104
Views
1
CrossRef citations to date
0
Altmetric
Original Article

Physicochemical characteristics and in vitro release from oil-based vehicles of peptidomimetics: parenteral depots for intra-articular administration

, , , , &
Pages 62-71 | Received 16 Feb 2010, Accepted 04 May 2010, Published online: 14 Jun 2010

References

  • Burton PS, Conradi RA, Ho NFH, Hilgers AR, Borchardt R. (1996). How structural features influence the biomembrane permeability of peptides. J Pharm Sci, 85:1336–40.
  • Steffansen B, Nielsen CU, Frokjaer S. (2005). Delivery aspects of small peptides and substrates for peptide transporters. Eur J Pharm Biopharm, 60:241–5.
  • Bundgaard H. (1992). Means to enhance penetration. (1) Prodrugs as a means to improve the delivery of peptide drugs. Adv Drug Deliv Rev, 8:1–38.
  • Gangwar S, Pauletti GM, Wang B, Siahaan TJ, Stella VJ, Borchardt R. (1997). Prodrug strategies to enhance the intestinal absorption of peptides. Drug Discov Today, 2:148–55.
  • Oliyai R. (1996). Prodrugs of peptides and peptidomimetics for improved formulation and delivery. Adv Drug Deliv Rev, 19:275–86.
  • Burton PS, Conradi RA, Hilgers AR, Ho NFH, Maggiora LL. (1992). The relationship between peptide structure and transport across epithelial cell monolayers. J Control Release, 19:87–98.
  • Conradi RA, Hilgers AR, Ho NFH, Burton PS. (1991). The influence of peptide structure on transport across Caco-2 cells. Pharm Res, 8:1453–60.
  • Conradi RA, Hilgers AR, Ho NFH, Burton PS. (1992). The influence of peptide structure on transport across Caco-2 cells. II. Peptide bond modification which results in improved permeability. Pharm Res, 9:435–9.
  • Goodwin JT, Conradi RA, Ho NFH, Burton PS. (2001). Physicochemical determinants of passive membrane permeability: Role of solute hydrogen-bonding potential and volume. J Med Chem, 44:3721–9.
  • Sudoh M, Pauletti GM, Yao W, Moser W, Yokoyama A, Pasternak A, . (1998). Transport characteristics of peptidomimetics. Effect of the pyrrolinone bioisostere on transport across Caco-2 cell monolayers. Pharm Res, 15:719–25.
  • Holland TA, Mikos AG. (2003). Advances in drug delivery for articular cartilage. J Control Release, 86:1–14.
  • Larsen C, Østergaard J, Larsen SW, Jensen H, Jacobsen S, Lindegaard C, . (2008). Intra-articular depot principles: Role in the management of postoperative pain and arthritic disorders. J Pharm Sci, 97:4622–54.
  • Kang F, Singh J. (2005). In vitro release of insulin and biocompatibility of in situ forming gel systems. Int J Pharm, 304:83–90.
  • Luan X, Bodmeier R. (2006). In situ forming microparticle system for controlled delivery of leuprolide acetate: Influence of the formulation and processing parameters. Eur J Pharm Sci, 27:143–9.
  • Packhaeuser CB, Schnieders J, Oster CG, Kissel T. (2004). In situ forming parenteral drug delivery systems: An overview. Eur J Pharm Biopharm, 58:445–55.
  • Pauletti GM, Okumu FW, Borchardt RT. (1997). Effect of size and charge on the passive diffusion of peptides across Caco-2 cell monolayers via the paracellular pathway. Pharm Res, 14:164–8.
  • Pedersen BT, Østergaard J, Larsen SW, Larsen C. (2005). Characterization of the rotating dialysis cell as an in vitro model potentially useful for simulation of the pharmacokinetic fate of intra-articularly administered drugs. Eur J Pharm Sci, 25:73–9.
  • Ishihama Y, Oda Y, Asakawa N. (1994). Microscale determination of dissolution constants of multivariant pharmaceuticals by capillary electrophoresis. J Pharm Sci, 83:1500–7.
  • Østergaard J, Hansen SH, Larsen C, Schou C, Heegaard NHH. (2003). Determination of octanol-water partition coefficients for carbonate esters and other small organic molecules by microemulsion electrokinetic chromatography. Electrophoresis, 24:1038–46.
  • Kok WT. (2000). Thermal management. Joule heating in CE. Chromatogr Suppl, 51:S24–7.
  • Dibbern HW, Wirbitzki E. (1983). Possibilities for determining the active substance release from hydrophobic carriers especially as suppositories. Pharm Ind, 45:985–90.
  • Schultz K, Møllgaard B, Frokjaer S, Larsen C. (1997). Rotating dialysis cell as in vitro release method for oily parenteral depot solutions. Int J Pharm, 157:163–9.
  • Jackman LM, Sternhell S. (1969). Applications of nuclear magnetic resonance spectroscopy in organic chemistry. 2nd ed. Oxford: Pergamon Press, 94ff.
  • Larsen DB, Fredholt K, Larsen C. (2001). Addition of hydrogen bond donating excipients to oil solutions: Effect on in vitro drug release rate and viscosity. Eur J Pharm Sci, 13:403–10.
  • Jain N, Yalkowsky SH. (2001). Estimation of the aqueous solubility I: Application to organic nonelectrolytes. J Pharm Sci, 90:234–52.
  • Larsen SW, Frost AB, Østergaard J, Marcher H, Larsen C. (2008). On the mechanism of drug release from oil suspensions in vitro using local anesthetics as model drug compounds. Eur J Pharm Sci, 34:37–44.
  • Larsen SW, Ankersen M, Larsen C. (2004). Kinetics of degradation and oil solubility of ester prodrugs of a model dipeptide (Gly-Phe). Eur J Pharm Sci, 22:399–408.
  • Goolcharran C, Borchardt RT. (1998). Kinetics of diketopiperazine formation using model peptides. J Pharm Sci, 87:283–8.
  • Østergaard J, Larsen SW, Parshad H, Larsen C. (2005). Bupivacaine salts of diflunisal and other aromatic hydroxycarboxylic acids: Aqueous solubility and release characteristics from solutions and suspensions using a rotating dialysis cell model. Eur J Pharm Sci, 26:280–7.
  • Larsen SW, Østergaard J, Friberg-Johansen H, Jessen MN, Larsen C. (2006). In vitro assessment of drug release rates from oil depot formulations intended for intra-articular administration. Eur J Pharm Sci, 29:348–54.
  • Larsen SW, Jessen MNB, Østergaard J, Larsen C. (2008). Assessment of drug release from oil depot formulations using an in vitro model – potential applicability in accelerated release testing. Drug Dev Ind Pharm, 34:297–304.
  • Yunker MH, Borodkin S. (1971). Determination of rate constants for in vitro three-compartment transfer using a two-phase system. J Pharm Sci, 60:52–6.
  • Caldwell JR. (1996). Intra-articular corticosteroids. Drugs, 52:507–14.
  • Yu LX, Foster TP, Sarver RW, Moseley WM. (1996). Preparation, characterization, and in vivo evaluation of an oil suspension of bovine growth hormone releasing factor analog. J Pharm Sci, 85:396–401.
  • Pedersen BT, Larsen SW, Østergaard J, Larsen C. (2008). In vitro assessment of lidocaine release from aqueous and oil solutions and from preformed, and in situ formed aqueous and oil suspensions. Parenteral depots for intra-articular administration. Drug Deliv, 15:23–30.
  • Larsen C, Larsen SW, Østergaard J, Pedersen BT. (2003). Drug-containing vehicles for local administrations of active drug substances. PA/DK 2003 01748.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.