621
Views
63
CrossRef citations to date
0
Altmetric
Research Article

Development of dry powder inhaler formulation loaded with alendronate solid lipid nanoparticles: solid-state characterization and aerosol dispersion performance

, &
Pages 1431-1437 | Received 28 Apr 2014, Accepted 13 Aug 2014, Published online: 15 Sep 2014

References

  • Miladi K, Sfar S, Fessi H, Elaissari A. Drug carriers in osteoporosis: preparation, drug encapsulation and applications. Int J Pharm 2013;445:181–95
  • Gupta VK, Jain R, Sharma S, et al. Quantitative determination of alendronate in human urine. Int J Electrochem Sci 2012;7:569–87
  • Ezzati Nazhad Dolatabadi J, Hamishehkar H, de la Guardia M, Valizadeh H. A fast and simple spectrofluorometric method for the determination of alendronate sodium in pharmaceuticals. BioImpacts 2014;4:39–42
  • Sultana S, Ali R, Talegaonkar S, et al. In vivo lung deposition and sub-acute inhalation toxicity studies of nano-sized alendronate sodium as an antidote for inhaled toxic substances in Sprague Dawley rats. Environ Toxicol Pharm 2013;36:636–47
  • Graham DY, Malaty HM. Alendronate gastric ulcers. Aliment Pharmacol Ther 1999;13:515–9
  • Marshall JK, Rainsford KD, James C, Hunt RH. A randomized controlled trial to assess alendronate-associated injury of the upper gastrointestinal tract. Aliment Pharmacol Ther 2000;14:1451–7
  • Lanza F. Bisphosphonate mucosal injury–the end of the story? Dig Liver Dis. (2003 35:67–70
  • Lin JH. Bisphosphonates: a review of their pharmacokinetic properties. Bone 1996;18:75–85
  • Karie S, Launay-Vacher V, Izzedine H, Deray G. [Drud-induced nephrotoxicity: Bibliography from January 2003 to December 2005]. Nephrol Ther 2006;2:368–78
  • Jaafar-Maalej C, Andrieu V, Elaissari A, Fessi H. Assessment methods of inhaled aerosols: technical aspects and applications. Expert Opin Drug Deliv 2009;6:941–59
  • Jaafar-Maalej C, Elaissari A, Fessi H. Lipid-based carriers: manufacturing and applications for pulmonary route. Expert Opin Drug Deliv 2012;9:1111–27
  • Sutton SC, Engle K, Fix JA. Intranasal delivery of the bisphosphonate alendronate in the rat and dog. Pharm Res 1993;10:924–6
  • Varshosaz J, Taymouri S, Hamishehkar H. Fabrication of polymeric nanoparticles of poly(ethylene-co-vinyl acetate) coated with chitosan for pulmonary delivery of carvedilol. J Appl Polym Sci 2014;131. doi: 10.1002/app.39694
  • Sultana S, Talegaonkar S, Ali R, et al. Inhalation of alendronate nanoparticles as dry powder inhaler for the treatment of osteoporosis. J Microencapsul 2012;29:445–54
  • Hamishehkar H, Emami J, Najafabadi AR, et al. Effect of carrier morphology and surface characteristics on the development of respirable PLGA microcapsules for sustained-release pulmonary delivery of insulin. Int J Pharm 2010;389:74–85
  • Telko MJ, Hickey AJ. Dry powder inhaler formulation. Resp Care 2005;50:1209–27
  • Saint-Lorant G, Leterme P, Gayot A, Flament MP. Influence of carrier on the performance of dry powder inhalers. Int J Pharm 2007;334:85–91
  • Cruz L, Fattal E, Tasso L, et al. Formulation and in vivo evaluation of sodium alendronate spray-dried microparticles intended for lung delivery. J Control Release 2011;152:370–5
  • Jaafar-Maalej C, Andrieu V, Elaissari A, Fessi H. Beclomethasone-loaded lipidic nanocarriers for pulmonary drug delivery: preparation, characterization and in vitro drug release. J Nanosci Nanotechnol 2011;11:1841–51
  • Rostami E, Kashanian S, Azandaryani AH, et al. Drug targeting using solid lipid nanoparticles. Chem Phys Lipids 2014;181:56–61
  • Müller RH, Mäder K, Gohla S. Solid lipid nanoparticles (SLN) for controlled drug delivery – a review of the state of the art. Eur J Pharm Biopharm 2000;50:161–77
