420
Views
33
CrossRef citations to date
0
Altmetric
Original Article

Characterization and stability study of a water-in-oil microemulsion incorporating quercetin

, , , &
Pages 47-55 | Received 04 Jan 2010, Accepted 30 Apr 2010, Published online: 15 Jun 2010

References

  • Lawrence MJ, Rees GD. (2000). Microemulsion-based media as novel drug delivery systems. Adv Drug Deliv Rev, 45:89–121.
  • Lehmann L, Keipert S, Gloor M. (2001). Effects of microemulsions on the stratum corneum and hydrocortisone penetration. Eur J Pharm Biopharm, 52:129–36.
  • Kreilgaard M. (2002). Influence of microemulsions on cutaneous drug delivery. Adv Drug Deliv Rev, 54(Suppl. 1):S77–98.
  • Vicentini FTMC, Simi TR, Del Ciampo JO, Wolga NO, Pitol DL, Iyomasa MM, . (2008). Quercetin in w/o microemulsion: In vitro and in vivo skin penetration and efficacy against UVB-induced skin damages evaluated in vivo. Eur J Pharm Biopharm, 69:948–57.
  • Bilia AR, Bergonzi MC, Morgenni F, Mazzi G, Vincieri FF. (2001). Evaluation of chemical stability of St. John's wort commercial extract and some preparations. Int J Pharm, 213:199–208.
  • Casagrande R, Georgetti SR, Verri Jr WA, Borin MF, Lopez RF, Fonseca MJ. (2007). In vitro evaluation of quercetin cutaneous absorption from topical formulations and its functional stability by antioxidant activity. Int J Pharm, 328:183–90.
  • Djordjevic L, Primorac M, Stupar M, Krajisnik D. (2004). Characterization of caprylocaproyl macrogolglycerides based microemulsion drug delivery vehicles for an amphiphilic drug. Int J Pharm, 271:11–9.
  • Vicentini FTMC, Georgetti SR, Jabor JR, Caris JA, Bentley MVLB, Fonseca MJV. (2007). Photostability of quercetin under exposure to UV irradiation. Lat Am J Pharm, 26:119–24.
  • Dinis TC, Maderia VM, Almeida LM. (1994). Action of phenolic derivatives (acetaminophen, salicylate, and 5-aminosalicylate) as inhibitors of membrane lipid peroxidation and as peroxyl radical scavengers. Arch Biochem Biophys, 315:161–9.
  • Singh S. (1999). Drug stability testing and shelf-life determination according to international guidelines. Pharm Technol, 23:68–88.
  • Singh S. (1999). Stability test storage conditions for zones III and IV—some unresolved issues. Pharm Technol, 23:131–41.
  • Delgado-Charro MB, Iglesias-Vilas G, Blanco-Méndez J, López‐Quintela MA, Marty JP, Guy RH. (1997). Delivery of a hydrophilic solute through the skin from novel microemulsion systems. Eur J Pharm Biopharm, 43:37–42.
  • Kogan A, Garti N. (2006). Microemulsions as transdermal drug delivery vehicles. Adv Colloid Interface Sci, 123–6:369–85.
  • Vicentini FTMC, Georgetti SR, Bentley MV, Fonseca MJ. (2009). Assessment of in vitro methodologies to determine topical and transdermal delivery of the flavonoid quercetin. Braz J Pharm Sci, 45:357–64.
  • Muller-Goymann CC. (2004). Physicochemical characterization of colloidal drug delivery systems such as reverse micelles, vesicles, liquid crystals and nanoparticles for topical administration. Eur J Pharm Biopharm, 58:343–56.
  • Sintov AC, Shapiro L. (2004). New microemulsion vehicle facilitates percutaneous penetration in vitro and cutaneous drug bioavailability in vivo. J Control Release, 95:173–83.
  • Casagrande R, Georgetti SR, Verri Jr WA, Jabor JR, Santos AC, Fonseca MJ. (2006). Evaluation of functional stability of quercetin as a raw material and in different topical formulations by its antilipoperoxidative activity. AAPS PharmSciTech, 7:E10.
  • Vicentini FTMC, Casagrande R, Georgetti SR, Bentley MVLB, Fonseca MJV. (2007). Influence of vehicle on antioxidant activity of quercetin: A liquid crystalline formulation. Lat Am J Pharm, 26:805–10.
  • Georgetti SR, Casagrande R, Di Mambro VM, Azzolini AE, Fonseca MJ. (2003). Evaluation of the antioxidant activity of different flavonoids by the chemiluminescence method. AAPS PharmSci, 5:E20.
  • Pinelo M, Manzocco L, Nuñez MJ, Nicoli MC. (2004). Solvent effect on quercetin antioxidant capacity. Food Chem, 88:201–7.
  • Silva MM, Santos MR, Caroco G, Rocha R, Justino G, Mira L. (2002). Structure-antioxidant activity relationships of flavonoids: A re-examination. Free Radic Res, 36:1219–27.
  • Nuutila AM, Puupponen-Pimiä R, Aarni M, Oksman-Caldentey K-M. (2003). Comparison of antioxidant activities of onion and garlic extracts by inhibition of lipid peroxidation and radical scavenging activity. Food Chem, 81:485–93.
  • Constantinides PP, Yiv SH. (1995). Particle size determination of phase-inverted water-in-oil microemulsions under different dilution and storage conditions. Int J Pharm, 115:225–34.
  • Guaratini T, Gianeti MD, Campos PM. (2006). Stability of cosmetic formulations containing esters of vitamins E and A: Chemical and physical aspects. Int J Pharm, 327:12–6.
  • ICH harmonized tripartite guideline (International conference on harmonization of technical requirements for registration of pharmaceuticals for human use). (2003). Stability testing of new drugs substances and products.
  • Blois MS. (1958). Antioxidant determinations by the use of a stable free radical. Nature, 181:1199–200.
  • Vicentini FTMC, Casagrande R, Verri Jr WA, Georgetti SR, Bentley MV, Fonseca MJ. (2008). Quercetin in lyotropic liquid crystalline formulations: Physical, chemical and functional stability. AAPS PharmSciTech, 9:591–6.
  • Smith GJ, Thomsen SJ, Markham KR, Andary C, Cardon D. (2000). The photostabilities of naturally occurring 5-hydroxyflavones, flavonols, their glycosides and their aluminium complexes. J Photochem Photobiol A Chem, 136:87–91.
  • Calabró ML, Tommasini S, Raneri D, Donato P, Ficarra P, Ficarra R. (2004). Selective reversed-phase liquid chromatography method for the kinetic investigation of 3-hydroxyflavone photostability. J Chromatogr B Analyt Technol Biomed Life Sci, 800:245–51.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.