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Review Article

Hearts beating through decellularized scaffolds: whole-organ engineering for cardiac regeneration and transplantation

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Pages 705-715 | Received 16 Sep 2014, Accepted 18 Dec 2014, Published online: 05 Mar 2015

References

  • Aubin H, Kranz A, Hülsmann J, et al. (2013). Decellularized whole heart for bioartificial heart. Cellular cardiomyoplasty. New York: Humana Press
  • Azhim A, Yamagami K, Muramatsu K, et al. (2011). The use of sonication treatment to completely decellularize blood arteries: a pilot study. Paper presented at: Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE. Boston, MA, USA: IEEE, 2468–71
  • Azhim A, Syazwani N, Morimoto Y, et al. (2014). The use of sonication treatment to decellularize aortic tissues for preparation of bioscaffolds. J Biomater Appl, 29, 130–41
  • Bursac N, Loo Y, Leong K, Tung L. (2007). Novel anisotropic engineered cardiac tissues: studies of electrical propagation. Biochem Biophys Res Commun, 361, 847–53
  • Carvalho J, de Carvalho P, Gomes D, Goes A. (2012). Characterization of decellularized heart matrices as biomaterials for regular and whole organ tissue engineering and initial in-vitro recellularization with iPS cells. Tissue Sci Eng, S:11–5
  • Cebotari S, Tudorache I, Jaekel T, et al. (2010). Detergent decellularization of heart valves for tissue engineering: toxicological effects of residual detergents on human endothelial cells. Artif Organs, 34, 206–10
  • Chiu LL, Radisic M. (2011). Controlled release of thymosin β4 using collagen–chitosan composite hydrogels promotes epicardial cell migration and angiogenesis. J Control Release, 155, 376–85
  • Cox B, Emili A. (2006). Tissue subcellular fractionation and protein extraction for use in mass-spectrometry-based proteomics. Nat Protoc, 1, 1872–8
  • Crapo PM, Gilbert TW, Badylak SF. (2011). An overview of tissue and whole organ decellularization processes. Biomaterials, 32, 3233–43
  • Deeken C, White A, Bachman S, et al. (2011). Method of preparing a decellularized porcine tendon using tributyl phosphate. J Biomed Mater Res B Appl Biomater, 96, 199–206
  • Dunmore-Buyze J, Boughner DR, Macris N, Vesely I. (1995). A comparison of macroscopic lipid content within porcine pulmonary and aortic valves: implications for bioprosthetic valves. J Thorac Cardiovasc Surg, 110, 1756–61
  • Eichhorn S, Baier D, Horst D, et al. (2013). Pressure shift freezing as potential alternative for generation of decellularized scaffolds. Int J Biomater, Article ID: 693793. doi: https://doi.org/http://dx.doi.org/10.1155/2013/693793
  • Elder BD, Eleswarapu SV, Athanasiou KA. (2009). Extraction techniques for the decellularization of tissue engineered articular cartilage constructs. Biomaterials, 30, 3749–56
  • Engelmayr GC, Cheng M, Bettinger CJ, et al. (2008). Accordion-like honeycombs for tissue engineering of cardiac anisotropy. Nat Mater, 7, 1003–10
  • Flynn L. (2010). The use of decellularized adipose tissue to provide an inductive microenvironment for the adipogenic differentiation of human adipose-derived stem cells. Biomaterials, 31, 4715–24
  • Friedrich EB, Böhm M. (2007). Management of end stage heart failure. Heart, 93, 626–31
  • Gálvez-Montón C, Prat-Vidal C, Roura S, et al. (2013). Cardiac tissue engineering and the bioartificial heart. Rev Esp Cardiol (Engl Ed), 66, 391–9
  • Gilbert TW, Sellaro TL, Badylak SF. (2006). Decellularization of tissues and organs. Biomaterials, 27, 3675–83
  • Gilbert TW, Wognum S, Joyce EM, et al. (2008). Collagen fiber alignment and biaxial mechanical behavior of porcine urinary bladder derived extracellular matrix. Biomaterials, 29, 4775–82
  • Gilpin SE, Guyette JP, Gonzalez G, et al. (2014). Perfusion decellularization of human and porcine lungs: bringing the matrix to clinical scale. J Heart Lung Transplant, 33, 298–308
  • Goissis G, Suzigan S, Parreira DR, et al. (2000). Preparation and characterization of collagen–elastin matrices from blood vessels intended as small diameter vascular grafts. Artif Organs, 24, 217–23
  • Golberg A, Yarmush ML. (2013). Nonthermal irreversible electroporation: fundamentals, applications, and challenges. IEEE Trans Biomed Eng, 60, 707–14
  • Gorschewsky O, Klakow A, Riechert K, et al. (2005). Clinical comparison of the tutoplast allograft and autologous patellar tendon (bone–patellar tendon–bone) for the reconstruction of the anterior cruciate ligament 2-and 6-year results. Am J Sports Med, 33, 1202–9
