Production and characterization of pellets using Avicel CL611 as spheronization aid

References

• Ghebre-Sellassie I. A general overview. In: Ghebre-Sellasie I, ed. Pharmaceutical pelletization technology. New York: Marcel Dekker; 1989:1–14
   Google Scholar
• Dukic-Ott A, Thommes M, Remon JP, et al. Production of pellets via extrusion-spheronisation without the incorporation of microcrystalline cellulose: a critical review. Eur J Pharm Biopharm 2009;71:38–46
   PubMed Web of Science ®Google Scholar
• Vervaet C, Baert L, Remon JP. Extrusion-spheronisation. A literature review. Int J Pharm 1995;116:131–46
   Web of Science ®Google Scholar
• Dreu R, Sirca J, Pintye-Hodi K, et al. Physicochemical properties of granulating liquids and their influence on microcrystalline cellulose pellets obtained by extrusion-spheronisation technology. Int J Pharm 2005;291:99–111
   PubMed Web of Science ®Google Scholar
• Dukic-Ott A, Remon JP, Foreman P, Vervaet C. Immediate release of poorly soluble drugs from starch based pellets via extrusion/spheronisation. Eur J Pharm Biopharm 2007;67:715–24
   PubMed Web of Science ®Google Scholar
• Lustig-Gustafsson C, Johal K, Podczeck F, Newton JM. The influence of water content and drug solubility on the formulation of pellets by extrusion and spheronisation. Eur J Pharm Sci 1999;8:147–52
   PubMed Web of Science ®Google Scholar
• Song B, Rough SL, Wilson DI. Effects of drying technique on extrusion–spheronisation granules and tablet properties. Int J Pharm 2007;332:38–44
   PubMed Web of Science ®Google Scholar
• Sousa JJ, Sousa A, Podczeck F, Newton JM. Factors influencing the physical characteristics of pellets obtained by extrusion-spheronisation. Int J Pharm 2002;232:91–106
   PubMed Web of Science ®Google Scholar
• Chitu TM, Oulahna D, Hemati M. Rheology, granule growth and granule strength: application to the wet granulation of lactose–MCC mixtures. Powder Technol 2011;208:441–53
   Web of Science ®Google Scholar
• Alvarez L, Concheiro A, Gomez-Amoza JL, et al. Powdered cellulose as excipient for extrusion-spheronization pellets of a cohesive hydrophobic drug. Eur J Pharm Biopharm 2003;55:291–5
   PubMed Web of Science ®Google Scholar
• Ek R, Newton JM. Microcrystalline cellulose as a sponge as an alternative concept to the crystallite-gel model for extrusion and spheronisation. Pharm Res 1998;15:509–11
   PubMed Web of Science ®Google Scholar
• Kleinebudde P. The crystallite-gel-model for microcrystalline cellulose in wet-granulation, extrusion, and spheronization. Pharm Res 1997;14:804–9
   PubMed Web of Science ®Google Scholar
• Al-Nimry SS, Assaf SM, Jalal IM, Najib NM. Adsorption of ketotifen onto some pharmaceutical excipients. Int J Pharm 1997;149:115–21
   Web of Science ®Google Scholar
• Jain SP, Singh PP, Amin PD. Alternative extrusion-spheronization aids. Drug Dev Ind Pharm 2010;36:1364–76
   PubMed Web of Science ®Google Scholar
• Liew CV, Gu L, Soh JLP, Heng PWS. Functionality of cross-linked polyvinylpyrrolidone as a spheronization aid: a promising alternative to microcrystalline cellulose. Pharm Res 2005;22:1387–98
   PubMed Web of Science ®Google Scholar
• Alvarez L, Concheiro A, Gomez-Amoza JL, et al. Effect of microcrystalline cellulose grade and process variables on pellets prepared by extrusion-spheronisation. Drug Dev Ind Pharm 2002;28:451–6
   PubMed Web of Science ®Google Scholar
• Heng PWS, Koo OMY. A study of the effects of the physical characteristics of microcrystalline cellulose on performance in extrusion spheronisation. Pharm Res 2001;18:480–7
   PubMed Web of Science ®Google Scholar
• Podczeck F, Knight P E, Newton JM. The evaluation of modified microcrystalline cellulose for the preparation of pellets with high drug loading by extrusion/spheronization. Int J Pharm 2008;350:145–54
   PubMed Web of Science ®Google Scholar
• Rowe RC, Sheskey PJ, Owen SC. Handbook of pharmaceutical excipients. 6th ed. London: Pharmaceutical Press; 2006
   Google Scholar
• Newton JM, Chow AK, Jeewa KB. The effect of excipient source on spherical granules made by extrusion/spheronisation. Pharm Tech Intl 1992;4:52–8
   Google Scholar
• Chohan RK, Newton JM. Analysis of extrusion of some wet powder masses used in extrusion/spheronisation. Int J Pharm 1996;131:201–7
   Web of Science ®Google Scholar
• Di Pretoro G, Zema L, Gazzaniga A, et al. Extrusion–spheronisation of highly loaded 5-ASA multiparticulate dosage forms. Int J Pharm 2010;402:153–64
   PubMed Web of Science ®Google Scholar
• Di Pretoro G, Zema L, Palugan L, et al. Optimisation and scale-up of a highly loaded 5-ASA multi-particulate dosage form using a factorial approach. Eur J Pharm Sci 2012;45:158–68
   PubMed Web of Science ®Google Scholar
• Podczeck F, Rahman SR, Newton JM. Evaluation of a standardised procedure to assess the shape of pellets using image analysis. Int J Pharm 1999;192:123–38
   PubMed Web of Science ®Google Scholar
