Publication Cover
Chronobiology International
The Journal of Biological and Medical Rhythm Research
Volume 28, 2011 - Issue 9
411
Views
8
CrossRef citations to date
0
Altmetric
Research Article

Advanced Light-Entrained Activity Onsets and Restored Free-Running Suprachiasmatic Nucleus Circadian Rhythms in Per2/Dec Mutant Mice

, &
Pages 737-750 | Received 03 Mar 2011, Accepted 16 Jul 2011, Published online: 14 Nov 2011

REFERENCES

  • Albrecht U, Oster H. (2001). The circadian clock and behavior. Behav. Brain Res. 125:89–91.
  • Albrecht U, Sun ZS, Eichele G, Lee CC. (1997). A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light. Cell 91:1055–1064.
  • Albrecht U, Zheng B, Larkin D, Sun ZS, Lee CC. (2001). MPer1 and mper2 are essential for normal resetting of the circadian clock. J. Biol. Rhythms 16:100–104.
  • Alvarez JD, Sehgal A. (2002). Circadian rhythms: finer clock control. Nature 419:798–799.
  • Archer SN, Robilliard DL, Skene DJ, Smits M, Williams A, Arendt J, von Schantz M. (2003). A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference. Sleep 26:413–415.
  • Azmi S, Sun H, Ozog A, Taneja R. (2003). mSharp-1/DEC2, a basic helix-loop-helix protein functions as a transcriptional repressor of E box activity and Stra13 expression. J. Biol. Chem. 278:20098–20109.
  • Bae K, Jin X, Maywood ES, Hastings MH, Reppert SM, Weaver DR. (2001). Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock. Neuron 30:525–536.
  • Brown SA, Kunz D, Dumas A, Westermark PO, Vanselow K, Tilmann-Wahnschaffe A, Herzel H, Kramer A. (2008). Molecular insights into human daily behavior. Proc. Natl. Acad. Sci. U. S. A. 105:1602–1607.
  • Dardente H, Fustin JM, Hazlerigg DG. (2009). Transcriptional feedback loops in the ovine circadian clock. Comp. Biochem. Physiol. 153:391–398.
  • Duguay D, Cermakian N. (2009). The crosstalk between physiology and circadian clock proteins. Chronobiol. Int. 26:1479–1513.
  • Ebisawa T, Uchiyama M, Kajimura N, Mishima K, Kamei Y, Katoh M, Watanabe T, Sekimoto M, Shibui K, Kim K, Kudo Y, Ozeki Y, Sugishita M, Toyoshima R, Inoue Y, Yamada N, Nagase T, Ozaki N, Ohara O, Ishida N, Okawa M, Takahashi K, Yamauchi T. (2001). Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome. EMBO Rep. 2:342–346.
  • Grechez-Cassiau A, Panda S, Lacoche S, Teboul M, Azmi S, Laudet V, Hogenesch JB, Taneja R, Delaunay F. (2004). The transcriptional repressor STRA13 regulates a subset of peripheral circadian outputs. J. Biol. Chem. 279:1141–1150.
  • Green CB, Takahashi JS, Bass J. (2008). The meter of metabolism. Cell 134:728–742.
  • Griffin EA Jr, Staknis D, Weitz CJ. (1999). Light-independent role of CRY1 and CRY2 in the mammalian circadian clock. Science 286:768–771.
  • Hamaguchi H, Fujimoto K, Kawamoto T, Noshiro M, Maemura K, Takeda N, Nagai R, Furukawa M, Honma S, Honma K, Kurihara H, Kato Y. (2004). Expression of the gene for Dec2, a basic helix-loop-helix transcription factor, is regulated by a molecular clock system. Biochem. J. 382:43–50.
  • He Y, Jones CR, Fujiki N, Xu Y, Guo B, Holder JL Jr, Rossner MJ, Nishino S, Fu YH. (2009). The transcriptional repressor DEC2 regulates sleep length in mammals. Science 325:866–870.
