Association Study of a Polymorphism in Clock Gene PERIOD3 and Risk of Inflammatory Bowel Disease

REFERENCES

• Abad VC, Sarinas PSA, Guilleminault C. (2008). Sleep and rheumatologic disorders. Sleep Med. Rev. 12:211–228.
   PubMed Web of Science ®Google Scholar
• Agostino PV, Harrington ME, Ralph MR, Golombek DA. (2009). Casein kinase-1-epsilon (CK1epsilon) and circadian photic responses in hamsters. Chronobiol. Int. 26:126–133.
   PubMed Web of Science ®Google Scholar
• Anderson CA, Boucher G, Lees CW, Franke A, D'Amato M, Taylor KD, Lee JC, Goyette P, Imielinski M, Latiano A, Lagacé C, Scott R, Amininejad L, Bumpstead S, Baidoo L, Baldassano RN, Barclay M, Bayless TM, Brand S, Büning C, Colombel JF, Denson LA, De Vos M, Dubinsky M, Edwards C, Ellinghaus D, Fehrmann RS, Floyd JA, Florin T, Franchimont D, Franke L, Georges M, Glas J, Glazer NL, Guthery SL, Haritunians T, Hayward NK, Hugot JP, Jobin G, Laukens D, Lawrance I, Lémann M, Levine A, Libioulle C, Louis E, McGovern DP, Milla M, Montgomery GW, Morley KI, Mowat C, Ng A, Newman W, Ophoff RA, Papi L, Palmieri O, Peyrin-Biroulet L, Panés J, Phillips A, Prescott NJ, Proctor DD, Roberts R, Russell R, Rutgeerts P, Sanderson J, Sans M, Schumm P, Seibold F, Sharma Y, Simms LA, Seielstad M, Steinhart AH, Targan SR, van den Berg LH, Vatn M, Verspaget H, Walters T, Wijmenga C, Wilson DC, Westra HJ, Xavier RJ, Zhao ZZ, Ponsioen CY, Andersen V, Torkvist L, Gazouli M, Anagnou NP, Karlsen TH, Kupcinskas L, Sventoraityte J, Mansfield JC, Kugathasan S, Silverberg MS, Halfvarson J, Rotter JI, Mathew CG, Griffiths AM, Gearry R, Ahmad T, Brant SR, Chamaillard M, Satsangi J, Cho JH, Schreiber S, Daly MJ, Barrett JC, Parkes M, Annese V, Hakonarson H, Radford-Smith G, Duerr RH, Vermeire S, Weersma RK, Rioux JD. (2011). Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat. Genet. 43:246–252.
   PubMed Web of Science ®Google Scholar
• Archer SN, Robilliard DL, Skene DJ, Smits M, Williams A, Arendt J, von Schantz M. (2003). A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference. Sleep 26:413–415.
   PubMed Web of Science ®Google Scholar
• Archer SN, Carpen JD, Gibson M, Lim GH, Johnston JD, Skene DJ, von Schantz M. (2010). Polymorphism in the PER3 promoter associates with diurnal preference and delayed sleep phase disorder. Sleep 33:695–701.
   PubMed Web of Science ®Google Scholar
• Arjona A, Sarkar DK. (2005). Circadian oscillations of clock genes, cytolytic factors, and cytokines in rat NK cells. J. Immunol. 174:7618–7624.
   PubMed Web of Science ®Google Scholar
• Arjona A, Sarkar DK. (2006a). The circadian gene mPer2 regulates the daily rhythm of IFN-gamma. J. Interferon Cytokine Res. 26:645–649.
   PubMed Web of Science ®Google Scholar
• Arjona A, Sarkar DK. (2006b). Evidence supporting a circadian control of natural killer cell function. Brain Behav. Immun. 20:469–476.
   PubMed Web of Science ®Google Scholar
• Brass SD, Duquette P, Proulx-Therrien J, Auerbach S. (2010). Sleep disorders in patients with multiple sclerosis. Sleep Med. Rev. 14:121–129.
