Publication Cover
Chronobiology International
The Journal of Biological and Medical Rhythm Research
Volume 29, 2012 - Issue 10
236
Views
27
CrossRef citations to date
0
Altmetric
Research Article

Physical Activity and Sex Modulate Obesity Risk Linked to 3111T/C Gene Variant of the CLOCK Gene in an Elderly Population: The SUN Project

, , , , &
Pages 1397-1404 | Received 07 May 2012, Accepted 24 Aug 2012, Published online: 06 Nov 2012

REFERENCES

  • Albrecht U, Eichele G. (2003). The mammalian circadian clock. Curr. Opin. Genet. Dev. 13:271–277.
  • Alonso A, Beunza JJ, Delgado-Rodriguez M, Martinez-Gonzalez MA. (2005). Validation of self reported diagnosis of hypertension in a cohort of university graduates in Spain. BMC Public Health 5:94.
  • Andreasen CH, Mogensen MS, Borch-Johnsen K, Sandbaek A, Lauritzen T, Sorensen TI, Hansen L, Almind K, Jorgensen T, Pedersen O, Hansen T. (2008a). Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes. PLoS ONE 3:e2872.
  • Andreasen CH, Stender-Petersen KL, Mogensen MS, Torekov SS, Wegner L, Andersen G, Nielsen AL, Albrechtsen A, Borch-Johnsen K, Rasmussen SS, Clausen JO, Sandbaek A, Lauritzen T, Hansen L, Jorgensen T, Pedersen O, Hansen T. (2008b). Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation. Diabetes 57:95–101.
  • Ben Ali S, Ben Yahia F, Sediri Y, Kallel A, Ftouhi B, Feki M, Elasmi M, Haj-Taieb S, Souheil O, Sanhagi H, Slimane H, Jemaa R, Kaabachi N. (2009). Gender-specific effect of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma-2 gene on obesity risk and leptin levels in a Tunisian population. Clin. Biochem. 42:1642–1647.
  • Benedetti F, Serretti A, Colombo C, Barbini B, Lorenzi C, Campori E, Smeraldi E. (2003). Influence of CLOCK gene polymorphism on circadian mood fluctuation and illness recurrence in bipolar depression. Am. J. Med. Genet. B Neuropsychiatr. Genet. 123B:23–26
  • Benedetti F, Dallaspezia S, Fulgosi MC, Lorenzi C, Serretti A, Barbini B, Colombo C, Smeraldi E. (2007). Actimetric evidence that CLOCK 3111 T/C SNP influences sleep and activity patterns in patients affected by bipolar depression. Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B:631–635.
  • Berentzen T, Dalgaard LT, Petersen L, Pedersen O, Sorensen TI. (2005). Interactions between physical activity and variants of the genes encoding uncoupling proteins-2 and -3 in relation to body weight changes during a 10-y follow-up. Int. J. Obes. (Lond.) 29:93–99.
  • Bes-Rastrollo M, Perez Valdivieso JR, Sánchez-Villegas A, Alonso A, Martinez-Gonzalez MA. (2005). Validación del peso e indice de masa corporal auto-declarados de los participantes de una cohorte de graduados universitarios. Rev. Esp. Obes. 3:183–189.
  • Beunza JJ, Toledo E, Hu FB, Bes-Rastrollo M, Serrano-Martinez M, Sanchez-Villegas A, Martinez JA, Martinez-Gonzalez MA. (2010). Adherence to the Mediterranean diet, long-term weight change, and incident overweight or obesity: the Seguimiento Universidad de Navarra (SUN) cohort. Am. J. Clin. Nutr. 92:1484–1493.
  • Corbalan MS, Marti A, Forga L, Martinez-Gonzalez MA, Martinez JA. (2002). The 27Glu polymorphism of the beta2-adrenergic receptor gene interacts with physical activity influencing obesity risk among female subjects. Clin. Genet. 61:305–307.
  • de la Fuente-Arrillaga C, Ruiz ZV, Bes-Rastrollo M, Sampson L, Martinez-Gonzalez MA. (2010). Reproducibility of an FFQ validated in Spain. Public Health Nutr. 13:1364–1372.
  • Demerath EW, Lutsey PL, Monda KL, Linda Kao WH, Bressler J, Pankow JS, North KE, Folsom AR. (2011). Interaction of FTO and physical activity level on adiposity in African-American and European-American adults: the ARIC study. Obesity (Silver Spring) 19:1866–1872.
