264
Views
26
CrossRef citations to date
0
Altmetric
Research Article

Aloin delivery on buccal mucosa: ex vivo studies and design of a new locoregional dosing system

, , , , , , & show all
Pages 1541-1547 | Received 04 May 2014, Accepted 26 Sep 2014, Published online: 14 Oct 2014

References

  • Sankar V, Hearnden V, Hull K, et al. Local drug delivery for oral mucosal diseases: challenges and opportunities. Oral Dis 2011;17:73–84
  • Weinberg BD, Ai H, Blanco E, et al. Antitumor efficacy and local distribution of doxorubicin via intratumoral delivery from polymer millirods. J Biomed Mater Res A 2007;81A:161–70
  • Desai KGH, Mallery SR, Holpuch AS, Schwendeman SP. Development and in vitro-in vivo evaluation of fenretinide-loaded oral mucoadhesive patches for site-specific chemoprevention of oral cancer. Pharm Res 2011;28:2599–609
  • Blanchard P, Baujat B, Holostenco V, et al. Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): a comprehensive analysis by tumour site. Radiother Oncol 2011;100:33–40
  • Worthington HV, Clarkson JE, Bryan G, et al. Interventions for preventing oral mucositis for patients with cancer receiving treatment. Cochrane Database System Rev 2011;4:Art. No. CD000978
  • Trotti A, Bellm LA, Epstein JB, et al. Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: a systematic literature review. Radiother Oncol 2003;66:253–62
  • Holpuch AS, Desai KGH, Schwendeman SP, Mallery SR. Optimizing therapeutic efficacy of chemopreventive agents: a critical review of delivery strategies in oral cancer chemoprevention clinical trials. J Carcinog 2011;10:23
  • Fotedar V, Fotedar S, Seam RK, Gupta MK. Oral cancer and chemoprevention. Int J Pharm Sci Inv 2013;2:16–20
  • Ramshankar V, Krishnamurthy A. Chemoprevention of oral cancer: green tea experience. J Nat Sci Biol Med 2014;5:3–7
  • Kispotta A, Srivastava MK, Dutta M. Free radical scavenging activity of ethanolic extracts and determination of aloin from Aloe vera L. leaf extract. Int J Med Arom Plants 2012;2:612–18
  • Ni Y, Tizard IR. Analytical methodology: the gel-analysis of aloe pulp and its derivatives. In: Reynolds T, ed. Aloes: the Genus Aloe. London: CRC Press; 2004;111–26
  • Gastrointestinal drugs. In: Sweetman SC, ed. Martindale, the complete drug reference. 36th ed. London, UK: Pharmaceutical Press; 2009:1705
  • Esmat AY, El-Gerzawy SM, Rafaat A. DNA ploidy and S phase fraction of breast and ovarian tumor cells treated with a natural antracycline analog (aloin). Cancer Biol Ther 2005;4:108–12
  • Xiao B, Guo J, Liu D, Zhang S. Aloe-emodin induces in vitro G2/M arrestand alkaline phosphatase activation in human oral cancer KB cells. Oral Oncol 2007;43:905–10
  • Chiu TH, Lai WW, Hsia TC, et al. Aloe-emodin induces cell death through S-phase arrest and caspase-dependent pathways in human tongue squamous cancer SCC-4 cells. Anticancer Res 2009;29:4503–12
  • Alves DS, Perez-Fons L, Estepa A, Micol V. Membrane-related effects underlying the biological activity of the anthraquinones emodin and barbaloin. Biochem Pharmacol 2004;68:549–61
  • Stafford JH, Thorpe PE. Increased exposure of phosphatidylethanolamine on the surface of tumor vascular endothelium. Neoplasia 2011;13:299–308
  • Tabolacci C, Rossi S, Lentini A, et al. Aloin enhances cisplatin antineoplastic activity in B16-F10 melanoma cells by transglutaminase-induced differentiation. Amino Acids 2013;44:293–300
