Medicinal plant cell suspension cultures: pharmaceutical applications and high-yielding strategies for the desired secondary metabolites

References

• Aburjai T, Bernasconi S, Manzocchi LA, Pelizzoni F. (1997). Effect of calcium and cell immobilization on the production of choleocalciferol and its derivatives by Solanum malacoxylon cell cultures. Phytochemistry, 46, 1015–18
   Web of Science ®Google Scholar
• Aly AH, Debbab A, Kjer J, Proksch P. (2010). Fungal endophytes from higher plants: a prolific source of phytochemicals and other bioactive natural products. Fungal Divers, 41, 1–16
   Web of Science ®Google Scholar
• Antognoni F, Iannello C, Mandrone M, et al. (2012). Elicited Teucrium chamaedrys cell cultures produce high amounts of teucrioside, but not the hepatotoxic neo-clerodane diterpenoids. Phytochemistry, 81, 50–9
   PubMed Web of Science ®Google Scholar
• Archambault J, Williams RD, Bédard C, Chavarie C. (1996). Production of sanguinarine by elicited plant cell culture I. Shake flask suspension cultures. J Biotechnol, 46, 95–105
   Google Scholar
• Aschehoug ET, Metlen KL, Callaway RM, Newcombe G (2012) Fungal endophytes directly increase the competitive effects of an invasive forb. Ecology, 93, 3–8
   PubMed Web of Science ®Google Scholar
• Baldi A, Dixit VK. (2008). Yield enhancement strategies for artemisinin production by suspension cultures of Artemisia annua. Bioresource Technol, 99, 4609–14
   PubMed Web of Science ®Google Scholar
• Bassetti L, Tramper J. (1995). Increased anthraquinone production by Morinda citrifolia in a two-phase system with Pluronic F-68. Enzyme Microb Tech, 17, 353–8
   Web of Science ®Google Scholar
• Belch I, Navarro S, Almagro L, et al. (2012). Early signaling events in grapevine cells elicited with cyclodextrins and methyl jasmonate. Plant Physiol Biochem, 62, 107–10
   PubMed Web of Science ®Google Scholar
• Bonfill M, Palaz ONJ, Cusid ORM, et al. (2003) Influence of elicitors on taxane production and 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in Taxus media cells. Plant Physiol Biochem, 41, 91–6
   Web of Science ®Google Scholar
• Bonfill M, Exposito O, Moyano E, et al. (2006). Manipulation by culture mixing and elicitation of paclitaxel and baccatin III production in Taxus baccata suspension cultures. In Vitro Cell Dev-Pl, 42, 422–6
   Web of Science ®Google Scholar
• Breuling M, Alfermann AW, Reinhard E. (1985). Cultivation of cell cultures of Berberis wilsonae in 20-L airlift bioreactors. Plant Cell Rep, 4, 220–3
   PubMed Web of Science ®Google Scholar
• Bulgakov VP, Kozyrenko MM, Fedoreyev SA, et al. (2001). Shikonin production by p-fluorophenylalanine resistant cells of Lithospermum erythrorhizon. Fitoterapia, 72, 394–401
   PubMed Web of Science ®Google Scholar
• Bunrathep S, Lockwood GB, Songsak T, Ruangrungsi N. (2006). Chemical constituents from leaves and cell cultures of Pogostemon cablin and use of precursor feeding to improve patchouli alcohol level. Sci Asia, 32, 293–6
   Google Scholar
• Cai Z, Kastell A, Knorr D, Smetanska I. (2012a). Exudation: an expanding technique for continuous production and release of secondary metabolites from plant cell suspension and hairy root cultures. Plant Cell Rep, 31, 461–77
   PubMed Web of Science ®Google Scholar
• Cai Z, Knorr D, Smetanska I. (2012b). Enhanced anthocyanins and resveratrol production in Vitis vinifera cell suspension culture by indanoyl-isoleucine, N-linolenoyl-l-glutamine and insect saliva. Enzyme Microb Tech, 50, 29–34
   PubMed Web of Science ®Google Scholar
• Chakraborty M, Karun A, Mitra A. (2009). Accumulation of phenylpropanoid derivatives in chitosan-induced cell suspension culture of Cocos nucifera. J Plant Physiol, 166, 63–71
   PubMed Web of Science ®Google Scholar
• Chandler SF, Dodds JH. (1983). The effect of phosphate, nitrogen and sucrose on the production of phenolics and solasodine in callus cultures of Solanum laciniatum. Plant Cell Rep, 2, 205–8
   PubMedGoogle Scholar
• Chattopadhyay S, Srivastava AK, Bhojwani SS, Bisaria VS. (2002). Production of podophyllotoxin by plant cell cultures of Podophyllum hexandrum in bioreactor. J Biosci Bioeng, 93, 215–20
   PubMed Web of Science ®Google Scholar
• Chen H, Chen F. (2000). Effects of yeast elicitor on the growth and secondary metabolism of a high-tanshinone-producing line of the Ti transformed Salvia miltiorrhiza cells in suspension culture. Process Biochem, 35, 837–40
   Web of Science ®Google Scholar
• Chen H, Yuan J, Chen F, et al. (1997). Tanshinone production in Ti-transformed Salvia miltiorrhiza cell suspension cultures. J Biotechnol, 58, 147–56
   PubMed Web of Science ®Google Scholar
• Chen S, Wang X, Zhao B, et al. (2003). Production of crocin using Crocus sativus callus by two-stage culture system. Biotechnol Lett, 25, 1235–8
   PubMed Web of Science ®Google Scholar
• Chen S, Zhao B, Wang X, et al. (2004). Promotion of the growth of Crocus sativus cells and the production of crocin by rare earth elements. Biotechnol Lett, 26, 27–30
   PubMed Web of Science ®Google Scholar