  • Honma S, Kawamoto T, Takagi Y, Fujimoto K, Sato F, Noshiro M, Kato Y, Honma K. (2002). Dec1 and Dec2 are regulators of the mammalian molecular clock. Nature 419:841–844.
  • Jakubcakova V, Oster H, Tamanini F, Cadenas C, Leitges M, van der Horst GT, Eichele G. (2007). Light entrainment of the mammalian circadian clock by a PRKCA-dependent posttranslational mechanism. Neuron 54:831–843.
  • Jones CR, Campbell SS, Zone SE, Cooper F, DeSano A, Murphy PJ, Jones B, Czajkowski L, Ptacek LJ. (1999). Familial advanced sleep-phase syndrome: a short-period circadian rhythm variant in humans. Nat. Med. 5:1062–1065.
  • Kawamoto T, Noshiro M, Sato F, Maemura K, Takeda N, Nagai R, Iwata T, Fujimoto K, Furukawa M, Miyazaki K, Honma S, Honma K, Kato Y. (2004). A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation. Biochem. Biophys. Res. Commun. 313:117–124.
  • Ko CH, Takahashi JS. (2006). Molecular components of the mammalian circadian clock. Human Mol. Genet. 15 (Spec. No 2):R271–R277.
  • Kopp C, Albrecht U, Zheng B, Tobler I. (2002). Homeostatic sleep regulation is preserved in mPer1 and mPer2 mutant mice. Eur. J. Neurosci. 16:1099–1106.
  • Kornhauser JM, Mayo KE, Takahashi JS. (1996). Light, immediate-early genes, and circadian rhythms. Behav. Genet. 26:221–240.
  • Kume K, Zylka MJ, Sriram S, Shearman LP, Weaver DR, Jin X, Maywood ES, Hastings MH, Reppert SM. (1999). mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell 98:193–205.
  • Li Y, Xie M, Song X, Gragen S, Sachdeva K, Wan Y, Yan B. (2003). DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter. J. Biol. Chem. 278:16899–16907.
  • Li Y, Song X, Ma Y, Liu J, Yang D, Yan B. (2004). DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1. Biochem. J. 382:895–904.
  • Liu Y, Sato F, Kawamoto T, Fujimoto K, Morohashi S, Akasaka H, Kondo J, Wu Y, Noshiro M, Kato Y, Kijima H. (2010). Anti-apoptotic effect of the basic helix-loop-helix (bHLH) transcription factor DEC2 in human breast cancer cells. Genes Cells 15:315–325.
  • Miyake S, Sumi Y, Yan L, Takekida S, Fukuyama T, Ishida Y, Yamaguchi S, Yagita K, Okamura H. (2000). Phase-dependent responses of Per1 and Per2 genes to a light-stimulus in the suprachiasmatic nucleus of the rat. Neurosci. Lett. 294:41–44.
  • Mrosovsky N. (1999). Masking: history, definitions, and measurement. Chronobiol. Int. 16:415–429.
  • Nakashima A, Kawamoto T, Honda KK, Ueshima T, Noshiro M, Iwata T, Fujimoto K, Kubo H, Honma S, Yorioka N, Kohno N, Kato Y. (2008). DEC1 modulates the circadian phase of clock gene expression. Mol. Cell. Biol. 28:4080–4092.
  • Noshiro M, Furukawa M, Honma S, Kawamoto T, Hamada T, Honma K, Kato Y. (2005). Tissue-specific disruption of rhythmic expression of Dec1 and Dec2 in clock mutant mice. J. Biol. Rhythms 20:404–418.
  • Obrietan K, Impey S, Storm DR. (1998). Light and circadian rhythmicity regulate MAP kinase activation in the suprachiasmatic nuclei. Nat. Neurosci. 1:693–700.
  • Oster H, Yasui A, van der Horst GT, Albrecht U. (2002). Disruption of mCry2 restores circadian rhythmicity in mPer2 mutant mice. Genes Dev. 16:2633–2638.
  • Oster H, van der Horst GT, Albrecht U. (2003a). Daily variation of clock output gene activation in behaviorally arrhythmic mPer/mCry triple mutant mice. Chronobiol. Int. 20:683–695.
