The hepatic circadian clock regulates the choline kinase α gene through the BMAL1-REV-ERBα axis

References

• Acosta-Rodriguez VA, Marquez S, Salvador GA, et al. (2013). Daily rhythms of glycerophospholipid synthesis in fibroblast cultures involve differential enzyme contributions. J Lipid Res. 54:1798–811
   PubMed Web of Science ®Google Scholar
• Adamovich Y, Rousso-Noori L, Zwighaft Z, et al. (2014). Circadian clocks and feeding time regulate the oscillations and levels of hepatic triglycerides. Cell Metab. 19:319–30
   PubMed Web of Science ®Google Scholar
• Aoyama C, Liao H, Ishidate K. (2004). Structure and function of choline kinase isoforms in mammalian cells. Prog Lipid Res. 43:266–81
   PubMed Web of Science ®Google Scholar
• Aoyama C, Ohtani A, Ishidate K. (2002). Expression and characterization of the active molecular forms of choline/ethanolamine kinase-alpha and -beta in mouse tissues, including carbon tetrachloride-induced liver. Biochem J. 363:777–84
   PubMed Web of Science ®Google Scholar
• Balsalobre A, Damiola F, Schibler U. (1998). A serum shock induces circadian gene expression in mammalian tissue culture cells. Cell. 93:929–37
   PubMed Web of Science ®Google Scholar
• Billah MM, Anthes JC. (1990). The regulation and cellular functions of phosphatidylcholine hydrolysis. Biochem J. 269:281–91
   PubMed Web of Science ®Google Scholar
• Brown SA, Ripperger J, Kadener S, et al. (2005). PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator. Science. 308:693–6
   PubMed Web of Science ®Google Scholar
• Bugge A, Feng D, Everett LJ, et al. (2012). Rev-erbα and Rev-erbβ coordinately protect the circadian clock and normal metabolic function. Genes Dev. 26:657–67
   PubMed Web of Science ®Google Scholar
• Buhr ED, Takahashi JS. (2013). Molecular components of the mammalian circadian clock. Handb Exp Pharmacol. 217:3–27
   PubMedGoogle Scholar
• Bunger MK, Walisser JA, Sullivan R, et al. (2005). Progressive arthropathy in mice with a targeted disruption of the Mop3/Bmal-1 locus. Genesis. 41:122–32
   PubMed Web of Science ®Google Scholar
• Burke L, Downes M, Carozzi A, et al. (1996). Transcriptional repression by the orphan steroid receptor RVR/Rev-erb beta is dependent on the signature motif and helix 5 in the E region: Functional evidence for a biological role of RVR in myogenesis. Nucleic Acids Res. 24:3481–9
   Google Scholar
• Campos H, Khoo C, Sacks FM. (2005). Diurnal and acute patterns of postprandial apolipoprotein B-48 in VLDL, IDL, and LDL from normolipidemic humans. Atherosclerosis. 181:345–51
   Google Scholar
• Cho H, Zhao X, Hatori M, et al. (2012). Regulation of circadian behaviour and metabolism by REV-ERB-alpha and REV-ERB-beta. Nature. 485:123–7
   PubMed Web of Science ®Google Scholar
• Crumbley C, Burris TP. (2011). Direct regulation of CLOCK expression by REV-ERB. PLoS One. 6:e17290
   PubMed Web of Science ®Google Scholar
• Dallmann R, Viola AU, Tarokh L, et al. (2012). The human circadian metabolome. Proc Natl Acad Sci USA. 109:2625–9
   PubMed Web of Science ®Google Scholar
• Delezie J, Dumont S, Dardente H, et al. (2012). The nuclear receptor REV-ERBα is required for the daily balance of carbohydrate and lipid metabolism. FASEB J. 26:3321–5
   PubMed Web of Science ®Google Scholar
• Duong HA, Robles MS, Knutti D, Weitz CJ. (2011). A molecular mechanism for circadian clock negative feedback. Science. 332:1436–9
   PubMed Web of Science ®Google Scholar
• Eckel-Mahan KL, Patel VR, Mohney RP, et al. (2012). Coordination of the transcriptome and metabolome by the circadian clock. Proc Natl Acad Sci USA. 109:5541–6
   PubMed Web of Science ®Google Scholar
• Everett LJ, Lazar MA. (2014). Nuclear receptor Rev-erbα: Up, down, and all around. Trends Endocrinol Metab. 25:586–92
   PubMed Web of Science ®Google Scholar