• Cheng X, Guo B, Zhou H, et al. (2005). Repeated elicitation enhances phenylethanoid glycosides accumulation in cell suspension cultures of Cistanche deserticola. Biochem Eng J, 24, 203–7
   Web of Science ®Google Scholar
• Cheng X, Zhou H, Cui X, et al. (2006). Improvement of phenylethanoid glycosides biosynthesis in Cistanche deserticola cell suspension cultures by chitosan elicitor. J Biotechnol, 121, 253–60
   PubMed Web of Science ®Google Scholar
• Chiang L, Abdullah MA. (2007). Enhanced anthraquinones production from adsorbent-treated Morinda elliptica cell suspension cultures in production medium strategy. Process Biochem, 42, 757–63
   Web of Science ®Google Scholar
• Choi H, Kim S, Son J, et al. (2000). Enhancement of paclitaxel production by temperature shift in suspension culture of Taxus chinensis. Enzyme Microb Tech, 27, 593–8
   PubMed Web of Science ®Google Scholar
• Choi H, Yun J, Kim S, et al. (2001). Enhanced production of paclitaxel by semi-continuous batch process (SCBP) in suspension culture of Taxus chinensis. Enzyme Microb Tech, 29, 583–6
   Web of Science ®Google Scholar
• Chong TM, Abdullah MA, Lai OM, et al. (2005). Effective elicitation factors in Morinda elliptica cell suspension culture. Process Biochem, 40, 3397–405
   Web of Science ®Google Scholar
• Collins-Pavao M, Chin C, Pedersen H. (1996). Taxol partitioning in two-phase plant cell cultures of Taxus brevifolia. J Biotechnol, 49, 95–100
   Web of Science ®Google Scholar
• Conceição LF, Ferreres F, Tavares RM, Dias AC. (2006). Induction of phenolic compounds in Hypericum perforatum L. cells by Colletotrichum gloeosporioides elicitation. Phytochemistry, 67, 149–55
   PubMed Web of Science ®Google Scholar
• Coste A, Vlase L, Halmagyi A, et al. (2011) Effects of plant growth regulators and elicitors on production of secondary metabolites in shoot cultures of Hypericum hirsutum and Hypericum maculatum. Plant CellTissue Organ Culture (PCTOC), 106, 279–88
   Web of Science ®Google Scholar
• Creche J, Trémouillaux-Guiller J, Ger DG, et al. (1993). Choisya ternata (Mexican Orange): in vitro culture and the production of alkaloids. In: Bajaj YPS, ed. Medicinal and aromatic plants V. Berlin, Heidelberg: Springer, 107–21
   Google Scholar
• Crespi-Perellino N, Guicciardi A, Malyszko G, et al. (1986). Occurrence of indole alkaloids in Ailanthus altissima cell cultures. J Nat Prod, 49, 1010–14
   Web of Science ®Google Scholar
• Curtin C, Zhang W, Franco C. (2003). Manipulating anthocyanin composition in Vitis vinifera suspension cultures by elicitation with jasmonic acid and light irradiation. Biotech Lett, 25, 1131–5
   PubMed Web of Science ®Google Scholar
• Danishefsky SJ, Bornmann WG, Queneau Y, et al. (1995) Total synthesis of taxol. US Patent 5416225
   Google Scholar
• De-Eknamkul W, Ellis BE. (2007). Rosmarinic acid production and growth characteristics of Anchusa officinalis cell suspension cultures. Planta Med, 50, 346–50
   Google Scholar
• Donnez D, Kim K, Antoine S, et al. (2011). Bioproduction of resveratrol and viniferins by an elicited grapevine cell culture in a 20 L stirred bioreactor. Process Biochem, 46, 1056–62
   Web of Science ®Google Scholar
• Dörnenburg H, Knorr D. (1995). Strategies for the improvement of secondary metabolite production in plant cell cultures. Enzyme Microb Tech, 17, 674–84
   Web of Science ®Google Scholar
• Ebel J, Cosio EG. (1994). Elicitors of plant defense responses. Int Rev Cytol, 148, 1–36
   Web of Science ®Google Scholar
• Edahiro J, Nakamura M, Seki M, Furusaki S. (2005). Enhanced accumulation of anthocyanin in cultured strawberry cells by repetitive feeding of L-phenylalanine into the medium. J Biosci Bioeng, 99, 43–7
   PubMed Web of Science ®Google Scholar
• Eibl R, Eibl D. (2002). Bioreactors for plant cell and tissue cultures. Plant biotechnology and transgenic plants. New York: Marcel Dekker, 163
   Google Scholar
• Eibl R, Eibl D. (2008). Design of bioreactors suitable for plant cell and tissue cultures. Phytochem Rev, 7, 593–8
   Google Scholar
• Endo T, Goodbody A, Vukovic J, Misawa M. (1987). Biotransformation of anhydrovinblastine to vinblastine by a cell-free extract of Catharanthus roseus cell suspension cultures. Phytochemistry, 26, 3233–4
   Web of Science ®Google Scholar
• Frick S, Kramell R, Kutchan TM. (2007). Metabolic engineering with a morphine biosynthetic P450 in opium poppy surpasses breeding. Metab Eng, 9, 169–76
   PubMed Web of Science ®Google Scholar
• Gamborg OLC, Miller RA, Ojima K. (1968). Nutrient requirements of suspension cultures of soybean root cells. Exp Cell Res, 50, 151–8
   PubMed Web of Science ®Google Scholar
• Georgiev MI, Weber J, Maciuk A. (2009). Bioprocessing of plant cell cultures for mass production of targeted compounds. Appl Microbiol Biotech, 83, 809–23
   PubMed Web of Science ®Google Scholar
• Giri A, Dhingra V, Giri CC, et al. (2001). Biotransformations using plant cells, organ cultures and enzyme systems: current trends and future prospects. Biotechnol Adv, 19, 175–99
