Elemene, One Ingredient of a Chinese Herb, Against Malignant Tumors: A Literature-based Meta-analysis

REFERENCES

• Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011;61:69–90.
   PubMed Web of Science ®Google Scholar
• Guo YT. Isolation and identification of elemene from the essential oil of Curcuma wenyujin. Zhong Yao Tong Bao 1983;8:31.
   PubMedGoogle Scholar
• Tang XH, Qin SK, Xie T. Status and progress of basic researches of elemene injection for anti-tumor. Chin J Clin Oncol 2010;15:266–273.
   Google Scholar
• Zhao YL, Peng XX, Wang YD. Elemene injections for pulmonary cancer: a systematic review. Chin J EBM 2005;5:216–223.
   Google Scholar
• Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996;17:1–12.
   PubMedGoogle Scholar
• DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986;7:177–188.
   PubMed Web of Science ®Google Scholar
• Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003;327:557–560.
   PubMed Web of Science ®Google Scholar
• Lu LQ, Liu ZJ, Chen FH. Effect of elemene emulsion against lung cancer by intervention therapy. Zhejiang J Oncol 1996;2:185.
   Google Scholar
• Li X, Xu SX, Shang GY. Comparison of elemene and general medicine against lung cancer by double artery injection. Zhong Liu Fang Zhi Yan Jiu 1996;23:369–371.
   Google Scholar
• Qin SK, Qian J, Wang L. The clinical study on the plan of elemene emulsion with CTV to treat lung cancer. Zhong Liu Fang Zhi Yan Jiu 1998;25:58–60.
   Google Scholar
• Wang J, Hu J, Jun M. Clinical observation of elemene emulsion associated with EP against small cell lung cancer. Chin J Clin Oncol 2000;27:312–313.
   Google Scholar
• Liu JF. Clinical observation of elemene emulsion associated with MVP against middle and advanced lung cancer. Henan J Oncol 2000;13:434–435.
   Google Scholar
• Li L, Li ZL, Shui LH. Effect of elemene emulsion associated with EP on 60 middle and advanced lung cancer patients. Shandong J Med 2001;41:44.
   Google Scholar
• Zhou D. Randomized controlled trial of elemene plus VP comparing with VP against advanced non-small-cell lung cancer. Chin J Clin Oncol 2001;28:470–471.
   Google Scholar
• Tang SS, Xue YB, Jiang GL. Elemene injection associated with EP against advanced non-small-cell lung cancer. Zhe Jiang Zhong Xi Yi Jie He Za Zhi 2002;12:215–216.
   Google Scholar
• Chen NJ, Li H, Tan SS. Clinical observation of docetaxel associated with elemene emulsion against 68 advanced non-small-cell lung cancer patients. Chin J Clin Oncol 2005;32:896–897.
   Google Scholar
• Guo HQ, Chen HL, Chu SL. The application of elemenum emulsion to multi-modality therapy for advanced non-small-cell lung cancer stage IIIB∼IV. J Chin Oncol 2007;16:471–473.
   Google Scholar
• Chen YP, Zhuang WB, Liu YC. Clinical observation of elemene emulsion associated with DC against advanced non-small-cell lung cancer. Shandong J Med 2008;48:54–55.
   Google Scholar
• Yan ZY, Wang LN. Clinical research of combined elemenum for injection with DP therapy in treating elderly patient with advanced non-small-cell lung cancer. J Hunan Coll Tradit Chin Med 2009;29:5–8.
   Google Scholar
• Zhou L, Liu FQ, Zhang HM. Clinical observation of elemene injection combined paclitaxel chemotherapy on advanced stage non-small-cell lung cancer. Zhong Yao Yao Li Yu Lin Chuang 2009;25:54–55.
   Google Scholar
• Chu DJ, Guo SG, Yao DE. To study elemene emulsion, gemcitabine, and cisplatin in the treatment of advanced non-small-cell lung cancer. Chin J Clin Med 2010;17:491–494.
   Google Scholar
• Wang LH, Shen F. Elemene emulsion combined with NP chemotherapy in the treatment of advanced NSCLC patients. J Chin Oncol 2010;20:547–550.
