426
Views
50
CrossRef citations to date
0
Altmetric
Research Article

Design, optimization and evaluation of poly-ɛ-caprolactone (PCL) based polymeric nanoparticles for oral delivery of lopinavir

, , , &
Pages 131-140 | Received 09 May 2013, Accepted 19 Sep 2013, Published online: 04 Nov 2013

References

  • Freed EO. HIV-1 replication. Somat Cell Mol Genet 2001;26:13–33
  • Schrager LK, D’Souza MP. Cellular and anatomical reservoirs of HIV-1 in patients receiving potent antiretroviral combination therapy. JAMA 1998;280:67–71
  • Pomerantz RJ. Reservoirs of human immunodeficiency virus type 1: the main obstacles to viral eradication. Clin Infect Dis 2002;34:91–7
  • Farmer P, Léandre F, Mukherjee J, et al. Community-based treatment of advanced HIV disease: introducing DOT-HAART (directly observed therapy with highly active antiretroviral therapy). Bull World Health Organ 2001;79:1145–51
  • Temesgen Z, Warnke D, Kasten MJ. Current status of antiretroviral therapy. Expert Opin Pharmacother 2006;7:1541–54
  • du Plooy M, Viljoen M, Rheeders M. Evidence for time dependent interactions between ritonavir and lopinavir/ritonavir plasma levels following P-glycoprotein inhibition in Sprague-Dawley rats. Biol Pharm Bull 2011;34:66–70
  • Pierson T, McArthur J, Siliciano RF. Reservoirs for HIV-1: mechanisms for viral persistence in the presence of antiviral immune responses and antiretroviral therapy. Annu Rev Immunol 2000;18:665–708
  • Piacenti FJ. An update and review of antiretroviral therapy. Pharmacotherapy 2006;26:1111–33
  • Ravi PR, Vats R, Thakur R, et al. Effect of grapefruit juice and ritonavir on pharmacokinetics of lopinavir in Wistar rats. Phytother Res 2012;26:1490–5
  • Agarwal S, Boddu SH, Jain R, et al. Peptide prodrugs: improved oral absorption of lopinavir, a HIV protease inhibitor. Int J Pharm 2008;359:7–14
  • Else LJ, Douglas M, Dickinson L, et al. Improved oral bioavailability of lopinavir in melt-extruded tablet formulation reduces impact of third trimester on lopinavir plasma concentrations. Antimicrob Agents Chemother 2012;56:816–24
  • Jain S, Sharma JM, Jain AK, Mahajan RR. Surface-stabilized lopinavir nanoparticles enhance oral bioavailability without co-administration of ritonavir. Nanomedicine (Lond) 2013;8:1639--55
  • Aji Alex MR, Chacko AJ, Jose S, Souto EB. Lopinavir loaded solid lipid nanoparticles (SLN) for intestinal lymphatic targeting. Eur J Pharm Sci 2011;42:11–18
  • Shibata A, McMullen E, Pham A, et al. Polymeric nanoparticles containing combination antiretroviral drugs for HIV type 1 treatment. AIDS Res Hum Retroviruses 2013;29:746--54
  • Kingsley JD, Dou H, Morehead J, et al. Nanotechnology: a focus on nanoparticles as a drug delivery system. J Neuroimmun Pharmacol 2006;1:340–50
  • Sharma P, Garg S. Pure drug and polymer based nanotechnologies for the improved solubility, stability, bioavailability and targeting of anti-HIV drugs. Adv Drug Deliv Rev 2010;62:491–502
  • Destache CJ, Belgum T, Goede M, et al. Antiretroviral release from poly(DL-lactide-co-glycolide) nanoparticles in mice. J Antimicrob Chemother 2010;65:2183–7
  • Prabu P, Dharmaraj AACN, Khil MS, et al. Preparation, characterization, in-vitro drug release and cellular uptake of poly(caprolactone) grafted dextran copolymeric nanoparticles loaded with anticancer drug. J Biomed Mater Res A 2008;90:1128–36