  • Oster H, Werner C, Magnone MC, Mayser H, Feil R, Seeliger MW, Hofmann F, Albrecht U. (2003b). cGMP-dependent protein kinase II modulates mPer1 and mPer2 gene induction and influences phase shifts of the circadian clock. Curr. Biol. 13:725–733.
  • Pendergast JS, Friday RC, Yamazaki S. (2010). Distinct functions of Period2 and Period3 in the mouse circadian system revealed by in vitro analysis. PLoS ONE 5:e8552.
  • Portaluppi F, Smolensky MH, Touitou Y. (2010). Ethics and methods for biological rhythm research on animals and human beings. Chronobiol. Int. 27:1911–1929.
  • Reppert SM, Weaver DR. (2002). Coordination of circadian timing in mammals. Nature 418:935–941.
  • Rossner MJ, Oster H, Wichert SP, Reinecke L, Wehr MC, Reinecke J, Eichele G, Taneja R, Nave KA. (2008). Disturbed clockwork resetting in Sharp-1 and Sharp-2 single and double mutant mice. PLoS ONE 3:e2762.
  • Sato F, Kawamoto T, Fujimoto K, Noshiro M, Honda KK, Honma S, Honma K, Kato Y. (2004). Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1. Eur. J. Biochem. 271:4409–4419.
  • Shearman LP, Zylka MJ, Weaver DR, Kolakowski LF Jr, Reppert SM. (1997). Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei. Neuron 19:1261–1269.
  • Shearman LP, Sriram S, Weaver DR, Maywood ES, Chaves I, Zheng B, Kume K, Lee CC, van der Horst GT, Hastings MH, Reppert SM. (2000). Interacting molecular loops in the mammalian circadian clock. Science 288:1013–1019.
  • Shigeyoshi Y, Taguchi K, Yamamoto S, Takekida S, Yan L, Tei H, Moriya T, Shibata S, Loros JJ, Dunlap JC, Okamura H. (1997). Light-induced resetting of a mammalian circadian clock is associated with rapid induction of the mPer1 transcript. Cell 91:1043–1053.
  • Shiromani PJ, Xu M, Winston EM, Shiromani SN, Gerashchenko D, Weaver DR. (2004). Sleep rhythmicity and homeostasis in mice with targeted disruption of mPeriod genes. Am. J. Physiol. Regul. Integr. Comp. Physiol. 287:R47–R57.
  • Spoelstra K, Albrecht U, van der Horst GT, Brauer V, Daan S. (2004). Phase responses to light pulses in mice lacking functional per or cry genes. J. Biol. Rhythms 19:518–529.
  • Takahashi JS, Hong HK, Ko CH, McDearmon EL. (2008). The genetics of mammalian circadian order and disorder: implications for physiology and disease. Nat. Rev. 9:764–775.
  • Toh KL, Jones CR, He Y, Eide EJ, Hinz WA, Virshup DM, Ptacek LJ, Fu YH. (2001). An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. Science 291:1040–1043.
  • Viola AU, Archer SN, James LM, Groeger JA, Lo JC, Skene DJ, von Schantz M, Dijk DJ. (2007). PER3 polymorphism predicts sleep structure and waking performance. Curr. Biol. 17:613–618.
  • Xu Y, Toh KL, Jones CR, Shin JY, Fu YH, Ptacek LJ. (2007). Modeling of a human circadian mutation yields insights into clock regulation by PER2. Cell 128:59–70.
  • Yan L, Silver R. (2002). Differential induction and localization of mPer1 and mPer2 during advancing and delaying phase shifts. Eur. J. Neurosci. 16:1531–1540.
  • Zheng B, Larkin DW, Albrecht U, Sun ZS, Sage M, Eichele G, Lee CC, Bradley A. (1999). The mPer2 gene encodes a functional component of the mammalian circadian clock. Nature 400:169–173.
  • Zheng B, Albrecht U, Kaasik K, Sage M, Lu W, Vaishnav S, Li Q, Sun ZS, Eichele G, Bradley A, Lee CC. (2001). Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock. Cell 105:683–694.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.