Safety assessment of thiolated polymers: effect on ciliary beat frequency in human nasal epithelial cells

References

• Cerchiara T, Luppi B, Chidichimo G, Bigucci F, Zecchi V. (2005). Chitosan and poly(methyl vinyl ether-co-maleic anhydride) microparticles as nasal sustained delivery systems. Eur J Pharm Biopharm, 61:195–200.
   PubMed Web of Science ®Google Scholar
• Grabovac V, Guggi D, Bernkop-Schnürch A. (2005). Comparison of the mucoadhesive properties of various polymers. Adv Drug Deliv Rev, 57:1713–1723.
   PubMed Web of Science ®Google Scholar
• Guggi D, Bernkop-Schnürch A. (2003). In vitro evaluation of polymeric excipients protecting calcitonin against degradation by intestinal serine proteases. Int J Pharm, 252:187–196.
   PubMed Web of Science ®Google Scholar
• Bernkop-Schnürch A, Obermair K, Greimel A, Palmberger TF. (2006). In vitro evaluation of the potential of thiomers for the nasal administration of Leu-enkephalin. Amino Acids, 30:417–423.
   PubMed Web of Science ®Google Scholar
• Ugwoke MI, Agu RU, Jorissen M, Augustijns P, Sciot R, Verbeke N et al. (2000). Nasal toxicological investigations of Carbopol 971P formulation of apomorphine: Effects on ciliary beat frequency of human nasal primary cell culture and in vivo on rabbit nasal mucosa. Eur J Pharm Sci, 9:387–396.
   PubMed Web of Science ®Google Scholar
• Jorissen M, Willems T, Van der Schueren B. (2000). Ciliary function analysis for the diagnosis of primary ciliary dyskinesia: Advantages of ciliogenesis in culture. Acta Otolaryngol, 120:291–295.
   PubMed Web of Science ®Google Scholar
• Bernkop-Schnürch A, Kast CE, Richter MF. (2001). Improvement in the mucoadhesive properties of alginate by the covalent attachment of cysteine. J Control Release, 71:277–285.
   PubMed Web of Science ®Google Scholar
• Bernkop-Schnürch A, Hornof M, Guggi D. (2004). Thiolated chitosans. Eur J Pharm Biopharm, 57:9–17.
   PubMed Web of Science ®Google Scholar
• Ellman GL. (1958). A colorimetric method for determining low concentrations of mercaptans. Arch Biochem Biophys, 74:443–450.
   PubMed Web of Science ®Google Scholar
• Habeeb AF. (1973). A sensitive method for localization of disulfide containing peptides in column effluents. Anal Biochem, 56:60–65.
   PubMed Web of Science ®Google Scholar
• Krauland AH, Leitner VM, Bernkop-Schnürch A. (2003). Improvement in the in situ gelling properties of deacetylated gellan gum by the immobilization of thiol groups. J Pharm Sci, 92:1234–1241.
   PubMed Web of Science ®Google Scholar
• Jorissen M, Van der Schueren B, Tyberghein J, Van der Berghe H, Cassiman JJ. (1989). Ciliogenesis and coordinated ciliary beating in human nasal epithelial cells cultured in vitro. Acta Otorhinolaryngol Belg, 43:67–73.
   PubMedGoogle Scholar
• Dimova S, Mugabowindekwe R, Willems T, Brewster ME, Noppe M, Ludwig A et al. (2003). Safety-assessment of 3-methoxyquercetin as an antirhinoviral compound for nasal application: Effect on ciliary beat frequency. Int J Pharm, 263:95–103.
   PubMed Web of Science ®Google Scholar
• Hofer E, Neher A, Gunkel AR, Nagl M. (2003). In vitro study on the influence of N-chlorotaurine on the ciliary beat frequency of nasal mucosa. Am J Rhinol, 17:149–152.
   PubMedGoogle Scholar
• Hofer E, Neher A, Schrott-Fischer A, Nagl M. (2004). Influence of amphotericin B on the ciliary beat frequency of nasal mucosa. Laryngoscope, 114:1964–1966.
   PubMed Web of Science ®Google Scholar
• Merkus P, Romeijn SG, Verhoef JC, Merkus FW, Schouwenburg PF. (2001). Classification of cilio-inhibiting effects of nasal drugs. Laryngoscope, 111:595–602.
   PubMed Web of Science ®Google Scholar
• Bernkop-Schnürch A, Kast CE, Guggi D. (2003). Permeation enhancing polymers in oral delivery of hydrophilic macromolecules: Thiomer/GSH systems. J Control Release, 93:95–103.
