Advanced search
Publication Cover
Drug Development and Industrial Pharmacy Volume 39, 2013 - Issue 9
Submit an article Journal homepage
192
Views
9
CrossRef citations to date
0
Altmetric
Research Article

HEC-cysteamine particles: influence of particle size, zeta potential, morphology and sulfhydryl groups on permeation enhancing properties

Deni Rahmat
,
Christiane MüllerDepartment of Pharmaceutical Technology, Institute of Pharmacy, Center for Chemistry and Biomedicine, Center for Molecular Biosciences, Leopold-Franzens-University Innsbruck, Innsbruck, Austria
,
Gul ShahnazDepartment of Pharmaceutical Technology, Institute of Pharmacy, Center for Chemistry and Biomedicine, Center for Molecular Biosciences, Leopold-Franzens-University Innsbruck, Innsbruck, Austria
,
Katharina LeithnerDepartment of Pharmaceutical Technology, Institute of Pharmacy, Center for Chemistry and Biomedicine, Center for Molecular Biosciences, Leopold-Franzens-University Innsbruck, Innsbruck, Austria
,
Flavia LaffleurDepartment of Pharmaceutical Technology, Institute of Pharmacy, Center for Chemistry and Biomedicine, Center for Molecular Biosciences, Leopold-Franzens-University Innsbruck, Innsbruck, Austria
,
Mohammad Imran KhanDepartment of Internal Medicine I, Medical University of Innsbruck, Innsbruck, Austria
,
Ronny MartienFaculty of Pharmacy, Gadjah Mada University, Sekip Utara, Yogyakarta, Indonesia
&
Andreas Bernkop SchnürchDepartment of Pharmaceutical Technology, Institute of Pharmacy, Center for Chemistry and Biomedicine, Center for Molecular Biosciences, Leopold-Franzens-University Innsbruck, Innsbruck, AustriaCorrespondence[email protected]
 show all
Pages 1338-1345 | Received 26 Mar 2012, Accepted 05 Jul 2012, Published online: 20 Aug 2012

References

  • Alli SMA, Ali SMA, Samanta A. (2011). Development and evaluation of intestinal targeted mucoadhesive microspheres of Bacillus coagulans. Drug Dev Ind Pharm, 37, 1329–1338.
  • Jiang L, Gao L, Wang X, Tang L, Ma J. (2010). The application of mucoadhesive polymers in nasal drug delivery. Drug Dev Ind Pharm, 36:323–336.
  • Ponchel G, Irache J. (1998). Specific and non-specific bioadhesive particulate systems for oral delivery to the gastrointestinal tract. Adv Drug Deliv Rev, 34:191–219.
  • Coupe AJ, Davis SS, Wilding IR. (1991). Variation in gastrointestinal transit of pharmaceutical dosage forms in healthy subjects. Pharm Res, 8:360–364.
  • Liu YH, Zhu X, Zhou D, Jin Y, Zhao CY, Zhang ZR et al. (2011). pH-sensitive and mucoadhesive microspheres for duodenum-specific drug delivery system. Drug Dev Ind Pharm, 37:868–874.
  • Hoyer H, Perera G, Bernkop-Schnürch A. (2010). Noninvasive delivery systems for peptides and proteins in osteoporosis therapy: a retroperspective. Drug Dev Ind Pharm, 36:31–44.
  • Bernkop-Schnürch A, Kast CE, Guggi D. (2003). Permeation enhancing polymers in oral delivery of hydrophilic macromolecules: thiomer/GSH systems. J Control Release, 93:95–103.
  • Muller C, Rahmat D, Sarti F, Leithner K, Bernkop-Schnurch A. (2012). Immobilization of 2-mercaptoethylamine on oxidized chitosan: a substantially mucoadhesive and permeation enhancing polymer. J Mater Chem, 22:3899–3908.
  • Millotti G, Perera G, Vigl C, Pickl K, Sinner FM, Bernkop-Schnürch A. (2011). The use of chitosan-6-mercaptonicotinic acid nanoparticles for oral peptide drug delivery. Drug Deliv, 18:190–197.
  • Sakloetsakun D, Iqbal J, Millotti G, Vetter A, Bernkop-Schnürch A. (2011). Thiolated chitosans: influence of various sulfhydryl ligands on permeation-enhancing and P-gp inhibitory properties. Drug Dev Ind Pharm, 37:648–655.
  • Rahmat D, Sakloetsakun D, Shahnaz G, Perera G, Kaindl R, Bernkop-Schnürch A. (2011). Design and synthesis of a novel cationic thiolated polymer. Int J Pharm, 411:10–17.
  • Rahmat D, Sakloetsakun D, Shahnaz G, Sarti F, Laffleur F, Schnürch AB. (2012). HEC-cysteamine conjugates: influence of degree of thiolation on efflux pump inhibitory and permeation enhancing properties. Int J Pharm, 422:40–46.
  • Sigfridsson K, Nordmark A, Theilig S, Lindahl A. (2011). A formulation comparison between micro- and nanosuspensions: the importance of particle size for absorption of a model compound, following repeated oral administration to rats during early development. Drug Dev Ind Pharm, 37:185–192.
  • Grabovac V, Bernkop-Schnürch A. (2007). Development and in vitro evaluation of surface modified poly(lactide-co-glycolide) nanoparticles with chitosan-4-thiobutylamidine. Drug Dev Ind Pharm, 33:767–774.
  • Albrecht K, Zirm EJ, Palmberger TF, Schlocker W, Bernkop-Schnürch A. (2006). Preparation of thiomer microparticles and in vitro evaluation of parameters influencing their mucoadhesive properties. Drug Dev Ind Pharm, 32:1149–1157.
  • Desai MP, Labhasetwar V, Amidon GL, Levy RJ. (1996). Gastrointestinal uptake of biodegradable microparticles: effect of particle size. Pharm Res, 13:1838–1845.
  • des Rieux A, Fievez V, Garinot M, Schneider YJ, Préat V. (2006). Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach. J Control Release, 116:1–27.
  • Schlocker W, Gschliesser S, Bernkop-Schnürch A. (2006). Evaluation of the potential of air jet milling of solid protein-poly(acrylate) complexes for microparticle preparation. Eur J Pharm Biopharm, 62:260–266.
  • Hoyer H, Schlocker W, Krum K, Bernkop-Schnürch A. (2008). Preparation and evaluation of microparticles from thiolated polymers via air jet milling. Eur J Pharm Biopharm, 69:476–485.
  • Hombach J, Bernkop-Schnürch A. (2009). Chitosan solutions and particles: evaluation of their permeation enhancing potential on MDCK cells used as blood brain barrier model. Int J Pharm, 376:104–109.
  • Ruano JLG, Parra A, Aleman J. (2008). Efficient synthesis of disulfides by air oxidation of thiols under sonication. Green Chem, 10:706–711.
  • Clausen AE, Bernkop-Schnürch A. (2000). In vitro evaluation of the permeation-enhancing effect of thiolated polycarbophil. J Pharm Sci, 89:1253–1261.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.