Immunoreactive Glutamic Acid Decarboxylase in the Trigeminal Nucleus Caudalis of the Cat: A Light- and Electron-Microscopic Analysis

References

• Aronin N., Difiglia M., Liotta A. S., Martin J. B. Ultrastructural localization and biochemical features of immunoreactive leuenkephalin in monkey dorsal horn. J. Neurosci. 1981; 1: 561–577
   PubMed Web of Science ®Google Scholar
• Barbaro N. M., Hammond D. L., Fields H. L. Effects of intrathecally administered methysergide and yohimbine on micro‐stimulation‐produced antinociception in the rat. Brain Res. 1985; 343: 223–229
   PubMed Web of Science ®Google Scholar
• Barber R. P., Vaughn J. E., Roberts E. The cytoarchitecture of GABAergic neurons in rat spinal cord. Brain Res. 1982; 238: 305–328
   PubMed Web of Science ®Google Scholar
• Barber R. P., Vaughn J. E., Saito K., McLaughlin B. J., Roberts E. GABAergic terminals are presynaptic to primary afferent terminals in the substantia gelatinosa of the rat spinal cord. Brain Res. 1978; 141: 35–55
   PubMed Web of Science ®Google Scholar
• Barker J. L., Nicoll R. A. Gamma‐aminobutyric acid: Role in primary afferent depolarization. Science 1972; 176: 1043–1045
   PubMed Web of Science ®Google Scholar
• Basbaum A. I. Functional analysis of the cytochemistry of the spinal dorsal horn. Adv. Pain Res. Ther. 1985; 9: 149–175
   Google Scholar
• Basbaum A. I., Fields H. L. Endogenous pain control mechanisms: Review and hypothesis. Ann. Neurol. 1978; 4: 451–462
   PubMed Web of Science ®Google Scholar
• Basbaum A. I., Fields H. L. Endogenous pain control systems: Brainstem‐spinal circuitry and endorphins. Ann. Rev. Neurosci. 1984; 7: 309–338
   PubMed Web of Science ®Google Scholar
• Basbaum A. I., Glazer E. J., Oertel W. A light and EM analysis of immunoreactive glutamic acid decarboxylase (GAD) in the spinal and trigeminal dorsal horn of the cat. Soc. Neurosci. Abstr. 1981; 7: 528
   Google Scholar
• Basbaum A. I., Moss M. S., Glazer E. J. Opiate and stimulation‐produced analgesia: The contribution of the monoamines. Adv. Pain Res. Ther. 1983; 5: 323–339
   Google Scholar
• Bowery N. G. Baclofen: 10 years on. Trends Pharm. Sci. 1982; 3: 400–403
   Web of Science ®Google Scholar
• Bowery N. G., Hill D. R., Hudson A. L., Doble A., Middlemiss D. N., Turnbull M. Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor. Nature 1980; 283: 92–94
   PubMed Web of Science ®Google Scholar
• Carstens E., Klumpp D., Randic M., Zimmermann M. Effect of iontophoretically applied 5‐hydroxytryptamine on the excitability of single primary afferent C‐ and A‐fibers in the cat spinal cord. Brain Res. 1982; 220: 151–158
   Web of Science ®Google Scholar
• Cruz L., Basbaum A. I. Multiple opioid peptides and the modulation of pain: Immuno‐histochemical analysis of dynorphin and enkephalin in the trigeminal nucleus caudalis and spinal cord of the cat. J. Comp. Neurol. 1985; 230: 331–348
   Google Scholar
• Curtis D. R., Lodge D., Brand S. J. GABA and spinal afferent terminal excitability in the cat. Brain Res. 1977; 130: 360–363
   PubMed Web of Science ®Google Scholar
• Davidoff R. A. Gamma‐aminobutyric acid antagonism and presynaptic inhibition in the frog spinal cord. Science 1972; 175: 331–333
   PubMed Web of Science ®Google Scholar