   PubMed Web of Science ®Google Scholar
• Cavadini G, Petrzilka S, Kohler P, Jud C, Tobler I, Birchler T, Fontana A. (2007). TNF-α suppresses the expression of clock genes by interfering with E-box-mediated transcription. Proc. Natl. Acad. Sci. U. S. A. 104:12843–12848.
   PubMed Web of Science ®Google Scholar
• Chandrasekhara PKS, Jayachandran NV, Rajasekhar L, Thomas J, Narsimulu G. (2009). The prevalence and associations of sleep disturbances in patients with systemic lupus erythematosus. Mod. Rheumatol. 19:407–415.
   PubMed Web of Science ®Google Scholar
• Chu G, Yoshida K, Narahara S, Uchikawa M, Kawamura M, Yamauchi N, Xi Y, Shigeyoshi Y, Hashimoto S, Hattori MA. (2011). Alterations of circadian clockworks during differentiation and apoptosis of rat ovarian cells. Chronobiol. Int. 28:477–487.
   PubMed Web of Science ®Google Scholar
• Ciarleglio CM, Ryckman KK, Servick SV, Hida A, Robbins S, Wells N, Hicks J, Larson SA, Wiedermann JP, Carver K, Hamilton N, Kidd KK, Kidd JR, Smith JR, Friedlaender J, McMahon DG, Williams SM, Summar ML, Johnson CH. (2008). Genetic differences in human circadian clock genes among worldwide populations. J. Biol. Rhythms 23:330–340.
   PubMed Web of Science ®Google Scholar
• Dardente H, Cermakian N. (2007). Molecular circadian rhythms in central and peripheral clocks in mammals. Chronobiol. Int. 24:195–213.
   PubMed Web of Science ®Google Scholar
• Demeter P, Visy KV, Gyulai N, Sike R, Tóth TG, Novák J, Magyar P. (2004). Severity of gastroesophageal reflux disease influences daytime somnolence: a clinical study of 134 patients underwent upper panendoscopy. World J. Gastroenterol. 10:1798–1801.
   PubMed Web of Science ®Google Scholar
• Dibner C, Schibler U, Albrecht U. (2010). The mammalian circadian timing system: organization and coordination of central and peripheral clocks. Annu. Rev. Physiol. 72:517–549.
   PubMed Web of Science ®Google Scholar
• Dijk DJ, Archer SN. (2010). PERIOD3, circadian phenotypes, and sleep homeostasis. Sleep Med. Rev. 14:147–160.
   PubMed Web of Science ®Google Scholar
• Dimitrov S, Lange T, Tieken S, Fehm HL, Born J. (2004). Sleep associated regulation of T helper 1/T helper 2 cytokine balance in humans. Brain Behav. Immun. 18:341–348.
   PubMed Web of Science ®Google Scholar
• D'Incà R, Annese V, di Leo V, Latiano A, Quaino V, Abazia C, Vettorato MG, Sturniolo GC. (2006). Increased intestinal permeability and NOD2 variants in familial and sporadic Crohn's disease. Aliment. Pharmacol. Ther. 23:1455–61.
   PubMed Web of Science ®Google Scholar
• Duguay D, Cermakian N. (2009). The crosstalk between physiology and circadian clock proteins. Chronobiol. Int. 26:1479–1513.
   PubMed Web of Science ®Google Scholar
• Ebisawa T. (2007). Circadian rhythms in the CNS and peripheral clock disorders: human sleep disorders and clock genes. J. Pharmacol. Sci. 103:150–154.
   PubMed Web of Science ®Google Scholar
• Ebisawa T, Uchiyama M, Kajimura N, Mishima K, Kamei Y, Katoh M, Watanabe T, Sekimoto M, Shibui K, Kim K, Kudo Y, Ozeki Y, Sugishita M, Toyoshima R, Inoue Y, Yamada N, Nagase T, Ozaki N, Ohara O, Ishida N, Okawa M, Takahashi K, Yamauchi T. (2001). Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome. EMBO Rep. 2:342–346.
