Google Scholar
• Peters CL, Morris CJ, Mapp PI, Blake DR, Lewis CE, Winrow VR. The transcription factors hypoxia-inducible factor 1alpha and Ets-1 colocalize in the hypoxic synovium of inflamed joints in adjuvant-induced arthritis. Arthritis Rheum 2004;50:291–6.
   PubMed Web of Science ®Google Scholar
• Zvaifler NJ, Tsai V, Alsalameh S, von Kempis J, Firestein GS, Lotz M. Pannocytes: distinctive cells found in rheumatoid arthritis articular cartilage erosions. Am J Pathol 1997;150:1125–38.
   PubMed Web of Science ®Google Scholar
• Gay S, Gay RE, Koopman WJ. Molecular and cellular mechanisms of joint destruction in rheumatoid arthritis: two cellular mechanisms explain joint destruction? Ann Rheum Dis 1993;52(Suppl 1):S39–47.
   Google Scholar
• Firestein GS. Starving the synovium: angiogenesis and inflammation in rheumatoid arthritis. J Clin Invest 1999;103:3–4.
   PubMed Web of Science ®Google Scholar