708
Views
13
CrossRef citations to date
0
Altmetric
Research Article

To evaluate the effect of various magnesium stearate polymorphs using powder rheology and thermal analysis

, &
Pages 1470-1478 | Received 11 Jul 2011, Accepted 26 Dec 2011, Published online: 05 Feb 2012

References

  • Nichols AG. (2008). Magnesium Anhydrate Report. Corporate Analytical Research, Mallinckrodt Pharmaceutical, Inc.
  • Nichols AG, Wu HS. (2008). Characterization of stearate-based lubricants for making tablets. AAPS Poster No. T3218, AM-08-00825.
  • Okoye P, Wu HS. (2007). Lubrication of direct-compressible blends with magnesium stearate monohydrate and dihydrate. Pharm Technol, 13:116–129.
  • Patel S, Kaushal AM, Bansal AK. (2007). Lubrication potential of magnesium stearate studied on instrumented rotary tablet press. AAPS Pharm Sci Tech, 8:E1–8. http://www.aapspharmscitech.org.
  • International Cosmetic Ingredient Dictionary and Handbook. (2008). Cosmetic, Toiletry and Fragrance Association (CTFA) 12th edn.
  • Young PM, Traini D. (2007). Advances in pulmonary therapy. Drug and the Pharm Sci, 172:16.
  • Ertel KD, Carstensen JT. (1988). Chemical, physical, and lubricant properties of magnesium stearate. J Pharm Sci, 77:625–629.
  • Sharpe SA, Celik M, Newman AW, Brittain HG. (1997). Physical characterization of the polymorphic variations of magnesium stearate and magnesium palmitate hydrate species. Struct Chem, 8:73–74.
  • Swaminathan V, Kildsig DO. (2002). Effect of magnesium stearate on the content uniformity of active ingredient in pharmaceutical powder mixtures. AAPS Pharm Sci Tech, 3:1–5.
  • Koivisto M, Jalonen HU, Lehto V. (2004). Effect of temperature and humidity on vegetable grade of magnesium stearate. Powder Technol, 147:79–85.
  • Leinonen UI, Jalonen HU, Vihervaara PA, Laine ES. (1992). Physical and lubrication properties of magnesium stearate. J Pharm Sci, 81:1194–1198.
  • Steffens KJ, Koglin J. (1993). The magnesium stearate problem. Manuf Chem Dec 1993:16–18.
  • Andrès C, Bracconi P, Pourcelot Y. (2001). On the difficulty of assessing the specific surface area of magnesium stearate. Int J Pharm, 218:153–163.
  • Bracconi P, Andrès C, Ndiaye A. (2003). Structural properties of magnesium stearate pseudopolymorphs: Effect of temperature. Int J Pharm, 262:109–124.
  • Swaminathan V, Kildsig DO. (2001). An examination of the moisture sorption characteristics of commercial magnesium stearate. AAPS Pharm Sci Tech, 2:1–7.
  • Almaya A, Aburub A. (2008). Effect of particle size on compaction of materials with different deformation mechanisms with and without lubricants. AAPS PharmSciTech, 9:414–418.
  • Shah RB, Tawakkul MA, Khan MA. (2008). Comparative evaluation of flow for pharmaceutical powders and granules. AAPS PharmSciTech, 9:250–258.
  • Ganderton D. (1969). The effect of distribution of magnesium stearate on the penetration of a tablet by water. J Pharm Pharmacol, 21:9S–18S.
  • Barra J, Somma R. (1996). Influence of the physicochemical variability of magnesium stearate on its lubricant properties: Possible solutions. Drug Dev and Ind Pharm, 22:1105–1120.
  • Freeman R. (2007). Measuring the flow properties of consolidated, conditioned and aerated powders—A comparative study using a powder rheometer and a rotational shear cell. Powder Technol, 174:25–33.
  • Cooke J, Freeman R. (2006). The flowability of powders and effect of flow additives. World Congress on Particle Tech, 5:1–12.
  • Brittain HG. (1995). Physical characterization of pharmaceutical solids. Marcel Dekker Inc, 70:253–300.
  • Martin A, Bustamante P, Chun AHC. (1993). Physical pharmacy: Physical chemical principles in the pharmaceutical sciences. Lea & Febiger:423–452.
  • Sun CC. (2008). Mechanism of moisture induced variations in true density and compaction properties of microcrystalline cellulose. Int J Pharm, 346:93–101.
  • Lieberman H, Lachman L, Schwartz JB. (1990). Pharmaceutical dosage forms: Tablets. Marcel Dekker Inc, 2:201–243.
  • Javadzadeh Y, Shariati H, Movahhed-Danesh E, Nokhodchi A. (2009). Effect of some commercial grades of microcrystalline cellulose on flowability, compressibility, and dissolution profile of piroxicam liquisolid compacts. Drug Dev Ind Pharm, 35:243–251.
  • Busignies V, Leclerc B, Truchon S, Tchoreloff P. (2011). Changes in the specific surface area of tablets composed of pharmaceutical materials with various deformation behaviors. Drug Dev Ind Pharm, 37:225–233.
  • Abdel-Hamid S, Betz G. (2011). Study of radial die-wall pressure changes during pharmaceutical powder compaction. Drug Dev Ind Pharm, 37:387–395.
  • Mužíková J, Eimerová I. (2011). A study of the compaction process and the properties of tablets made of a new co-processed starch excipient. Drug Dev Ind Pharm, 37:576–582.
  • Perrault M, Bertrand F, Chaouki J. (2001). An experimental investigation of the effect of the amount of lubricant on tablet properties. Drug Dev and Ind Pharm, 37:234–242.
  • Weber D, Pu Y, Cooney CL. (2008). Quantification of lubricant activity of magnesium stearate by atomic force microscopy. Drug Dev Ind Pharm, 34:1097–1099.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.