   PubMed Web of Science ®Google Scholar
• Giri A, Narasu ML. (2000). Transgenic hairy roots: recent trends and applications. Biotechnol Adv, 18, 1–22
   PubMed Web of Science ®Google Scholar
• Goossens A, Häkkinen ST, Laakso I, et al. (2003). A functional genomics approach toward the understanding of secondary metabolism in plant cells. Proc Natl Acad Sci, 100, 8595–600
   PubMed Web of Science ®Google Scholar
• Han J, Zhong J. (2003). Effects of oxygen partial pressure on cell growth and ginsenoside and polysaccharide production in high density cell cultures of Panax notoginseng. Enzyme Microb Tech, 32, 498–503
   Web of Science ®Google Scholar
• Hansen JOR, Jørgensen JE,, Stougaard J, Marcker KA. (1989). Hairy roots – a short cut to transgenic root nodules. Plant Cell Rep, 8, 12–15
   PubMed Web of Science ®Google Scholar
• Hara Y, Yoshioka T, Morimoto T, et al. (1988). Enhancement of berberine production in suspension cultures of Coptis japonica by gibberellic acid treatment. J Plant Physiol, 133, 12–15
   Web of Science ®Google Scholar
• Hippolyte I, Marin B, Baccou JC, Jonard R. (1992). Growth and rosmarinic acid production in cell suspension cultures of Salvia officinalis L. Plant Cell Rep, 11, 109–12
   PubMed Web of Science ®Google Scholar
• Ho H, Liang K, Lin W, et al. (2010). Regulation and improvement of triterpene formation in plant cultured cells of Eriobotrya japonica Lindl. J Biosci Bioeng, 110, 588–92
   PubMed Web of Science ®Google Scholar
• Hockin NL, Mock T, Mulholland F, et al. (2012) The response of diatom central carbon metabolism to nitrogen starvation is different from that of green algae and higher plants. Plant Physiol, 158, 299–312
   PubMed Web of Science ®Google Scholar
• Holková I, Bezáková L, Bilka F, et al. (2010) Involvement of lipoxygenase in elicitor-stimulated sanguinarine accumulation in Papaver somniferum suspension cultures. Plant Physiol Biochem, 48, 887–92
   PubMed Web of Science ®Google Scholar
• Huang C, Qian Z, Zhong J. (2013). Enhancement of ginsenoside biosynthesis in cell cultures of Panax ginseng by N, N'-dicyclohexylcarbodiimide elicitation. J Biotechnol, 165, 30–6
   PubMed Web of Science ®Google Scholar
• Hughes EH, Shanks JV. (2002). Metabolic engineering of plants for alkaloid production. Metab Eng, 4, 41–8
   PubMed Web of Science ®Google Scholar
• Huang F, Kutchan TM. (2000). Distribution of morphinan and benzo-phenanthridine alkaloid gene transcript accumulation in Papaver somniferum. Phytochemistry, 53, 555–64
   PubMed Web of Science ®Google Scholar
• Huang T, McDonald KA. (2009). Bioreactor engineering for recombinant protein production in plant cell suspension cultures. Biochem Eng J, 45, 168–84
   Web of Science ®Google Scholar
• Ibrahim AK, Khalifa S, Khafagi I, et al. (2007). Stimulation of oleandrin production by combined Agrobacterium tumefaciens mediated transformation and fungal elicitation in Nerium oleander cell cultures. Enzyme Microb Tech, 41, 331–6
   Web of Science ®Google Scholar
• Ishihara K, Hamada H, Hirata T, Nakajima N. (2003). Biotransformation using plant cultured cells. J Mol Catal B Enzym, 23, 145–70
   Web of Science ®Google Scholar
• Ishimaru K, Arakawa H, Neera S. (1993). Polyphenol production in cell cultures of Cornus kousa. Phytochemistry, 32, 1193–7
   Web of Science ®Google Scholar
• Jang YP, Lee YJ, Kim YC, Huh H. (1998). Production of a hepatoprotective cerebroside from suspension cultures of Lycium chinense. Plant Cell Rep, 18, 252–4
   Web of Science ®Google Scholar
• Jeong C, Murthy HN, Hahn E, Paek K. (2008). Improved production of ginsenosides in suspension cultures of ginseng by medium replenishment strategy. J Biosci Bioeng, 105, 288–91
   PubMed Web of Science ®Google Scholar
• Jha S, Sahu NP, Sen J, et al. (1991). Production of emetine and cephaeline from cell suspension and excised root cultures of Cephaelis ipecacuanha. Phytochemistry, 30, 3999–4003
   Web of Science ®Google Scholar
• John Tam WH, Constabel F, Kurz WGW. (1980). Codeine from cell suspension cultures of Papaver somniferum. Phytochemistry, 19, 486–7
   Web of Science ®Google Scholar
• Kajani AA, Mofid MR, Abolfazli K, Tafreshi SAH. (2010). Encapsulated activated charcoal as a potent agent for improving taxane synthesis and recovery from cultures. Biotechnol Appl Biochem, 56, 71–6
   PubMed Web of Science ®Google Scholar
• Kang S, Min J, Kim Y, et al. (2009). Effect of biotic elicitors on the accumulation of bilobalide and ginkgolides in Ginkgo biloba cell cultures. J Biotechnol, 139, 84–8
   PubMed Web of Science ®Google Scholar
• Kieran PM, MacLoughlin PF, Malone DM. (1997). Plant cell suspension cultures: some engineering considerations. J Biotechnol, 59, 39–52
   PubMed Web of Science ®Google Scholar
• Kitamura Y, Ikenaga T, Ooe Y, et al. (1998) Induction of furanocoumarin biosynthesis in Glehnia littoralis cell suspension cultures by elicitor treatment. Phytochemistry, 48, 113–7
   PubMed Web of Science ®Google Scholar
• Kleckner N, Roth J, Botstein D. (1977). Genetic engineering in Vivo using translocatable drug-resistance elements: new methods in bacterial genetics. J Mol Biol, 116, 125–59