  • Souto EB, Wissing SA, Barbosa CM, Müller RH. Evaluation of the physical stability of SLN and NLC before and after incorporation into hydrogel formulations. Eur J Pharm Biopharm 2004;58:83–90
  • Das S, Ng WK, Tan RBH. Are nanostructured lipid carriers (NLCs) better than solid lipid nanoparticles (SLNs): development, characterizations and comparative evaluations of clotrimazole-loaded SLNs and NLCs? Eur J Pharm Sci 2012;47:139–51
  • Ezzati Nazhad Dolatabadi J, Hamishehkar H, Eskandani M, Valizadeh H. Formulation, characterization and cytotoxicity studies of alendronate sodium-loaded solid lipid nanoparticles. Colloids Surf B Biointerfaces 2014;117:21–8
  • Eskandani M, Nazemiyeh H. Self-reporter shikonin-act-loaded solid lipid nanoparticle: formulation, physicochemical characterization and geno/cytotoxicity evaluation. Eur J Pharm Sci 2014;59:49–57
  • Kashanian S, Rostami E. PEG-stearate coated solid lipid nanoparticles as levothyroxine carriers for oral administration. J Nanopart Res 2014;16:1–10
  • Bose S, Du Y, Takhistov P, Michniak-Kohn B. Formulation optimization and topical delivery of quercetin from solid lipid based nanosystems. Int J Pharm 2013;441:56–66
  • Mussi SV, Silva RC, Oliveira MCd, et al. New approach to improve encapsulation and antitumor activity of doxorubicin loaded in solid lipid nanoparticles. Eur J Pharm Sci 2013;48:282–90
  • Pilpel N. The flow properties of magnesia. J Pharm Pharmacol 1964;16:705–16
  • Carr R. Evaluating flow properties of solids. Chem Eng 1965;72:163–8
  • Carr R. Classifying flow properties of solids. Chem Eng 1965;72:69–72
  • Bosquillon C, Lombry C, Préat V, Vanbever R. Influence of formulation excipients and physical characteristics of inhalation dry powders on their aerosolization performance. J Control Release 2001;70:329–39
  • Chougule M, Padhi B, Misra A. Development of spray dried liposomal dry powder inhaler of dapsone. AAPS PharmSciTech 2008;9:47–53
  • Ahmad MZ, Akhter S, Ahmad I, et al. In vitro and in vivo evaluation of Assam Bora rice starch-based bioadhesive microsphere as a drug carrier for colon targeting. Expert Opin Drug Deliv 2012;9:141–9
  • Zhao M, You Y, Ren Y, et al. Formulation, characteristics and aerosolization performance of azithromycin DPI prepared by spray-drying. Powder Technol 2008;187:214–21
  • Kramek-Romanowska K, Odziomek M, Sosnowski TR, Gradoń L. Effects of process variables on the properties of spray-dried mannitol and mannitol/disodium cromoglycate powders suitable for drug delivery by inhalation. Ind Eng Chem Res 2011;50:13922–31
  • Littringer EM, Noisternig MF, Mescher A, et al. The morphology and various densities of spray dried mannitol. Powder Technol 2013;246:193–200
  • Rahimpour Y, Hamishehkar H. Lactose engineering for better performance in dry powder inhalers. Adv Pharm Bull 2012;2:183–7
  • Kho K, Hadinoto K. Dry powder inhaler delivery of amorphous drug nanoparticles: effects of the lactose carrier particle shape and size. Powder Technol 2013;233:303–11
  • Pilcer G, Wauthoz N, Amighi K. Lactose characteristics and the generation of the aerosol. Adv Drug Deliv Rev 2012;64:233–56
  • Wan F, You J, Sun Y, et al. Studies on PEG-modified SLNs loading vinorelbine bitartrate (I): preparation and evaluation in vitro. Int J Pharm 2008;359:104–10
  • Kaialy W, Martin GP, Ticehurst MD, et al. The enhanced aerosol performance of salbutamol from dry powders containing engineered mannitol as excipient. Int J Pharm 2010;392:178–88
  • Maas SG, Schaldach G, Littringer EM, et al. The impact of spray drying outlet temperature on the particle morphology of mannitol. Powder Technol 2011;213:27–35
  • Mansour HM, Xu Z, Hickey AJ. Dry powder aerosols generated by standardized entrainment tubes from alternative sugar blends: 3. Trehalose dihydrate and D-mannitol carriers. J Pharm Sci 2010;99:3430–41

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.