232
Views
31
CrossRef citations to date
0
Altmetric
Research Article

Lyophilization monophase solution technique for preparation of amorphous flutamide dispersions

, , &
Pages 754-764 | Received 10 Sep 2010, Accepted 08 Nov 2010, Published online: 05 Jan 2011

References

  • Adel MS, Geneidi AS, Ali Shoukri R, Saad I. (1997). In vitro evaluation of flutamide-carrier systems. Part 1: Preparation and evaluation of flutamide systems with polyvinyl pyrrolidone and polyethylene glycol 4000 and 6000. Pharmazie 52:373–375.
  • Ahuja N, Katare OP, Singh B. (2007). Studies on dissolution enhancement and mathematical modeling of drug release of a poorly water-soluble drug using water-soluble carriers. Eur J Pharm Biopharm 65:26–38.
  • Chen Y, Zhang GG, Neilly J, Marsh K, Mawhinney D, Sanzgiri YD. (2004). Enhancing the bioavailability of ABT-963 using solid dispersion containing Pluronic F-68. Int J Pharm 286:69–80.
  • Cirri M, Mura P, Rabasco AM, Ginés JM, Moyano JR, Gònzalez-Rodrìguez ML. (2004). Characterization of ibuproxam binary and ternary dispersions with hydrophilic carriers. Drug Dev Ind Pharm 30:65–74.
  • Elgindy N, Elkhodairy K, Molokhia A, Elzoghby A. (2010). Lyophilization monophase solution technique for improvement of the physicochemical properties of an anticancer drug, flutamide. Eur J Pharm Biopharm 74:397–405.
  • Goddeeris C, Van den Mooter G. (2008). Free flowing solid dispersions of the anti-HIV drug UC 781 with Poloxamer 407 and a maximum amount of TPGS 1000: investigating the relationship between physicochemical characteristics and dissolution behaviour. Eur J Pharm Sci 35:104–113.
  • Goldberg AH, Gibaldi M, Kanig JL. (1965). Increasing dissolution rates and gastrointestinal absorption of drugs via solid solutions and eutectic mixtures. I. Theoretical considerations and discussion of the literature. J Pharm Sci 54:1145–1148.
  • Hancock BC, Zografi G. (1997). Characteristics and significance of the amorphous state in pharmaceutical systems. J Pharm Sci 86:1–12.
  • Higuchi T, Connors KA. (1965). Phase solubility techniques. Adv Anal Chem Instrum 4:117–212.
  • Kabanov AV, Batrakova EV, Alakhov VY. (2002). Pluronic block copolymers as novel polymer therapeutics for drug and gene delivery. J Control Release 82:189–212.
  • Karavas E, Georgarakis E, Sigalas MP, Avgoustakis K, Bikiaris D. (2007). Investigation of the release mechanism of a sparingly water-soluble drug from solid dispersions in hydrophilic carriers based on physical state of drug, particle size distribution and drug–polymer interactions. Eur J Pharm Biopharm 66:334–347.
  • Kirk AO, Josh DE, BoC, Brian DS, Thomas EM, KeithPJ, Robert OW. (2007). Novel ultra-rapid freezing particle engineering process for enhancement of dissolution rates of poorly water-soluble drugs. Eur J Pharm Biopharm 65:57–67.
  • Kushida I, Ichikawa M, Asakawa N. (2002). Improvement of dissolution and oral absorption of ER-34122, a poorly water-soluble dual 5-lipoxygenase/cyclooxygenase inhibitor with anti-inflammatory activity by preparing solid dispersion. J Pharm Sci 91:258–266.
  • Leuner C, Dressman J. (2000). Improving drug solubility for oral delivery using solid dispersions. Eur J Pharm Biopharm 50:47–60.
  • Martínez-Ohárriz MC, Martín C, Goñi MM, Rodríguez-Espinosa C, Tros-Ilarduya MC, Zornoza A. (1999). Influence of polyethylene glycol 4000 on the polymorphic forms of diflunisal. Eur J Pharm Sci 8:127–132.
  • Paradkar A, Ambike AA, Jadhav BK, Mahadik KR. (2004). Characterization of curcumin–PVP solid dispersion obtained by spray drying. Int J Pharm 271:281–286.
  • Rawlinson CF, Williams AC, Timmins P, Grimsey I. (2007). Polymer-mediated disruption of drug crystallinity. Int J Pharm 336:42–48.
  • Rouchotas C, Cassidy OE, Rowley G. (2000). Comparison of surface modification and solid dispersion techniques for drug dissolution. Int J Pharm 195:1–6.
  • Sekiguchi K, Obi N. (1961). Studies on absorption of eutectic mixture. I. A comparison of the behavior of eutectic mixture of sulfathiazole and that of ordinary sulfathiazole in man. Chem Pharm Bull 9:866–872.
  • Sun N, Wei X, Wu B, Chen J, Lu Y, Wu W. (2008). Enhanced dissolution of silymarin/polyvinylpyrrolidone solid dispersion pellets prepared by a one-step fluid-bed coating technique. Powder Technol 182:72–80.
  • Teagarden DL, Baker DS. (2002). Practical aspects of lyophilization using non-aqueous co-solvent systems. Eur J Pharm Sci 15:115–133.
  • Umrethia ML, Ghosh PK, Majithiya RJ, Murthy RSR. (2005). A new reverse phase high performance liquid chromatographic method for determination of flutamide in liposomes, rat blood plasma and tablet dosage forms. Ars Pharm, 46:109–124.
  • Van den Mooter G, Augustijns P, Blaton N, Kinget R. (1998). Physico-chemical characterization of solid dispersions of temazepam with polyethylene glycol 6000 and PVP K30. Int J Pharm 164:67–80.
  • Van Drooge DJ, Hinrichs WL, Frijlink HW. (2004). Incorporation of lipophilic drugs in sugar glasses by lyophilization using a mixture of water and tertiary butyl alcohol as solvent. J Pharm Sci 93:713–725.
  • Wang Z, Deng Y, Sun S, Zhang X. (2006). Preparation of hydrophobic drugs cyclodextrin complex by lyophilization monophase solution. Drug Dev Ind Pharm 32:73–83.
  • Williams III RO, Johnson KP, Hu J. (2003). Spray freezing into liquid (SFL) particle engineering technology to enhance dissolution of poorly water soluble drugs: organic solvent versus organic/aqueous cosolvent systems. Eur J Pharm Sci 20:295–303.
  • Yamashita K, Nakate T, Okimoto K, Ohike A, Tokunaga Y, Ibuki R, Higaki K, Kimura T. (2003). Establishment of new preparation method for solid dispersion formulation of tacrolimus. Int J Pharm 267:79–91.
  • Yu L. (2001). Amorphous pharmaceutical solids: preparation, characterization and stabilization. Adv Drug Deliv Rev 48:27–42.
  • Zerrouk N, Mennini N, Maestrelli F, Chemtob C, Mura P. (2004). Comparison of the effect of chitosan and polyvinylpyrrolidone on dissolution properties and analgesic effect of naproxen. Eur J Pharm Biopharm 57:93–99.
  • Zhong Z, Bruce S, Glen k, James D, Leonard IW. (2000). Hydroxypropyl-β-cyclodextrin–flutamide inclusion complex. I. Formulation, physical characterization and absorption studies using the Caco-2 in vitro model. J Pharm Pharmaceut Sci 3:220–227.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.