329
Views
15
CrossRef citations to date
0
Altmetric
Research Article

Development of phyllanthin-loaded self-microemulsifying drug delivery system for oral bioavailability enhancement

, , , &
Pages 207-217 | Received 26 Apr 2013, Accepted 09 Oct 2013, Published online: 18 Nov 2013

References

  • Krithika R, Mohankumar R, Verma RJ, et al. Isolation, characterization and antioxidative effect of phyllanthin against CCl4-induced toxicity in HepG2 cell line. Chem Biol Interact 2009;181:351–8
  • Syamasundar KV, Singh B, Thakur RS, et al. Antihepatotoxic principles of Phyllanthus niruri herbs. J Ethnopharmacol 1985;14:41–4
  • Chirdchupunseree H, Pramyothin P. Protective activity of phyllanthin in ethanol-treated primary culture of rat hepatocytes. J Ethnopharmacol 2010;128:172–6
  • Murugaiyah V, Chan KL. Antihyperuricemic lignans from the leaves of Phyllanthus niruri. Planta Med 2006;72:1262–7
  • Murugaiyah V, Chan KL. Mechanisms of antihyperuricemic effect of Phyllanthus niruri and its lignan constituents. J Ethnopharmacol 2009;124:233–9
  • Somanabandhu A, Nitayangkura S, Mahidol C, et al. 1H and 13C-NMR assignments of phyllanthin and hypophyllathin lignans that enhance cytotoxic responses with cultured multidrug-resistant cells. J Nat Prod 1993;5:233–9
  • Leite DF, Kassuya CA, Mazzuco TL, et al. The cytotoxic effect and the multidrug resistance reversing action of lignans from Phyllanthus amarus. Planta Med 2006;72:1353–8
  • Murugaiyah V, Chan KL. Analysis of lignans from Phyllanthus niruri L. in plasma using a simple HPLC method with fluorescence detection and its application in a pharmacokinetic study. J Chromatogr B 2007;852:138–44
  • Constantinides PP. Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects. Pharm Res 1995;12:1561–72
  • Constantinides PP, Scalart J. Formulation and physical characterization of water-in-oil microemulsion containing long-versus medium-chain glycerides. Int J Pharm 1997;158:57–68
  • Holm R, Jensen IHM, Sonnergaard J. Optimization of self-microemulsifying drug delivery systems (SMEDDS) using a D-optimal design and the desirability function. Drug Dev Ind Pharm 2006;32:1025–32
  • Fernandez-Tarrio M, Yanez F, Immesoete K, et al. Pluronic and tetronic copolymers with polyglycolyzed oils as self-emulsifying drug delivery systems. AAPS PharmSciTech 2008;9:471–9
  • Borhade V, Nair H, Hegde D. Design and evaluation of self-microemulsifying drug delivery system (SMEDDS) of tacrolimus. AAPS PharmSciTech 2008;9:13–21
  • Yang SC, Gursoy RN, Lambert G, Benita S. Enhanced oral absorption of paclitaxel in a novel self-microemulsifying drug delivery system with or without concomitant use of P-glycoprotein inhibitors. Pharm Res 2004;21:261–70
  • Gershanik T, Benita S. Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs. Eur J Pharm Biopharm 2000;50:179–88
  • Kang BK, Lee JS, Chon SK, et al. Development of self-microemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs. Int J Pharm 2004;274:65–73
  • Zhang P, Liu Y, Feng N, Xu J. Preparation and evaluation of selfmicroemulsifying drug delivery system of oridonin. Int J Pharm 2008;355:269–76
  • Wu X, Xu J, Huang X, Wen C. Self-microemulsifying drug delivery system improves curcumin dissolution and bioavailability. Drug Dev Ind Pharm 2011;37:15–23
  • Li X, Yuan Q, Huang Y, et al. Development of silymarin self-microemulsifying drug delivery system with enhanced oral bioavailability. AAPS PharmSciTech 2010;11:672–8
  • Rege BD, Kao JP, Polli JE. Effects of nonionic surfactants on membrane transporters in Caco-2 cell monolayers. Eur J Pharm Sci 2002;16:237–46
  • Takahashi Y, Kondo H, Yasuda T, et al. Common solubilizers to estimate the Caco-2 transport of poorly water-soluble drugs. Int J Pharm 2002;246:85–94
  • Lin YL, Shen Q, Katsumi H, et al. Effects of Labrasol and other pharmaceutical excipients on the intestinal transport and absorption of rhodamine123, a P-glycoprotein substrate, in rats. Biol Pharm Bull 2007;30:1301–7
  • Djordjevic L, Primorac M, Stupar M, Krajisnik D. Characterization of caprylocaproyl macrogolglycerides based microemulsion drug delivery vehicles for an amphiphilic drug. Int J Pharm 2004;271:11–19
  • Rhee YS, Choi JG, Park ES, Chi SC. Transdermal delivery of ketoprofen using microemulsions. Int J Pharm 2001;228:161–70
  • Mukherjee T, Plakogiannis FM. Development and oral bioavailability assessment of a supersaturated self-microemulsifying drug delivery system (SMEDDS) of albendazole. J Pharm Pharmacol 2010;62:1112–20
  • Chen Y, Li G, Wu X, et al. Self-microemulsifying drug delivery system (SMEDDS) of vinpocetine: formulation development and in vivo assessment. Biol Pharm Bull 2008;31:118–25
  • Pouton CW. Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and ‘self-microemulsifying’ drug delivery systems. Eur J Pharm Sci 2000;11:S93–8
  • Lawrence MJ, Rees GD. Microemulsion-based media as novel drug delivery systems. Adv Drug Deliv Rev 2000;45:89–121
  • Gursoy RN, Benita S. Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Biomed Pharmacother 2004;58:173–82
  • Bandivadeka MM, Pancholi SS, Kaul-Ghanekar R, et al. Self-microemulsifying smaller molecular volume oil (Capmul MCM) using non-ionic surfactants: a delivery system for poorly water-soluble drug. Drug Dev Ind Pharm 2012;38:883–92
  • Zhu J-X, Tang D, Feng L, et al. Development of self-microemulsifying drug delivery system for oral bioavailability enhancement of berberine hydrochloride. Drug Dev Ind Pharm 2013;39:499–506
  • Subramanian N, Ray S, Ghosal SK, et al. Formulation design of self-microemulsifying drug delivery systems for improved oral bioavailability of celecoxib. Biol Pharm Bull 2004;27:1993–9
  • Kreilgaard M, Pedersen EJ, Jaroszewski JW. NMR characterization and transdermal drug delivery potential of microemulsion systems. J Control Release 2000;69:421–33
  • Bowte WJ. Materials, process and manufacturing considerations for lipid-based hard capsules formats. In: Hauss DJ, ed. Oral lipid-based formulations – enhancing the bioavailability of poorly water-soluble drugs. New York: Informa Healthcare USA Inc.; 2007:13–39

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.