   Google Scholar
• Fan WJ, Zhang FJ, Shen JL. Effect of elemene against eighty-two cases suffering from middle and terminal liver cancer in artery thrombosis. Chin J Clin Med 2001;17:926–927.
   Google Scholar
• Zhang ZP. Elemene emulsion combined with transcatheter arterial chemoembolization in the treatment for 22 cases with primary hepatocellular carcinoma. J Bengbu Med Coll 2001;26: 341.
   Google Scholar
• Chen J, Wang F, Yang BH. Effect of elemene associated with intervention treatment against ninety-two cases suffering from middle and terminal live cancer. J Interv Radiol 2002;11:210–212.
   Google Scholar
• Chen P, Huang P, Wu JB. Observation on the therapeutic effect of transcatheter arterial infusion chemotherapy combined with elemene emulsion for the treatment intermediate and late stage hepatic carcinoma. J Jiangxi Med Coll 2005;45:96–98.
   Google Scholar
• Song J, Xu H, Tang JQ. Transcatheter hepatic arterial infusion chemotherapy combined with elemene emulsion for treatment of primary hepatic carcinoma. J Chin Pharmaceut 2007;16:23–24.
   Google Scholar
• Lu LQ, Zhao TW. Observation on the therapeutic effect of transcatheter hepatic arterial chemoembolization infusion combined with elemene emulsion for metastatic liver carcinomas. Chin Arch Tradit Chin Med 2011;29:253–255.
   Google Scholar
• Xu XM, Chen MC, Chen DL. Beta-elemene emulsion combined with transcatheter arterial chemoembolization in the treatment for 21 cases with advanced hepatocellular carcinoma. J Clin Oncol 2011;17:363–365.
   Google Scholar
• Yin ZM, Zhang Y, Xie Z. Elemene plus fluorouracil in the treatment of advanced gastric cancer. Chin J Clin Oncol 1996;23:810–813.
   Google Scholar
• Ma XZ, Yao Y, Zhang H. Clinical study of LEF versus EFP program in the treatment of advanced gastric carcinoma. J Binzhou Med Coll 1999;22:242–244.
   Google Scholar
• Wu CM, Li QQ, Zhao YL. Effect of elemene emulsion and 5-Fu therapy on advanced gastric carcinoma. J North Sichuan Med Coll 2000;15:12–13.
   Google Scholar
• Li X, Jia LQ, Chen ZQ. Clinical observation of elemene injection combined 5-Fu biochemical adjustment therapy on gastrointestinal adeno-carcinoma. J Chin-Japan Friendship Hosp 2004;18:6–9.
   Google Scholar
• Huang XJ. Clinical observation of elemene emulsion associated with chemotherapy against gastric carcinoma. Chin J Tradit Chin Med 2005;3:40–41.
   Google Scholar
• Wei QL, Shou JW. Elemenum emulsion combined with fluorouracil/paclitaxel in the treatment of progressive gastric cancer. Zhengjiang J Clin Med 2008;10:588–589.
   Google Scholar
• Qin ZQ, Lu LQ, Yuan GR. Elemene combined OLF program of treatment of advanced gastric cancer. Chin Arch Tradit Chin Med 2010;28:435–437.
   Google Scholar
• Gu H, Li YK, Li MX. Efficacy of elemene injection combined chemotherapy in treatment of advanced gastric carcinoma. Mod J Integr Tradit Chin West Med 2011;20:1438–1441.
   Google Scholar
• Xu QL, Jie XY, Yin JL. Clinical observation of elemene emulsion combined with chemotherapy in the treatment of metastatic brain carcinomas. Zhong Liu Yan Jiu Yu Lin Chuang 2001;13:47–48.
   Google Scholar
• Xu YH, Dong B, Zhou HY. Observation on the therapeutic effect of transcatheter carotid infusion with elemene emulsion for metastatic brain carcinomas. Clin J Oncol 2004;31:1423–1424.
   Google Scholar
• Zhao P, Yu CM, Hu YQ. Effect of elemene emulsion combined with chemotherapy against acute leukemia. Chin J Clin Oncol 1999;26:395–396.