   PubMed Web of Science ®Google Scholar
• Kolewe ME, Gaurav V, Roberts SC. (2008). Pharmaceutically active natural product synthesis and supply via plant cell culture technology. Mol Pharm, 5, 243–56
   PubMedGoogle Scholar
• Komaraiah P, Kishor PBK, Carlsson M, et al. (2005). Enhancement of anthraquinone accumulation in Morinda citrifolia suspension cultures. Plant Sci, 168, 1337–44
   Web of Science ®Google Scholar
• Komaraiah P, Ramakrishna SV, Reddanna P, Kavi Kishor PB. (2003). Enhanced production of plumbagin in immobilized cells of Plumbago rosea by elicitation and in situ adsorption. J Biotechnol, 101, 181–7
   PubMed Web of Science ®Google Scholar
• Komatsuda T, Lee W, Oka S. (1992). Maturation and germination of somatic embryos as affected by sucrose and plant growth regulators in soybeans Glycine gracilis Skvortz and Glycine max (L.) Merr. Plant Cell Tissue Organ Culture, 28, 103–13
   Web of Science ®Google Scholar
• Kouamo K, Creche J, Chénieux J, et al. (1985). Alkaloid production by Ochrosia ellipticacell suspension cultures. J Plant Physiol, 118, 277–83
   PubMed Web of Science ®Google Scholar
• Kreis W, Reinhard E. (1992). 12β-Hydroxylation of digitoxin by suspension-cultured Digitalis lanata cells: production of digoxin in 20-litre and 300-litre air-lift bioreactors. J Biotechnol, 26, 257–73
   PubMed Web of Science ®Google Scholar
• Lessard PA, Kulaveerasingam H, York GM, et al. (2002) Manipulating gene expression for the metabolic engineering of plants. Metab Eng, 4, 67–79
   PubMed Web of Science ®Google Scholar
• Li Y, Tao W. (2009). Paclitaxel-producing fungal endophyte stimulates the accumulation of taxoids in suspension cultures of Taxus cuspidate. Sci Hortic-Amsterdam, 121, 97–102
   Web of Science ®Google Scholar
• Liu J, Guo Z, Zeng Z. (2007). Improved accumulation of phenylethanoid glycosides by precursor feeding to suspension culture of Cistanche salsa. Biochem Eng J, 33, 88–93
   Web of Science ®Google Scholar
• Luo J, He G. (2004). Optimization of elicitors and precursors for paclitaxel production in cell suspension culture of Taxus chinensis in the presence of nutrient feeding. Process Biochem, 39, 1073–9
   Web of Science ®Google Scholar
• Malik S, Cusidó RM, Mirjalili MH, et al. (2011) Production of the anticancer drug taxol in Taxus baccata suspension cultures: a review. Process Biochem, 46, 23–34
   Web of Science ®Google Scholar
• Mandujano-Chávez A, Schoenbeck MA, Ralston LF, et al. (2000). Differential induction of sesquiterpene metabolism in tobacco cell suspension cultures by methyl jasmonate and fungal elicitor. Arch Biochem Biophys, 381, 285–94
   PubMed Web of Science ®Google Scholar
• Memelink J, Verpoorte R, Kijne JW. (2001). ORCAnization of jasmonate-responsive gene expression in alkaloid metabolism. Trends Plant Sci, 6, 212–19
   PubMed Web of Science ®Google Scholar
• Mizukami H, Ogawa T, Ohashi H, Ellis BE. (1992). Induction of rosmarinic acid biosynthesis in Lithospermum erythrorhizon cell suspension cultures by yeast extract – Springer. Plant Cell Rep, 11, 480–3
   PubMed Web of Science ®Google Scholar
• Moscatiello R, Baldan B, Navazio L. (2013). Plant cell suspension cultures – Springer. In: Yehuda S, Mostofsky DI, eds. Plant mineral nutrients. Totowa, NJ: Humana Press, 77–93
   Google Scholar
• Moyano E, Palazón J, Bonfill M, et al. (2007). Biotransformation of hyoscyamine into scopolamine in transgenic tobacco cell cultures. J Plant Physiol, 164, 521–4
   PubMed Web of Science ®Google Scholar
• Muir SR, Collins GJ, Robinson S, et al. (2001) Overexpression of petunia chalcone isomerase in tomato results in fruit containing increased levels of flavonols. Nat Biotechnol, 19, 470–4
   PubMed Web of Science ®Google Scholar
• Mukherjee S, Ghosh B, Jha S. (2000). Establishment of forskolin yielding transformed cell suspension cultures of Coleus forskohlii as controlled by different factors. J Biotechnol, 76, 73–81
   PubMed Web of Science ®Google Scholar
• Mustafa NR, Kim HK, Choi YH, et al. (2009). Biosynthesis of salicylic acid in fungus elicited Catharanthus roseus cells. Phytochemistry, 70, 532–9
   PubMed Web of Science ®Google Scholar
• Nagella P, Murthy HN. (2010). Establishment of cell suspension cultures of Withania somnifera for the production of withanolide A. Bioresource Technol, 101, 6735–9
   PubMed Web of Science ®Google Scholar
• Nakagawa K, Konagai A, Fukui H, Tabata M. (1984). Release and crystallization of berberine in the liquid medium of Thalictrum minus cell suspension cultures. Plant Cell Rep, 3, 254–7
   PubMed Web of Science ®Google Scholar
• Nazif NM, Rady MR, Seif El-Nasr MM. (2000). Stimulation of anthraquinone production in suspension cultures of Cassia acutifolia by salt stress. Fitoterapia, 71, 34–40
   PubMed Web of Science ®Google Scholar
• Nims E, Dubois CP, Roberts SC, Walker EL. (2006). Expression profiling of genes involved in paclitaxel biosynthesis for targeted metabolic engineering. Metab Eng, 8, 385–94