  • Garaulet M, Lee YC, Shen J, Parnell LD, Arnett DK, Tsai MY, Lai CQ, Ordovas JM. (2009). CLOCK genetic variation and metabolic syndrome risk: modulation by monounsaturated fatty acids. Am. J. Clin. Nutr. 90:1466–1475.
  • Garaulet M, Corbalan MD, Madrid JA, Morales E, Baraza JC, Lee YC, Ordovas JM. (2010a). CLOCK gene is implicated in weight reduction in obese patients participating in a dietary programme based on the Mediterranean diet. Int. J. Obes. (Lond.) 34:516–523.
  • Garaulet M, Lee YC, Shen J, Parnell LD, Arnett DK, Tsai MY, Lai CQ, Ordovas JM. (2010b). Genetic variants in human CLOCK associate with total energy intake and cytokine sleep factors in overweight subjects (GOLDN population). Eur. J. Hum. Genet. 18:364–369.
  • Garaulet M, Sanchez-Moreno C, Smith CE, Lee YC, Nicolas F, Ordovas JM. (2011). Ghrelin, sleep reduction and evening preference: relationships to CLOCK 3111 T/C SNP and weight loss. PLoS ONE 6:e17435.
  • Garaulet M, Esteban Tardido A, Lee YC, Smith CE, Parnell LD, Ordovas JM. (2012). SIRT1 and CLOCK 3111T→C combined genotype is associated with evening preference and weight loss resistance in a behavioral therapy treatment for obesity. Int. J. Obes. (Lond.) Epub ahead of print. doi: 10.1038/ijo.2011.270.
  • Garenc C, Vohl MC, Bouchard C, Perusse L. (2009). LIPE C-60G influences the effects of physical activity on body fat and plasma lipid concentrations: the Quebec Family Study. Hum. Genomics 3:157–168.
  • Gomez-Abellan P, Madrid JA, Lujan JA, Frutos MD, Gonzalez R, Martinez-Augustin O, de Medina FS, Ordovas JM, Garaulet M. (2012). Sexual dimorphism in clock genes expression in human adipose tissue. Obes. Surg. 22:105–112.
  • Grimes DA, Schulz KF. (2002). Cohort studies: marching towards outcomes. Lancet 359:341–345.
  • Hakanen M, Raitakari OT, Lehtimaki T, Peltonen N, Pahkala K, Sillanmaki L, Lagstrom H, Viikari J, Simell O, Ronnemaa T. (2009). FTO genotype is associated with body mass index after the age of seven years but not with energy intake or leisure-time physical activity. J. Clin. Endocrinol. Metab. 94:1281–1287.
  • Jonsson A, Renstrom F, Lyssenko V, Brito EC, Isomaa B, Berglund G, Nilsson PM, Groop L, Franks PW. (2009). Assessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15,925 Swedish and 2,511 Finnish adults. Diabetologia 52:1334–1338.
  • Jozkow P, Slowinska-Lisowska M, Laczmanski L, Jakubiec D, Medras M. (2011). Melanocortin-4 receptor gene polymorphism and the level of physical activity in men (HALS Study). Endocrine 39:62–68.
  • Kilpelainen TO, Qi L, Brage S, Sharp SJ, Sonestedt E, Demerath E, Ahmad T, Mora S, Kaakinen M, Sandholt CH, Holzapfel C, Autenrieth CS, Hypponen E, Cauchi S, He M, Kutalik Z, Kumari M, Stancakova A, Meidtner K, Balkau B, Tan JT, Mangino M, Timpson NJ, Song Y, Zillikens MC, Jablonski KA, Garcia ME, Johansson S, Bragg-Gresham JL, Wu Y, van Vliet-Ostaptchouk JV, Onland-Moret NC, Zimmermann E, Rivera NV, Tanaka T, Stringham HM, Silbernagel G, Kanoni S, Feitosa MF, Snitker S, Ruiz JR, Metter J, Larrad MT, Atalay M, Hakanen M, Amin N, Cavalcanti-Proenca C, Grontved A, Hallmans G, Jansson JO, Kuusisto J, Kahonen M, Lutsey PL, Nolan JJ, Palla L, Pedersen O, Perusse L, Renstrom F, Scott RA, Shungin D, Sovio U, Tammelin TH, Ronnemaa T, Lakka TA, Uusitupa M, Rios MS, Ferrucci L, Bouchard C, Meirhaeghe A, Fu M, Walker M, Borecki IB, Dedoussis GV, Fritsche A, Ohlsson C, Boehnke M, Bandinelli S, van Duijn CM, Ebrahim S, Lawlor DA, Gudnason V, Harris TB, Sorensen TI, Mohlke KL, Hofman A, Uitterlinden AG, Tuomilehto J, Lehtimaki T, Raitakari O, Isomaa B, Njolstad PR, Florez JC, Liu S, Ness A, Spector TD, Tai ES, Froguel P, Boeing H, Laakso M, Marmot M, Bergmann S, Power C, Khaw KT, Chasman D, Ridker P, Hansen T, Monda KL, Illig T, Jarvelin MR, Wareham NJ, Hu FB, Groop LC, Orho-Melander M, Ekelund U, Franks PW, Loos RJ. (2011). Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med. 8:e1001116.