  • Shah LK, Amiji MM. Intracellular delivery of saquinavir in biodegradable polymeric nanoparticles for HIV/AIDS. Pharm Res 2006;23:2638–45
  • Ulery BD, Nair LS, Laurencin CT. Biomedical applications of biodegradable polymers. J Polym Sci B Polym Phys 2011;49:832–64
  • Woodruff MA, Hutmacher DW. The return of a forgotten polymer – polycaprolactone in the 21st century. Prog Polym Sci 2010;35:1217–56
  • Byun Y, Hwang JB, Bang SH, et al. Formulation and characterization of α-tocopherol loaded poly-ε-caprolactone (PCL) nanoparticles. LWT Food Sci Technol 2011;44:24–8
  • Yue PF, Lu XY, Zhang ZZ, et al. The study on the entrapment efficiency and in vitro release of Puerarin submicron emulsion. AAPS PharmSciTech 2009;10:376–83
  • Vats R, Murthy AN, Ravi PR. Simple, rapid and validated LC determination of lopinavir in rat plasma and its application in pharmacokinetic studies. Sci Pharm 2011;79:849–63
  • Shah M, Pathak K. Development and statistical optimization of solid lipid nanoparticles of simvastatin by using 23 Full-Factorial Design. AAPS PharmSciTech 2010;11:489–96
  • Barzegar-Jalali M, Adibkia K, Valizadeh H, et al. Kinetic analysis of drug release from nanoparticles. J Pharm Pharm Sci 2008;11:167–77
  • ICH Q 1 A (R2). Stability testing of new drug substances and products. (CPMP/ICH/2736/99). Available from: http://www.emea.eu.int/pdfs/human/ich/273699en.pdf
  • Barthe L, Woodley J, Houin G. Gastrointestinal absorption of drugs: methods and studies. Fundam Clin Pharmacol 1999;13:154–68
  • Lamprecht A, Ubrich N, Hombreiro Pérez M, et al. Influences of process parameters on nanoparticle preparation performed by a double emulsion pressure homogenization technique. Int J Pharm 2000;196:177–82
  • Ma Y, Zheng Y, Zeng X, et al. Novel docetaxel-loaded nanoparticles based on PCL-Tween 80 copolymer for cancer treatment. Int J Nanomed 2011;6:2679–88
  • Mayank S, Krishna C, Mishra A, Pathak K. Oral solid compritol 888 ATO nanosuspension of simvastatin: optimization and biodistribution studies. Drug Dev Ind Pharm 2011;37:526–37
  • Yang Y, Chung T, Bai X, Chan, W. Effect of preparation conditions on morphology and release profiles of biodegradable polymeric microspheres containing protein fabricated by double-emulsion method. Chem Eng Sci 2000;55:2223–36
  • Vyas TK, Shah L, Amiji MM. Nanoparticulate drug carriers for delivery of HIV/AIDS therapy to viral reservoir sites. Expert Opin Drug Deliv 2006;3:613–28
  • Zhang Z, Gao F, Bu H, et al. Solid lipid nanoparticles loading candesartan cilexetil enhance oral bioavailability: in vitro characteristics and absorption mechanism in rats. Nanomedicine 2012;8:740–7
  • Roger E, Lagarce F, Garcion E, Benoit JP. Lipid nanocarriers improve paclitaxel transport throughout human intestinal epithelial cells by using vesicle-mediated transcytosis. J Control Release 2009;140:174–81
  • Albanese A, Tang PS, Chan WCW. The effect of nanoparticle size, shape, and surface chemistry on biological systems. Annu Rev Biomed Eng 2012;14:1–16
  • Porter C, Trevaskis N, Charman W. Lipids and lipid based formulations: optimizing the oral delivery of lipophilic drugs. Nat Rev Drug Discov 2007;6:231–48
  • Wong HL, Chattopadhyay N, Wu XY, Bendayan R. Nanotechnology applications for improved delivery of antiretroviral drugs to the brain. Adv Drug Del Rev 2010;62:503–15

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.