   PubMed Web of Science ®Google Scholar
• Onrubia M, Moyano E, Bonfill M, et al. (2012). Coronatine, a more powerful elicitor for inducing taxane biosynthesis in Taxus media cell cultures than methyl jasmonate. J Plant Physiol, 170, 211–19
   PubMed Web of Science ®Google Scholar
• Orbán N, Boldizsár I, Szűcs Z, Dános B. (2008). Influence of different elicitors on the synthesis of anthraquinone derivatives in Rubia tinctorum L. cell suspension cultures. Dyes Pigments, 77, 249–57
   Web of Science ®Google Scholar
• Orihara Y, Ebizuka Y. (2010). Chapter 38 – Production of triterpene acids by cell-suspension cultures of Olea europaea. Chem Pharm Bull (Tokyo), 55, 341–7
   Google Scholar
• Orihara Y, Furuya T. (1990). Production of theanine and other γ-glutamyl derivatives by Camellia sinensis cultured cells – Springer. Plant Cell Rep, 9, 65–8
   PubMed Web of Science ®Google Scholar
• Ouyang J, Wang X, Zhao B, Wang Y. (2005). Enhanced production of phenylethanoid glycosides by precursor feeding to cell culture of Cistanche deserticola. Process Biochem 40, 3480–4
   Web of Science ®Google Scholar
• de Pádua RM, Meitinger N, Waibel R, et al. (2012). Biotransformation of 21-O-acetyl-deoxycorticosterone by cell suspension cultures of Digitalis lanata (strain W. 1.4). Steroids, 77, 1373–80
   PubMed Web of Science ®Google Scholar
• Palacio L, Cantero JJ, Cusidó RM, Goleniowski ME. (2012) Phenolic compound production in relation to differentiation in cell and tissue cultures of Larrea divaricata (Cav.). Plant Sci, 193–19, 1–7
   Web of Science ®Google Scholar
• Pan Z, Wang H, Zhong J. (2000). Scale-up study on suspension cultures of Taxus chinensis cells for production of taxane diterpene. Enzyme Microb Tech, 27, 714–23
   PubMed Web of Science ®Google Scholar
• Park JM, Yoon SY, Giles KL, et al. (1992). Production of sanguinarine by suspension culture of Papayer somniferum in bioreactors. J Fermen Bioeng, 74, 292–6
   Google Scholar
• Pasqua G, Silvestrini A, Monacelli B, et al. (2006). Triterpenoids and ellagic acid derivatives from in vitro cultures of Camptotheca acuminata Decaisne. Plant Physiol Biochem, 44, 220–5
   PubMed Web of Science ®Google Scholar
• Pawar KD, Thengane SR. (2009). Influence of hormones and medium components on expression of dipyranocoumarins in cell suspension cultures of Calophyllum inophyllum L. Process Biochem, 44, 916–22
   Web of Science ®Google Scholar
• Perassolo M, Quevedo C, Busto V, et al. (2007). Enhance of anthraquinone production by effect of proline and aminoindan-2-phosphonic acid in Rubia tinctorum suspension cultures. Enzyme Microb Tech, 41, 181–5
   Web of Science ®Google Scholar
• Perassolo M, Quevedo CV, Busto VD, et al. (2011) Role of reactive oxygen species and proline cycle in anthraquinone accumulation in Rubia tinctorum cell suspension cultures subjected to methyl jasmonate elicitation. Plant Physiol Biochem, 49, 758–63
   PubMed Web of Science ®Google Scholar
• Porras-Alfaro A, Bayman P. (2011). Hidden fungi, emergent properties: endophytes and microbiomes. Phytopathology, 49, 291--315
   Web of Science ®Google Scholar
• Prakash G, Srivastava AK. (2007). Azadirachtin production in stirred tank reactors by Azadirachta indica suspension culture. Process Biochem, 42, 93–7
   Web of Science ®Google Scholar
• Pras N, Woerdenbag HJ, Batterman S, et al. (1993) Mucuna pruriens: improvement of the biotechnological production of the anti-Parkinson drug L-dopa by plant cell selection. Pharm World Sci, 15, 263–8
   PubMedGoogle Scholar
• Praveen N, Murthy HN, Chung IM. (2011). Improvement of growth and gymnemic acid production by altering the macro elements concentration and nitrogen source supply in cell suspension cultures of Gymnema sylvestre R. Br Ind Crop Prod, 33, 282–6
   Web of Science ®Google Scholar
• Qu J, Zhang W, Yu X. (2011). A combination of elicitation and precursor feeding leads to increased anthocyanin synthesis in cell suspension cultures of Vitis vinifera. Plant Cell Tissue Organ Culture (PCTOC), 107, 261–9
   Web of Science ®Google Scholar
• Rueffer M. (1985). The production of isoquinoline alkaloids by plant cell cultures. In: Phillipson JD, Roberts MF, Zenk ΜH, eds. The chemistry and biology of isoquinoline alkaloids. Berlin: Springer, 265–80
   Google Scholar
• Ramachandra Rao S, Ravishankar GA. (2002). Plant cell cultures: chemical factories of secondary metabolites. Biotechnol Adv, 20, 101–53
   PubMed Web of Science ®Google Scholar
• Ramani S, Chelliah J. (2007). UV-B-induced signaling events leading to enhanced-production of catharanthine in Catharanthus roseus cell suspension cultures. BMC Plant Biol, 7, 61
   PubMedGoogle Scholar
• Raval KN, Hellwig S, Prakash G, et al. (2003). Necessity of a two-stage process for the production of azadirachtin-related limonoids in suspension cultures of Azadirachta indica. J Biosci Bioeng, 96, 16–22
   PubMed Web of Science ®Google Scholar
• Roberts MF. (1994). Brucea spp.: in vitro culture and the production of canthinone alkaloids and other secondary metabolites. In: Bajaj YPS, ed. Medicinal and aromatic plants VI. Berlin: Springer, 21–45
