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Scandinavian Journal of Rheumatology Volume 18, 1988 - Issue sup77
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Original Article

Changes in Proteoglycans of Human Osteoarthritic Cartilage Maintained in Explant Culture: Implications for Understanding Repair in Osteoarthritis

C. J. Malemud Departments of Medicine, Developmental Genetics, Ohio, USA; Developmental Genetics, Ohio, USA
,
R. Shuckett Department of Medicine, University of Manitoba, Health Sciences Centre, Winnipeg, Manitoba, Canada
&
V. M. Goldberg Department of Orthopaedics, Case Western Reserve University, Cleveland, Ohio, USA
Pages 7-12 | Published online: 12 Jul 2009

References

  • Malemud C J, Norby D P, Sokoloff L. Explain culture of human and rabbit articular clwndrocytes. Connect Tissue Res 1978; 6: 171–9
  • Shuckett R, Malemud CJ. An in vitro model of ageing of human articular cartilage sulphated proteoglycans. Mech Age Devel 1986; 34: 73–90
  • Martel-Pelletier J, Pelletier J-P, Cloutier J-M, Malemud CJ. Newly synthesized and endogenous proteoglycans in human osteoarthritic knee cartilage. J Rheumatol 1987; 14: 321–8
  • Martel-Pelletier J, Pelletier J-P, Malemud CJ. Activation of neutral metalloprotease in human osteoarthilic knee cartilage: evidence for degradation in the core protein of sulphated proteoglycan. Ann Rheum Dis 1988, in press
  • Keiser H D, Malemud CJ. A comparison of the proteoglycans produced by rabbit articular chondrocytes in monolayer and spinner culture and those of bovine nasal cartilage. Connect Tissue Res 1983; 11: 273–84
  • Bitter T, Muir H. A modified uremic acid carbazole reaction. Anal Biochem 1962; 4: 330–4
  • Kresina T F, Malemud CI. Murine monoclonal antibodies recognizing rabbit proteoglycans. Collagen Rel Res 1986; 6: 15–39
  • Lowry O H, Rosebrough N J, Farr A L, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 3: 265–75
  • Wagner WD. A more sensitive assay discriminating galactosamine and glucosamine in mixtures. Anal Biochem 1979; 94: 384–96
  • Sweet M, Thonar EJ M-A, Immelman A, Solomon L. Biochemical changes in progressive osteoarthrosis. Ann Rheum Dis 1977; 36: 387–98
  • Sommarin Y, Heinegård D. Four classes of cell-associated proteoglycans in suspension cultures of articular-cartilage chondrocytes. Biochem J 1986; 233: 809–18
  • Thonar EJ M-A, Kuettner KE. Biochemical basis of age-related changes in proteoglycans. Biology of Proteoglycans, T N Wight, R P Mecham. Academic Press, New York 1987; 211–46
  • Brocklehurst R, Bayliss M, Maroudas A, et al. A composition of normal and osteoarthritic articular cartilage from human knee joints. J Bone Joint Surg [Amer] 1984; 66: 95–106
  • Thonar EJ M-A, Sweet M BE. An oligosaccharide component in proteoglycans of articular cartilage. Biochim Biophys Acta 1979; 584: 353–7

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