Mapping of Arthritogenic/Autoimmune Epitopes of Cartilage Aggrecans in Proteoglycan-Induced Arthritis

References

• Giant IT, Mikecz K, Arzoumanian A, Poole AR. Proteoglycan-induced arthritis in BALB/c mice. Clinical features and histopathology. Arthritis Rheum 1987; 30: 201–12
   PubMedGoogle Scholar
• Mikecz K, Glant T T, Poole AR. Immunity to cartilage proteoglycans in BALB/c mice with progressive polyarthritis and ankylosing spondylitis induced by injection of human cartilage proteoglycan. Arthritis Rheum 1987; 30: 306–18
   PubMed Web of Science ®Google Scholar
• Glant T T, Mikecz K, Thonar EJ-MA, Kuettner KE. Immune responses to cartilage proteoglycans in inflammatory animal models and human diseases. Cartilage Degradation: Basic and Clinical Aspects, J F Woessner, D S Howell. Marcel Dekker Inc., New York 1992; 435–73
   Google Scholar
• Mikecz K, Glant IT, Buzás E, Poole AR. Cartilage proteoglycans as potential autoantigens in humans and in experimental animals. Agents Actions 1988; 23: 63–6
   PubMedGoogle Scholar
• Cs-Szabó G, Roughley P J, Plaas A, Glant TT. Large and small proteoglycans retained in osteoarthritic and rheumatoid articular cartilages. Arthritis Rheum 1994, in press
   Google Scholar
• Mikecz K, Glant T T, Buzás E, Poole AR. Proteoglycan-induced polyarthritis and spondylitis adoptively transferred to naive (nonimmunized) BALB/c mice. Arthritis Rheum 1990; 33: 866–76
   PubMed Web of Science ®Google Scholar
• Mikecz K, Glant TT. Migration and homing of lymphocytes to lymphoid and synovial tissues in proteoglycan-induced murine arthritis. Arthritis Rheum 1994; 37: 1395–403
   PubMed Web of Science ®Google Scholar
• Banerjee S, Webber C, Poole AR. The induction of arthritis in mice by the cartilage proteoglycan aggrecan: roles of CD4+ and CD8+ T cells. Cell Immunol 1992; 144: 347–57
   PubMed Web of Science ®Google Scholar
• Dayer E, Mathai L, Glant T T, Mikecz K, Poole AR. Cartilage proteoglycan-induced arthritis in BALB/c mice: Antibodies recognize human and mouse cartilage proteoglycan and can cause depletion of cartilage proteoglycan with little or no synovitis. Arthritis Rheum 1990; 33: 1394–405
   PubMed Web of Science ®Google Scholar
• Giant T, Mikecz K. Antigenic profile of human, bovine and canine articular chondrocytes. Cell Tissue Res 1986; 224: 359–69
   Google Scholar
• Griffiths M M, Cremer M A, Harper D S, McCall S, Cannon GW. Immunogenetics of collagen-induced arthritis in rats Both MHC and non-MHC gene products determine the epitopc specificicty of immune response to bovinc and chick type II collagens. J Immunol 1992; 149: 309–16
   PubMed Web of Science ®Google Scholar
• Wooley P H, Siegner S W, Whalen J D, Karvonen R I, Fernandez-Madrid F. Dependence of proteoglycan induced arthritis in BALB/c mice on the development of autoantibodies to high density proteoglycans. Ann Rheum Dis 1992; 51: 983–91
   PubMed Web of Science ®Google Scholar
• Glant T T, Walcz E, Deák F, Horváth P., Fülöp C. Primary structure of mouse aggrecan: a cartilage proteoglycan with arthritogenic potential. Arthritis Rheum 1992; 35: S74
   Google Scholar
• Glmt T T, Mikecz K, Poole AR. Monoclonal antibodies to different protein-related epitopes of human articular cartilage proteoglycans. Biochem J 1986; 234: 31–41
   PubMed Web of Science ®Google Scholar
• Ludwigs U, Elgavish A, Esko J D, Meezan E, Roden L. Reaction of unsaturated uronic acid residues with mercuric salts Cleavage of the hyaluronic acid disaccharide. Biochem J 1987; 245: 795–804
   PubMed Web of Science ®Google Scholar
• Williams J M, Zurawski J, Mikecz K, Glant TT. Functional assessment of joint use in experimental inflammatory murine arthritis. J Orthop Res 1993; 11: 172–80
   PubMed Web of Science ®Google Scholar
• Thonar EJ-MA, Lenz M E, Maldonado B, Otten L, Glant T, Kuettner KE. Measurement of antigenic keratan sulfate by an enzyme-linked immunosorbent assay. Methods in Cartilage Research, A Maroudas, K E Kuettner. Academic Press, London 1990; 170–2
   Google Scholar
• Carney S L, Bayliss M T, Collier J M, Muir H. Electrophoresis of 35S-labeled proteoglycans on polyacrylamide-agarose composite gels and their visualization by fluorography. Anal Biochem 1986; 156: 38–44
   PubMed Web of Science ®Google Scholar
