REFERENCES
- Patel T. Worldwide trends in mortality from biliary tract malignancies. BMC Cancer 2002;2:10.
- Stefania Mosconi, Giordano D Beretta, Roberto Labianca, Cholangiocarcinoma. Oncology/Hematology 2009;69:259–270.
- Trauner M, Fickert P, Halilbasic E, Lessons from the toxic bile concept for the pathogenesis and treatment of cholestatic liver diseases. Wien Med Wochenschr 2008;158:542–548.
- Burnat G, Rau T, Elshimi E, Bile acids induce overexpression of homeobox gene CDX-2 and vascular endothelial growth factor (VEGF) in human Barrett's esophageal mucosa and adenocarcinoma cell line. Scand J Gastroenterology 2007;42:1460–1465.
- Schramm G, Surmann EM, Wiesberg S, Analyzing the regulation of metabolic pathways in human breast cancer. BMC Med Genomics 2010;3:39.
- Bernstein H, Bernstein C, Payne CM, Bile acids as endogenous etiologic agents in gastrointestinal cancer. World J Gastroenterology 2009;15:3329–3340.
- Debruyne PR, Brunel EA, Karaguni IM, Bile acids stimulate invasion and haptotaxis in human colorectal cancer cells through activation of multiple oncogenic signaling pathways. Oncogene 2002;21:6740–6750.
- Park MJ, Kim KH, Kim HY, Bile acid induces expression of COX-2 through the homeodomain transcription factor CDX1 and orphan nuclear receptor SHP in human gastric cancer cells. Carcinogenesis 2008;29:2385–2393.
- Jiaqi Dai, Hongxia Wang, Yihui Shi, Impact of bile acids on the growth of human cholangiocarcinoma via FXR. JHO 2011;4:41.
- Wang YD, Chen WD, Wang M, Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response. Hepatology 2008; 48:1632–1643.
- Raza SA, Clifford GM, Franceschi S. Worldwide variation in the relative importance of hepatitis B and hepatitis C viruses in hepatocellular carcinoma: a systematic review. Br J Cancer 2007;96:1127–1134.
- Jens J. W. Tischendorf, Andreas Geier, Christian Trautwein. Current diagnosis and management of primary sclerosing cholangitis. Liver Transplantation 2008;4:735–746.
- Gu X, Ke S, Liu D, Role of NF-kappaB in regulation of PXR-mediated gene expression: a mechanism for the suppression of cytochrome P-450 3A4 by proinflammatory agents. J Biol Chem 2006;281:17882–17889.
- Ghosh S, Kann M. Missing pieces in the NF-kappa puzzle. Cell 2002;109(supp1):81–96.
- Balk F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet 2001;357:539–545.
- Aggarwal BB. Nuclear factor-kappaB: the enemy within Cancer. Cell 2004;6(3):203–208.
- Wehbe H, Henson R, Meng F, et a1. Interleukin-6 contributes to growth in cholangiocarcinoma cells by aberrant promoter methylation and gene expression. Cancer Res 2006;66:10517–10524.
- Isomoto H. Epigenetic alterations in cholangiocarcinoma-sustained IL-6/STAT3 signaling in cholangiocarcinoma due to SOCS3 epigenetic silencing. Digestion 2009;1:2–8.
- Carmichael J, DeGraff WG, Gazdar AF, Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer Res 1987;47:936–392.
- Wang J, Shi YQ, Yi J, Suppression of growth of pancreatic cancer cell and expression of vascular endothelial growth factor by gene silencing with RNA interference. J Dig Dis 2008;9: 228–237.
- Swales KE, Korbonits M, Carpenter R, The farnesoid X receptor is expressed in breast cancer and regulates apoptosis and aromatase expression. Cancer Res 2006;66:10120–10126.
- Blechacz B, Gores GJ. Cholangiocarcinoma: advances in pathogenesis, diagnosis, and treatment. Hepatology 2008;48: 308–321.
- Khan SA, Thomas HC, Davidson BR, Cholangiocarcinoma. Lancet 2005;366:1303–1314.
- Fava G, Marzioni M, Benedetti A, Molecular pathology of biliary tract cancers. Cancer Lett 2007;250:155–167.