• Feng D, Lazar MA. (2012). Clocks, metabolism, and the epigenome. Mol Cell. 47:158–67
   PubMed Web of Science ®Google Scholar
• Feng D, Liu T, Sun Z, et al. (2011). A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism. Science. 331:1315–19
   PubMed Web of Science ®Google Scholar
• Gibellini F, Smith TK. (2010). The Kennedy pathway--De novo synthesis of phosphatidylethanolamine and phosphatidylcholine. IUBMB Life. 62:414–28
   PubMed Web of Science ®Google Scholar
• Gilardi F, Migliavacca E, Naldi A, et al. (2014). Genome-wide analysis of SREBP1 activity around the clock reveals its combined dependency on nutrient and circadian signals. PLoS Genet. 10:e1004155
   Google Scholar
• Glunde K, Bhujwalla ZM, Ronen SM. (2011). Choline metabolism in malignant transformation. Nat Rev Cancer. 11:835–48
   PubMed Web of Science ®Google Scholar
• Gorne LD, Acosta-Rodriguez VA, Pasquare SJ, et al. (2014). The mouse liver displays daily rhythms in the metabolism of phospholipids and in the activity of lipid synthesizing enzymes. Chronobiol Int. 32:11–26
   Google Scholar
• Grechez-Cassiau A, Rayet B, Guillaumond F, et al. (2008). The circadian clock component BMAL1 is a critical regulator of p21WAF1/CIP1 expression and hepatocyte proliferation. J Biol Chem. 283:4535–42
   PubMed Web of Science ®Google Scholar
• Guillaumond F, Dardente H, Giguere V, Cermakian N. (2005). Differential control of Bmal1 circadian transcription by REV-ERB and ROR nuclear receptors. J Biol Rhythms. 20:391–403
   PubMed Web of Science ®Google Scholar
• Huang W, Ramsey KM, Marcheva B, Bass J. (2011). Circadian rhythms, sleep, and metabolism. J Clin Invest. 121:2133–41
   PubMed Web of Science ®Google Scholar
• Koike N, Yoo SH, Huang HC, et al. (2012). Transcriptional architecture and chromatin landscape of the core circadian clock in mammals. Science. 338:349–54
   PubMed Web of Science ®Google Scholar
• Kojetin DJ, Burris TP. (2014). REV-ERB and ROR nuclear receptors as drug targets. Nat Rev Drug Discov. 13:197–216
   PubMed Web of Science ®Google Scholar
• Kornmann B, Schaad O, Bujard H, et al. (2007). System-driven and oscillator-dependent circadian transcription in mice with a conditionally active liver clock. PLoS Biol. 5:e34
   PubMed Web of Science ®Google Scholar
• Lamia KA, Storch KF, Weitz CJ. (2008). Physiological significance of a peripheral tissue circadian clock. Proc Natl Acad Sci USA. 105:15172–7
   PubMed Web of Science ®Google Scholar
• Le Martelot G, Claudel T, Gatfield D, et al. (2009). REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis. PLoS Biol. 7:e1000181
   PubMed Web of Science ®Google Scholar
• Li Z, Vance DE. (2008). Phosphatidylcholine and choline homeostasis. J Lipid Res. 49:1187–94
   PubMed Web of Science ®Google Scholar
• Malito E, Sekulic N, Too WC, et al. (2006). Elucidation of human choline kinase crystal structures in complex with the products ADP or phosphocholine. J Mol Biol. 364:136–51
   Google Scholar
• Maury E, Hong HK, Bass J. (2014). Circadian disruption in the pathogenesis of metabolic syndrome. Diabetes Metab. 40:338–46
   PubMed Web of Science ®Google Scholar
• Minami Y, Kasukawa T, Kakazu Y, et al. (2009). Measurement of internal body time by blood metabolomics. Proc Natl Acad Sci USA. 106:9890–5
   PubMed Web of Science ®Google Scholar
• Mohawk JA, Green CB, Takahashi JS. (2012). Central and peripheral circadian clocks in mammals. Annu Rev Neurosci. 35:445–62
   PubMed Web of Science ®Google Scholar
• Nishizuka Y. (1992). Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science. 258:607–14
   PubMed Web of Science ®Google Scholar
• Obayashi K, Saek, K, Kurumatani N. (2015). Light exposure at night is associated with subclinical carotid atherosclerosis in the general elderly population: The HEIJO-KYO cohort. Chronobiol Int. 32:310–17