   PubMed Web of Science ®Google Scholar
• Ellis J, von Schantz M, Jones KH, Archer SN. (2009). Association between specific diurnal preference questionnaire items and PER3 VNTR genotype. Chronobiol. Int. 26:464–473.
   PubMed Web of Science ®Google Scholar
• Farrokhyar F, Marshall JK, Easterbrook B, Irvine EJ. (2006). Functional gastrointestinal disorders and mood disorders in patients with inactive inflammatory bowel disease: prevalence and impact on health. Inflamm. Bowel Dis. 12:38–46.
   PubMed Web of Science ®Google Scholar
• Franke A, McGovern DP, Barrett JC, Wang K, Radford-Smith GL, Ahmad T, Lees CW, Balschun T, Lee J, Roberts R, Anderson CA, Bis JC, Bumpstead S, Ellinghaus D, Festen EM, Georges M, Green T, Haritunians T, Jostins L, Latiano A, Mathew CG, Montgomery GW, Prescott NJ, Raychaudhuri S, Rotter JI, Schumm P, Sharma Y, Simms LA, Taylor KD, Whiteman D, Wijmenga C, Baldassano RN, Barclay M, Bayless TM, Brand S, Büning C, Cohen A, Colombel JF, Cottone M, Stronati L, Denson T, De Vos M, D'Inca R, Dubinsky M, Edwards C, Florin T, Franchimont D, Gearry R, Glas J, Van Gossum A, Guthery SL, Halfvarson J, Verspaget HW, Hugot JP, Karban A, Laukens D, Lawrance I, Lemann M, Levine A, Libioulle C, Louis E, Mowat C, Newman W, Panés J, Phillips A, Proctor DD, Regueiro M, Russell R, Rutgeerts P, Sanderson J, Sans M, Seibold F, Steinhart AH, Stokkers PC, Torkvist L, Kullak-Ublick G, Wilson D, Walters T, Targan SR, Brant SR, Rioux JD, D'Amato M, Weersma RK, Kugathasan S, Griffiths AM, Mansfield JC, Vermeire S, Duerr RH, Silverberg MS, Satsangi J, Schreiber S, Cho JH, Annese V, Hakonarson H, Daly MJ, Parkes M. (2010). Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat. Genet. 42:1118–1125.
   PubMed Web of Science ®Google Scholar
• Franken P, Dijk DJ. (2009). Circadian clock genes and sleep homeostasis. Eur. J. Neurosci. 29:1820–1829.
   PubMed Web of Science ®Google Scholar
• Graff LA, Vincent N, Walker JR, Clara I, Carr R, Ediger J, Miller N, Rogala L, Rawsthorne P, Lix L, Bernstein CN. (2010). A population-based study of fatigue and sleep difficulties in inflammatory bowel disease. Inflamm. Bowel Dis. 17:1882–1889.
   PubMed Web of Science ®Google Scholar
• Guess J, Burch JB, Ogoussan K, Armstead CA, Zhang H, Wagner S, Hebert JR, Wood P, Youngstedt SD, Hofseth LJ, Singh UP, Xie D, Hrushesky WJ. (2009). Circadian disruption, Per3, and human cytokine secretion. Integr. Cancer Ther. 8:329–336.
   PubMed Web of Science ®Google Scholar
• Hastings MH, Reddy AB, Maywood ES. (2003). A clockwork web: circadian timing in brain and periphery, in health and disease. Nat. Rev. Neurosci. 4:649–661.
   PubMed Web of Science ®Google Scholar
• Hoogerwerf WA, Sinha M, Conesa A, Luxon BA, Shahinian VB, Cornélissen G, Halberg F, Bostwick J, Timm J, Cassone VM. (2008). Transcriptional profiling of mRNA expression in the mouse distal colon. Gastroenterology 135:2019–2029.
