327
Views
35
CrossRef citations to date
0
Altmetric
Research Article

Pharmacokinetics and efficiency of brain targeting of ginsenosides Rg1 and Rb1 given as Nao-Qing microemulsion

, , , , , , , , & show all
Pages 224-231 | Received 12 May 2013, Accepted 09 Oct 2013, Published online: 18 Nov 2013

References

  • Frey WH. Intranasal delivery: bypassing the blood-brain barrier to deliver therapeutic agents to brain and spinal cord. Drug Deliv Sci Technol 2002;2:46–9
  • Wardlaw JM, Sandercock PA, Dennis MS, Starr J. Is breakdown of the blood-brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia? Stroke 2003;34:806–12
  • Koziara JM, Lockman PR, Allen DD, Mumper RJ. The blood-brain barrier and brain drug delivery. J Nanosci Nanotechnol 2006;6:2712–35
  • Shao NF, Zhu WF, Feng XG, et al. Clinical studies of Nao-Qing nasal drops and the treatment of ischemic stroke. Shandong J Tradit Chin Med 1999;18:58–61
  • Huang YH, Zhu WF. Clinical studies of Nao-Qing microemulsion under intranasal administration and the treatment of acute ischemic stroke. J Chin Med Mater 2012;35:167–9
  • Yu C. Progress in research on cardioprotective effects of ginsenoside. Tianjin Pharm 2010;22:45–7
  • Chen XM. Feasibility study of ginsenoside Rg1 administrated via intranasal route. China J Chin Mater Med 2010;35:229–31
  • Lu T, Jiang Y, Zhou Z, et al. Intranasal ginsenoside Rb1 targets the brain and ameliorates cerebral ischemia/reperfusion injury in rats. Biol Pharm Bull 2011;34:1319–24
  • Yang F, Pan YF, Chen Y. Nasal spray microemulsion preparation for clearing brain, preparation method and application thereof: China, CN200910036693.9. 2009.07.08
  • Chen Y. To prepare Nao-Qing nasal spray microemulsion [dissertation]. Guangzhou: Guangdong Pharmaceutical University; 2009
  • National Pharmacopoeia Committee. Pharmacopoeia of People’s Republic of China. Part 2, Appendix VI G. Beijing, 2010
  • Chen Y, Yang F. The protective effects of Nao-Qing spray microemulsion in PC12 cells damage model. Chin J Basic Med Tradit Chin Med 2011;17:790–2
  • Ibrahim F, Gershkovich P, Sivak O, et al. Pharmacokinetics and tissue distribution of amphotericin B following oral administration of three lipid-based formulations to rats. Drug Dev Ind Pharm 2013;39:1277–83
  • Gao Y, Li Z, Sun M, et al. Preparation, characterization, pharmacokinetics, and tissue distribution of curcumin nanosuspension with TPGS as stabilizer. Drug Dev Ind Pharm 2010;36:1225–34
  • Zhang Q, Jiang X, Jiang W, et al. Preparation of nimodipine-loaded microemulsion for intranasal delivery and evaluation on the targeting efficiency to the brain. Int J Pharm 2004;275:85–96
  • Illum L. Transport of drugs from the nasal cavity to the central nervous system. Eur J Pharm Sci 2000;11:1–18
  • Ojeda M, Rojas S, Boutonnet M, et al. Synthesis of Rh nano-particles by the microemulsion technology: particle size effect on the CO+H2 reaction. Appl Catal A Gen 2004;274:33–41
  • National Pharmacopoeia Committee. Pharmacopoeia of People’s Republic of China. Part 1, Appendix 181–2. Beijing, 2010
  • He BS, Nie SF, Yan TX, et al. Preparation of dipyridamole microemulsion and its quality evaluation. Chin J New Drugs 2010;19:444–8
  • Wang JL, Sun J, He ZG. Microemulsions and its applications in pharmacy. Chin J Pharm 2009;7:356–64
  • Feng YP. The pathophysiology of ischemic stroke and drug treatment status. Acta Pharm Sin 1999;34:72–8
  • Zhao WB, Zhao RC, Zhang CQ, et al. Traditional Chinese medicine in the treatment of ischemic stroke clinical advances. Guiding J Tradit Chin Med Pharm 2012;18:90–2
  • Shi ZQ, Ma ZH, Zhang HX, et al. Clinical research of Huayu Qutan Xifeng decoction on patients with ischemic stroke. Chin Tradit Patent Med 2012;34:404–6
  • Fu ZP. Diaphoretic and wind-eliminating drugs joint western medicine treatment of acute ischemic stroke, single-blind randomized parallel-group study. J Pract Tradit Chin Intern Med 2012;26:59–61
  • Xu HF, Yang HJ, Yu L. Recent progress in the extraction methods for the active ingredients of Chinese herbal drugs. Strait Pharm J 2012;24:13–18
  • Wan ML, Liu L, Wu HF, et al. Dispersion behavior of effective ingredients in Chinese medicine decoctions. J Chin Med Mater 2011;34:455–8
  • Li F, Feng J, Cheng Q, et al. Delivery of 125I-cobrotoxin after intranasal administration to the brain: a microdialysis study in freely moving rats. Int J Pharm 2007;328:161–7
  • Chen XM, Zhu JB, Sun WD, Zhang LJ. Effects of absorption enhancer borneol on ginsenoside Rg1 and the nasal ciliotoxicity. Chin Pharm J 2006;41:261–4
  • Lockman PR, Koziara JM, Mumper RJ, Allen DD. Nanoparticle surface charges alter blood-brain barrier integrity and permeability. J Drug Target 2004;12:635–41
  • Wei FH, Wang YG, Luo JB. Review about multiple-peak of pharmacokinetics. Chin Pharm J 2005;40:1772–4
  • Plusquellec Y, Campistron G, Staveris S, et al. A double-peak phenomenon in the pharmacokinetics of veralipride after oral administration: a double-site model for drug absorption. J Pharmacokinet Biopharm 1987;15:225–39
  • Zhang JT. Comparison of pharmacological effects of ginsenoside Rg1 and Rb1. Basic Med Sci Clin 2000;20:388–90
  • Song L, Zhang CN, Guo SR, Xu QF. Determination and stability of ginsenoside Rb1. Chin J Clin Pharm 2004;13:211–13

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.