   Google Scholar
• Roberts SC. (2007). Production and engineering of terpenoids in plant cell culture. Nat Chem Biol, 3, 387–95
   PubMed Web of Science ®Google Scholar
• Rodríguez-Monroy M, Galindo E. (1999). Broth rheology, growth and metabolite production of Beta vulgaris suspension culture: a comparative study between cultures grown in shake flasks and in a stirred tank. Enzyme Microb Tech, 24, 687–93
   Web of Science ®Google Scholar
• Runguphan W, O'Connor SE. (2009). Metabolic reprogramming of periwinkle plant culture. Nat Chem Biol, 5, 151–3
   PubMed Web of Science ®Google Scholar
• Saad I, Díaz E, Chávez I, et al. (2000) Antifungal monoterpene production in elicited cell suspension cultures of Piqueria trinervia. Phytochemistry, 55, 51–7
   PubMed Web of Science ®Google Scholar
• Sakurai M, Mori T. (1996). Stimulation of anthocyanin synthesis by conditioned medium produced by strawberry suspension cultures. J Plant Physiol, 149, 599–604
   Web of Science ®Google Scholar
• Sánchez-Sampedro MA, Fernández-Tárrago J, Corchete P. (2005). Yeast extract and methyl jasmonate-induced silymarin production in cell cultures of Silybum marianum (L.) Gaertn. J Biotechnol, 119, 60–9
   PubMed Web of Science ®Google Scholar
• Sato F, Hashimoto T, Hachiya A, et al. (2001). Metabolic engineering of plant alkaloid biosynthesis. Proc Natl Acad Sci USA, 98, 367–72
   Google Scholar
• Schenk RU, Hildebrandt AC. (1972). Medium and techniques for induction and growth of monocotyledonous and dicotyledonous plant cell cultures. Can J Bot, 50, 199–204
   Google Scholar
• Schripsema J, Ramos-Valdivia A, Verpoorte R. (1999). Robustaquinones, novel anthraquinones from an elicited Cinchona robusta suspension culture. Phytochemistry, 51, 55–60
   Web of Science ®Google Scholar
• Scragg AH, Allan EJ (1986) Production of the triterpenoid quassin in callus and cell suspension cultures of Picrasma quassioides Bennett. Plant Cell Rep, 5, 356–9
   PubMed Web of Science ®Google Scholar
• Sharma S, Shahzad A. (2013). Elicitation: an alternative approach towards commercialization of secondary metabolite production. In: Shahid M, Shahzad A, Malik A, Saha A, eds. Recent trends in biotechnology and therapeutic applications of medicinal plants. Berlin: Springer, 79–91
   Google Scholar
• Shimoda K, Kondo Y, Nishida T, et al. (2006) Biotransformation of thymol, carvacrol, and eugenol by cultured cells of Eucalyptus perriniana. Phytochemistry, 67, 2256–61
   PubMed Web of Science ®Google Scholar
• Shimoda K, Kwon S, Utsuki A, et al. (2007). Glycosylation of capsaicin and 8-nordihydrocapsaicin by cultured cells of Catharanthus roseus. Phytochemistry, 68, 1391–6
   PubMed Web of Science ®Google Scholar
• Shinde AN, Malpathak N, Fulzele DP. (2009). Studied enhancement strategies for phytoestrogens production in shake flasks by suspension culture of Psoralea corylifolia. Bioresource Technol, 100, 1833–9
   PubMed Web of Science ®Google Scholar
• Shohael AM, Murthy HN, Hahn EJ, et al. (2008). Increased eleutheroside production in Eleutherococcus sessiliflorus embryogenic suspension cultures with methyl jasmonate treatment. Biochem Eng J, 38, 270–3
   Web of Science ®Google Scholar
• Smart NJ, Fowler MW. (1984). An airlift column bioreactor suitable for large-scale cultivation of plant cell suspensions. J Exp Bot, 35, 531–7
   Web of Science ®Google Scholar
• Smetanska I. (2008). Production of secondary metabolites using plant cell cultures. In: Food BiotechSpringer. Adv Biochem Engin/Biotechnol, 111, 187–228
   Google Scholar
• Smith SL, Slywka GW, Krueger RJ. (1981). Anthocyanins of Strobilanthes dyeriana and their production in callus culture. J Nat Prod, 44, 609–10
   Web of Science ®Google Scholar
• Stachel SE, Nester EW, Zambryski PC. (1986). A plant cell factor induces Agrobacterium tumefaciens vir gene expression. Proc Natl Acad Sci USA, 83, 379–83
   PubMed Web of Science ®Google Scholar
• Stafford AM. (2002). Plant cell cultures as a source of bioactive small molecules. Curr Opin Drug Disc, 5, 296--303
   PubMedGoogle Scholar
• Staniszewska I, Królicka A, Maliński E, et al. (2003). Elicitation of secondary metabolites in in vitro cultures of Ammi majus L. Enzyme Microb Tech, 33, 565–8
   Web of Science ®Google Scholar
• Stevenson DD, Szczeklik A. (2006). Clinical and pathologic perspectives on aspirin sensitivity and asthma. J Allergy Clin Immun, 118, 773–86
   PubMed Web of Science ®Google Scholar
• Sudha G, Ravishankar GA. (2003). Putrescine facilitated enhancement of capsaicin production in cell suspension cultures of Capsicum frutescens. J Plant Physiol, 160, 339–46
   PubMed Web of Science ®Google Scholar
• Sumaryono W, Proksch P, Hartmann T, et al. (1991) Induction of rosmarinic acid accumulation in cell suspension cultures of Orthosiphon aristatus after treatment with yeast extract. Phytochemistry, 30, 3267–71
   Web of Science ®Google Scholar