   PubMed Web of Science ®Google Scholar
• Hugot JP, Chamaillard M, Zouali H, Lesage S, Cézard JP, Belaiche J, Almer S, Tysk C, O'Morain CA, Gassull M, Binder V, Finkel Y, Cortot A, Modigliani R, Laurent-Puig P, Gower-Rousseau C, Macry J, Colombel JF, Sahbatou M, Thomas G. (2001). Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411:599–603.
   PubMed Web of Science ®Google Scholar
• IBD Working Group of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition. (2005). Inflammatory bowel disease in children and adolescents: recommendations for diagnosis—the Porto criteria. J. Pediatr. Gastroenterol. Nutr. 41:1–7.
   PubMed Web of Science ®Google Scholar
• Iurisci I, Filipski E, Sallam H, Harper F, Guettier C, Maire I, Hassan M, Iacobelli S, Lévi F. (2009). Liver circadian clock, a pharmacologic target of cyclin-dependent kinase inhibitor seliciclib. Chronobiol. Int. 26:1169–1188
   Google Scholar
• Jenkins A, Archer SN, von Schantz M. (2005). Expansion during primate radiation of a variable number tandem repeat in the coding region of the circadian clock gene period3. J. Biol. Rhythms 20:470–472.
   PubMed Web of Science ®Google Scholar
• Jones KH, Ellis J, von Schantz M, Skene DJ, Dijk DJ, Archer SN. (2007). Age-related change in the association between a polymorphism in the PER3 gene and preferred timing of sleep and waking activities. J. Sleep Res. 16:12–16.
   PubMed Web of Science ®Google Scholar
• Kaser A, Zeissig S, Blumberg RS. (2010). Inflammatory bowel disease. Annu. Rev. Immunol. 28:573–621.
   PubMed Web of Science ®Google Scholar
• Khor B, Gardet A, Xavier RJ. (2011). Genetics and pathogenesis of inflammatory bowel disease. Nature 474:307–317.
   PubMed Web of Science ®Google Scholar
• Koch JM, Hagenauer MH, Lee TM. (2009). The response of Per1 to light in the suprachiasmatic nucleus of the diurnal degu (Octodon degus). Chronobiol. Int. 26:1263–1271.
   PubMed Web of Science ®Google Scholar
• Lange T, Dimitrov S, Fehm HL, Westermann J, Born J. (2006). Shift of monocyte function toward cellular immunity during sleep. Arch. Intern. Med. 166:1695–1700.
   PubMed Web of Science ®Google Scholar
• Latiano A, Palmieri O, Valvano MR, Bossa F, Latiano T, Corritore G, DeSanto E, Andriulli A, Annese V. (2007). Evaluating the role of the genetic variations of PTPN22, NFKB1, and FcGRIIIA genes in inflammatory bowel disease: a meta-analysis. Inflamm. Bowel Dis. 13:1212–1219.
   PubMed Web of Science ®Google Scholar
• Latiano A, Palmieri O, Cucchiara S, Castro M, D'Incà R, Guariso G, Dallapiccola B, Valvano MR, Latiano T, Andriulli A, Annese V. (2009). Polymorphism of the IRGM gene might predispose to fistulizing behavior in Crohn's disease. Am. J. Gastroenterol. 104:110–116.
   PubMed Web of Science ®Google Scholar
• Leibetseder V, Humpeler S, Svoboda M, Schmid D, Thalhammer T, Zuckermann A, Marktl W, Ekmekcioglu C. (2009). Clock genes display rhythmic expression in human hearts. Chronobiol. Int. 26:621–636.
   PubMed Web of Science ®Google Scholar
• Lemmer B. (2009). Discoveries of rhythms in human biological functions: a historical review. Chronobiol. Int. 26:1019–1068.
