Systematic aging of degradable nanosuspension ameliorates vibrating-mesh nebulizer performance

References

• Lebhardt T, Roesler S, Beck-Broichsitter M, Kissel T. Polymeric nanocarriers for drug delivery to the lung. J Drug Delivery Sci Technol 2010;20:171–80
   Web of Science ®Google Scholar
• Beck-Broichsitter M, Merkel OM, Kissel T. Controlled pulmonary drug and gene delivery using polymeric nano-carriers. J Control Release 2012;161:214–24
   PubMed Web of Science ®Google Scholar
• Gessler T, Seeger W, Schmehl T. Inhaled prostanoids in the therapy of pulmonary hypertension. J Aerosol Med 2008;21:1–12
   Google Scholar
• Carvalho TC, Peters JI, Williams RO III. Influence of particle size on regional lung deposition: what evidence is there? Int J Pharm 2011;406:1–10
   PubMed Web of Science ®Google Scholar
• Hofmann W. Modelling inhaled particle deposition in the human lung – a review. J Aerosol Sci 2011;42:693–724
   Web of Science ®Google Scholar
• Dailey LA, Schmehl T, Gessler T, et al. Nebulization of biodegradable nanoparticles: impact of nebulizer technology and nanoparticle characteristics on aerosol features. J Control Release 2003;86:131–44
   PubMed Web of Science ®Google Scholar
• Dailey LA, Kleemann E, Wittmar M, et al. Surfactant-free, biodegradable nanoparticles for aerosol therapy based on the branched polyesters, DEAPA-PVAL-g-PLGA. Pharm Res 2003;20:2011–20
   PubMed Web of Science ®Google Scholar
• Steckel H, Eskandar F. Factors affecting aerosol performance during nebulization with jet and ultrasonic nebulizers. Eur J Pharm Sci 2003;19:443–55
   PubMed Web of Science ®Google Scholar
• Beck-Broichsitter M, Kleimann P, Schmehl T, et al. Impact of lyoprotectants for the stabilization of biodegradable nanoparticles on the performance of air-jet, ultrasonic, and vibrating-mesh nebulizers. Eur J Pharm Biopharm 2012;82:272–80
   PubMed Web of Science ®Google Scholar
• Beck-Broichsitter M, Knuedeler MC, Schmehl T, Seeger W. Following the concentration of polymeric nanoparticles during nebulization. Pharm Res 2013;30:16–24
   PubMed Web of Science ®Google Scholar
• Beck-Broichsitter M, Gauss J, Packhaeuser CB, et al. Pulmonary drug delivery with aerosolizable nanoparticles in an ex vivo lung model. Int J Pharm 2009;367:169–78
   PubMed Web of Science ®Google Scholar
• Beck-Broichsitter M, Kleimann P, Gessler T, et al. Nebulization performance of biodegradable sildenafil-loaded nanoparticles using the Aeroneb® Pro: formulation aspects and nanoparticle stability to nebulization. Int J Pharm 2012;422:398–408
   PubMed Web of Science ®Google Scholar
• Ghazanfari T, Elhissi AMA, Ding Z, Taylor KMG. The influence of fluid physicochemical properties on vibrating-mesh nebulization. Int J Pharm 2007;339:103–11
   PubMed Web of Science ®Google Scholar
• Zhang G, David A, Wiedmann TS. Performance of the vibrating membrane aerosol generation device: aeroneb micropump nebulizer. J Aerosol Med 2007;20:408–16
   PubMedGoogle Scholar
• Baumann R, Glöckl G, Nagel S, Weitschies W. Preparation and characterization of magnetizable aerosols. Eur J Pharm Sci 2012;45:693–7
   PubMed Web of Science ®Google Scholar
• Najlah M, Vali A, Taylor M, et al. A study of the effects of sodium halides on the performance of air-jet and vibrating-mesh nebulizers. Int J Pharm 2013;456:520–7
   PubMed Web of Science ®Google Scholar
• Beck-Broichsitter M, Oesterheld N, Knuedeler MC, et al. On the correlation of output rate and aerodynamic characteristics in vibrating-mesh-based aqueous aerosol delivery. Int J Pharm 2014;461:34–7
   PubMed Web of Science ®Google Scholar
• Beck-Broichsitter M, Knuedeler MC, Oesterheld N, et al. Boosting the aerodynamic properties of vibrating-mesh nebulized polymeric nanoparticles. Int J Pharm 2014;459:23–9
   PubMed Web of Science ®Google Scholar