• Desarmenien M., Feltz P., Occhipiniti G., Santangelo F., Schlichter R. Coexistence of GABAa and GABAb receptors on A and C primary afferents. Brit. J. Pharmacol. 1984; 81: 327–333
   PubMed Web of Science ®Google Scholar
• Deschenes M., Feltz P., Lamour Y. A model for an estimate in vivo of the ionic basis of presynaptic inhibition: An intracellular analysis of the GABA‐induced depolarization in rat dorsal root ganglia. Brain Res. 1976; 118: 486–493
   PubMed Web of Science ®Google Scholar
• Dickenson A. H., Brewer C. M., Hayes N. A. Effects of baclofen on C fibre‐evoked neuronal activity in the rat dorsal horn. Neuro‐science 1985; 14: 557–562
   Google Scholar
• Fitzgerald M., Woolf C. The stereospecific effect of naloxone on rat dorsal horn neurones: Inhibition in superficial laminae and excitation in deeper laminae. Pain 1980; 9: 293–306
   PubMed Web of Science ®Google Scholar
• Glazer E. J., Basbaum A. I. Immunohistochemical localization of leucine‐enkephalin in the spinal cord of the cat: Enkephalin‐containing marginal neurons and pain modulation. J. Comp. Neurol. 1981; 196: 377–389
   PubMed Web of Science ®Google Scholar
• Glazer E. J., Basbaum A. I. Opioid neurons and pain modulation: An ultrastructural analysis of enkephalin in cat superficial dorsal horn. Neuroscience 1983; 10: 357–376
   PubMed Web of Science ®Google Scholar
• Glusman S. Correlation between the topographical distribution of 3H GABA uptake and primary afferent depolarization in the frog spinal cord. Brain Res. 1975; 88: 109–114
   PubMed Web of Science ®Google Scholar
• Gmelin G., Zimmermann M. Effects of γ‐aminobutyrate and bicuculline on primary afferent depolarization of cutaneous fibers in the cat spinal cord. Neuroscience 1983; 10: 869–874
   PubMed Web of Science ®Google Scholar
• Gobel S. Synaptic organization of the substantia gelatinosa glomeruli in the spinal trigeminal nucleus of the adult cat. J. Neurocytol. 1974; 3: 219–243
   PubMedGoogle Scholar
• Gobel S. Golgi studies of the neurons in layer II of the dorsal horn of the medulla (trigeminal nucleus caudalis). J. Comp. Neurol. 1978; 180: 395–414
   PubMedGoogle Scholar
• Gobel S. Neural circuitry in the substantia gelatinosa of Rolando: Anatomical insights. Adv. Pain Res. Ther. 1979; 3: 175–195
   Google Scholar
• Gobel S., Falls W. M., Bennett G. J., Abdelmounmene M., Hayashi H., Humphrey E. An EM analysis of the synaptic connections of horseradish peroxidase‐filled stalked cells and islet cells in the substantia gelatinosa of adult cat spinal cord. J. Comp. Neurol. 1980; 194: 781–807
   PubMed Web of Science ®Google Scholar
• Henry J. L. Effects of intravenously administered enantiomers of baclofen on functionally identified units in lumbar dorsal horn of the spinal cat. Neuropharmacology 1982a; 21: 1073–1083
   PubMed Web of Science ®Google Scholar
• Henry J. L. Pharmacological studies on the prolonged depressant effects of baclofen on lumbar dorsal horn units in the cat. Neuropharmacology 1982b; 21: 1085–1093
   PubMed Web of Science ®Google Scholar
• Hentall I. D., Fields H. L. Actions of opiates, substance P, and serotonin on the excitability of primary afferent terminals and observations on interneuronal activity in the neonatal rat's dorsal horn in vitro. Neuroscience 1983; 9: 521–528
   PubMed Web of Science ®Google Scholar
