198
Views
11
CrossRef citations to date
0
Altmetric
Research Article

Influence of surface characteristics of modified glass beads as model carriers in dry powder inhalers (DPIs) on the aerosolization performance

, &
Pages 1710-1717 | Received 03 Jun 2014, Accepted 04 Dec 2014, Published online: 30 Jan 2015

References

  • Pilcer G, Wauthoz N, Amighi K. Lactose characteristics and the generation of the aerosol. Adv Drug Deliv Rev 2012;64:233–56
  • Zeng XM, Martin GP, Marriott C, Pritchard J. The influence of carrier morphology on drug delivery by dry powder inhalers. Int J Pharm 2000;200:93–106
  • Rahimpour Y, Kouhsoltani M, Hamishehkar H. Alternative carriers in dry powder inhaler formulations. Drug Discov Today 2014;19:618–26
  • Zeng XM, Pandhal KH, Martin GP. The influence of lactose carrier on the content homogeneity and dispersibility of beclomethasone dipropionate from dry powder aerosols. Int J Pharm 2000;197:41–52
  • Maas SG, Schaldach G, Littringer EM, et al. The impact of spray drying outlet temperature on the particle morphology of mannitol. Powder Technol 2011;213:27–35
  • Littringer EM, Mescher A, Eckhard S, et al. Spray drying of mannitol as a drug carrier – the impact of process parameters on product properties. Dry Technol 2012;30:114–24
  • Steckel H, Markefka P, TeWierik H, Kammelar R. Effect of milling and sieving on functionality of dry powder inhalation products. Int J Pharm 2006;309:51–9
  • Larhrib H, Martin GP, Marriott C, Prime D. The influence of carrier and drug morphology on drug delivery from dry powder formulations. Int J Pharm 2003;257:283–96
  • Zeng XM, Martin GP, Marriott C, Pritchard J. The influence of crystallization conditions on the morphology of lactose intended for use as a carrier for dry powder aerosols. J Pharm Pharmacol 2000;52:633–43
  • Zeng XM, Martin GP, Marriott C, Pritchard J. Crystallization of lactose from carbopol gels. Pharm Res 2000;17:879–86
  • Zeng XM, Martin GP, Marriott C, Pritchard J. The use of lactose recrystallised from carbopol gels as a carrier for aerosolised salbutamol sulphate. Eur J Pharm Biopharm 2001;51:55–62
  • Zeng XM, Martin GP, Marriott C, Pritchard J. Lactose as a carrier in dry powder formulations: the influence of surface characteristics on drug delivery. J Pharm Sci 2001;90:1424–34
  • Iida K, Inagaki Y, Todo H, et al. Effects of surface processing of lactose carrier particles on dry powder inhalation properties of salbutamol sulfate. Chem Pharm Bull (Tokyo) 2004;52:938–42
  • Zellnitz S, Redlinger-Pohn JD, Kappl M, et al. Preparation and characterization of physically modified glass beads used as model carriers in dry powder inhalers. Int J Pharm 2013;447:132–8
  • Young PM, Roberts D, Chiou H, et al. Composite carriers improve the aerosolisation efficiency of drugs for respiratory delivery. J Aerosol Sci 2008;39:82–93
  • Kawashima Y, Serigano T, Hino T, et al. Effect of surface morphology of carrier lactose on dry powder inhalation property of pranlukast hydrate. Int J Pharm 1998;172:179–88
  • Kern W. The evolution of silicon wafer cleaning technology. J Electrochem Soc 1990;137:1887–92
  • Klapetek P, Necas D, Anderson C. Gwyddion user guide [Internet]. 2012:1–126. Available from: http://gwyddion.net/download/user-guide/gwyddion-user-guide-en.pdf [last accessed 4 May 2014]
  • Littringer EM, Zellnitz S, Hammernik K, et al. Spray drying of aqueous salbutamol sulfate solutions using the nano spray dryer B-90 – the impact of process parameters on particle size. Dry Technol 2013;31:1346–53

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.