  • Grauss R, Hazekamp M, Van Vliet S, et al. (2003). Decellularization of rat aortic valve allografts reduces leaflet destruction and extracellular matrix remodeling. J Thorac Cardiovasc Surg, 126, 2003–10
  • Grauss RW, Hazekamp MG, Oppenhuizen F, et al. (2005). Histological evaluation of decellularised porcine aortic valves: matrix changes due to different decellularisation methods. Eur J Cardiothorac Surg, 27, 566–71
  • Halloran P, Gourishankar S. (2001). Principles and overview of immunosuppression. Primer on Transplantation Mt Laurel, NJ: American Society of Transplantation
  • Hashimoto Y, Funamoto S, Sasaki S, et al. (2010). Preparation and characterization of decellularized cornea using high-hydrostatic pressurization for corneal tissue engineering. Biomaterials, 31, 3941–8
  • Hawkins JA, Hillman ND, Lambert LM, et al. (2003). Immunogenicity of decellularized cryopreserved allografts in pediatric cardiac surgery: comparison with standard cryopreserved allografts. J Thorac Cardiovasc Surg, 126, 247–52
  • Heidenreich PA, Trogdon JG, Khavjou OA, et al. (2011). Forecasting the future of cardiovascular disease in the United States a policy statement from the American Heart Association. Circulation, 123, 933–44
  • Hodde J, Hiles M. (2002). Virus safety of a porcine-derived medical device: evaluation of a viral inactivation method. Biotechnol Bioeng, 79, 211–6
  • Hopkinson A, Shanmuganathan VA, Gray T, et al. (2008). Optimization of amniotic membrane (AM) denuding for tissue engineering. Tissue Eng Part C Methods, 14, 371–81
  • Kasimir M, Rieder E, Seebacher G, et al. (2003). Comparison of different decellularization procedures of porcine heart valves. Int J Artif Organs, 26, 421–7
  • Ketchedjian A, Jones AL, Krueger P, et al. (2005). Recellularization of decellularized allograft scaffolds in ovine great vessel reconstructions. Ann Thorac Surg, 79, 888–96
  • Kidane AG, Burriesci G, Edirisinghe M, et al. (2009). A novel nanocomposite polymer for development of synthetic heart valve leaflets. Acta Biomater, 5, 2409–17
  • Laflamme MA, Murry CE. (2005). Regenerating the heart. Nat Biotechnol, 23, 845–56
  • Lehr EJ, Rayat GR, Chiu B, et al. (2011). Decellularization reduces immunogenicity of sheep pulmonary artery vascular patches. J Thorac Cardiovasc Surg, 141, 1056–62
  • Levy R, Vyavahare N, Ogle M, et al. (2003). Inhibition of cusp and aortic wall calcification in ethanol- and aluminum-treated bioprosthetic heart valves in sheep: background, mechanisms, and synergism. J Heart Valve Dis, 12, 209–16
  • Li S, Vert M. (1996). Hydrolytic degradation of coral/poly (dl-lactic acid) bioresorbable material. J Biomater Sci Polym Ed, 7, 817–27
  • Lu TY, Lin B, Kim J, et al. (2013). Repopulation of decellularized mouse heart with human induced pluripotent stem cell-derived cardiovascular progenitor cells. Nat Commun, 4, 2307
  • Lynch AP, Ahearne M. (2013). Strategies for developing decellularized corneal scaffolds. Exp Eye Res, 108, 42–7
  • Malick LE, Wilson RB, Stetson, D. (1975). Modified thiocarbohydrazide procedure for scanning electron microscopy: routine use for normal, pathological, or experimental tissues. Biotech Histochem, 50, 265–9
  • Meyer SR, Chiu B, Churchill TA, et al. (2006). Comparison of aortic valve allograft decellularization techniques in the rat. J Biomed Mater Res A, 79, 254–62
  • Miyahara Y, Nagaya N, Kataoka M, et al. (2006). Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction. Nat Med, 12, 459–65
  • Montoya CV, McFetridge PS. (2009). Preparation of ex vivo-based biomaterials using convective flow decellularization. Tissue Eng Part C Methods, 15, 191–200
  • Ott HC, Matthiesen TS, Goh SK, et al. (2008). Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart. Nat Med, 14, 213–21
  • Pang K, Du L, Wu X. (2010). A rabbit anterior cornea replacement derived from acellular porcine cornea matrix, epithelial cells and keratocytes. Biomaterials, 31, 7257–65
  • Patnaik SS, Wang B, Weed B, et al. (2013). Decellularized scaffolds: concepts, methodologies, and applications in cardiac tissue engineering and whole-organ regeneration. In: Liu Q, ed. Tissue regeneration: where nanostructure meets biology. London, UK: World Scientific Press, 77–124
  • Penn I. (2000). Post-transplant malignancy. Drug Saf, 23, 101–13
  • Petersen, TH, Calle EA, Zhao L, et al. (2010). Tissue-engineered lungs for in vivo implantation. Science, 329, 538–41