• Hunt S. P., Kelly J. S., Emson P. C. The electron microscopic localization of methionine‐enkephalin within the superficial layers (I and II) of the spinal cord. Neuroscience 1980; 5: 1871–1890
   PubMed Web of Science ®Google Scholar
• Hunt S. P., Kelly J. S., Emson P. C., Kimmel J. R., Miller R. J., Wu J. Y. An immunohistochemical study of neuronal populations containing neuropeptides or γ‐aminobutyrate within the superficial layers of the rat dorsal horn. Neuroscience 1981; 6: 1883–1898
   PubMed Web of Science ®Google Scholar
• Iversen L. L., Bloom F. E. Studies of the uptake of 3H GAB A and 3H glycine in slices and homogenates of rat brain and spinal cord by electron microscopic autoradiography. Brain Res. 1972; 41: 131–143
   PubMed Web of Science ®Google Scholar
• Jensen T. S., Yaksh T. L. II. Examination of spinal monoamine receptors through which brainstem opiate‐sensitive systems act in the rat. Brain Res. 1986; 363: 114–127
   PubMed Web of Science ®Google Scholar
• Jessel T. M., Iversen L. L. Opiate analgesics inhibit substance P release from rat trigeminal nucleus. Nature 1977; 268: 549–551
   PubMed Web of Science ®Google Scholar
• LaMotte C. C., de Lanerolle N. C. Ultrastructure of chemically defined neuron systems in the dorsal horn of the monkey: II. Methionine‐enkephalin immunoreactivity. Brain Res. 1983a; 274: 51–63
   PubMed Web of Science ®Google Scholar
• LaMotte C. C., de Lanerolle N. C. Ultrastructure of chemically defined neuron systems in the dorsal horn of the monkey: III. Serotonin immunoreactivity. Brain Res. 1983b; 274: 65–77
   PubMed Web of Science ®Google Scholar
• Levy R. A. GABA: A direct depolarizing action at the mammalian primary afferent terminal. Brain Res. 1974; 76: 155–160
   PubMed Web of Science ®Google Scholar
• Levy R. A. The role of GABA in primary afferent depolarization. Prog. Neurobiol. 1977; 9: 211–267
   PubMed Web of Science ®Google Scholar
• Light A. R., Kavookjian A. M., Petrusz P. The ultrastructure and synaptic connections of serotonin‐immunoreactive terminals in spinal laminae I and II. Somatosens. Res. 1983; 1: 33–50
   PubMed Web of Science ®Google Scholar
• Ljungdahl A., Hokfelt T. Autoradiographic uptake patterns of 3H GABA and 3H glycine in central nervous tissues with special reference to the cat spinal cord. Brain Res. 1973; 62: 587–595
   PubMed Web of Science ®Google Scholar
• Lovick T. A. Enkephalin blocks primary afferent depolarization of Aδ tooth pulp afferents evoked by stimulation in nucleus raphe magnus in the decerebrate cat. Neurosci. Lett. 1983a; 37: 273–278
   PubMed Web of Science ®Google Scholar
• Lovick T. A. The role of 5‐HT, GABA and opioid peptides in presynaptic inhibition of tooth pulp from the medial brainstem. Brain Res. 1983b; 289: 135–142
   PubMed Web of Science ®Google Scholar
• McLaughlin B. J., Barber R., Saito K., Roberts E., Wu J. ‐Y. Immunocytochemical localization of glutamate decarboxylase in rat spinal cord. J. Comp. Neurol. 1975; 164: 305–322
   PubMed Web of Science ®Google Scholar
• Miyata Y., Otsuka M. Quantitative histochemistry of γ‐aminobutyric acid in cat spinal cord with special reference to presynaptic inhibition. J. Neurochem. 1975; 24: 239–244
   Google Scholar
• Moreau J. L., Fields H. L. Evidence for GABA involvement in midbrain control of medullary neurons that modulate nociceptive transmission. Brain Res.
