429
Views
26
CrossRef citations to date
0
Altmetric
Research Article

Low diagnostic and predictive value of anti-dsDNA antibodies in unselected patients with recent onset of rheumatic symptoms: results from a long-term follow-up Scandinavian multicentre study

, , , , , , , , , & show all
Pages 311-316 | Accepted 07 Jan 2013, Published online: 16 Mar 2013

References

  • Heidenreich U, Mayer G, Herold M, Klotz W, Stempfl Al-Jazrawi K, Lhotta K. Sensitivity and specificity of autoantibody tests in the differential diagnosis of lupus nephritis. Lupus 2009;18: 1276–80.
  • Ho A, Magder LS, Barr SG, Petri M. Decreases in anti-double-stranded DNA levels are associated with concurrent flares in patients with systemic lupus erythematosus. Arthritis Rheum 2001;44:2342–9.
  • Lopez-Hoyos M, Cabeza R, Martinez-Taboada VM, Crespo J, SanSegundo D, Blanco R, . Clinical disease activity and titers of anti-dsDNA antibodies measured by an automated immunofluorescence assay in patients with systemic lupus erythematosus. Lupus 2005;14:505–9.
  • Swaak AJ, Groenwold J, Aarden LA, Statius van Eps LW, Feltkamp EW. Prognostic value of anti-dsDNA in SLE. Ann Rheum Dis 1982;41:388–95.
  • Bootsma H, Spronk P, Derksen R, de Boer G, Wolters-Dicke H, Hermans J, . Prevention of relapses in systemic lupus erythematosus. Lancet 1995;345:1595–9.
  • Touma Z, Gladman DD, Tulloch-Reid D, Toloza SM, Ibanez D, Fortin PR, . Burden of autoantibodies and association with disease activity and damage in systemic lupus erythematosus. Clin Exp Rheumatol 2010;28:525–31.
  • Swaak T, Smeenk R. Detection of anti-dsDNA as a diagnostic tool: a prospective study in 441 non-systemic lupus erythematosus patients with anti-dsDNA antibody (anti-dsDNA). Ann Rheum Dis 1985;44:245–51.
  • Gripenberg M, Helve T. Outcome of systemic lupus erythematosus. A study of 66 patients over 7 years with special reference to the predictive value of anti-DNA antibody determinations. Scand J Rheumatol 1991;20:104–9.
  • Manoussakis MN, Garalea KL, Tzioufas AG, Moutsopoulos HM. Testing for antibodies to ENA and to dsDNA is not indicated in FANA-negative sera. Clin Rheumatol 1988;7:465–9.
  • Haugbro K, Nossent JC, Winkler T, Figenschau Y, Rekvig OP. Anti-dsDNA antibodies and disease classification in antinuclear antibody positive patients: the role of analytical diversity. Ann Rheum Dis 2004;63:386–94.
  • Launay D, Schmidt J, Lepers S, Mirault T, Lambert M, Kyndt X, . Comparison of the Farr radioimmunoassay, 3 commercial enzyme immunoassays and Crithidia luciliae immunofluorescence test for diagnosis and activity assessment of systemic lupus erythematosus. Clin Chim Acta 2010;411:959–64.
  • Chiang M, Chia D, Barnett EV. Evaluation of fluorescent antinuclear antibody assays, Crithidia luciliae substrate, and single-stranded DNA-binding capacity in diagnosis of four rheumatic diseases. J Clin Microbiol 1982;15:684–7.
  • Ballou SP, Kushner I. Immunochemical characteristics of antibodies to DNA in patients with active systemic lupus erythematosus. Clin Exp Immunol 1979;37:58–67.
  • Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, . The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982;25:1271–7.
  • Heinlen LD, McClain MT, Merrill J, Akbarali YW, Edgerton CC, Harley JB, . Clinical criteria for systemic lupus erythematosus precede diagnosis, and associated autoantibodies are present before clinical symptoms. Arthritis Rheum 2007; 56:2344–51.
  • Arbuckle MR, James JA, Kohlhase KF, Rubertone MV, Dennis GJ, Harley JB. Development of anti-dsDNA autoantibodies prior to clinical diagnosis of systemic lupus erythematosus. Scand J Immunol 2001;54:211–19.
  • Eriksson C, Kokkonen H, Johansson M, Hallmans G, Wadell G, Rantapaa-Dahlqvist S. Autoantibodies predate the onset of systemic lupus erythematosus in northern Sweden. Arthritis Res Ther 2011;13:R30.
  • Smeenk R, Hylkema M. Detection of antibodies to DNA: a technical assessment. Mol Biol Rep 1992;17:71–9.
  • Swaak AJ, Groenwold J, Aarden LA, Feltkamp TE. Detection of anti-dsDNA as diagnostic tool. Ann Rheum Dis 1981;40:45–9.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.