Effects of spray drying process parameters on the solubility behavior and physical stability of solid dispersions prepared using a laboratory-scale spray dryer

References

• Lipinsky C. (2002). Poor aqueous solubility - an industry wide problem in drug discovery. Am Pharm Rev, 5: 82–85.
   Google Scholar
• Takano R, Furumoto K, Shiraki K, Takata N, Hayashi Y, Aso Y et al. (2008). Rate-limiting steps of oral absorption for poorly water-soluble drugs in dogs; prediction from a miniscale dissolution test and a physiologically-based computer simulation. Pharm Res, 25:2334–2344.
   PubMed Web of Science ®Google Scholar
• Kennedy M, Hu J, Gao P, Li L, Ali-Reynolds A, Chal B et al. (2008). Enhanced bioavailability of a poorly soluble VR1 antagonist using an amorphous solid dispersion approach: a case study. Mol Pharm, 5:981–993.
   PubMed Web of Science ®Google Scholar
• Chokshi RJ, Zia H, Sandhu HK, Shah NH, Malick WA. (2007). Improving the dissolution rate of poorly water soluble drug by solid dispersion and solid solution: pros and cons. Drug Deliv, 14:33–45.
   PubMed Web of Science ®Google Scholar
• Bak A, Gore A, Yanez E, Stanton M, Tufekcic S, Syed R et al. (2008). The co-crystal approach to improve the exposure of a water-insoluble compound: AMG 517 sorbic acid co-crystal characterization and pharmacokinetics. J Pharm Sci, 97:3942–3956.
   PubMed Web of Science ®Google Scholar
• Shiraki K, Takata N, Takano R, Hayashi Y, Terada K. (2008). Dissolution improvement and the mechanism of the improvement from cocrystallization of poorly water-soluble compounds. Pharm Res, 25:2581–2592.
   PubMed Web of Science ®Google Scholar
• Sakai K, Maeda H, Yoshimori T, Obata K, Ogawa Y. (2009). High-throughput formulation screening system for self-microemulsifying drug delivery. Drug Dev Ind Pharm, 35:746–755.
   PubMed Web of Science ®Google Scholar
• Hancock BC, Zografi G. (1997). Characteristics and significance of the amorphous state in pharmaceutical systems. J Pharm Sci, 86:1–12.
   PubMed Web of Science ®Google Scholar
• Hancock BC, Shamblin SL, Zografi G. (1995). Molecular mobility of amorphous pharmaceutical solids below their glass transition temperatures. Pharm Res, 12:799–806.
   PubMed Web of Science ®Google Scholar
• Hancock BC, Shalaev EY, Shamblin SL. (2002). Polyamorphism: a pharmaceutical science perspective. J Pharm Pharmacol, 54:1151–1152.
   PubMed Web of Science ®Google Scholar
• Serajuddin AT. (1999). Solid dispersion of poorly water-soluble drugs: early promises, subsequent problems, and recent breakthroughs. J Pharm Sci, 88:1058–1066.
   PubMed Web of Science ®Google Scholar
• Chokshi RJ, Sandhu HK, Iyer RM, Shah NH, Malick AW, Zia H. (2005). Characterization of physico-mechanical properties of indomethacin and polymers to assess their suitability for hot-melt extrusion processs as a means to manufacture solid dispersion/solution. J Pharm Sci, 94:2463–2474.
   PubMed Web of Science ®Google Scholar
• El-Gazayerly ON. (2000). Characterization and evaluation of tenoxicam coprecipitates. Drug Dev Ind Pharm, 26: 925–930.
   PubMed Web of Science ®Google Scholar
• Thybo P, Pedersen BL, Hovgaard L, Holm R, Mullertz A. (2008). Characterization and physical stability of spray dried solid dispersions of probucol and PVP-K30. Pharm Dev Technol, 13:375–386.
   PubMed Web of Science ®Google Scholar
• Janssens S, De Zeure A, Paudel A, Van Humbeeck J, Rombaut P, Van den Mooter G. (2010). Influence of preparation methods on solid state supersaturation of amorphous solid dispersions: a case study with itraconazole and eudragit e100. Pharm Res, 27:775–785.
