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Research Article

Physical stability and resistance to peroxidation of a range of liquid-fill hard gelatin capsule products on extreme long-term storage

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Pages 685-693 | Received 11 May 2010, Accepted 25 Oct 2010, Published online: 30 Mar 2011

References

  • Bowtle W. (2007). Materials, process and manufacturing considerations for lipid-based hard-capsule formats. In: Hauss D, ed. Lipid-based Formulations for Oral Drug Delivery. New York: Informa Healthcare, pp. 79–106.
  • Brown J, Madit N, Cole ET, Wilding IR, Cadé D. (1998). The effect of cross-linking on the in vivo disintegration of hard gelatin capsules. Pharm Res 15:1026–1030.
  • Cole ET. (2007). Challenges and opportunities in the encapsulation of liquid and semi-solid formulations into gelatin and non-gelatin capsules. Effective Utilization of Lipid-based Systems to Enhance the Delivery of Poorly Soluble Drugs: Physicochemical, Biopharmaceutical and Product Development Considerations, AAPS workshop, Bethesda. Available at: http://www.aapspharmaceutica.com/meetings/files/85/13cole.pdf. Accessed on May 04, 2010.
  • Rowley G. (2004). Filling of liquids and semi-solids into hard two-piece capsules. In: Podczeck F, Jones BE, eds. Pharmaceutical Capsules. London: Pharmaceutical Press, pp. 69–194.
  • Shah R, Augsburger LL. (1989). Measurement of Oxygen Permeation through Band-Sealed and Unsealed Hard Gelatin Capsules. Poster PT462, 4th Annual AAPS Meeting, Atlanta, Georgia.
  • Young V, Bowtle W. (1999). Suitability of two-piece HPMC capsules for oxidation-sensitive liquids. AAPSPharmSci 2310.

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