   PubMed Web of Science ®Google Scholar
• Liu S, Cai Y, Sothern RB, Guan Y, Chan P. (2007). Chronobiological analysis of circadian patterns in transcription of seven key clock genes in six peripheral tissues in mice. Chronobiol. Int. 24:793–820.
   PubMed Web of Science ®Google Scholar
• Mazzoccoli G, Pazienza V, Vinciguerra M. (2012). Clock genes and clock-controlled genes in the regulation of metabolic rhythms. Chronobiol. Int. 29:227–251.
   Google Scholar
• Nievergelt CM, Kripke DF, Barrett TB, Burg E, Remick RA, Sadovnick AD, McElroy SL, Keck PE, Schork NJ, Kelsoe JR. (2006). Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder. Am. J. Med. Genet. B Neuropsychiatr. Genet. 141:234–241.
   Web of Science ®Google Scholar
• Nojkov B, Rubenstein J, Chey WD, Hoogerwerf WA. (2010). The impact of rotating shift work on the prevalence of irritable bowel syndrome in nurses. Am. J. Gastroenterol. 105:842–847.
   PubMed Web of Science ®Google Scholar
• Opp MR. (2005). Cytokines and sleep. Sleep Med. Rev. 9:355–364.
   PubMed Web of Science ®Google Scholar
• Osland TM, Bjorvatn BR, Steen VM, Pallesen S. (2011). Association study of a variable-number tandem repeat polymorphism in the clock gene PERIOD3 and chronotype in Norwegian university students. Chronobiol. Int. 28:764–770.
   Google Scholar
• Panda S, Antoch MP, Miller BH, Su AI, Schook AB, Straume M, Schultz PG, Kay SA, Takahashi JS, Hogenesch JB. (2002). Coordinated transcription of key pathways in the mouse by the circadian clock. Cell 109:307–320.
   PubMed Web of Science ®Google Scholar
• Petrzilka S, Taraborrelli C, Cavadini G, Fontana A, Birchler T. (2009). Clock gene modulation by TNF-alpha depends on calcium and pp38 MAP kinase signaling. J. Biol. Rhythms 24:283–294.
   PubMed Web of Science ®Google Scholar
• Podolsky DK. (2002). Inflammatory bowel disease. N. Engl. J. Med. 347:417–429.
   PubMed Web of Science ®Google Scholar
• Polidarová L, Soták M, Sládek M, Pacha J, Sumová A. (2009). Temporal gradient in the clock gene and cell-cycle checkpoint kinase Wee1 expression along the gut. Chronobiol. Int. 26:607–620.
   PubMed Web of Science ®Google Scholar
• Polidarová L, Sládek M, Soták M, Pácha J, Sumová A. (2011). Hepatic, duodenal, and colonic circadian clocks differ in their persistence under conditions of constant light and in their entrainment by restricted feeding. Chronobiol. Int. 28:204–215.
   PubMed Web of Science ®Google Scholar
• Portaluppi F, Smolensky MH, Touitou Y. (2010). Ethics and methods for biological rhythm research on animals and human beings. Chronobiol. Int. 27:1911–1929.
   PubMed Web of Science ®Google Scholar
• Preuss F, Tang Y, Laposky AD, Arble D, Keshavarzian A, Turek F. (2008). Adverse effects of chronic circadian desynchronization in animals in a ‘challenging’ environment. Am. J. Physiol. Regul. Integr. Comp. Physiol. 295:R2034–R2040.
   PubMed Web of Science ®Google Scholar
• Puttonen S, Viitasalo K, Härmä M. (2011). Effect of shiftwork on systemic markers of inflammation. Chronobiol. Int. 28:528–535.
   PubMed Web of Science ®Google Scholar
• Ranjbaran Z, Keefer L, Farhadi A, Stepanski E, Sedghi S, Keshavarzian A. (2007). Impact of sleep disturbances in inflammatory bowel disease. J. Gastroenterol. Hepatol. 22:1748–1753.
