Does Regional Lymph Node Irradiation Improve the Outcome of N0 and pN0 Breast Cancer?

REFERENCES

• Gralow, J.R.; Burstein, H.J.; Wood, W.; Hortobagyi, G.N.; Gianni, L.; von Minckwitz, G.; Buzdar, A.U.; Smith, I.E.; Symmans, W.F.; Singh, B.; Winer, E.P. Preoperative therapy in invasive breast cancer: pathologic assessment and systemic therapy issues in operable disease. J Clin Oncol 2008, 26(5), 814–819.
   PubMed Web of Science ®Google Scholar
• Overgaard, M.; Hansen, P.S.; Overgaard, J.; Rose, C.; Andersson, M.; Bach, F.; Kjaer, M.; Gadeberg, C.C.; Mouridsen, H.T.; Jensen, M.B.; Zedeler, K. Postoperative radiotherapy in high-risk premenopausal women with breast cancer who receive adjuvant chemotherapy. Danish breast cancer cooperative group 82b trial. N Engl J Med 1997, 337(14), 949–955.
   PubMed Web of Science ®Google Scholar
• Overgaard, M.; Jensen, M.B.; Overgaard, J.; Hansen, P.S.; Rose, C.; Andersson, M.; Kamby, C.; Kjaer, M.; Gadeberg, C.C.; Rasmussen, B.B.; Blichert-Toft, M.; Mouridsen, H.T. Postoperative radiotherapy in high-risk postmenopausal breast-cancer patients given adjuvant tamoxifen: Danish breast cancer cooperative group DBCG 82c randomised trial. Lancet 1999, 353(9165), 1641–1648.
   PubMed Web of Science ®Google Scholar
• Ragaz, J.; Jackson, S.M.; Le, N.; Plenderleith, I.H.; Spinelli, J.J.; Basco, V.E.; Wilson, K.S.; Knowling, M.A.; Coppin, C.M.; Paradis, M.; Coldman, A.J.; Olivotto, I.A. Adjuvant radiotherapy and chemotherapy in node-positive premenopausal women with breast cancer. N Engl J Med 1997, 337(14), 956–962.
   PubMed Web of Science ®Google Scholar
• Whelan, T.J.; Julian, J.; Wright, J.; Jadad, A.R.; Levine, M.L. Does locoregional radiation therapy improve survival in breast cancer? A meta-analysis. J Clin Oncol 2000, 18(6), 1220–1229. .
   PubMed Web of Science ®Google Scholar
• Van de Steene, J.; Soete, G.; Storme, G. Adjuvant radiotherapy for breast cancer significantly improves overall survival: the missing link. Radiother Oncol 2000, 55(3), 263–272.
   PubMed Web of Science ®Google Scholar
• Clarke, M.; Collins, R.; Darby, S.; Davies, C.; Elphinstone, P.; Evans, E.; Godwin, J.; Gray, R.; Hicks, C.; James, S.; MacKinnon, E.; McGale, P.; McHugh, T.; Peto, R.; Taylor, C.; Wang, Y. Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005, 366(9503), 2087–2106.
   PubMed Web of Science ®Google Scholar
• McGuire, S.E.; Gonzalez-Angulo, A.M.; Huang, E.H.; Tucker, S.L.; Kau, S.W.; Yu, T.K.; Strom, E.A.; Oh, J.L.; Woodward, W.A.; Tereffe, W.; Hunt, K.K.; Kuerer, H.M.; Sahin, A.A.; Hortobagyi, G.N.; Buchholz, T.A. Postmastectomy radiation improves the outcome of patients with locally advanced breast cancer who achieve a pathologic complete response to neoadjuvant chemotherapy. Int J Radiat Oncol Biol Phys 2007, 68(4), 1004–1009.
   PubMed Web of Science ®Google Scholar
• Huang, E.H.; Tucker, S.L.; Strom, E.A.; McNeese, M.D.; Kuerer, H.M.; Buzdar, A.U.; Valero, V.; Perkins, G.H.; Schechter, N.R.; Hunt, K.K.; Sahin, A.A.; Hortobagyi, G.N.; Buchholz, T.A. Postmastectomy radiation improves local-regional control and survival for selected patients with locally advanced breast cancer treated with neoadjuvant chemotherapy and mastectomy. J Clin Oncol 2004, 22(23), 4691–4699.
