882
Views
13
CrossRef citations to date
0
Altmetric
Review Article

Antibody mimetics: promising complementary agents to animal-sourced antibodies

, , &
Pages 268-275 | Received 14 Jan 2014, Accepted 14 Jul 2014, Published online: 29 Sep 2014

References

  • Ahlgren S, Wållberg H, Tran TA, et al. (2009). Targeting of HER2-expressing tumors with a site-specifically 99mTc-labeled recombinant affibody molecule, ZHER2: 2395, with C-terminally engineered cysteine. J Nuclear Med, 50, 781–9
  • Arnoux B, Ducruix A, Prange T. (2002). Anisotropic behaviour of the C-terminal Kunitz-type domain of the 3 chain of human type VI collagen at atomic resolution (0.9 A). Acta Crystallographica D: Biol Crystallograph, 58, 1252–4
  • Balsitis S, Dick F, Dyson N, Lambert PF. (2006). Critical roles for non-pRb targets of human papillomavirus type 16 E7 in cervical carcinogenesis. Cancer Res, 66, 9393–400
  • Beuttler J, Rothdiener M, Müller D, et al. (2009). Targeting of epidermal growth factor receptor (EGFR)-expressing tumor cells with sterically stabilized affibody liposomes (SAL). Bioconjugate Chem, 20, 1201–8
  • Cai S, Singh BR. (2007). Strategies to design inhibitors of clostridium botulinum neurotoxins. Infect Disord Drug Target, 7, 47–57
  • Chames P, Van Regenmortel M, Weiss E, Baty D. (2009). Therapeutic antibodies: successes, limitations and hopes for the future. Br J Pharmacol, 157, 220–33
  • Covagen, Advanced Biopharmaceuticals. Covagen utilizes the unique versatility of Fynomers to create next generation biologic. Available from: http://www.covagen.com/index.php?id=118 [last accessed 21 Jun 2013].
  • Ebersbach H, Fiedler E, Scheuermann T, et al. (2007). Affilin–novel binding molecules based on human γ-b-crystallin, an all β-sheet protein. J Mol Biol, 372, 172–85
  • Eggenstein E, Eichinger A, Kim H-J, Skerra A. (2013). Structure-guided engineering of Anticalins with improved binding behavior and biochemical characteristics for application in radio-immuno imaging and/or therapy. J Struct Biol, 185, 203–14
  • Eyer F, Steimer W, Nitzsche T, et al. (2012). Intravenous application of an anticalin dramatically lowers plasma digoxin levels and reduces its toxic effects in rats. Toxicol Appl Pharmacol, 263, 352–9
  • Gao J, Li B, Li H, et al. (2009). Development and characterization of a fully functional small anti-HER2 antibody. BMB Rep, 42, 636–41
  • Gebauer M, Schiefner A, Matschiner G, Skerra A. (2012). Combinatorial design of an Anticalin directed against the extra-domain B for the specific targeting of oncofetal fibronectin. J Mol Biol, 425, 780–802
  • Göstring L, Malm M, Höidén-Guthenberg I, et al. (2012). Cellular effects of HER3-specific affibody molecules. PLoS One, 7, e40023
  • Grabulovski D, Kaspar M, Neri D. (2007). A novel, non-immunogenic Fyn SH3-derived binding protein with tumor vascular targeting properties. J Biol Chem, 282, 3196–204
  • Hey T, Fiedler E, Rudolph R, Fiedler M. (2005). Artificial, non-antibody binding proteins for pharmaceutical and industrial applications. Trends Biotechnol, 23, 514–22
  • Hirano T. (1992). Interleukin-6 and its relation to inflammation and disease. Clin Immunol Immunopathol, 62, S60–5
  • Jefferis R. (2009). Glycosylation as a strategy to improve antibody-based therapeutics. Nat Rev Drug Discov, 8, 226–34
  • Jeong KJ, Mabry R, Georgiou G. (2005). Avimers hold their own. Nature Biotechnol, 23, 1493–4
  • Khalili H, Godwin A, Choi J-w, et al. (2013). Fab-PEG-Fab as a potential antibody mimetic. Bioconjugate Chem, 24, 1870–82
  • Köhler G, Milstein C. (1975). Continuous cultures of fused cells secreting antibody of predefined specificity. Nature, 256, 495–7
  • Koide A, Koide S. (2007). Monobodies: antibody mimics based on the scaffold of the fibronectin type III domain. Meth Mol Biol, 352, 95–109
  • Krehenbrink M, Chami M, Guilvout I, et al. (2008). Artificial binding proteins (Affitins) as probes for conformational changes in secretin PulD. J Mol Biol, 383, 1058–68
  • Ladner RC. (2007). Antibodies cut down to size. Nat Biotechnol, 25, 875–7
  • Lee CM, Shrieve DC, Zempolich KA, et al. (2005). Correlation between human epidermal growth factor receptor family (EGFR, HER2, HER3, HER4), phosphorylated Akt (P-Akt), and clinical outcomes after radiation therapy in carcinoma of the cervix. Gynecol Oncol, 99, 415–21
  • Linsley PS, Golstein P. (1996). Lymphocyte activation: T-cell regulation by CTLA-4. Curr Biol, 6, 398–400
  • Lipovšek D. (2011). Adnectins: engineered target-binding protein therapeutics. Protein Eng Design Select, 24, 3–9