   PubMed Web of Science ®Google Scholar
• Ikechukwu Ugwoke M, Kaufmann G, Verbeke N, Kinget R. (2000). Intranasal bioavailability of apomorphine from carboxymethylcellulose-based drug delivery systems. Int J Pharm, 202:125–131.
   PubMedGoogle Scholar
• Hasçiçek C, Gönül N, Erk N. (2003). Mucoadhesive microspheres containing gentamicin sulfate for nasal administration: Preparation and in vitro characterization. Farmaco, 58:11–16.
   PubMedGoogle Scholar
• Girard PR, Kennedy JR. (1986). Calcium regulation of ciliary activity in rabbit tracheal epithelial explants and outgrowth. Eur J Cell Biol, 40:203–209.
   PubMed Web of Science ®Google Scholar
• Agu RU, Jorissen M, Willems T, Van den Mooter G, Kinget R, Augustijns P. (1999). Effects of pharmaceutical compounds on ciliary beating in human nasal epithelial cells: A comparative study of cell culture models. Pharm Res, 16:1380–1385.
   PubMed Web of Science ®Google Scholar
• Ugwoke MI, Agu RU, Jorissen M, Augustijns P, Sciot R, Verbeke N et al. (2000). Toxicological investigations of the effects carboxymethylcellulose on ciliary beat frequency of human nasal epithelial cells in primary suspension culture and in vivo on rabbit nasal mucosa. Int J Pharm, 205:43–51.
   PubMed Web of Science ®Google Scholar
• Merkus FW, Verhoef JC, Schipper NG, Marttin E. (1998). Nasal mucociliary clearance as a factor in nasal drug delivery. Adv Drug Deliv Rev, 29:13–38.
   PubMed Web of Science ®Google Scholar
• Marttin E, Schipper NGM, Verhoef JC, Merkus FWHM. (1998). Nasal mucociliary clearance as a factor in nasal drug delivery. Adv Drug Deliv Rev, 29, 13–38.
   PubMed Web of Science ®Google Scholar
• Green A, Smallman LA, Logan AC, Drake-Lee AB. (1995). The effect of temperature on nasal ciliary beat frequency. Clin Otolaryngol Allied Sci, 20:178–180.
   PubMed Web of Science ®Google Scholar
• Clary-Meinesz CF, Cosson J, Huitorel P, Blaive B. (1992). Temperature effect on the ciliary beat frequency of human nasal and tracheal ciliated cells. Biol Cell, 76:335–338.
   PubMed Web of Science ®Google Scholar
• Kissel T, Werner U. (1998). Nasal delivery of peptides: An in vitro cell culture model for the investigation of transport and metabolism in human nasal epithelium. J Control Release, 53:195–203.
   PubMed Web of Science ®Google Scholar
• Knoll M, Shaoulian R, Magers T, Talbot P. (1995). Ciliary beat frequency of hamster oviducts is decreased in vitro by exposure to solutions of mainstream and sidestream cigarette smoke. Biol Reprod, 53:29–37.
   PubMed Web of Science ®Google Scholar
• Tien D, Schnaare RL, Kang F, Cohl G, McCormick TJ, Moench TR et al. (2005). In vitro and in vivo characterization of a potential universal placebo designed for use in vaginal microbicide clinical trials. AIDS Res Hum Retroviruses, 21:845–853.
   PubMed Web of Science ®Google Scholar
• Haffejee N, Du Plessis J, Müller DG, Schultz C, Kotzé AF, Goosen C. (2001). Intranasal toxicity of selected absorption enhancers. Pharmazie, 56:882–888.
   PubMed Web of Science ®Google Scholar
• Guggi D, Langoth N, Hoffer MH, Wirth M, Bernkop-Schnürch A. (2004). Comparative evaluation of cytotoxicity of a glucosamine-TBA conjugate and a chitosan-TBA conjugate. Int J Pharm, 278:353–360.
   PubMed Web of Science ®Google Scholar
• Hoyer H, Schlocker W, Krum K, Bernkop-Schnürch A. (2008). Preparation and evaluation of microparticles from thiolated polymers via air jet milling. Eur J Pharm Biopharm, 69:476–485.
   PubMed Web of Science ®Google Scholar
• Vetter A, Martien R, Bernkop-Schnürch A. (2010). Thiolated polycarbophil as an adjuvant for permeation enhancement in nasal delivery of antisense oligonucleotides. J Pharm Sci, 99:1427–1439.
   PubMed Web of Science ®Google Scholar
• Krauland AH, Leitner VM, Grabovac V, Bernkop-Schnürch A. (2006). In vivo evaluation of a nasal insulin delivery system based on thiolated chitosan. J Pharm Sci, 95:2463–2472.
   PubMed Web of Science ®Google Scholar