   PubMed Web of Science ®Google Scholar
• Paszat, L.F.; Vallis, K.A.; Benk, V.M.; Groome, P.A.; Mackillop, W.J.; Wielgosz, A. A population-based case-cohort study of the risk of myocardial infarction following radiation therapy for breast cancer. Radiother Oncol 2007, 82(3), 294–300.
   PubMed Web of Science ®Google Scholar
• World Health Organization. The World Health Organization histological typing of breast tumors—Second edition. Am. J. Clin Pathol 1982, 78(6), 806–816.
   PubMed Web of Science ®Google Scholar
• Kwiatkowski, F.; Girard, M.; Hacène, K.; Berlie, J. SEM: a statistical software suitable for research in oncology. Bull Cancer 2000, 87(10), 715–721.
   PubMed Web of Science ®Google Scholar
• Yu, T.; Mittendorf, E.A.; Nagar, H.; Gomez, P.; Strom, E.A.; Perkins, G.H.; Oh, J.L.; Tereffe, W.; Woodward, W.A.; Buchholz, T.A. Local-regional recurrence with and without radiation after neoadjuvant chemotherapy and mastectomy for T1-2/N0-1 breast cancer patients. Int J Radiat Oncol 2008, 72(1), S88–S89. supplement: abstract 197.
   Web of Science ®Google Scholar
• Poortmans, P. Evidence based radiation oncology: breast cancer. Radiother Oncol 2007, 84(1), 84–101.
   PubMed Web of Science ®Google Scholar
• Strom, E.A.; Woodward, W.A.; Katz, A.; Buchholz, T.A.; Perkins, G.H.; Jhingran, A.; Theriault, R.; Singletary, E.; Sahin, A.; McNeese, M.D. Clinical investigation: regional nodal failure patterns in breast cancer patients treated with mastectomy without radiotherapy. Int J Radiat Oncol Biol Phys 2005, 63(5), 1508–1513.
   PubMed Web of Science ®Google Scholar
• Handley, R.S. Cancer of the breast. Am Surg 1975, 41(11), 667–670.
   PubMed Web of Science ®Google Scholar
• Veronesi, U.; Cascinelli, N.; Greco, M.; Bufalino, R.; Morabito, A.; Galluzzo, D.; Conti, R.; De Lellis, R.; Delle Donne, V.; Piotti, P.; Sacchini, V.; Clemente, C.; Salvadori, B. Prognosis of breast cancer patients after mastectomy and dissection of internal mammary nodes. Ann Surg 1985, 202(6), 702–707.
   PubMed Web of Science ®Google Scholar
• Van den bogaert, W.; Struikmans, H.; Fourquet, A. Internal mammary and medial supraclavicular (IM-MS) lymph node chain irradiation in stage I-III breast cancer. A phase III randomised trial of the EORTC, protocol 22922/10925, May 1996, revision May 1999, Brussels.
   Google Scholar
• Buchholz, T.A.; Tucker, S.L.; Masullo, L.; Kuerer, H.M.; Erwin, J.; Salas, J.; Frye, D.; Strom, E.A.; McNeese, M.D.; Perkins, G.; Katz, A.; Singletary, S.E.; Hunt, K.K.; Buzdar, A.U.; Hortobagyi, G.N. Predictors of local-regional recurrence after neoadjuvant chemotherapy and mastectomy without radiation. J Clin Oncol 2002, 20(1), 17–23.
   PubMed Web of Science ®Google Scholar
• Fisher, B.; Bryant, J.; Wolmark, N.; Mamounas, E.; Brown, A.; Fisher, E.R.; Wickerham, D.L.; Begovic, M.; DeCillis, A.; Robidoux, A.; Margolese, R.G.; Cruz, A.B.Jr; Hoehn, J.L.; Lees, A.W.; Dimitrov, N.V.; Bear, H.D. Effect of preoperative chemotherapy on the outcome of women with operable breast cancer. J Clin Oncol 1998, 16(8), 2672–2685.
   PubMed Web of Science ®Google Scholar
• Pierga, J.Y.; Mouret, E.; Laurence, V.; Diéras, V.; Savigioni, A.; Beuzeboc, P.; Dorval, T.; Palangié, T.; Jouve, M.; Pouillart, P. Prognostic factors for survival after neoadjuvant chemotherapy in operable breast cancer: the role of clinical response. Eur J Cancer 2003, 39(8), 1089–1096.
   PubMed Web of Science ®Google Scholar