Evaluation of hepatic glucose metabolism via gluconeogenesis and glycogenolysis after oral administration of insulin nanoparticles

References

• Khafagy el-S, Morishita M, Onuki Y, Takayama K. (2007). Current challenges in non-invasive insulin delivery systems: a comparative review. Adv Drug Deliv Rev, 59:1521–1546.
   PubMed Web of Science ®Google Scholar
• Cherrington AD. (2005). The role of hepatic insulin receptors in the regulation of glucose production. J Clin Invest, 115:1136–1139.
   PubMed Web of Science ®Google Scholar
• Delgado TC, Silva C, Fernandes I, Caldeira M, Bastos M, Baptista C et al. (2009). Sources of hepatic glycogen synthesis during an oral glucose tolerance test: effect of transaldolase exchange on flux estimates. Magn Reson Med, 62:1120–1128.
   PubMed Web of Science ®Google Scholar
• Owens DR, Zinman B, Bolli G. (2003). Alternative routes of insulin delivery. Diabet Med, 20:886–898.
   PubMed Web of Science ®Google Scholar
• Woitiski CB, Neufeld RJ, Veiga F, Carvalho RA, Figueiredo IV. (2010). Pharmacological effect of orally delivered insulin facilitated by multilayered stable nanoparticles. Eur J Pharm Sci, 41:556–563.
   PubMed Web of Science ®Google Scholar
• Woitiski CB, Veiga F, Ribeiro A, Neufeld R. (2009). Design for optimization of nanoparticles integrating biomaterials for orally dosed insulin. Eur J Pharm Biopharm, 73:25–33.
   PubMed Web of Science ®Google Scholar
• Champion JA, Katare YK, Mitragotri S. (2007). Particle shape: a new design parameter for micro- and nanoscale drug delivery carriers. J Control Release, 121:3–9.
   PubMed Web of Science ®Google Scholar
• Katz J, Lee WN, Wals PA, Bergner EA. (1989). Studies of glycogen synthesis and the Krebs cycle by mass isotopomer analysis with [U-13C]glucose in rats. J Biol Chem, 264:12994–13004.
   PubMed Web of Science ®Google Scholar
• Newgard CB, Hirsch LJ, Foster DW, McGarry JD. (1983). Studies on the mechanism by which exogenous glucose is converted into liver glycogen in the rat. A direct or an indirect pathway? J Biol Chem, 258:8046–8052.
   PubMed Web of Science ®Google Scholar
• Shulman GI, Rothman DL, Smith D, Johnson CM, Blair JB, Shulman RG et al. (1985). Mechanism of liver glycogen repletion in vivo by nuclear magnetic resonance spectroscopy. J Clin Invest, 76:1229–1236.
   PubMed Web of Science ®Google Scholar
• Soares AF, Jones JG. (2010). Alterations on the hepatic glycogen and lipid metabolism following the induction of diabetes in rats. ISMRM Annual Meeting & Exhibition. Stockholm, Sweden.
   Google Scholar
• Soares AF, Viega FJ, Carvalho RA, Jones JG. (2009). Quantifying hepatic glycogen synthesis by direct and indirect pathways in rats under normal ad libitum feeding conditions. Magn Reson Med, 61:1–5.
   PubMed Web of Science ®Google Scholar
• Bischof MG, Bernroider E, Krssak M, Krebs M, Stingl H, Nowotny P et al. (2002). Hepatic glycogen metabolism in type 1 diabetes after long-term near normoglycemia. Diabetes, 51:49–54.
   PubMed Web of Science ®Google Scholar
• Perdigoto R, Rodrigues TB, Furtado AL, Porto A, Geraldes CF, Jones JG. (2003). Integration of [U-13C]glucose and 2H2O for quantification of hepatic glucose production and gluconeogenesis. NMR Biomed, 16:189–198.
   PubMed Web of Science ®Google Scholar
• Perdigoto R, Furtado AL, Porto A, Rodrigues TB, Geraldes CF, Jones JG. (2003). Sources of glucose production in cirrhosis by 2H2O ingestion and 2H NMR analysis of plasma glucose. Biochim Biophys Acta, 1637:156–163.
   PubMed Web of Science ®Google Scholar
• Esenmo E, Chandramouli V, Schumann WC, Kumaran K, Wahren J, Landau BR. (1992). Use of 14CO2 in estimating rates of hepatic gluconeogenesis. Am J Physiol, 263:E36–E41.
   PubMed Web of Science ®Google Scholar
• Peroni O, Large V, Diraison F, Beylot M. (1997). Glucose production and gluconeogenesis in postabsorptive and starved normal and streptozotocin-diabetic rats. Metab Clin Exp, 46:1358–1363.
   PubMed Web of Science ®Google Scholar
• Tayek JA, Katz J. (1996). Glucose production, recycling, and gluconeogenesis in normals and diabetics: a mass isotopomer [U-13C]glucose study. Am J Physiol, 270:E709–E717.
   PubMed Web of Science ®Google Scholar
• Tayek JA, Katz J. (1997). Glucose production, recycling, Cori cycle, and gluconeogenesis in humans: relationship to serum cortisol. Am J Physiol, 272:E476–E484.
   PubMed Web of Science ®Google Scholar
• Landau BR, Wahren J, Chandramouli V, Schumann WC, Ekberg K, Kalhan SC. (1996). Contributions of gluconeogenesis to glucose production in the fasted state. J Clin Invest, 98:378–385.