• McDevitt C A, Muir H. Gel electrophoresis of proteoglycans and glycosaminoglycans on large-pore composite polyacrylamide-agarose gels. Anal Biochem 1971; 44: 612–22
   PubMed Web of Science ®Google Scholar
• Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications. Proc Natl Acad Sci USA 1979; 76: 4350–4
   PubMed Web of Science ®Google Scholar
• Glant T T, Mikecz K, Roughley P J, Buzás E, Poole AR. Age-related changes in protein-related epitopes of human articular-cartilage proteoglycans. Biochem J 1986; 236: 71–5
   PubMed Web of Science ®Google Scholar
• Sweet M BE, Thonar EJ-MA, Marsh J. Age-related changes in proteoglycan structure. Arch Biochem Bio-phys 1979; 198: 439–48
   PubMed Web of Science ®Google Scholar
• Hascall VC. Proteoglycans: the chondroitin sul-fate/keratan sulfate proteoglycan of cartilage. ISI Atlas Sci Biochem 1988; 1: 189–98
   Web of Science ®Google Scholar
• Glant T, Hadas E, Nagy M. Cell-mediated and humoral immune responses to cartilage antigenic components. Scand J Immunol 1979; 9: 39–44
   PubMed Web of Science ®Google Scholar
• Banerjee S, Poole AR. Immunity to cartilage proteoglycans. J Rheumatol 1992; 19: 36–9, (Suppl 33)
   Web of Science ®Google Scholar
• Van Vollenhoven R F, Soriano A, McCarthy P E, Schwartz R L, Garbrecht F C, Thorbecke G J, Siskind GW. The role of immunity to cartilage proteoglycan in adjuvant induced arthritis Intravenous injection of bovine proteoglycan enhances adjuvant arthritis. J Immunol 1988; 141: 1168–73
   PubMed Web of Science ®Google Scholar
• Van Eden W, Holoshitz J, Nevo Z, Frenkel A, Klajman A, Cohen IR. Arthritis induced by a T-lymphocyte clone that responds to Mycobacterium tuberculosis and to cartilage proteoglycans. Proc Natl Acad Sci USA 1985; 82: 5117–20
   PubMed Web of Science ®Google Scholar
• Van den Broek M F, Van den Befg W B, Arntz O J, Van de Putte L BA. Reaction of bacterium-primed murine T cells to cartilage components: a clue for the pathogenesis of arthritis?. Clin Exp Immunol 1988; 72: 9–14
   PubMed Web of Science ®Google Scholar
• Torisu M, Miyahara T, Shinohara N, Ohsato K, Sonozaki M. A new side effect of BCG immunotherapy-BCG-induced arthritis in man. Cancer Immunol Immunother 1978; 5: 77–83
   Web of Science ®Google Scholar
• Glant T, Csongor J, Szllcs T. Immunopathologic role of proteoglycan antigens in rheumatoid joint diseases. Scand J Immunol 1980; 11: 247–52
   PubMed Web of Science ®Google Scholar
• Glant T T, Fülöp C, Mikecz K, Buzás E, Molnár G, Erhardt P. Proteoglycm-specific autoreactive antibodies and T-lymphocytes in experimental arthritis and human rheumatoid joint diseases. Biochem Soc Trans 1990; 18: 796–9
   PubMed Web of Science ®Google Scholar
• Golds E E, Stephen I BM, Esdaile J M, Strawczynski H, Poole AR. Lymphocyte transformation to connective tissue antigens in adult and juvenile rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, systemic lupus ery-thematosus and a non-arthritic control population. Cell Immunol 1983; 82: 196–209
   PubMed Web of Science ®Google Scholar
• Herman J H, Herzig E B, Crissmann J D, Dennis M V, Hess EV. Idiopathic chondrolysis An immunopathologic study. J Rheumatol 1980; 7: 694–705
   PubMed Web of Science ®Google Scholar
• Golds E E, Poole AR. Connective tissue antigens stimulate collagenase production in arthritic diseases. Cell Immunol 1984; 86: 190–205
   PubMed Web of Science ®Google Scholar
• Thonar EJ-MA, Sweet M BE. Cellular hypersensitivity in rheumatoid arthritis, ankylosing spondylitis, and anterior nongranulomatous uveitis. Arthritis Rheum 1976; 19: 539–44
   PubMedGoogle Scholar
• Mikecz K, Glant T T, Baron M, Poole AR. Isolation of proteoglycan specific T-cells from patients with ankylosing spondylitis. Cell Immunol 1988; 11255–63
   Web of Science ®Google Scholar
• Leroux J-Y, Poole A R, Webber C, Vipparti V, Choi H U, Rosenberg L C, Banerjee S. Characterization of proteoglycan-reactive T cell lines and hybridomas from mice with proteoglycan-induced arthritis. J Immunol 1992; 148: 2090–6
   PubMed Web of Science ®Google Scholar
• Walcz E, Deák F, Erhardt P, Coulter S N, Fülöp C, Horváth P, et al. Complete coding sequence, deduced primary structure chromosomal localization and structural analysis of murine aggrecan. Genomics 1994; 22: 364–71
   PubMed Web of Science ®Google Scholar