  • Lee HJ, Kim IK, Kang JH, Ahn Y, Han BG, Lee JY, Song J. (2010). Effects of common FTO gene variants associated with BMI on dietary intake and physical activity in Koreans. Clin. Chim. Acta 411:1716–1722.
  • Lee YC, Lai CQ, Ordovas JM, Parnell LD. (2011). A Database of Gene-Environment Interactions Pertaining to Blood Lipid Traits, Cardiovascular Disease and Type 2 Diabetes. J. Data Mining Genomics Proteomics 2(1): pii:106.
  • Liu G, Zhu H, Lagou V, Gutin B, Stallmann-Jorgensen IS, Treiber FA, Dong Y, Snieder H. (2010). FTO variant rs9939609 is associated with body mass index and waist circumference, but not with energy intake or physical activity in European- and African-American youth. BMC Med. Genet. 11:57.
  • Macho-Azcarate T, Marti A, Gonzalez A, Martinez JA, Ibanez J. (2002). Gln27Glu polymorphism in the beta2 adrenergic receptor gene and lipid metabolism during exercise in obese women. Int. J. Obes. Relat. Metab. Disord. 26:1434–1441.
  • Magi R, Lindgren CM, Morris AP. (2010). Meta-analysis of sex-specific genome-wide association studies. Genet. Epidemiol. 34:846–853.
  • Marti A, Corbalan MS, Martinez-Gonzalez MA, Martinez JA. (2002). TRP64ARG polymorphism of the beta 3-adrenergic receptor gene and obesity risk: effect modification by a sedentary lifestyle. Diabetes Obes. Metab. 4:428–430.
  • Martinez-Gonzalez MA, Sanchez-Villegas A, De Irala J, Marti A, Martinez JA. (2002). Mediterranean diet and stroke: objectives and design of the SUN project. Seguimiento Universidad de Navarra. Nutr. Neurosci. 5:65–73.
  • Martinez-Gonzalez MA, Lopez-Fontana C, Varo JJ, Sanchez-Villegas A, Martinez JA. (2005). Validation of the Spanish version of the physical activity questionnaire used in the Nurses' Health Study and the Health Professionals' Follow-up Study. Public Health Nutr. 8:920–927.
  • Mishima K, Tozawa T, Satoh K, Saitoh H, Mishima Y. (2005). The 3111T/C polymorphism of hClock is associated with evening preference and delayed sleep timing in a Japanese population sample. Am. J. Med. Genet. B Neuropsychiatr. Genet. 133B:101–104.
  • Monteleone P, Tortorella A, Docimo L, Maldonato MN, Canestrelli B, De Luca L, Maj M. (2008). Investigation of 3111T/C polymorphism of the CLOCK gene in obese individuals with or without binge eating disorder: association with higher body mass index. Neurosci. Lett. 435:30–33.
  • Nilsson L, Olsson AH, Isomaa B, Groop L, Billig H, Ling C. (2011). A common variant near the PRL gene is associated with increased adiposity in males. Mol. Genet. Metab. 102:78–81.
  • Ober C, Loisel DA, Gilad Y. (2008). Sex-specific genetic architecture of human disease. Nat. Rev. Genet. 9:911–922.
  • Otabe S, Clement K, Dina C, Pelloux V, Guy-Grand B, Froguel P, Vasseur F. (2000). A genetic variation in the 5' flanking region of the UCP3 gene is associated with body mass index in humans in interaction with physical activity. Diabetologia 43:245–249.
  • Portaluppi F, Smolensky MH, Touitou Y. (2010). Ethics and methods for biological rhythm research on animals and human beings. Chronobiol. Int. 27:1911–1929.
  • Rampersaud E, Mitchell BD, Pollin TI, Fu M, Shen H, O'Connell JR, Ducharme JL, Hines S, Sack P, Naglieri R, Shuldiner AR, Snitker S. (2008). Physical activity and the association of common FTO gene variants with body mass index and obesity. Arch. Intern. Med. 168:1791–1797.