• Szabo E, Thelen A, Petersen M. (1999). Fungal elicitor preparations and methyl jasmonate enhance rosmarinic acid accumulation in suspension cultures of Coleus blumei. Plant Cell Rep, 18, 485–9
   Web of Science ®Google Scholar
• Taha HS, Abd El-Kawy AM, Fathalla MAE. (2012). A new approach for achievement of inulin accumulation in suspension cultures of Jerusalem artichoke (Helianthus tuberosus) using biotic elicitors. J Genet Eng Biotechnol, 10, 33–8
   Google Scholar
• Tal B, Rokem JS, Gressel J, Goldberg I. (1984). The effect of chlorophyll-bleaching herbicides on growth, carotenoid and diosgenin levels in cell suspension cultures of Dioscorea deltoidea. Phytochemistry, 23, 1333–5
   Web of Science ®Google Scholar
• Tassoni A, Durante L, Ferri M. (2012). Combined elicitation of methyl-jasmonate and red light on stilbene and anthocyanin biosynthesis. J Plant Physiol, 169, 775–81
   PubMed Web of Science ®Google Scholar
• Ten Hoopen HJG, Vinke JL, Moreno PRH, et al. (2002). Influence of temperature on growth and ajmalicine production by Catharantus roseus suspension cultures. Enzyme Microb Tech, 30, 56–65
   Web of Science ®Google Scholar
• Toubiana D, Fernie AR, Nikoloski Z, Fait A. (2012). Network analysis: tackling complex data to study plant metabolism. Trends Biotechnol, 31, 29–36
   PubMed Web of Science ®Google Scholar
• Trung Thanh N, Niranjana Murthy H, Yu K, et al. (2006) Effect of oxygen supply on cell growth and saponin production in bioreactor cultures of Panax ginseng. J Plant Physiol, 163, 1337–41
   PubMed Web of Science ®Google Scholar
• Tsutomu N, Hitoshi M, Masao N, et al. (1983). Production of cryptotanshinone and ferruginol in cultured cells of Salvia miltiorrhiza. Phytochemistry, 22, 721–2
   Web of Science ®Google Scholar
• Upadhyay G, Singh AK, Kumar A, et al. (2008). Resveratrol modulates pyrogallol-induced changes in hepatic toxicity markers, xenobiotic metabolizing enzymes and oxidative stress. Eur J Pharmacol, 596, 146–52
   PubMed Web of Science ®Google Scholar
• Van der Fits L, Memelink J. (2000). ORCA3, a jasmonate-responsive transcriptional regulator of plant primary and secondary metabolism. Science, 289, 295–7
   PubMed Web of Science ®Google Scholar
• Van Der Fits L, Memelink J. (2001). The jasmonate-inducible AP2/ERF-domain transcription factor ORCA3 activates gene expression via interaction with a jasmonate-responsive promoter element. Plant J, 25, 43–53
   PubMed Web of Science ®Google Scholar
• Walker TS, Pal Bais H, Vivanco JM. (2002). Jasmonic acid-induced hypericin production in cell suspension cultures of Hypericum perforatum L. (St. John's wort). Phytochemistry, 60, 289–93
   PubMed Web of Science ®Google Scholar
• Wang J, Liao X, Zhang H, et al. (2003). Accumulation of chlorogenic acid in cell suspension cultures of Eucommia ulmoides. Plant Cell Tissue Organ Culture, 74, 193–5
   Web of Science ®Google Scholar
• Wang JW, Wu JY. (2004). Involvement of nitric oxide in elicitor-induced defense responses and secondary metabolism of Taxus chinensis cells. Nitric Oxide, 11, 298–306
   PubMed Web of Science ®Google Scholar
• Wang JW, Wu JY. (2013). Effective elicitors and process strategies for enhancement of secondary metabolite production in hairy root cultures. Adv Biochem Eng Biotechnol, 134, 55–89
   PubMed Web of Science ®Google Scholar
• Wang JW, Xia ZH, Chu JH, Tan RX. (2004). Simultaneous production of anthocyanin and triterpenoids in suspension cultures of Perilla frutescens. Enzyme Microb Tech, 34, 651–6
   Web of Science ®Google Scholar
• Wiktorowska E, D L Ugosz M, Janiszowska W (2010) Significant enhancement of oleanolic acid accumulation by biotic elicitors in cell suspension cultures of Calendula officinalis L. Enzyme Microb Tech, 46, 14–20
   Web of Science ®Google Scholar
• Wong PL, Royce AJ, Lee-Parsons CW. (2004). Improved ajmalicine production and recovery from Catharanthus roseus suspensions with increased product removal rates. Biochem Eng J, 21, 253–8
   Web of Science ®Google Scholar
• Woragidbumrung K, Sae-Tang P, Yao H, et al. (2001) Impact of conditioned medium on cell cultures of Panax notoginseng in an airlift bioreactor. Process Biochem, 37, 209–13
   Web of Science ®Google Scholar
• Wu J, Zhong J. (1999). Production of ginseng and its bioactive components in plant cell culture: current technological and applied aspects. J Biotechnol, 68, 89–99
   PubMed Web of Science ®Google Scholar
• Xu M, Dong J. (2005a). Nitric oxide stimulates indole alkaloid production in Catharanthus roseus cell suspension cultures through a protein kinase-dependent signal pathway. Enzyme Microb Tech, 37, 49–53
   Web of Science ®Google Scholar
• Xu M, Dong J. (2005b). Elicitor-induced nitric oxide burst is essential for triggering catharanthine synthesis in Catharanthus roseus suspension cells. Appl Microb Biotech, 67, 40–4
   PubMed Web of Science ®Google Scholar
• Xu J, Ge X, Dolan MC. (2011a). Towards high-yield production of pharmaceutical proteins with plant cell suspension cultures. Biotechnol Adv, 29, 278–99
   PubMed Web of Science ®Google Scholar