  • Phillips M, Maor E, Rubinsky B. (2010). Nonthermal irreversible electroporation for tissue decellularization. J Biomech Eng, 132, 091003
  • Prasertsung I, Kanokpanont S, Bunaprasert T, et al. (2008). Development of acellular dermis from porcine skin using periodic pressurized technique. J Biomed Mater Res B Appl Biomater, 85, 210–9
  • Quint C, Kondo Y, Manson RJ, et al. (2011). Decellularized tissue-engineered blood vessel as an arterial conduit. Proc Natl Acad Sci USA, 108, 9214–9
  • Radisic M, Fast VG, Sharifov OF, et al. (2008). Optical mapping of impulse propagation in engineered cardiac tissue. Tissue Eng Part A, 15, 851–60
  • Reing JE, Brown BN, Daly KA, et al. (2010). The effects of processing methods upon mechanical and biologic properties of porcine dermal extracellular matrix scaffolds. Biomaterials, 31, 8626–33
  • Remlinger N, Wearden P, Gilbert T. (2011). Procedure for decellularization of porcine heart by retrograde coronary perfusion. J Vis Exp, 70, e50059
  • Sasaki S, Funamoto S, Hashimoto Y, et al. (2009). In vivo evaluation of a novel scaffold for artificial corneas prepared by using ultrahigh hydrostatic pressure to decellularize porcine corneas. Mol Vis, 15, 2022–8
  • Sawada K, Terada D, Yamaoka T, et al. (2008). Cell removal with supercritical carbon dioxide for acellular artificial tissue. J Chem Technol Biotechnol, 83, 943–9
  • Schenke-Layland K, Opitz F, Gross M, et al. (2003a). Complete dynamic repopulation of decellularized heart valves by application of defined physical signals—an in vitro study. Cardiovasc Res, 60, 497–509
  • Schenke-Layland K, Vasilevski O, Opitz F, et al. (2003b). Impact of decellularization of xenogeneic tissue on extracellular matrix integrity for tissue engineering of heart valves. J Struct Biol, 143, 201–8
  • Sheridan WS, Duffy GP, Murphy BP. (2013). Optimum parameters for freeze-drying decellularized arterial scaffolds. Tissue Eng Part C Methods, 19, 981–90
  • Song JJ, Ott HC. (2011). Organ engineering based on decellularized matrix scaffolds. Trends Mol Med, 17, 424–32
  • Song JJ, Guyette JP, Gilpin SE, et al. (2013). Regeneration and experimental orthotopic transplantation of a bioengineered kidney. Nat Med, 19, 646–51
  • Taylor DO, Edwards LB, Boucek MM, et al. (2006). Registry of the International Society for Heart and Lung Transplantation: twenty-third official adult heart transplantation report—2006. J Heart Lung Transplant, 25, 869–79
  • Totonelli G, Maghsoudlou P, Garriboli M, et al. (2012). A rat decellularized small bowel scaffold that preserves villus-crypt architecture for intestinal regeneration. Biomaterials, 33, 3401–10
  • Traphagen S, Yelick PC. (2009). Reclaiming a natural beauty: whole-organ engineering with natural extracellular materials. Regen Med, 4, 747–58
  • Uygun BE, Soto-Gutierrez A, Yagi H, et al. (2010). Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix. Nat Med, 16, 814–20
  • Vunjak-Novakovic G, Tandon N, Godier A, et al. (2009). Challenges in cardiac tissue engineering. Tissue Eng Part B Rev, 16, 169–87
  • Vyavahare N, Hirsch D, Lerner E, et al. (1997). Prevention of bioprosthetic heart valve calcification by ethanol preincubation efficacy and mechanisms. Circulation, 95, 479–88
  • Wagner DE, Bonvillain RW, Jensen T, et al. (2013). Can stem cells be used to generate new lungs? Ex vivo lung bioengineering with decellularized whole lung scaffolds. Respirology, 18, 895–911
  • Wang B, Tedder ME, Perez CE, et al. (2012). Structural and biomechanical characterizations of porcine myocardial extracellular matrix. J Mater Sci Mater Med, 23, 1835–47
  • Weymann A, Loganathan S, Takahashi H, et al. (2010). Development and evaluation of a perfusion decellularization porcine heart model – generation of 3-dimensional myocardial neoscaffolds. Circ Res, 75, 852–60
  • Yang B, Zhang Y, Zhou L, et al. (2010). Development of a porcine bladder acellular matrix with well-preserved extracellular bioactive factors for tissue engineering. Tissue Eng Partc C Methods, 16, 1201–11
  • Zhang X, Sarras M. (1994). Cell–extracellular matrix interactions under in vivo conditions during interstitial cell migration in Hydra vulgaris. Development, 120, 425–32
  • Zhou J, Hu S, Ding J, et al. (2013). Tissue engineering of heart valves: PEGylation of decellularized porcine aortic valve as a scaffold for in vitro recellularization. Biomed Eng Online, 12, 87
  • Zou Y, Zhang Y. (2012). Mechanical evaluation of decellularized porcine thoracic aorta. J Surg Res, 175, 359–68

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