374
Views
26
CrossRef citations to date
0
Altmetric
Research Article

A phospholipid complex to improve the oral bioavailability of flavonoids

, , , , , , & show all
Pages 1693-1703 | Received 03 Aug 2014, Accepted 13 Nov 2014, Published online: 11 Dec 2014

References

  • Zhu F, Huang B, Hu CY, et al. Effects of total flavonoids of Hippophae rhamnoides L. on intracellular free calcium in cultured vascular smooth muscle cells of spontaneously hypertensive rats and Wistar-Kyoto rats. Chin J Integr Med 2005;11:287–92
  • Geetha S, Sai Ram M, Singh V, et al. Anti-oxidant and immunomodulatory properties of seabuckthorn (Hippophae rhamnoides) – an in vitro study. J Ethnopharmacol 2002;79:373–8
  • Yogendra Kumar MS, Tirpude RJ, Maheshwari DT, et al. Antioxidant and antimicrobial properties of phenolic rich fraction of Seabuckthorn (Hippophae rhamnoides L.) leaves in vitro. Food Chem 2013;141:3443–50
  • Wang J, Zhang W, Zhu D, et al. Hypolipidaemic and hypoglycaemic effects of total flavonoids from seed residues of Hippophae rhamnoides L. in mice fed a high-fat diet. J Sci Food Agric 2011;91:1446–51
  • Maheshwari DT, Yogendra Kumar MS, Verma SK, et al. Antioxidant and hepatoprotective activities of phenolic rich fraction of Seabuckthorn (Hippophae rhamnoides L.) leaves. Food Chem Toxicol 2011;49:2422–8
  • Wu Y, Wang Y, Wang B, et al. Effects of total flavones of fructus Hippophae (TFH) on cardiac function and hemodynamics of anesthetized open-chest dogs with acute heart failure. Zhongguo Zhong yao za zhi 1997;22:429–31, 448
  • Cheng J, Kondo K, Suzuki Y, et al. Inhibitory effects of total flavones of Hippophae Rhamnoides L on thrombosis in mouse femoral artery and in vitro platelet aggregation. Life Sci 2003;72:2263–71
  • Zhao G, Duan J, Xie Y, et al. Effects of solid dispersion and self-emulsifying formulations on the solubility, dissolution, permeability and pharmacokinetics of isorhamnetin, quercetin and kaempferol in total flavones of Hippophae rhamnoides L. Drug Dev Ind Pharm 2013;39:1037–45
  • Barve A, Chen C, Hebbar V, et al. Metabolism, oral bioavailability and pharmacokinetics of chemopreventive kaempferol in rats. Biopharm Drug Dispos 2009;30:356–65
  • Khaled KA, El-Sayed YM, Al-Hadiya BM. Disposition of the flavonoid quercetin in rats after single intravenous and oral doses. Drug Dev Ind Pharm 2003;29:397–403
  • Rabinovich-Guilatt L, Dubernet C, Gaudin K, et al. Phospholipid hydrolysis in a pharmaceutical emulsion assessed by physicochemical parameters and a new analytical method. Eur J Pharm Biopharm 2005;61:69–76
  • Rao SV, Shao J. Self-nanoemulsifying drug delivery systems (SNEDDS) for oral delivery of protein drugs: I. Formulation development. Int J Pharm 2008;362:2–9
  • Henmi T, Fujii M, Kikuchi K, et al. Application of an oily gel formed by hydrogenated soybean phospholipids as a percutaneous absorption-type ointment base. Chem Pharm Bull (Tokyo) 1994;42:651–5
  • Sha XY, Guo J, Chen YZ, Fang XL. Effect of phospholipid composition on pharmacokinetics and biodistribution of epirubicin liposomes. J Liposome Res 2012;22:80–8
  • Garcia-Moreno PJ, Frisenfeldt Horn A, Jacobsen C. Influence of casein–phospholipid combinations as emulsifier on the physical and oxidative stability of fish oil-in-water emulsions. J Agric Food Chem 2014;62:1142–52
  • Yue PF, Yuan HL, Xie H, et al. Preparation, characterization, and bioavailability of ursodeoxycholic acid-phospholipid complex in vivo. Drug Dev Ind Pharm 2008;34:708–18
  • Yue PF, Yuan HL, Li XY, et al. Process optimization, characterization and evaluation in vivo of oxymatrine-phospholipid complex. Int J Pharm 2010;387:139–46
  • Bhattacharyya S, Ahmmed SM, Saha BP, Mukherjee PK. Soya phospholipid complex of mangiferin enhances its hepatoprotectivity by improving its bioavailability and pharmacokinetics. J Sci Food Agric 2013;94:1380–8
  • Yue PF, Zhang WJ, Yuan HL, et al. Process optimization, characterization and pharmacokinetic evaluation in rats of ursodeoxycholic acid–phospholipid complex. AAPS PharmSciTech 2008;9:322–9
  • Xiao YY, Song YM, Chen ZP, Ping QN. Preparation of silybin–phospholipid complex and its bioavailability in rats. Yao Xue Xue Bao 2005;40:611–17
  • Maiti K, Mukherjee K, Gantait A, et al. Enhanced therapeutic potential of naringenin-phospholipid complex in rats. J Pharm Pharmacol 2006;58:1227–33
  • Zhang Z, Huang Y, Gao F, et al. Daidzein–phospholipid complex loaded lipid nanocarriers improved oral absorption: in vitro characteristics and in vivo behavior in rats. Nanoscale 2011;3:1780–7