  • Pan Q, Pan H, Lou H, et al. Inhibition of the angiogenesis and growth of Aloin in human colorectal cancer in vitro and in vivo. Cancer Cell Int 2013;13:69
  • Ahmadi A. Potential prevention: aloe vera mouthwash may reduce radiation-induced oral mucositis in head and neck cancer patients. Chin J Integr Med 2012;18:635–40
  • Mansourian A, Momen-Heravi F, Saheb-Jamee M, et al. Comparison of aloe vera mouthwash with triamcinolone acetonide 0.1% on oral lichen planus: a randomized double-blinded clinical trial. Am J Med Sci 2011;342:447–51
  • Wang Z, Polavaram R, Stanley M, Shapshay SM. Topical inhibition of oral carcinoma cell with polymer delivered celecoxib. Cancer Lett 2003;198:53–8
  • De Caro V, Giandalia G, Siragusa MG, et al. Galantamine delivery on buccal mucosa: permeation enhancement and design of matrix tablets. J Bioequiv Availab 2009;1:127–34
  • Campisi G, Giannola LI, Fucarino A, et al. Medium-term culture of primary oral squamous cell carcinoma in a three-dimensional model: effects on cell survival following topical 5-Fluororacile delivery by drug-loaded matrix tablets. Curr Pharm Des 2012;18:5411–20
  • Gal JY, Fovet Y, Adib-Yadzi M. About a synthetic saliva for in vitro studies. Talanta 2001;53:1103–15
  • De Caro V, Giandalia G, Siragusa MG, et al. New perspectives in treatment of Parkinson's disease: studies on permeation of ropinirole through buccal mucosa. Int J Pharm 2012;429:78–83
  • Giannola LI, De Caro V, Giandalia G, et al. 5-Fluorouracil buccal tablets for locoregional chemotherapy of oral squamous cell carcinoma: formulation, drug release and histological effects on reconstituted human oral epithelium and porcine buccal mucosa. Curr Drug Del 2010;7:109–17
  • De Caro V, Giandalia G, Siragusa MG, Giannola LI. Buccal delivery of methimazole as an alternative means for improvement of drug bioavailability: permeation studies and matrix system design. Curr Pharm Des 2012;18:5405–10
  • Farmacopea Ufficiale della Repubblica Italiana XII ed. Capitolo 2.5 Saggi. Roma: Istituto Superiore di Sanità; 2008
  • Kassem MAA, ElMeshad AN, Fares AR. Enhanced bioavailability of buspirone hydrochloride via cup and core buccal tablets: formulation and in vitro/in vivo evaluation. Int J Pharm 2014;463:68–80
  • Semalty M, Semalty A, Kumar G. Formulation and characterization of mucoadhesive buccal films of glipizide. Ind J Pharm Sci 2008;70:43–8
  • Giannola LI, De Caro V, Giandalia G, et al. Transbuccal tablets of carbamazepine: formulation release and absorption pattern. Int J Immunopathol Pharmacol 2005;18:21–31
  • Siepmann J, Peppas NA. Higuchi equation: derivation, applications, use and misuse. Int J Pharm 2011;418:6–12
  • Frenning G. Modelling drug release from inert matrix systems: from moving-boundary to continuous-field descriptions. Int J Pharm 2011;418:88–99
  • Siepmann J, Siepmann F. Mathematical modeling of drug delivery. Int J Pharm 2008;364:328–43
  • Joshi M. Role of Eudragit in targeted drug delivery. Int J Curr Pharm Res 2013;2:58–62
  • Sarı A, Biçer A, Karaipekli A. Synthesis, characterization, thermal properties of a series of stearic acid esters as novel solid–liquid phase change materials. Mater Lett 2009;63:1213–16
  • Meng-Lund E, Jacobsen J, Jin J, et al. Azone decreases the buccal mucosal permeation of diazepam in a concentration-dependent manner via a reservoir effect. J Pharm Sci 2014;103:1133–41

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.