   Google Scholar
• Zhao SM, Zang H, Gu XC. Effect of elemene emulsion combined with chemotherapy against refractory acute nonlymphocytic leukemia. Chin J Clin Oncol 1999;26:530–531.
   Google Scholar
• Zheng CP, Wang XL, Zhang WP. Effect of elemene emulsion combined with chemotherapy against refractory acute nonlymphocytic leukemia. Chin J Clin Oncol 1999;26:237–238.
   Google Scholar
• Zheng CP, Zhang WP, Xu J. Effect of elemene emulsion combined with chemotherapy in treatment of refractory acute nonlymphocytic leukemia. J Clin Hematol 2001;14:211–212.
   Google Scholar
• Chen J, Yang JM, Dong DY. Application of elemene emulsion in the elderly refractory leucemia. Zhong Guo Zhong Xi Yi Jie He Za Zhi 2004;24:935–936.
   Google Scholar
• Zhu X, Wu CY, Lin JH. Effect of elemene emulsion combined with chemotherapy against osteogenic sarcoma. Guang Ming Zhong Yi 2011;26:2091–2092.
   Google Scholar
• Hao LW, Lu SB, Yu LM. Effect of β-elemene derivative in combined with ADM on CEM/ADM cells growth. J Dalian Med Coll 2002;22:165–167.
   Google Scholar
• Li X, Wang G, Zhao JH. Antiproliferative effect of β-elemene in chemoresistant ovarian carcinoma cells is mediated through arrest of the cell cycle at the G2-M phase. CMLS Cell Mol Life Sci 2005;62:894–904.
   PubMed Web of Science ®Google Scholar
• Li QD, Wang GD, Zhang MC. β-elemene, a novel plant-derived antineoplastic agent, increases cisplatin chemosensitivity of lung tumor cells by triggering apoptosis. Oncol Rep 2009;22:161–170.
   PubMed Web of Science ®Google Scholar
• Wu WZ, Liu KD, Tang XL. Preliminary study on the antitumour immuno-protective mechanism of β-elemene. Chin J Oncol 1999;21:405–407.
   Google Scholar
• Jin M, Shi GX, Pu H. Comparative study on the active immunization antitumor effects strengthen way of elemene-combo tumor cell vaccine. J Dalian Med Coll 1999;21:168–169.
   Google Scholar
• Chen LB, Zhang J, Wang QH. Effects of β-elemene on immune function in mice with tomour. Zhong Liu Fang Zhi Za Zhi 1998;25:54.
   Google Scholar
• Yao SJ, Liu BY, Hu F. Effects of β-elemene on NK and IL-2 activities in mice with tomour. Chin Pharmaceut 2000;9: 19–20.
   Google Scholar
• Chen G, Ding XF, Xiao JF. Effects of elemene piperazine on immune function in mice with tumor. J Shengyang Pharmaceut Coll 2007;24:238–241.
   Google Scholar
• Xiao XP, Zhao YL, Liang XY, Wu LJ, Cui SQ, Guo AM, Wang W. Assessing the quality of RCTs on the effect of β-elemene, one ingredient of a Chinese herb, against malignant tumors. Contemp Clin Trials 2006;27:70–82.
   PubMed Web of Science ®Google Scholar
• Hewitt C, Hahn S, Torgerson DJ, Watson J, Bland JM. Adequacy and reporting of allocation concealment: review of recent trials published in four general medical journals. BMJ 2005;330:1057–1058.
   PubMed Web of Science ®Google Scholar
• He J, Du L, Liu GJ, Fu J, He X, Yu J. Quality assessment of reporting of randomization, allocation concealment, and blinding in traditional Chinese medicine RCTs: a review of 3159 RCTs identified from 260 systematic reviews. Trials 2011;12:122.
   PubMedGoogle Scholar
• Marwick C. Complementary, alternative therapies should face rigorous testing. IOM concludes. J Natl Cancer Inst 2005;97: 255–256.
   PubMed Web of Science ®Google Scholar