   Web of Science ®Google Scholar
• Nicoll R. A., Alger B. E., Jahr R. A. Enkephalin blocks inhibitory pathways in the vertebrate CNS. Nature 1980; 287: 22–25
   PubMed Web of Science ®Google Scholar
• Oertel W. H., Schmechel D. E., Tappaz M. L., Kopin I. J. Production of a specific antiserum to rat brain glutamic acid decarboxylase by injection of an antigen‐antibody complex. Neuroscience 1981; 6: 2689–2700
   PubMed Web of Science ®Google Scholar
• Patrick J. T., McBride W. J., Felten D. L. Distribution of glycine, GABA, aspartate and glutamate in the rat spinal cord. Brain Res. 1983; 10: 415–418
   Web of Science ®Google Scholar
• Perez de la Mora M., Possani L. D., Tapia R., Teran L., Palacios R., Fuxe K., Hokfelt T., Ljungdahl A. Demonstration of central γ‐aminobutyrate‐continuing nerve terminals by means of antibodies against glutamate decarboxylase. Neuroscience 1981; 6: 875–895
   PubMed Web of Science ®Google Scholar
• Price G. W., Wilkin G. P., Turnbull M. J., Bowery N. G. Are baclofen sensitive GABAb receptors present on primary afferent terminals of the spinal cord?. Nature 1984; 307: 71–74
   PubMed Web of Science ®Google Scholar
• Proudfit H. K., Larson A. A., Anderson E. G. The role of GABA and serotonin in the mediation of raphe‐evoked spinal cord dorsal root potentials. Brain Res. 1980; 195: 149–165
   PubMed Web of Science ®Google Scholar
• Proudfit H. K., Levy R. A. Delimitation of neuronal substrate necessary for the analgesic action of baclofen and morphine. Eur. J. Pharmacol. 1978; 47: 159–166
   PubMed Web of Science ®Google Scholar
• Ralston H. J., III, Ralston D. D. The distribution of dorsal root axons in laminae I, II and III of the macaque spinal cord: A quantitative electron microscope study. J. Comp. Neurol. 1979; 184: 643–684
   PubMed Web of Science ®Google Scholar
• Randic M. Presynaptic effect of γ‐aminobutyric acid and substance P on intraspinal single cutaneous C‐ and A‐fibers. Spinal Cord Sensation, A. G. Brown, M. Rethelyi. Scottish Academic Press, Edinburgh 1981; 285–294
   Google Scholar
• Ribeiro‐da‐Silva A., Coimbra A. Neuronal uptake of 3H GABA and 3H glycine in laminae I‐III (substantia gelatinosa Rolandi) of the rat spinal cord: An autoradiographic study. Brain Res. 1980; 188: 449–464
   PubMed Web of Science ®Google Scholar
• Ruda M. A. Opiates and pain pathways: Demonstration of enkephalin synapses on dorsal horn projection neurons. Science 1982; 215: 1523–1524
   PubMed Web of Science ®Google Scholar
• Ruda A., Coffield J., Steinbusch H. W. M. Immunocytochemical analysis of serotonergic axons in laminae I and II of the lumbar spinal cord of the cat. J. Neurosci. 1982; 2: 1660–1671
   PubMed Web of Science ®Google Scholar
• Sastry B. R. γ‐Aminobutryric acid and primary afferent depolarization in feline spinal cord. Can. J. Physiol. Pharmacol. 1979; 57: 1157–1167
   PubMed Web of Science ®Google Scholar
• Sastry B. R., Goh J. W. Actions of morphine and met‐enkephalin‐amide on nociceptor driven neurones in substantia gelatinosa and deeper dorsal horn. Neuropharmacology 1983; 22: 119–122
   PubMed Web of Science ®Google Scholar
• Sawynok J., LaBella F. S. On the involvement of GABA in the analgesia produced by baclofen, muscimol and morphine. Neuropharmacology 1982; 21: 397–403
   PubMed Web of Science ®Google Scholar
• Schlicter R., Demeneix B. A., Desarmenien M., Desaulles E., Loeffler J. P., Feltz P. Properties of the GABA receptors located on spinal primary afferent neurons and hypophyseal neuroendocrine cells of the rat. Neurosci. Lett. 1984; 47: 257–263
   PubMed Web of Science ®Google Scholar
• Sternberger L. A. Immunocytochemistry2nd ed. Wiley, New York 1979
   Google Scholar
• Sumal K. K., Pickel V. M., Miller R. J., Reis D. J. Enkephalin‐containing neurons in substantia gelatinosa of spinal trigeminal complex: Ultrastructural and synaptic interaction with primary sensory afferents. Brain Res. 1982; 248: 223–236
   PubMed Web of Science ®Google Scholar
• Wilson P. R., Yaksh T. L. Baclofen is antinociceptive in the spinal intrathecal space of animals. Eur. J. Pharmacol. 1978; 51: 323–330
   PubMed Web of Science ®Google Scholar
• Yoshimura M., North R. A. Substantia gelatinosa neurons hyperpolarized in vitro by enkephalin. Nature 1983; 305: 529–530
   PubMed Web of Science ®Google Scholar
• Zorman G., Belcher G., Adams J. E., Fields H. L. Lumbar intrathecal naloxone blocks analgesia produced by microstimulation of the ventromedial medulla in the rat. Brain Res. 1982; 236: 77–84
   PubMed Web of Science ®Google Scholar