   PubMed Web of Science ®Google Scholar
• Sancar A, Lindsey-Boltz LA, Kang T-H, Reardon JT, Lee JH, Ozturk N. (2010). Circadian clock control of the cellular response to DNA damage. FEBS Lett. 584:2618–2625.
   PubMed Web of Science ®Google Scholar
• Sandborn WJ. (2008). Current directions in IBD therapy: what goals are feasible with biological modifiers? Gastroenterology 135:1442–1447.
   PubMed Web of Science ®Google Scholar
• Sartor RB. (2006). Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. Nat. Clin. Pract. Gastroenterol. Hepatol. 3:390–407.
   PubMedGoogle Scholar
• Sawada K, Kusugami K, Suzuki Y, Bamba T, Munakata A, Hibi T, Shimoyama T. (2005). Leukocytapheresis in ulcerative colitis: results of a multicenter double-blind prospective case–control study with sham apheresis as placebo treatment. Am. J. Gastroenterol. 100:1362–1369.
   PubMed Web of Science ®Google Scholar
• Schibler U, Sassone-Corsi P. (2002). A web of circadian pacemakers. Cell 111:919–922.
   PubMed Web of Science ®Google Scholar
• Segawa K, Nakazawa S, Tsukamoto Y, Kurita Y, Goto H, Fukui A, Takano K. (1987). Peptic ulcer is prevalent among shift workers. Dig. Dis. Sci. 32:449–453.
   PubMed Web of Science ®Google Scholar
• Silverberg MS, Satsangi J, Ahmad T, Arnott ID, Bernstein CN, Brant SR, Caprilli R, Colombel JF, Gasche C, Geboes K, Jewell DP, Karban A, Loftus Jr EV, Peña AS, Riddell RH, Sachar DB, Schreiber S, Steinhart AH, Targan SR, Vermeire S, Warren BF. (2005). Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can. J. Gastroenterol. 19( Suppl. A):P5.
   PubMed Web of Science ®Google Scholar
• Storch KF, Lipan O, Leykin I, Viswanathan N, Davis FC, Wong WH, Weitz CJ. (2002). Extensive and divergent circadian gene expression in liver and heart. Nature 417:78–83.
   PubMed Web of Science ®Google Scholar
• Swanson GR, Burgess HJ, Keshavarzian A. (2011). Sleep disturbances and inflammatory bowel disease: a potential trigger for disease flare? Expert Rev. Clin. Immunol. 7:29–36.
   PubMed Web of Science ®Google Scholar
• Takahashi JS, Hong HK, Ko CH, McDearmon EL. (2008). The genetics of mammalian circadian order and disorder: implications for physiology and disease. Nat. Rev. Genet. 9:764–775.
   PubMed Web of Science ®Google Scholar
• Tang Y, Preuss F, Turek FW, Jakate S, Keshavarzian A. (2009). Sleep deprivation worsens inflammation and delays recovery in a mouse model of colitis. Sleep Med. 10:597–603.
   PubMed Web of Science ®Google Scholar
• Targan SR, Hanauer SB, van Deventer SJ, Mayer L, Present DH, Braakman T, DeWoody KL, Schaible TF, Rutgeerts PJ. (1997). A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor α for Crohn's disease. Crohn's Disease cA2 Study Group. N. Engl. J. Med. 337:1029–1035.
   PubMed Web of Science ®Google Scholar
• Viola AU, Archer SN, James LM, Groeger JA, Lo JC, Skene DJ, von Schantz M, Dijk DJ. (2007). PER3 polymorphism predicts sleep structure and waking performance. Curr. Biol. 17:613–618.
   PubMed Web of Science ®Google Scholar
• Zhu Y, Brown HN, Zhang Y, Stevens RG, Zheng T. (2005). Period3 structural variation: a circadian biomarker associated with breast cancer in young women. Cancer Epidemiol. Biomarkers Prev. 14:268–270.
   PubMed Web of Science ®Google Scholar