  • Löfblom J, Feldwisch J, Tolmachev V, et al. (2010). Affibody molecules: engineered proteins for therapeutic, diagnostic and biotechnological applications. FEBS Lett, 584, 2670–80
  • Löfblom J, Frejd FY. (2011). Alternative scaffolds as bispecific antibody mimetics. In: Kontermann RE, ed. Bispecific antibodies. Berlin Heidelberg: Springer-Verlag, 115–33
  • Mamluk R, Carvajal IM, Morse BA, et al. (2010). Anti-tumor effect of CT-322 as an adnectin inhibitor of vascular endothelial growth factor receptor-2. Landes Biosci, 2, 199–208
  • Mirecka EA, Hey T, Fiedler U, et al. (2009). Affilin molecules selected against the human papillomavirus E7 protein inhibit the proliferation of target cells. J Mol Biol, 390, 710–21
  • Mouratou B, Schaeffer F, Guilvout I, et al. (2007). Remodeling a DNA-binding protein as a specific in vivo inhibitor of bacterial secretin PulD. Proc Natl Acad Sci, 104, 17983–8
  • Murali R, Greene MI. (2012). Structure based antibody-like peptidomimetics. Pharmaceuticals, 5, 209–35
  • Murphree AL, Benedict WF. (1984). Retinoblastoma: clues to human oncogenesis. Science, 223, 1028–33
  • Qiu X-Q, Wang H, Cai B, et al. (2007). Small antibody mimetics comprising two complementarity-determining regions and a framework region for tumor targeting. Nat Biotechnol, 25, 921–9
  • Renberg B, Nordin J, Merca A, et al. (2007). Affibody molecules in protein capture microarrays: evaluation of multidomain ligands and different detection formats. J Prot Res, 6, 171–9
  • Romero PA, Arnold FH. (2009). Exploring protein fitness landscapes by directed evolution. Nat Rev Mol Cell Biol, 10, 866–76
  • Rusconi CP, Roberts JD, Pitoc GA, et al. (2004). Antidote-mediated control of an anticoagulant aptamer in vivo. Nature Biotechnol, 22, 1423–8
  • Russell WMS, Burch RL, Hume CW. (1959). The principles of humane experimental technique. London: Methuen & Co
  • Schlatter D, Brack S, Banner DW, et al. (2012). Generation, characterization and structural data of chymase binding proteins based on the human Fyn kinase SH3 domain. Landes Biosci, 4, 497–508
  • Schlehuber S, Skerra A. (2005). Anticalins as an alternative to antibody technology. Expert Opin Biol Therap, 5, 1453–62
  • Schönfeld D, Matschiner G, Chatwell L, et al. (2009). An engineered lipocalin specific for CTLA-4 reveals a combining site with structural and conformational features similar to antibodies. Proc Natl Acad Sci, 106, 8198–203
  • Schweizer A, Rusert P, Berlinger L, et al. (2008). CD4-specific designed ankyrin repeat proteins are novel potent HIV entry inhibitors with unique characteristics. PLoS Pathog, 4, e1000109
  • Scott CJ, Taggart CC. (2010). Biologic protease inhibitors as novel therapeutic agents. Biochimie, 92, 1681–8
  • Seidman A, Hudis C, Pierri MK, et al. (2002). Cardiac dysfunction in the trastuzumab clinical trials experience. J Clin Oncol, 20, 1215–21
  • Silverman J, Lu Q, Bakker A, et al. (2005). Multivalent avimer proteins evolved by exon shuffling of a family of human receptor domains. Nature Biotechnol, 23, 1556–61
  • Skerra A. (2001). ‘Anticalins’: a new class of engineered ligand-binding proteins with antibody-like properties. Rev Mol Biotechnol, 74, 257–75
  • Skerra A. (2008). Alternative binding proteins: anticalins–harnessing the structural plasticity of the lipocalin ligand pocket to engineer novel binding activities. FEBS J, 275, 2677–83
  • Stumpp MT, Amstutz P. (2007). DARPins: a true alternative to antibodies. Curr Opin Drug Discov Dev, 10, 153–9
  • Suffredini AF, Fantuzzi G, Badolato R, et al. (1999). New insights into the biology of the acute phase response. J Clin Immunol, 19, 203–14
  • Tolmachev V, Orlova A, Pehrson R, et al. (2007). Radionuclide therapy of HER2-positive microxenografts using a 177Lu-labeled HER2-specific Affibody molecule. Cancer Res, 67, 2773–82
  • Tran T, Engfeldt T, Orlova A, et al. (2007). 99mTc-maEEE-ZHER2: 342, an Affibody molecule-based tracer for the detection of HER2 expression in malignant tumors. Bioconjugate Chem, 18, 1956–64
  • Wållberg H, Löfdahl P-Å, Tschapalda K, et al. (2011). Affinity recovery of eight HER2-binding affibody variants using an anti-idiotypic affibody molecule as capture ligand. Protein Expres Purif, 76, 127–35
  • Wurch T, Pierré A, Depil S. (2012). Novel protein scaffolds as emerging therapeutic proteins: from discovery to clinical proof-of-concept. Trends Biotechnol, 30, 575–82
  • Zielinski R, Lyakhov I, Jacobs A, et al. (2009). Affitoxin–a novel recombinant, HER2-specific, anti-cancer agent for targeted therapy of HER2-positive tumors. J Immunotherapy (Hagerstown, Md: 1997), 32, 817–25

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.