• Xu X, Zhang W, Cao X, Xue S. (2011b). Abietane diterpenoids synthesized by suspension-cultured cells of Cephalotaxus fortunei. Phytochem Lett, 4, 52–5
   Web of Science ®Google Scholar
• Yahia A, Kevers C, Gaspar T, et al. (1998). Cytokinins and ethylene stimulate indole alkaloid accumulation in cell suspension cultures of Catharanthus roseus by two distinct mechanisms. Plant Sci, 133, 9–15
   Web of Science ®Google Scholar
• Yamada J, Fujita K, Sakai K. (2002). Feedback regulation of β-thujaplicin production and formation of its methyl ether in a suspension culture of Cupressus lusitanica. Phytochemistry, 60, 447–50
   PubMed Web of Science ®Google Scholar
• Yamamoto H, Yazaki K, Inoue K. (2000). Simultaneous analysis of shikimate-derived secondary metabolites in Lithospermum erythrorhizon cell suspension cultures by high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl, 738, 3–15
   PubMed Web of Science ®Google Scholar
• Yamamoto O, Yamada Y. (1986). Production of reserpine and its optimization in cultured Rauwolfia serpentina Benth cells. Plant Cell Rep, 5, 50–3
   PubMed Web of Science ®Google Scholar
• Yazaki K. (2005). Transporters of secondary metabolites. Curr Opin Plant Biol, 8, 301–7
   PubMed Web of Science ®Google Scholar
• Ye M, Ning L, Zhan J, et al. (2003) Biotransformation of cinobufagin by cell suspension cultures of Catharanthus roseus and Platycodon grandiflorum. J Mol Catal B Enzym, 22, 89–95
   Web of Science ®Google Scholar
• Yoshida K, Hayashi T, Sano K. (1988). Colchicine precursors and the formation of alkaloids in suspension-cultured Colchicum autumnale. Phytochemistry, 27, 1375–8
   Web of Science ®Google Scholar
• Yu O, McGonigle B. (2005). Metabolic engineering of isoflavone biosynthesis. Adv Agron, 86, 147–90
   Web of Science ®Google Scholar
• Yuan X, Zhao B, Wang Y. (2004). Cell culture of Saussurea medusa in a periodically submerged air-lift bioreactor. Biochem Eng J, 21, 235–9
   Web of Science ®Google Scholar
• Yue X, Zhang W, Deng M. (2011). Hyper-production of 13C-labeled trans-resveratrol in Vitis vinifera suspension cell culture by elicitation and in situ adsorption. Biochem Eng J, 53, 292–6
   Web of Science ®Google Scholar
• Zare K, Nazemiyeh H, Movafeghi A, et al. (2010). Bioprocess engineering of Echium italicum L.: induction of shikonin and alkannin derivatives by two-liquid-phase suspension cultures. Plant Cell Tissue Organ Culture (PCTOC), 100, 157–64
   Web of Science ®Google Scholar
• Zhang W, Seki M, Furusaki S. (1997). Effect of temperature and its shift on growth and anthocyanin production in suspension cultures of strawberry cells. Plant Sci, 127, 207–14
   Web of Science ®Google Scholar
• Zhang X, Ye M, Dong Y, et al. (2011). Biotransformation of bufadienolides by cell suspension cultures of Saussurea involucrata. Phytochemistry, 72, 1779–85
   PubMed Web of Science ®Google Scholar
• Zhang Y, Zhong J. (1997). Hyperproduction of ginseng saponin and polysaccharide by high density cultivation of Panax notoginseng cells. Enzyme Microb Tech, 21, 59–63
   Web of Science ®Google Scholar
• Zhang Y, Zhong J, Yu J. (1996). Enhancement of ginseng saponin production in suspension cultures of Panax notoginseng: manipulation of medium sucrose. J Biotechnol, 51, 49–56
   Web of Science ®Google Scholar
• Zhao D, Fu C, Han Y, Lu D. (2005a). Effects of elicitation on jaceosidin and hispidulin production in cell suspension cultures of Saussurea medusa. Process Biochem, 40, 739–45
   Web of Science ®Google Scholar
• Zhao J, Davis LC, Verpoorte R, et al. (2005b). Elicitor signal transduction leading to production of plant secondary metabolites. Biotechnol Adv, 23, 283
   PubMed Web of Science ®Google Scholar
• Zhao J, Zhu W, Hu Q. (2001). Selection of fungal elicitors to increase indole alkaloid accumulation in Catharanthus roseus suspension cell culture. Enzyme Microb Tech, 28, 666–72
   PubMed Web of Science ®Google Scholar
• Zhao P, Hamada C, Inoue K, Yamamoto H. (2003). Efficient production and capture of 8-prenylnaringenin and leachianone Gbiosynthetic intermediates of sophoraflavanone G – by the addition of cork tissue to cell suspension cultures of Sophora flavescens. Phytochemistry, 62, 1093–9
   PubMed Web of Science ®Google Scholar
• Zhao P, Iwamoto Y, Kouno I, et al. (2004). Stimulating the production of homoisoflavonoids in cell suspension cultures of Caesalpinia pulcherrima using cork tissue. Phytochemistry, 65, 2455–61
   PubMed Web of Science ®Google Scholar
• Zheng Z, Wu M. (2004). Cadmium treatment enhances the production of alkaloid secondary metabolites in Catharanthus roseus. Plant Sci, 166, 507–14
   Web of Science ®Google Scholar
• Zhi C, Rorrer GL. (1996). Photolithotrophic cultivation of Laminaria saccharina gametophyte cells in a bubble-column bioreactor. Enzyme Microb Tech, 18, 291–9
   Web of Science ®Google Scholar
• Zhong JJ, Bai Y, Wang SJ. (1996). Effects of plant growth regulators on cell growth and ginsenoside saponin production by suspension cultures of Panax quinquefolium. J Biotechnol, 45, 227–34
   Web of Science ®Google Scholar