IGF-1 Partially Restores Chemotherapy-Induced Reductions in Neural Cell Proliferation in Adult C57BL/6 Mice

REFERENCES

• American Cancer Society. Cancer Facts and Figures 2008. Atlanta, GA: American Cancer Society, 2008.
   Google Scholar
• Ganz, P.A. A teachable moment for oncologists: cancer survivors, 10 million strong and growing! J Clin Oncol 2005, 23(24), 5458–5460.
   PubMed Web of Science ®Google Scholar
• Vardy, J.; Rourke, S.; Tannock, I.F. Evaluation of cognitive function associated with chemotherapy: a review of published studies and recommendations for future research. J Clin Oncol 2007, 25(17), 2455–2463.
   PubMed Web of Science ®Google Scholar
• Bower, J.E. Behavioral symptoms in patients with breast cancer and survivors. J Clin Oncol 2008, 26(5), 768–777.
   PubMed Web of Science ®Google Scholar
• Wefel, J.S.; Lenzi, R.; Theriault, R.L.; Davis, R.N.; Meyers, C.A. The cognitive sequelae of standard-dose adjuvant chemotherapy in women with breast carcinoma: results of a prospective, randomized, longitudinal trial. Cancer 2004, 100(11), 2292–2299.
   PubMed Web of Science ®Google Scholar
• van Dam, F.S.; Schagen, S.B.; Muller, M.J.; Boogerd, W.; vd Wall, E.; Droogleever Fortuyn, M.E.; Rodenhuis, S. Impairment of cognitive function in women receiving adjuvant treatment for high-risk breast cancer: high-dose versus standard-dose chemotherapy. J Natl Cancer Inst 1998, 90(3), 210–218.
   PubMed Web of Science ®Google Scholar
• Schultz, P.N.; Beck, M.L.; Stava, C. Vassilopoulou-Sellin, R. Health profiles in 5836 long-term cancer survivors. Int J Cancer 2003, 104(4), 488–495.
   PubMed Web of Science ®Google Scholar
• Inagaki, M.; Yoshikawa, E.; Matsuoka, Y.; Sugawara, Y.; Nakano, T.; Akechi, T.; Wada, N.; Imoto, S.; Murakami, K.; Uchitomi, Y. Smaller regional volumes of brain gray and white matter demonstrated in breast cancer survivors exposed to adjuvant chemotherapy. Cancer 2007, 109(1), 146–156.
   PubMed Web of Science ®Google Scholar
• Saykin, A.J.; Ahles, T.A.; McDonald, B.C. Mechanisms of chemotherapy-induced cognitive disorders: neuropsychological, pathophysiological, and neuroimaging perspectives. Semin Clin Neuropsychiatry 2003, 8(4), 201–216.
   PubMedGoogle Scholar
• Zhao, C.; Deng, W.; Gage, F.H. Mechanisms and functional implications of adult neurogenesis. Cell 2008, 132(4), 645–660.
   PubMed Web of Science ®Google Scholar
• Parker, W.B.; Cheng, Y.C. Metabolism and mechanism of action of 5-fluorouracil. Pharmacol Ther 1990, 48(3), 381–395.
   PubMed Web of Science ®Google Scholar
• Mustafa, S.; Walker, A.; Bennett, G.; Wigmore, P. M. 5-Fluorouracil chemotherapy affects spatial working memory and newborn neurons in the adult rat hippocampus. Eur J Neurosci 2008, 28(2), 323–330.
   PubMed Web of Science ®Google Scholar
• Dietrich, J.; Han, R.; Yang, Y.; Mayer-Proschel, M.; Noble, M. CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo. J Biol 2006, 5(7), 22.
   PubMedGoogle Scholar
• Seigers, R.; Schagen, S.B.; Beerling, W.; Boogerd, W.; van Tellingen, O.; van Dam, F.S.; Koolhaas, J.M.; Buwalda, B. Long-lasting suppression of hippocampal cell proliferation and impaired cognitive performance by methotrexate in the rat. Behav Brain Res 2008, 186(2), 168–175.
   PubMed Web of Science ®Google Scholar
• Lledo, P.M.; Alonso, M.; Grubb, M.S. Adult neurogenesis and functional plasticity in neuronal circuits. Nat Rev Neurosci 2006, 7(3), 179–193.
   PubMed Web of Science ®Google Scholar
• Lichtenwalner, R.J.; Forbes, M.E.; Bennett, S.A.; Lynch, C.D.; Sonntag, W.E.; Riddle, D.R. Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis. Neuroscience 2001, 107(4), 603–613.
   PubMed Web of Science ®Google Scholar
• Markowska, A.L.; Mooney, M.; Sonntag, W.E. Insulin-like growth factor-1 ameliorates age-related behavioral deficits. Neuroscience 1998, 87(3), 559–569.
   PubMed Web of Science ®Google Scholar
• West, M.J.; Slomianka, L.; Gundersen, H.J. Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat Rec 1991, 231(4), 482–497.
   PubMedGoogle Scholar
• Kenward, M.G.; Roger, J.H. Small sample inference for fixed effects from restricted maximum likelihood. Biometrics 1997, 53(3), 983–997.
   PubMed Web of Science ®Google Scholar
• Anderson, M.F.; Aberg, M.A.; Nilsson, M.; Eriksson, P.S. Insulin-like growth factor-I and neurogenesis in the adult mammalian brain. Brain Res Dev Brain Res 2002, 134(1–2), 115–122.
   PubMedGoogle Scholar
• Schinkel, A.H. P-Glycoprotein, a gatekeeper in the blood-brain barrier. Adv Drug Deliv Rev 1999, 36(2–3), 179–194.
   PubMed Web of Science ®Google Scholar
• Aberg, M.A.; Aberg, N.D.; Hedbacker, H.; Oscarsson, J.; Eriksson, P.S. Peripheral infusion of IGF-I selectively induces neurogenesis in the adult rat hippocampus. J Neurosci 2000, 20(8), 2896–2903.
   PubMed Web of Science ®Google Scholar
• Aberg, M.A.; Aberg, N.D.; Palmer, T.D.; Alborn, A.M.; Carlsson-Skwirut, C.; Bang, P.; Rosengren, L.E.; Olsson, T.; Gage, F.H.; Eriksson, P.S. IGF-I has a direct proliferative effect in adult hippocampal progenitor cells. Mol Cell Neurosci 2003, 24(1), 23–40.
   PubMed Web of Science ®Google Scholar
• Mirescu, C.; Gould, E. Stress and adult neurogenesis. Hippocampus 2006, 16(3), 233–238.
   PubMed Web of Science ®Google Scholar
• Santarelli, L.; Saxe, M.; Gross, C.; Surget, A.; Battaglia, F.; Dulawa, S.; Weisstaub, N.; Lee, J.; Duman, R.; Arancio, O.; Belzung, C.; Hen, R. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 2003, 301(5634), 805–809.
   PubMed Web of Science ®Google Scholar
• Mirescu, C.; Peters, J.D.; Noiman, L.; Gould, E. Sleep deprivation inhibits adult neurogenesis in the hippocampus by elevating glucocorticoids. Proc Natl Acad Sci U S A 2006, 103(50), 19170–19175.
   PubMed Web of Science ®Google Scholar