- Lamireau T, Zoltowska M, Levy E, Effects of bile acids on biliary epithelial cells: proliferation, cytotoxicity, and cytokine secretion. Life Sci 2003;72:1401–1411.
- Horowitz NS, Hua J, Powell MA, Novel cytotoxic agents from an unexpected source: bile acids and ovarian tumor apoptosis. Gynecol Oncol 2007;107:344–349.
- Baker PR, Wilton JC, Jones CE, Bile acids influence the growth, oestrogen receptor and oestrogen-regulated proteins of MCF-7 human breast cancer cells. Br J Cancer 1992;65: 566–572.
- Werneburg NW, Yoon JH, Higuchi H, Gores GJ. Bile acids activate EGF receptor via a TGF-alpha-dependent mechanism in human cholangiocyte cell lines. Am J Physiol Gastrointest Liver Physiol. 2003;285(1):G31–6.
- Suzuki S, Hashizume K. Do PPARgamma ligands suppress the growth of cholangiocarcinoma or the cholangiohepatitis induced by the tumor? PPAR Res 2008; 2008:587401.
- Beg AA, Sha WC, Bronson RT, et a1. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. Nature 1995;376(6536):167–170.
- Wang YD, Chen WD, Wang M, Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response. Hepatology 2008;48:1632–1643.
- Lin MT, Zuon CY, Chang CC, Cyr61 induces gastric cancer cell motility/invasion via activation of the integrin/nuclear factor-kappaB/cyclooxygenase-2 signaling pathway. Clin Cancer Res 2005;11:5809–5820.
- Glinghammar B, Inoue H, Rafter JJ. Deoxycholic acid causes DNA damage in colonic cells with subsequent induction of caspases, COX-2 promoter activity and the transcription factors NF-kB and AP-1. Carcinogenesis 2002;23:839–845.
- Karin M, Greten FR. NF-kappaB: linking inflammation and immunity to cancer development and progression. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 2005;5:749–759.
- Calmus Y, Guechot J, Podevin P, Differential effects of chenodeoxycholic and ursodeoxycholic acids on interleukin 1, interleukin 6 and tumor necrosis factor-alpha production by monocytes. Hepatology 1992;16:719–723.
- Dvorak K, Chavarria M, Payne CM, Activation of the interleukin-6/STAT3 antiapoptotic pathway in esophageal cells by bile acids and low pH: relevance to barrett's esophagus. Clin Cancer Res 2007;13:5305–5313.
- Wehbe H, Henson R, Meng F, et a1. Interleukin-6 contributes to growth in cholangiocarcinoma cells by aberrant promoter methylation and gene expression. Cancer Res 2006;66:10517–10524.
- Meng F, Yamagiwa Y, Ueno Y, et a1. Over-expression of intexleukin-6 enhances cellsurvival and transformed cell growth in human malignant cholangiocytes. J Hepatol 2006;44: 1055–1065.
- Isomoto H. Epigenetic alterations in cholangiocarcinoma-sustained IL-6/STAT3 signaling in cholangiocarcinoma due to SOCS3 epigenetic silencing. Digestion 2009;1:2–8.
- Yamagiwa Y, Meng F, Patel T. Interleukin-6 decreases senescence and increases telomerase activity in malignant human cholangiocytes. Life Sci 2006;78(21);2494–2502.
- Mühlbauer M, Allard B, Bosserhoff AK, Differential effects of deoxycholic acid and taurodeoxycholic acid on NF-kappa B signal transduction and IL-8 gene expression in colonic epithelial cells. Am J Physiol Gastrointest Liver Physiol 2004;286(6):G1000–1008.
- Yoon JH, Higuchi H, Werneburg NW, Bile acids induce cycooxygenase-2 expression via the epidermal growth factor receptor in a human cholangiocarcinoma cell line. Gastroenterology 2002;122(4):985–993.
- Yoon JH, Canbay AE, Werneburg NW, Oxysterols induce cyclooxygenase-2 expression in cholangiocytes: Implications for biliary tract carcinogenesis. Hepatology 2004;39(3):732–738.