  • Razquin C, Marti A, Martinez JA. (2011). Evidences on three relevant obesogenes: MC4R, FTO and PPARgamma. Approaches for personalized nutrition. Mol. Nutr. Food Res. 55:136–149.
  • Reppert SM, Weaver DR. (2001). Molecular analysis of mammalian circadian rhythms. Annu. Rev. Physiol. 63:647–676.
  • Ridderstrale M, Johansson LE, Rastam L, Lindblad U. (2006). Increased risk of obesity associated with the variant allele of the PPARGC1A Gly482Ser polymorphism in physically inactive elderly men. Diabetologia 49:496–500.
  • Rudic RD, McNamara P, Curtis AM, Boston RC, Panda S, Hogenesch JB, Fitzgerald GA. (2004). BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis. PLoS Biol. 2:e377.
  • Ruiz JR, Labayen I, Ortega FB, Legry V, Moreno LA, Dallongeville J, Martinez-Gomez D, Bokor S, Manios Y, Ciarapica D, Gottrand F, De Henauw S, Molnar D, Sjostrom M, Meirhaeghe A. (2010). Attenuation of the effect of the FTO rs9939609 polymorphism on total and central body fat by physical activity in adolescents: the HELENA study. Arch. Pediatr. Adolesc. Med. 164:328–333.
  • Sayon-Orea C, Bes-Rastrollo M, Basterra-Gortari FJ, Beunza JJ, Guallar-Castillon P, de la Fuente-Arrillaga C, Martinez-Gonzalez MA. (2011). Consumption of fried foods and weight gain in a Mediterranean cohort: the SUN project. Nutr. Metab. Cardiovasc. Dis. Epub ahead of print. doi: 10.1016/j.nut.2010.08.023.
  • Scott EM, Carter AM, Grant PJ. (2008). Association between polymorphisms in the Clock gene, obesity and the metabolic syndrome in man. Int. J. Obes. (Lond.) 32:658–662.
  • Scott RA, Bailey ME, Moran CN, Wilson RH, Fuku N, Tanaka M, Tsiokanos A, Jamurtas AZ, Grammatikaki E, Moschonis G, Manios Y, Pitsiladis YP. (2010). FTO genotype and adiposity in children: physical activity levels influence the effect of the risk genotype in adolescent males. Eur. J. Hum. Genet. 18:1339–1343.
  • Segui-Gomez M, de la Fuente C, Vazquez Z, de Irala J, Martinez-Gonzalez MA. (2006). Cohort profile: the 'Seguimiento Universidad de Navarra' (SUN) study. Int. J. Epidemiol. 35:1417–1422.
  • Smith PG, Day NE. (1984). The design of case-control studies: the influence of confounding and interaction effects. Int. J. Epidemiol. 13:356–365.
  • Sookoian S, Gemma C, Gianotti TF, Burgueno A, Castano G, Pirola CJ. (2008). Genetic variants of Clock transcription factor are associated with individual susceptibility to obesity. Am. J. Clin. Nutr. 87:1606–1615.
  • Tortorella A, Monteleone P, Martiadis V, Perris F, Maj M. (2007). The 3111T/C polymorphism of the CLOCK gene confers a predisposition to a lifetime lower body weight in patients with anorexia nervosa and bulimia nervosa: a preliminary study. Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B:992–995.
  • Tsuzaki K, Kotani K, Sano Y, Fujiwara S, Takahashi K, Sakane N. (2010). The association of the Clock 3111 T/C SNP with lipids and lipoproteins including small dense low-density lipoprotein: results from the Mima study. BMC Med. Genet. 11:150.
  • Turek FW, Joshu C, Kohsaka A, Lin E, Ivanova G, McDearmon E, Laposky A, Losee-Olson S, Easton A, Jensen DR, Eckel RH, Takahashi JS, Bass J. (2005). Obesity and metabolic syndrome in circadian Clock mutant mice. Science 308:1043–1045.
  • Vimaleswaran KS, Li S, Zhao JH, Luan J, Bingham SA, Khaw KT, Ekelund U, Wareham NJ, Loos RJ. (2009). Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO gene. Am. J. Clin. Nutr. 90:425–428.
  • Willett WC, Colditz GA. (1998). Approaches for conducting large cohort studies. Epidemiol. Rev. 20:91–99.
  • Wolff G, Esser KA. (2012). Scheduled exercise phase shifts the circadian clock in skeletal muscle. Med. Sci. Sports Exerc. 44(9):1663–1670. in press.
  • Yamamoto H, Nagai K, Nakagawa H. (1987). Role of SCN in daily rhythms of plasma glucose, FFA, insulin and glucagon. Chronobiol. Int. 4:483–491.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.