251
Views
3
CrossRef citations to date
0
Altmetric
Research Article

Effects of capsicine on rat cytochrome P450 isoforms CYP1A2, CYP2C19, and CYP3A4

, , , &
Pages 1824-1828 | Received 31 Jul 2014, Accepted 17 Jan 2015, Published online: 13 Feb 2015

References

  • Bode AM, Dong Z. The two faces of capsaicin. Cancer Res 2011;71:2809–14
  • Reyes-Escogido Mde L, Gonzalez-Mondragon EG, Vazquez-Tzompantzi E. Chemical and pharmacological aspects of capsaicin. Molecules 2011;16:1253–70
  • Diaz-Laviada I. Effect of capsaicin on prostate cancer cells. Future Oncol 2010;6:1545–50
  • Gooding SM, Canter PH, Coelho HF, et al. Systematic review of topical capsaicin in the treatment of pruritus. Int J Dermatol 2010;49:858–65
  • Josse AR, Sherriffs SS, Holwerda AM, et al. Effects of capsinoid ingestion on energy expenditure and lipid oxidation at rest and during exercise. Nutr Metab (Lond) 2010;7:65
  • Belza A, Frandsen E, Kondrup J. Body fat loss achieved by stimulation of thermogenesis by a combination of bioactive food ingredients: a placebo-controlled, double-blind 8-week intervention in obese subjects. Int J Obes (Lond) 2007;31:121–30
  • Hachiya S, Kawabata F, Ohnuki K, et al. Effects of CH-19 Sweet, a non-pungent cultivar of red pepper, on sympathetic nervous activity, body temperature, heart rate, and blood pressure in humans. Biosci Biotechnol Biochem 2007;71:671–6
  • Lim K, Yoshioka M, Kikuzato S, et al. Dietary red pepper ingestion increases carbohydrate oxidation at rest and during exercise in runners. Med Sci Sports Exerc 1997;29:355–61
  • Zhai XJ, Chen JG, Liu JM, et al. Food-drug interactions: effect of capsaicin on the pharmacokinetics of simvastatin and its active metabolite in rats. Food Chem Toxicol 2013;53:168–73
  • Zhai XJ, Lu YN. Food-drug interactions: effect of capsaicin on the pharmacokinetics of galantamine in rats. Xenobiotica 2012;42:1151–5
  • Babbar S, Chanda S, Bley K. Inhibition and induction of human cytochrome P450 enzymes in vitro by capsaicin. Xenobiotica 2010;40:807–16
  • Reilly CA, Ehlhardt WJ, Jackson DA, et al. Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells. Chem Res Toxicol 2003;16:336–49
  • Zadoyan G, Rokitta D, Klement S, et al. Effect of Ginkgo biloba special extract EGb 761(R) on human cytochrome P450 activity: a cocktail interaction study in healthy volunteers. Eur J Clin Pharmacol 2012;68:553–60
  • Pirmohamed M. Drug-grapefruit juice interactions: two mechanisms are clear but individual responses vary. BMJ 2013;346:f1
  • Fukunaga K, Orito K. Time-course effects of St John's wort on the pharmacokinetics of cyclosporine in dogs: interactions between herbal extracts and drugs. J Vet Pharmacol Ther 2012;35:446–51
  • Breimer DD. Interindividual variations in drug disposition. Clinical implications and methods of investigation. Clin Pharmacokinet 1983;8:371–7
  • Tanaka E, Kurata N, Yasuhara H. How useful is the “cocktail approach” for evaluating human hepatic drug metabolizing capacity using cytochrome P450 phenotyping probes in vivo? J Clin Pharm Ther 2003;28:157–65
  • Zlokarnik G, Grootenhuis PD, Watson JB. High throughput P450 inhibition screens in early drug discovery. Drug Discov Today 2005;10:1443–50
  • Guengerich FP, Wu ZL, Bartleson CJ. Function of human cytochrome P450s: characterization of the orphans. Biochem Biophys Res Commun 2005;338:465–9
  • Izzo AA, Ernst E. Interactions between herbal medicines and prescribed drugs: an updated systematic review. Drugs 2009;69:1777–98
  • Pelkonen O, Turpeinen M, Hakkola J, et al. Inhibition and induction of human cytochrome P450 enzymes: current status. Arch Toxicol 2008;82:667–715
  • Saxena A, Tripathi KP, Roy S, et al. Pharmacovigilance: effects of herbal components on human drugs interactions involving cytochrome P450. Bioinformation 2008;3:198–204
  • Johnson WW. Cytochrome P450 inactivation by pharmaceuticals and phytochemicals: therapeutic relevance. Drug Metab Rev 2008;40:101–47
  • Shimada T, Yamazaki H, Mimura M, et al. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ther 1994;270:414–23
  • Zhou SF, Liu JP, Chowbay B. Polymorphism of human cytochrome P450 enzymes and its clinical impact. Drug Metab Rev 2009;41:89–295
  • Gray IC, Nobile C, Muresu R, et al. A 2.4-megabase physical map spanning the CYP2C gene cluster on chromosome 10q24. Genomics 1995;28:328–32
  • Goldstein JA, de Morais SM. Biochemistry and molecular biology of the human CYP2C subfamily. Pharmacogenetics 1994;4:285–99
  • Watkins PB, Wrighton SA, Schuetz EG, et al. Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man. J Clin Invest 1987;80:1029–36
  • Paolini M, Pozzetti L, Sapone A, Cantelli-Forti G. Effect of licorice and glycyrrhizin on murine liver CYP-dependent monooxygenases. Life Sci 1998;62:571–82
  • Danton AC, Montastruc F, Sommet A, et al. Importance of cytochrome P450 (CYP450) in adverse drug reactions due to drug–drug interactions: a PharmacoVigilance study in France. Eur J Clin Pharmacol 2013;69:885–8

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.