140
Views
4
CrossRef citations to date
0
Altmetric
Research Article

In vivo evaluation of a mucoadhesive polymeric caplet for intravaginal anti-HIV-1 delivery and development of a molecular mechanistic model for thermochemical characterization

, , , , , , & show all
Pages 1274-1287 | Received 26 Feb 2014, Accepted 15 Jul 2014, Published online: 11 Aug 2014

References

  • Kim J, Lu L, Sreearunothai P, et al. Optoelectronic and charge transport properties at organic–organic semiconductor interfaces: comparison between polyfluorene-based polymer blend and copolymer. J Am Chem Soc 2008;130:13120–31
  • Müller-Buschbaum P, Bauer E, Pfister S, et al. Creation of multi-scale stripe-like patterns in thin polymer blend films. Europhys Lett 2006;73:35–41
  • Arthanareeswaran G, Kumar SA. Effect of additives concentration on performance of cellulose acetate and polyethersulfone blend membranes. J Porous Mater 2010;7:515–22
  • Edlund U, Albertsson AC. Copolymerization and polymer blending of trimethylene carbonate and adipic anhydride for tailored drug delivery. J Appl Polym Sci 1999;72:227–39
  • Charles J, Ramkumaar GR, Azhagiri S, Gunasekaran S. FTIR and thermal studies on nylon-66 and 30% glass fibre reinforced nylon-66. E-J Chem 2009;6:23–33
  • Matyjaszewski K. Macromolecular engineering: from rational design through precise macromolecular synthesis and processing to targeted macroscopic material properties. Prog Polym Sci 2005;30:8–9
  • Shi Y, Li Z, Sun H, et al. Effect of the properties of the polymer materials on the quality of selective laser sintering parts. Proceedings of the Institution of Mechanical Engineers Part L. J Mater Mat Design and Appl 2004;218:247–52
  • Dolbin V, Burya AI, Kozlov GV. The structure and thermal stability of polymer materials. A Fractal Model 2007;45:355–8
  • Liu TX, Liu ZH, Ma KX, et al. Morphology, thermal and mechanical behavior of polyamide 6/layered-silicate nanocomposites. Compos Sci Technol 2003;634:331–7
  • Parija S, Nayak SK, Verma SK, Tripathy SS. Studies on physico-mechanical properties and thermal characteristics of polypropylene/layered silicate nanocomposites. Polym Compos 2004;25:646–52
  • Ribeiro M. Grolier JPE. Temperature modulated DSC for the investigation of polymer materials: a brief account of recent studies. J Therm Anal Calorim 1999;57:253–63
  • Font J, Muntasell J, Cesari E. Cold-crystallization of Poly(ether-ether-ketone) amorphized by ball milling. Mater Res Bull 2001;36:1665–73
  • Rebbapragada A, Kaul R. More than their sum in your parts: the mechanisms that underpin the mutually advantageous relationship between HIV and sexually transmitted infections. Drug Discov Today Dis Mech 2007;4:237–46
  • Vicent MJ, Dieudonné LR, Carbajo J, Pineda-Lucena A. Polymer conjugates as therapeutics: future trends, challenges and opportunities. Expert Opin Drug Deliv 2008;5:593–614
  • Saraswathi B, Balaji B, Umashankar MS. Polymers in mucoadhesive drug delivery system-latest updates. Int J Pharm Pharm Sci 2013;5:423–30
  • Shaikh R, Singh TRR, Garland MJ, et al. Mucoadhesive drug delivery systems. J Pharm Bioallied Sci 2011;3:89–100
  • Bondupalli BM, Mohamed ZNK, Nath RA, Banji D. Mucoadhesive drug delivery system: an overview. J Adv Pharm Technol Res 2010;1:381–7
  • Valence MK, Ndesendo VP, Yahya EC. A controlled release intravaginal polymeric pharmaceutical dosage form. Patents, No. WO 2010061284 A2. Available from: http://www.google.com/patents/WO2010061284A2?cl=en [last accessed 11 June 2014]
  • D'Cruz OJ, Uckun FM. Pre-clinical safety evaluation of novel nucleoside analogue-based dual-function microbicides (WHI-05 and WHI-07). J Antimicrob Chemother 2002;50:793–803
  • Levinson P, Kaul R, Kimani J, et al.; Kibera HIV Study Group. Levels of innate immune factors in genital fluids: association of alpha defensins and LL-37 with genital infections and increased HIV acquisition. AIDS 2009;23:309–17
  • Sheung A, Rebbapragada A, Shin LYY, Dobson-Belaire W. Mucosal Neisseria gonorrhoeae co-infection during HIV acquisition is associated with enhanced systemic HIV-specific CD8 T-cell responses. AIDS 2008;22:1729–37
  • Broliden K, Haase AT, Ahuja SK, et al. Back to basics: mucosal immunity and novel HIV vaccine concepts. J Intern Med 2009;26:5–17
  • Hendrix CW, Cao YJ, Fuchs EJ. Topical microbicides to prevent HIV: clinical drug development challenges. Annu Rev Pharmacol Toxicol 2009;49:349–75
