103
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLE

Recurrent Abnormal Clones in Myelodysplastic Syndrome Marrow Originate from Cells at a Pluripotent Stem Level and Maintain Their Early Differentiation Potency

, , , , , & show all
Pages 369-377 | Received 16 Feb 2015, Accepted 21 Apr 2015, Published online: 02 Jul 2015

REFERENCES

  • Greenberg PL. The multifaceted nature of myelodysplastic syndromes: clinical, molecular, and biological prognostic features. J Natl Compr Canc Netw 2013;11:877–884, quiz 885.
  • Kroef MJ, Bolk MJ, Muus P, Wessels JW, Beverstock GC, Willemze R, Landegent JE. Mosaicism of the 5q deletion as assessed by interphase FISH is a common phenomenon in MDS and restricted to myeloid cells. Leukemia 1997;11:519–523.
  • Saitoh K, Miura I, Takahashi N, Miura AB. Fluorescence in situ hybridization of progenitor cells obtained by fluorescence-activated cell sorting for the detection of cells affected by chromosome abnormality trisomy 8 in patients with myelodysplastic syndromes. Blood 1998;92:2886–2892.
  • Bigoni R, Cuneo A, Milani R, Cavazzini F, Bardi A, Roberti MG, Agostini P, della Porta M, Specchia G, Rigolin GM, Castoldi G. Multilineage involvement in the 5q-syndrome: a fluorescent in situ hybridization study on bone marrow smears. Haematologica 2001;86:375–381.
  • Shen Y, Xue Y, Li J, Pan J, Chen S. Study on the origin of aberrant clones with chromosome abnormalities in MDS. Zhonghua Yi Xue Za Zhi 2002;82:1450–1453.
  • Aul C, Gattermann N, Schneider W. Epidemiological and etiological aspects of myelodysplastic syndromes. Leuk Lymphoma 1995;16:247–262.
  • Faderl S, Talpaz M, Estrov Z, O'Brien S, Kurzrock R, Kantarjian HM. The biology of chronic myeloid leukemia. N Engl J Med 1999;341:164–172.
  • Heaney ML, Golde DW. Myelodysplasia. N Engl J Med 1999;340:1649–1660.
  • Nilsson L, Astrand-Grundström I, Arvidsson I, Jacobsson B, Hellström-Lindberg E, Hast R, Jacobsen SE. Isolation and characterization of hematopoietic progenitor/stem cells in 5q-deleted myelodysplastic syndromes: evidence for involvement at the hematopoietic stem cell level. Blood 2000;96:2012–2021.
  • Miura I, Kobayashi Y, Takahashi N, Saitoh K, Miura AB. Involvement of natural killer cells in patients with myelodysplastic syndrome carrying monosomy 7 revealed by the application of fluorescence in situ hybridization to cells collected by means of fluorescence-activated cell sorting. Br J Haematol 2000;110:876–879.
  • Nilsson L, Edén P, Olsson E, Månsson R, Astrand-Grundström I, Strömbeck B, Theilgaard-Mönch K, Anderson K, Hast R, Hellström-Lindberg E, Samuelsson J, Bergh G, Nerlov C, Johansson B, Sigvardsson M, Borg A, Jacobsen SE. The molecular signature of MDS stem cells supports a stem-cell origin of 5q-myelodysplastic syndromes. Blood 2007;110:3005–3014.
  • Nilsson L, Astrand-Grundström I, Anderson K, Arvidsson I, Hokland P, Bryder D, Kjeldsen L, Johansson B, Hellström-Lindberg E, Hast R, Jacobsen SE. Involvement and functional impairment of the CD34(+)CD38(−)Thy-1(+) hematopoietic stem cell pool in myelodysplastic syndromes with trisomy 8. Blood 2002;100:259–267.
  • Huang WT, Yang X, Zhou X, Monzon FA, Wen J, Hagenkord JM, Wu LY, Keever-Taylor C, Novoa-Takara L, Wong ST, Young K, Chang CC. Multiple distinct clones may co-exist in different lineages in myelodysplastic syndromes. Leuk Res 2009;33:847–853.
  • Terstappen LW, Huang S, Safford M, Lansdorp PM, Loken MR. Sequential generations of hematopoietic colonies derived from single nonlineage-committed CD34+CD38− progenitor cells. Blood 1991;77:1218–1227.
  • Larochelle A, Vormoor J, Hanenberg H, Wang JC, Bhatia M, Lapidot T, Moritz T, Murdoch B, Xiao XL, Kato I, Williams DA, Dick JE. Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene therapy. Nat Med 1996;2:1329–1337.
  • Barlow JL, Drynan LF, Hewett DR, Holmes LR, Lorenzo-Abalde S, Lane AL, Jolin HE, Pannell R, Middleton AJ, Wong SH, Warren AJ, Wainscoat JS, Boultwood J, McKenzie AN. A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q-syndrome. Nat Med 2010;16:59–66.
  • Geest CR, Buitenhuis M, Vellenga E, Coffer PJ. Ectopic expression of C/EBPa and ID1 is sufficient to restore defective neutrophil development in low-risk myelodysplasia. Haematologica 2009;94:1075–1084.
  • Bellos F, Alpermann T, Gouberman E. Evaluation of flow cytometric assessment of myeloid nuclear differentiation antigen expression as a diagnostic marker for myelodysplastic syndromes in a series of 269 patients. Cytometry B Clin Cytom 2012;82:295–304.
  • Li X, Wu L, Ying S, Chang C, He Q, Pu Q. Differentiation and hematopoietic-support of clonal cells in myelodysplastic syndromes. Leuk Lymphoma 2007;48:1353–1371.
  • de Souza Fernandez T, Ornellas MH, Otero de Carvalho L, Tabak D, Abdelhay E. Chromosomal alterations associated with evolution from myelodysplastic syndrome to acute myeloid leukemia. Leuk Res 2000;24:839–848.
  • Fujimura T, Yukawa N, Nakashima R, Imura Y, Kawabata D, Nojima T, Ohmura K, Fujii T, Usui T, Mimori T. Periodic fever and erythema nodosum associated with MDS with trisomy 8: report of two cases and review of the literature. Mod Rheumatol 2010;20:413–419.
  • Toyonaga T, Nakase H, Matsuura M, Minami N, Yamada S, Honzawa Y, Hukata N, Yoshino T, Chiba T, Okazaki K. Refractoriness of intestinal Behçet's disease with myelodysplastic syndrome involving trisomy 8 to medical therapies—our case experience and review of the literature. Digestion 2013;88: 217–221.
  • Kerbauy DM, Lesnikov V, Torok-Storb B, Bryant E, Deeg HJ. Engraftment of distinct clonal MDS-derived hematopoietic precursors in NOD/SCID-beta2-microglobulin-deficient mice after intramedullary transplantation of hematopoietic and stromal cells. Blood 2004;104;2202–2203.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.