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Drug Development and Industrial Pharmacy Volume 24, 1998 - Issue 6
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Research Article

Effect of Glycine/Citric Acid on the Dissolution Stability of Hard Gelatin Capsules

T. A. Adesunloye Pharmaceutical Research and Development, Geneva Pharmaceuticals, Broomfield, Colorado, 80038-0446
&
P. E. Stach Pharmaceutical Research and Development, Geneva Pharmaceuticals, Broomfield, Colorado, 80038-0446
Pages 493-500 | Published online: 20 Oct 2008

References

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  • Murthy K. S., Enders N. A., Fawzi M. B. Dissolution stability of hard-shell capsule products, part 1: The effect of exaggerated storage conditions. Pharm. Technol. 1989; 13(3)72–85
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  • Jones B. E. Hard gelatin capsules, Manuf. Chem. Aerosol News 1969, February
  • Digenis G. A., Gold T. B., Shah V. P. Cross-linking of gelatin capsules and its relevance to their in vitro-in vivoperformance. J. Pharm. Sci. 1994; 83(7)915–921
  • Marks C. A., Tourtellotte E., Andux A. The phenomenon of gelatin insolubility. Food Technol. 1968; 22: 1433
  • Dey M., Enever R., Kramt M., Prue D., Smith D., Weierstall R. The dissolution and bioavailability of Etodolac from capsules exposed to condition of high relative humidity and temperature. Pharm. Res. 1993; 10(9)1295–1300
  • Murthy K. S., Reisch R. G., Jr., Fawzi M. B. Dissolution stability of hard-shell capsule products, part II: The effect of dissolution test conditions on in vitrodrug release. Pharm. Technol. 1989; 13(6)53–58
  • Dahl T. C., Sue L. T., Yum A. The effect of pan-creatin on the dissolution performance of gelatin-coated tablets exposed to high-humidity condition. Pharm. Res. 1991; 8(3)412–414
  • Florey K. Analytical Profile of Drug Substances. Academic Press, Inc., New York 1981; Vol. 10: 405–441

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