  • Shen H, Iwasaki A. A crucial role for plasmacytoid dendritic cells in antiviral protection by CpG ODN-based vaginal microbicide. J Clin Invest 2006;11:62237–43
  • Iijima N, Linehan MMM, Zamora E, et al. Dendritic cells and B cells maximize mucosal Th1 memory response to herpes simplex virus. J Exp Med 2008;205:3041–52
  • Gupta P, Kakumanu VK, Bansal AK. Stability and solubility of celecoxib-PVP amorphous dispersions: a molecular perspective. Pharm Res 2004;21:1762–9
  • Simoes JA, Citron DM, Aroutcheva AR, et al. Two novel vaginal microbicides (polystyrene sulfonate and cellulose sulfate) inhibit Gardnerella vaginalis and anaerobes commonly associated with bacterial vaginosis. Antimicrob Agents Chemother 2002;46:2692–5
  • Kolawole OA, Pillay V, Choonara YE. Novel polyamide 6,10 variants synthesized by modified interfacial polymerization for application as a rate-modulated monolithic drug delivery system. J Bioact Compat Pol 2007;22:281–313
  • Ndesendo VMK, Pillay V, Choonara YE, et al. In vivo evaluation of the release of zidovudine and polystyrene sulfonate from a dual intravaginal bioadhesive polymeric device in the pig model. J Pharm Sci 2011;1004:16–1435
  • Kumar P, Pillay V, Choonara YE, et al. In silico theoretical molecular modeling for Alzheimer's disease: the nicotine-curcumin paradigm in neuroprotection and neurotherapy. Int J Mol Sci 2011;12:694–724
  • Ngwuluka NC, Pillay V, Choonara YE, et al. Fabrication, modeling and characterization of multi-crosslinked methacrylate copolymeric nanoparticles for oral drug delivery. Int J Mol Sci 2011;12:6194–225
  • Owen DH, Katz DF. A vaginal fluid stimulant. Contraception 1999;59:91–5
  • Notari S, Bocedi A, Ippolito G, et al. Simultaneous determination of 16 anti-HIV drugs in human plasma by high-performance liquid chromatography. J Chromatogr B 2005;1–2:258–66
  • Zelkó R, Süvegh K. Correlation between the release characteristics of theophylline and the free volume of polyvinylpyrrolidone. Eur J Pharm Sci 2005;24:351–4
  • de Candia F, Maglio G, Palumbo R, Sirletti M. Synthesis and physical behavior of polyamide 6,10-poly(butadiene-co-acrylonitrile) segmented block copolymers. Colloid Polym Sci 1998;26:9–15
  • Vey E, Roger C, Meehan L, et al. Degradation mechanism of poly(lactic-co-glycolic) acid block copolymer cast films in phosphate buffer solution. Polym Degrad Stab 2008;93:1869–76
  • Park TG. Degradation of poly(lactic-co-glycolic acid) microspheres: effect of copolymer composition. Biomaterials 1995;16:1123–30
  • Rouse JJ, Mohamed F, van der Walle CF. Physical ageing and thermal analysis of PLGA microspheres encapsulating protein or DNA. Int J Pharm 2007;339112–20
  • Peppas NA, Hansen PJ. Crystallization kinetics of poly(vinyl alcohol. J Appl Polym Sci 2003;27:4787–97
  • Sugama T, Kukacka LE, Carciello N. Nature of interfacial interaction mechanisms between polyacrylic acid macromolecules and oxide metal surfaces. J Mater Sci 1984;19:4045–56
  • Lu X, Weiss RA. Development of miscible blends of polyamide-6 and manganese sulfonated polystyrene using specific interactions. Macromolecules 1991;24:4381–5
  • Chung Y, Kamal MR. Morphology of PA-6 vibration welded joints and its effect on weld strength. Polym Eng Sci 2008;48:240–8
  • Chang K, Robertson ML, Hillmyer MA. Phase inversion in polylactide/soybean oil blends compatibilized by poly(isoprene-b-lactide) block copolymers. ACS Appl Mater Interfaces 2009;1:2390–9
  • Li J, Barrow D, Howell H, Sid K. In vitro drug release study of methacrylate polymer blend system: effect of polymer blend composition, drug loading and solubilizing surfactants on drug release. J Mater Sci Mater Med 2010;21:583–8
  • Ndesendo VMK, Pillay V, Choonara YE, et al. Investigation of the physicochemical and physicomechanical properties of a novel intravaginal bioadhesive polymeric device in the pig model. AAPS J Pharm Tech 2010;11:793–808
  • Makadia HK, Siege SJ. Poly Lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier. Polymers 2011;3:1377–97
  • Pu Q, Ng S, Mok V, Chen SB. Ion bridging effects on electroviscosity of flexible polyelectrolytes. J Phys Chem B 2004;108:14124–9
  • Chu H, Yeo Y, Chuang KS. Entry in emulsion polymerization using a mixture of sodium polystyrene sulfonate and sodium dodecyl sulfate as the surfactant. Polymer 2007;48:2298–305

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.