   PubMed Web of Science ®Google Scholar
• Jones J, Barosa C, Gomes F, Mendes AC, Delgado TC, Diogo L et al. (2006). NMR derivatives for quantification of 2H and 13C enrichment of human glucuronide from metabolic tracers. J Carb Chem, 25:203–217.
   Web of Science ®Google Scholar
• Jones JG, Merritt M, Malloy C. (2001). Quantifying tracer levels of (2)H(2)O enrichment from microliter amounts of plasma and urine by (2)H NMR. Magn Reson Med, 45:156–158.
   PubMed Web of Science ®Google Scholar
• Reis CP, Ribeiro AJ, Veiga F, Neufeld RJ, Damgé C. (2008). Polyelectrolyte biomaterial interactions provide nanoparticulate carrier for oral insulin delivery. Drug Deliv, 15:127–139.
   PubMed Web of Science ®Google Scholar
• Santander-Ortega MJ, Csaba N, Alonso MJ, Ortega-Vinuesa JL, Bastos-González D. (2007). Stability and physicochemical characteristics of PLGA, PLGA: poloxamer and PLGA: poloxamine blend nanoparticles: a comparative study. Colloid Surfaces A Physicochem Eng Aspects, 296(1–3):132–140.
   Web of Science ®Google Scholar
• Howald L, Haefke H, Lüthi R, Meyer E, Gerth G, Rudin H et al. (1994). Ultrahigh-vacuum scanning force microscopy: atomic-scale resolution at monatomic cleavage steps. Phys Rev, B Condens Matter, 49:5651–5656.
   PubMed Web of Science ®Google Scholar
• Ramirez-Aguilar KA, Rowlen KL. (1998). Tip characterization from AFM images of nanometric spherical particles. Langmuir, 14:2562–2566.
   Web of Science ®Google Scholar
• Dunne M, Corrigan I, Ramtoola Z. (2000). Influence of particle size and dissolution conditions on the degradation properties of polylactide-co-glycolide particles. Biomaterials, 21:1659–1668.
   PubMed Web of Science ®Google Scholar
• Lamprecht A, Schäfer U, Lehr CM. (2001). Size-dependent bioadhesion of micro- and nanoparticulate carriers to the inflamed colonic mucosa. Pharm Res, 18:788–793.
   PubMed Web of Science ®Google Scholar
• Shinde Patil VR, Campbell CJ, Yun YH, Slack SM, Goetz DJ. (2001). Particle diameter influences adhesion under flow. Biophys J, 80:1733–1743.
   PubMed Web of Science ®Google Scholar
• Cedersund G, Strålfors P. (2009). Putting the pieces together in diabetes research: towards a hierarchical model of whole-body glucose homeostasis. Eur J Pharm Sci, 36:91–104.
   PubMed Web of Science ®Google Scholar
• Burgess SC, Nuss M, Chandramouli V, Hardin DS, Rice M, Landau BR et al. (2003). Analysis of gluconeogenic pathways in vivo by distribution of 2H in plasma glucose: comparison of nuclear magnetic resonance and mass spectrometry. Anal Biochem, 318:321–324.
   PubMed Web of Science ®Google Scholar
• Chandramouli V, Ekberg K, Schumann WC, Kalhan SC, Wahren J, Landau BR. (1997). Quantifying gluconeogenesis during fasting. Am J Physiol, 273:E1209–E1215.
   PubMed Web of Science ®Google Scholar
• Jones JG, Carvalho RA, Sherry AD, Malloy CR. (2000). Quantitation of gluconeogenesis by (2)H nuclear magnetic resonance analysis of plasma glucose following ingestion of (2)H(2)O. Anal Biochem, 277:121–126.
   PubMed Web of Science ®Google Scholar
• Hellerstein MK, Neese RA, Linfoot P, Christiansen M, Turner S, Letscher A. (1997). Hepatic gluconeogenic fluxes and glycogen turnover during fasting in humans. A stable isotope study. J Clin Invest, 100:1305–1319.
   PubMed Web of Science ®Google Scholar
• Wi JK, Kim JK, Youn JH. (1996). Mechanisms of postabsorptive hyperglycemia in streptozotocin diabetic rats. Am J Physiol, 270:E752–E758.
   PubMed Web of Science ®Google Scholar
• Kida K, Nakajo S, Kamiya F, Toyama Y, Nishio T, Nakagawa H. (1978). Renal net glucose release in vivo and its contribution to blood glucose in rats. J Clin Invest, 62:721–726.
   PubMed Web of Science ®Google Scholar
• Mithieux G, Vidal H, Zitoun C, Bruni N, Daniele N, Minassian C. (1996). Glucose-6-phosphatase mRNA and activity are increased to the same extent in kidney and liver of diabetic rats. Diabetes, 45:891–896.
   PubMed Web of Science ®Google Scholar
• Shimomura I, Matsuda M, Hammer RE, Bashmakov Y, Brown MS, Goldstein JL. (2000). Down regulation of IRS- 2 and Up-regulation of SREBP-1c leads to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Molecular Cell 6, 77–86.
   PubMed Web of Science ®Google Scholar
• Lam TK, van de Werve G, Giacca A. (2003). Free fatty acids increase basal hepatic glucose production and induce hepatic insulin resistance at different sites. Am J Physiol Endocrinol Metab, 284:E281–E290.
   PubMed Web of Science ®Google Scholar
• Wu C, Okar DA, Stoeckman AK, Peng LJ, Herrera AH, Herrera JE et al. (2004). A potential role for fructose-2,6-bisphosphate in the stimulation of hepatic glucokinase gene expression. Endocrinology, 145:650–658.
   PubMed Web of Science ®Google Scholar