  • Chen ZP, Sun J, Chen HX, et al. Comparative pharmacokinetics and bioavailability studies of quercetin, kaempferol and isorhamnetin after oral administration of Ginkgo biloba extracts, Ginkgo biloba extract phospholipid complexes and Ginkgo biloba extract solid dispersions in rats. Fitoterapia 2010;81:1045–52
  • Tedesco D, Steidler S, Galletti S, et al. Efficacy of silymarin–phospholipid complex in reducing the toxicity of aflatoxin B1 in broiler chicks. Poult Sci 2004;83:1839–43
  • Li Y, Pan WS, Chen SL, et al. Studies on preparation of puerarin phytosomes and their solid dispersion. Chin Pharm J 2006;41:1162–7
  • Li GW, Zeng XL, Xie Y, et al. Pharmacokinetic properties of isorhamnetin, kaempferol and quercetin after oral gavage of total flavones of Hippophae rhamnoides L. in rats using a UPLC-MS method. Fitoterapia 2012;83:182–91
  • Zhang J, Peng Q, Shi S, et al. Preparation, characterization, and in vivo evaluation of a self-nanoemulsifying drug delivery system (SNEDDS) loaded with morin–phospholipid complex. Int J Nanomed 2011;6:3405–14
  • Li Y, Yang DJ, Chen SL, et al. Comparative physicochemical characterization of phospholipids complex of puerarin formulated by conventional and supercritical methods. Pharm Res 2008;25:563–77
  • Sikarwar MS, Sharma S, Jain AK, Parial SD. Preparation, characterization and evaluation of marsupsin–phospholipid complex. AAPS PharmSciTech 2008;9:129–37
  • Shi K, Cui FD, Yu YW, et al. Preparation and characterization of a novel insulin–phospholipid complex. Asian J Pharm Sci 2006;1:168–74
  • Yanyu X, Yunmei S, Zhipeng C, Qineng P. The preparation of silybin–phospholipid complex and the study on its pharmacokinetics in rats. Int J Pharm 2006;307:77–82
  • Singh C, Bhatt TD, Gill MS, Suresh S. Novel rifampicin–phospholipid complex for tubercular therapy: synthesis, physicochemical characterization and in-vivo evaluation. Int J Pharm 2014;460:220–7
  • Singh D, Rawat MSM, Semalty A, Semalty M. Rutin–phospholipid complex: an innovative technique in novel drug delivery system – NDDS. Curr Drug Deliv 2012;9:305–14
  • Rawat DS, Thakur BK, Semalty M, et al. Baicalein–phospholipid complex: a novel drug delivery technology for phytotherapeutics. Curr Drug Discov Technol 2013;10:224–32
  • Korinth G, Wellner T, Schaller KH, Drexler H. Potential of the octanol–water partition coefficient (logP) to predict the dermal penetration behaviour of amphiphilic compounds in aqueous solutions. Toxicol Lett 2012;215:49–53
  • Singh D, Rawat MSM, Semalty A, Semalty M. Chrysophanol–phospholipid complex A drug delivery strategy in herbal novel drug delivery system (HNDDS). J Therm Anal Calorim 2013;111:2069–77
  • Tan Q, Liu S, Chen X, et al. Design and evaluation of a novel evodiamine–phospholipid complex for improved oral bioavailability. AAPS PharmSciTech 2012;13:534–47
  • Husch J, Dutagaci B, Glaubitz C, et al. Structural properties of so-called NSAID–phospholipid-complexes. Eur J Pharm Sci 2011;44:103–16
  • DuPont MS, Day AJ, Bennett RN, et al. Absorption of kaempferol from endive, a source of kaempferol-3-glucuronide, in humans. Eur J Clin Nutr 2004;58:947–54
  • Schulz HU, Schurer M, Bassler D, Weiser D. Investigation of the bioavailability of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin following single and multiple oral dosing of a hypericum extract containing tablet. Arzneim-Forsch 2005;55:15–22
  • Lin JH. Species similarities and differences in pharmacokinetics. Drug Metab Dispos 1995;23:1008–21
  • Walgren RA, Karnaky KJ Jr, Lindenmayer GE, Walle T. Efflux of dietary flavonoid quercetin 4′-beta-glucoside across human intestinal Caco-2 cell monolayers by apical multidrug resistance-associated protein-2. J Pharmacol Exp Ther 2000;294:830–6
  • Pal D, Mitra AK. MDR- and CYP3A4-mediated drug–herbal interactions. Life Sci 2006;78:2131–45
  • Wang Y, Cao J, Zeng S. Involvement of P-glycoprotein in regulating cellular levels of Ginkgo flavonols: quercetin, kaempferol, and isorhamnetin. J Pharm Pharmacol 2005;57:751–8
  • Limtrakul P, Khantamat O, Pintha K. Inhibition of P-glycoprotein function and expression by kaempferol and quercetin. J Chemother 2005;17:86–95
  • Chang TK, Chen J, Yeung EY. Effect of Ginkgo biloba extract on procarcinogen-bioactivating human CYP1 enzymes: identification of isorhamnetin, kaempferol, and quercetin as potent inhibitors of CYP1B1. Toxicol Appl Pharmacol 2006;213:18–26
  • Chang Q, Zuo Z, Ho WK, Chow MS. Comparison of the pharmacokinetics of hawthorn phenolics in extract versus individual pure compound. J Clin Pharmacol 2005;45:106–12

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.