   PubMed Web of Science ®Google Scholar
• Okimoto K, Miyake M, Ibuki R, Yasumura M, Ohnishi N, Nakai T. Dissolution mechanism and rate of solid dispersion particles of nilvadipine with hydroxypropylmethylcellulose. Int J Pharm, 1997; 159: 85–93.
   Web of Science ®Google Scholar
• Hirasawa N, Ishise S, Miyata H, Danjo K. (2003). Physicochemical characterization and drug release studies of nilvadipine solid dispersions using water-insoluble polymer as a carrier. Drug Dev Ind Pharm, 29:339–344.
   PubMed Web of Science ®Google Scholar
• Cilurzo F, Minghetti P, Casiraghi A, Montanari L. (2002). Characterization of nifedipine solid dispersions. Int J Pharm, 242:313–317.
   PubMed Web of Science ®Google Scholar
• Geppi M, Guccione S, Mollica G, Pignatello R, Veracini CA. (2005). Molecular properties of ibuprofen and its solid dispersions with Eudragit RL100 studied by solid-state nuclear magnetic resonance. Pharm Res, 22:1544–1555.
   PubMed Web of Science ®Google Scholar
• Aso Y, Yoshioka S. (2006). Molecular mobility of nifedipine-PVP and phenobarbital-PVP solid dispersions as measured by 13C-NMR spin-lattice relaxation time. J Pharm Sci, 95:318–325.
   PubMed Web of Science ®Google Scholar
• Matsumoto T, Zografi G. (1999). Physical properties of solid molecular dispersions of indomethacin with poly(vinylpyrrolidone) and poly(vinylpyrrolidone-co-vinyl-acetate) in relation to indomethacin crystallization. Pharm Res, 16:1722–1728.
   PubMed Web of Science ®Google Scholar
• Forster A, Hempenstall J, Rades T. (2001). Characterization of glass solutions of poorly water-soluble drugs produced by melt extrusion with hydrophilic amorphous polymers. J Pharm Pharmacol, 53:303–315.
   PubMed Web of Science ®Google Scholar
• Taylor LS, Zografi G. (1997). Spectroscopic characterization of interactions between PVP and indomethacin in amorphous molecular dispersions. Pharm Res, 14:1691–1698.
   PubMed Web of Science ®Google Scholar
• Taylor LS, Langkilde FW, Zografi G. (2001). Fourier transform Raman spectroscopic study of the interaction of water vapor with amorphous polymers. J Pharm Sci, 90:888–901.
   PubMed Web of Science ®Google Scholar
• Zhang J, Bunker M, Chen X, Parker AP, Patel N, Roberts CJ. (2009). Nanoscale thermal analysis of pharmaceutical solid dispersions. Int J Pharm, 380:170–173.
   PubMed Web of Science ®Google Scholar
• Gander B, Wehrli E, Alder R, Merkle HP. (1995). Quality improvement of spray-dried, protein-loaded D,L-PLA microspheres by appropriate polymer solvent selection. J Microencapsul, 12:83–97.
   PubMed Web of Science ®Google Scholar
• Iskandar F, Gradon L, Okuyama K. (2003). Control of the morphology of nanostructured particles prepared by the spray drying of a nanoparticle sol. J Colloid Interface Sci, 265:296–303.
   PubMed Web of Science ®Google Scholar
• Sen D, Spalla O, Taché O, Haltebourg P, Thill A. (2007). Slow drying of a spray of nanoparticles dispersion. In situ SAXS investigation. Langmuir, 23:4296–4302.
   PubMed Web of Science ®Google Scholar
• He X, Pei L, Tong HH, Zheng Y. (2011). Comparison of spray freeze drying and the solvent evaporation method for preparing solid dispersions of baicalein with Pluronic F68 to improve dissolution and oral bioavailability. AAPS PharmSciTech, 12:104–113.
   PubMed Web of Science ®Google Scholar