   PubMed Web of Science ®Google Scholar
• Pan X, Jiang XC, Hussain MM. (2013). Impaired cholesterol metabolism and enhanced atherosclerosis in clock mutant mice. Circulation. 128:1758–69
   Google Scholar
• Pelech SL, Vance DE. (1984). Regulation of phosphatidylcholine biosynthesis. Biochim Biophys Acta. 779:217–51
   PubMed Web of Science ®Google Scholar
• Peters JM, Hennuyer N, Staels B, et al. (1997). Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alpha-deficient mice. J Biol Chem. 272:27307–12
   PubMed Web of Science ®Google Scholar
• Portaluppi F, Smolensky MH, Touitou Y. (2010). Ethics and methods for biological rhythm research on animals and human beings. Chronobiol Int. 27:1911–29
   PubMed Web of Science ®Google Scholar
• Preitner N, Damiola F, Lopez-Molina L, et al. (2002). The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell. 110:251–60
   PubMed Web of Science ®Google Scholar
• Purchase JF. (1989). Existing chemicals: International activities. Pol J Occup Med. 2:337–49
   Google Scholar
• Ramirez de Molina A, Gallego-Ortega D, Sarmentero-Estrada J, et al. (2008). Choline kinase as a link connecting phospholipid metabolism and cell cycle regulation: Implications in cancer therapy. Int J Biochem Cell Biol. 40:1753–63
   Google Scholar
• Raspé E, Duez H, Mansén A, et al. (2002). Identification of Rev-erbalpha as a physiological repressor of apoC-III gene transcription. J Lipid Res. 43:2172–9
   PubMed Web of Science ®Google Scholar
• Reddy AB, Karp NA, Maywood ES, et al. (2006). Circadian orchestration of the hepatic proteome. Curr Biol. (CB). 16:1107–15
   PubMed Web of Science ®Google Scholar
• Reischl S, Kramer A. (2011). Kinases and phosphatases in the mammalian circadian clock. FEBS Lett. 585:1393–9
   PubMed Web of Science ®Google Scholar
• Reppert SM, Weaver DR. (2002). Coordination of circadian timing in mammals. Nature. 418: 935–41
   PubMed Web of Science ®Google Scholar
• Sahar S, Sassone-Corsi P. (2013). The epigenetic language of circadian clocks. Handb Exp Pharmacol. 217:29–44
   Google Scholar
• Sangoram AM, Saez L, Antoch MP, et al. (1998). Mammalian circadian autoregulatory loop: A timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription. Neuron. 21:1101–13
   PubMed Web of Science ®Google Scholar
• Scheer FA, Hilton MF, Mantzoros CS, Shea SA. (2009). Adverse metabolic and cardiovascular consequences of circadian misalignment. Proc Natl Acad Sci USA. 106:4453–8
   PubMed Web of Science ®Google Scholar
• Stratmann M, Schibler U. (2006). Properties, entrainment, and physiological functions of mammalian peripheral oscillators. J Biol Rhythms. 21:494–506
   PubMed Web of Science ®Google Scholar
• Ueda HR, Chen W, Adachi A, et al. (2002). A transcription factor response element for gene expression during circadian night. Nature. 418:534–9
   PubMed Web of Science ®Google Scholar
• Vanselow K, Kramer A. (2007). Role of phosphorylation in the mammalian circadian clock. Cold Spring Harbor Symp Quant Biol. 72:167–76
   PubMedGoogle Scholar
• Virshup DM, Eide EJ, Forger DB, et al. (2007). Reversible protein phosphorylation regulates circadian rhythms. Cold Spring Harbor Symp Quant Biol. 72:413–20
   PubMedGoogle Scholar
• Vollmers C, Gill S, DiTacchio L, et al. (2009). Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression. Proc Natl Acad Sci USA. 106:21453–8
   PubMed Web of Science ®Google Scholar
• Yamazaki S, Numano R, Abe M, et al. (2000). Resetting central and peripheral circadian oscillators in transgenic rats. Science. 288:682–5
   PubMed Web of Science ®Google Scholar
• Yao ZM, Vance DE. (1990). Reduction in VLDL, but not HDL, in plasma of rats deficient in choline. Biochem Cell Biol. 68:552–8
   PubMed Web of Science ®Google Scholar