• Shipway PH, Hutchings IM. Attrition of brittle spheres by fracture under compression and impact loading. Powder Technol 1993;76:23–30
   Web of Science ®Google Scholar
• Kleinebudde P, Schoroder M, Schultz P, et al. Importance of the fraction of microcrystalline cellulose and spheronisation speed on the properties of extruded pellets made from binary mixtures. Pharm Dev Technol 1999;4:397–404
   PubMed Web of Science ®Google Scholar
• Wan LSC, Heng PWS, Liew CV. Spheronization conditions on spheroid shape and size. Int J Pharm 1993;96:59–65
   Web of Science ®Google Scholar
• Almeida-Prieto S, Blanco-Méndez J, Otero-Espinar FJ. Microscopic image analysis techniques for the morphological characterization of pharmaceutical particles: influence of the software, and the factor algorithms used in the shape factor estimation. Eur J Pharm Biopharm 2007;67:766–76
   PubMed Web of Science ®Google Scholar
• Kranz H, Jurgens K, Pinier M, Siepmann J. Drug release from MCC and carrageenan-based pellets: experiment and theory. Eur J Pharm Biopharm 2009;73:302–9
   PubMed Web of Science ®Google Scholar
• Luenburger H. Moist agglomeration in pharmaceutical powders. In: Chulia D, Deleuil M, Pourcelot Y, eds. Powder technology and pharmaceutical processes. Amsterdam: Elservier; 1994:377–89
   Google Scholar
• Podczeck F, Wood AV. The relationship between granule growth mechanism, amount of liquid binder added and properties of the wet powder mass determined using a split bed shear tester. Int J Pharm 2003;257:57–67
   PubMed Web of Science ®Google Scholar
• Boutell S, Newton JM, Bloor JR, Hayes G. The influence of liquid binder on the liquid mobility and preparation of spherical granules by the process of extrusion/spheronization. Int J Pharm 2002;238:61–76
   PubMed Web of Science ®Google Scholar
• Umprayn K, Chitropas P, Amarekajorn S. Influence of process variables on physical properties of the pellets using extruder and spheronizer. Drug Dev Ind Pharm 1999;25:45–61
   PubMed Web of Science ®Google Scholar
• Tomer G, Newton JM. Water movement evaluation during extrusion of wet powder masses by collecting extrudate fractions. Int J Pharm 1999;182:71–7
   PubMed Web of Science ®Google Scholar
• Mascia S, Patel MJ, Rough SL, et al. Liquid phase migration in the extrusion and squeezing of microcrystalline cellulose pastes. Eur J Pharm Sci 2006;29:22–34
   PubMed Web of Science ®Google Scholar
• Fielden KE, Newton JM, Rowe RC. The influence of lactose particle size on spheronisation of extrudate processed by a ram extruder. Int J Pharm 1992;81:205–24
   Web of Science ®Google Scholar
• O’Connor RE, Schwartz JB. Spheronisation II: Drug Release from drug diluent mixtures. Drug Dev Ind Pharm 1985;11:1837–57
   Web of Science ®Google Scholar
• Harrison PJ, Newton JM, Rowe RC. The characterisation of wet powder masses suitable for extrusion/spheronisation. J Pharm Pharmacol 1985;37:686–91
   PubMed Web of Science ®Google Scholar
• Rough SL, Wilson DI, Bridgwater J. A model describing liquid phase migration within an extruding microcrystalline cellulose paste. Chem Eng Res Des 2002;80:701–14
   Web of Science ®Google Scholar
• Hasznos L, Langer I, Gyarmathy M. Some factors influencing pellet characteristics made by an extrusion/spheronisation process. Part I: effects on size characteristics and moisture content decrease of pellets. Drug Dev Ind Pharm 1992;18:409–37
   Web of Science ®Google Scholar
• Baert L, Vermeersch H, Remon JP, et al. Study of parameters important in the spheronisation process. Int J Pharm 1993;96:225–9
   Web of Science ®Google Scholar
• Newton JM, Chapman SR, Rowe RC. The influence of process variables on the preparation and properties of spherical granules by the process of extrusion and spheronisation. Int J Pharm 1995;190:101–9
   Web of Science ®Google Scholar
• Sousa JJ, Podczeck F, Newton JM. Influence of process conditions on drug release from pellets. Int J Pharm 1996;144:159–69
   Web of Science ®Google Scholar
• Debunne A, Vervaet C, Remon JP. Development and in vitro evaluation of an enteric-coated multiparticulate drug delivery system for the administration of piroxicam to dogs. Eur J Pharm Biopharm 2002;54:343–8
   PubMed Web of Science ®Google Scholar
• Thommes M, Kleinebudde P. Use of kappa-carrageenan as alternative pelletisation aid to microcrystalline cellulose in extrusion/spheronisation. I. Influence of type and fraction of filler. Eur J Pharm Biopharm 2006;63:59–67
   PubMed Web of Science ®Google Scholar
• Verheyen P, Steffens KJ, Kleinebudde P. Use of crospovidone as pelletization aid as alternative to microcrystalline cellulose: effects on pellet properties. Drug Dev Ind Pharm 2009;35:1325–32
   PubMed Web of Science ®Google Scholar
• Krueger C, Thommes M, Kleinebudde P. MCC SANAQ burst—a new type of cellulose and its suitability to prepare fast disintegrating pellets. J Pharm Innov 2010;5:45–57
   Web of Science ®Google Scholar