• Beck-Broichsitter M, Knuedeler MC, Seeger W, Schmehl T. Controlling the droplet size of formulations nebulized by vibrating-mesh technology. Eur J Pharm Biopharm 2014;87:524–9
   PubMed Web of Science ®Google Scholar
• Beck-Broichsitter M, Rytting E, Lebhardt T, et al. Preparation of nanoparticles by solvent displacement for drug delivery: a shift in the “ouzo region” upon drug loading. Eur J Pharm Sci 2010;41:244–53
   PubMed Web of Science ®Google Scholar
• Beck-Broichsitter M, Ruppert C, Schmehl T, et al. Biophysical investigation of pulmonary surfactant surface properties upon contact with polymeric nanoparticles in vitro. Nanomedicine 2011;7:341–50
   PubMed Web of Science ®Google Scholar
• Filipe V, Hawe A, Jiskoot W. Critical evaluation of Nanoparticle Tracking Analysis (NTA) by NanoSight for the measurement of nanoparticles and protein aggregates. Pharm Res 2010;27:796–810
   PubMed Web of Science ®Google Scholar
• Reul R, Renette T, Bege N, Kissel T. Nanoparticles for paclitaxel delivery: a comparative study of different types of dendritic polyesters and their degradation behavior. Int J Pharm 2011;407:190–6
   PubMed Web of Science ®Google Scholar
• Chu D, Curdy C, Riebesehl B, et al. Enzyme-responsive surface erosion of poly(ethylene carbonate) for controlled drug release. Eur J Pharm Biopharm 2013;85:1232–7
   PubMed Web of Science ®Google Scholar
• Clark RC. The use of laser diffraction for the evaluation of the aerosol clouds generated by medical nebulizers. Int J Pharm 1995;115:69–78
   Web of Science ®Google Scholar
• Mitchell JP, Nagel MW, Nichols S, Nerbrink O. Laser diffractometry as a technique for the rapid assessment of aerosol particle size from inhalers. J Aerosol Med 2006;19:409–33
   PubMedGoogle Scholar
• Beck-Broichsitter M, Dalla-Bona AC, Kissel T, et al. Polymer nanoparticle-based controlled pulmonary drug delivery. Methods Mol Biol 2014;1141:133–45
   PubMedGoogle Scholar
• Knoch M, Keller M. The customised electronic nebuliser: a new category of liquid aerosol drug delivery system. Expert Opin Drug Deliv 2005;2:377–90
   PubMedGoogle Scholar
• Lass JS, Sant A, Knoch M. New advances in aerosolised drug delivery: vibrating membrane nebuliser technology. Expert Opin Drug Deliv 2006;3:693–702
   PubMedGoogle Scholar
• Waldrep JC, Dhand R. Advanced nebulizer designs employing vibrating mesh/aperture plate technologies for aerosol generation. Curr Drug Delivery 2008;5:114–19
   PubMedGoogle Scholar
• Watts AB, McConville JT, Williams RO III. Current therapies and technological advances in aqueous aerosol drug delivery. Drug Dev Ind Pharm 2008;34:913–22
   PubMed Web of Science ®Google Scholar
• Germershaus O, Schultz I, Lühmann T, et al. Insulin-like growth factor-I aerosol formulations for pulmonary delivery. Eur J Pharm Biopharm 2013;85:61–8
   PubMed Web of Science ®Google Scholar
• Kleemann E, Schmehl T, Gessler T, et al. Iloprost-containing liposomes for aerosol application in pulmonary arterial hypertension: formulation aspects and stability. Pharm Res 2007;24:277–87
   PubMed Web of Science ®Google Scholar
• Beck-Broichsitter M, Rieger M, Reul R, et al. Correlation of drug release with pulmonary drug absorption profiles for nebulizable liposomal formulations. Eur J Pharm Biopharm 2013;84:106–14
   PubMed Web of Science ®Google Scholar
• Lemoine D, Francois C, Kedzierewicz F, et al. Stability study of nanoparticles of poly(ɛ-caprolactone), poly(D,L-lactide) and poly(d,l-lactide-co-glycolide). Biomaterials 1996;17:2191–7
   PubMed Web of Science ®Google Scholar
• Panyam J, Dali MM, Sahoo SK, et al. Polymer degradation and in vitro release of a model protein from poly(d,l-lactide-co-glycolide) nano- and microparticles. J Control Release 2003;92:173–87
   PubMed Web of Science ®Google Scholar
• Fuchs NA. The mechanics of aerosols. New York: Dover Publications; 1989
   Google Scholar
• Garrett BC. Ions at the air/water interface. Science 2004;303:1146–7
   PubMed Web of Science ®Google Scholar