Cisplatin Chronotherapy and Disulfiram Rescue Reduce Toxicity without Interfering with Anticancer Activity: Animal Findings and Preliminary Clinical Experiences

References

• Hrushesky W J M. Selected aspects of cisplatin nephrotoxicity in the rat and man. Platinum Coordination Complexes in Cancer Chemotherapy, M P Hacker, E B Douple, I H Krakoff. Martinus Nijhoff Publishers, Boston 1984; 165–186
   Google Scholar
• Levi F A, Hrushesky W J, Blomquist C H, Lakatua D J, Haus E., Halberg F., Kennedy B J. Reduction of cis,-diamminedichloroplatinum nephrotoxicity in rats by optimal circadian timing. Cancer Res 1982; 42: 950–955
   PubMed Web of Science ®Google Scholar
• Hrushesky W J M., Haus E., Lakatua D J, Langevin T., Halberg F., Kennedy B J. Chapter 87: Marker rhythms for cancer chrono-chemotherapy. Chronobiology 1981–1983. Karger, New York 1984; 493–499
   Google Scholar
• Borch R. F., Pleasants M E. Inhibition of cis,-platinum nephrotoxicity by diethyldithiocarbamate rescue in the rat model. Proc Natl Acad Sci USA 1979; 76: 6611–6614
   PubMed Web of Science ®Google Scholar
• Borch R F, Katz J C, Lieder P H, Pleasants M E. Effect of diethyldithiocarbamate rescue on tumor response to cis,-platinum in a rat model. Proc Natl Acad Sci USA 1980; 77: 5441–5444
   PubMed Web of Science ®Google Scholar
• Bodenner D L. The lack of interference of diethyldithiocarbamate on the antitumor mechanism of cis,-diamminedichloroplatinum (II). Thesis, Graduate School, University of Minnesota. 1984
   Google Scholar
• Gringeri A., Borch R F. The effect of diethyldithiocarbamate (DDTC) on bone marrow cells treated with cis,-diamminedichloroplatinum (DDP) and its analogs. Proc Am Assoc Cancer Res 1984; 25(1471)371
   Google Scholar
• Evans R G, Wheatley C., Engel C., Nielsen J., Ciborowski L J. Modification of the bone marrow toxicity of cis,-diamminedichloroplatinum (II) in mice by diethyldithiocarbamate. Cancer Res 1984; 44: 3686–3690
   PubMed Web of Science ®Google Scholar
• Gale G R, Atkins L M. Cis-platinum and diethyldithiocarbamate in treatment of L1210 leukemia. J Clin Hematol Oncol 1981; 11: 41–45
   Google Scholar
• Dedon P C, Borch R. Diethyldithiocarbamate (DDTC) reversal of cisplatin (DDP) nephrotoxicity. Proc Am Assoc Cancer Res 1984; 25: 1470
   Google Scholar
• Lieder P H. The effect of diethyldithiocarbamate on the biological actions of cisplatin. Thesis, University of Minnesota. 1984
   Google Scholar
• Borch R F, Bodenner D L, Katz J C. Diethyldithiocarbamate and cis,-platinum toxicity. Platinum Coordination Complexes in Cancer Chemotherapy, M P Hacker, E B Douple, I H Krakoff. Martinus Nijhoff Publishers, Boston 1984; 154–164
   Google Scholar
• Sunderman F W. The treatment of acute nickel-carbomyl poisoning with sodium diethyldithiocarbamate. Ann Clin Res 1971; 3: 182–185
   PubMedGoogle Scholar
• Faiman M D. Biochemical pharmacology of disulfiram. Biochemistry and Pharmacology of Ethanol, E. Majchrowicz, E P Nobel. Plenum Press, New York 1979; Vol. II.: 325–348
   Google Scholar
• Horak E., Sundermann F J. Measurements of serum urea nitrogen by conductivimetric unrease assay. Ann Clin Lab Sci 1972; 2: 425–431
   PubMedGoogle Scholar
• Jensen J C, Faiman M D, Hurwitz A. Elimination characteristics of disulfiram over time in five alcoholic volunteers: a preliminary study. Am J Psychiatry 1982; 139: 1596–1598
   PubMed Web of Science ®Google Scholar
• Gralla R J. Metochlopramide. A review of antiemetic trials. Drugs 1983; 25(Suppl. 1)63–73
   PubMed Web of Science ®Google Scholar
• Halberg Johnson F. E. A., Nelson W., Runge W., Sothern R. Autorhythmometry procedures for physiologic self-measurements and their analysis. Physiol Teach 1972; 1: 1–11
   Google Scholar
• Burchenal J H, Kalaher K., Dew K., Lokys L., Gale G. Studies of cross-resistance, synergistic combinations and blocking of activity of platinum derivatives. Biochimie 1978; 60: 961–965
   Web of Science ®Google Scholar
• Slater T F, Ahmet M., Ibrahim S A. Studies on the nephrotoxicity of cis,-dichlorodiammine platinum2+ and related substances. J Clin Hematol Oncol 1977; 7: 534–546
   Google Scholar
• Filipski J., Kohn K W, Prather R., Bonner W M. Thiourea reverses cross-links and restores biological activity in DNA treated with dichlorodiamminoplatinum (II). Science 1979; 204: 181–182
   PubMed Web of Science ®Google Scholar
• Howell S B, Pfeifle C L, Wung W E, Olshen R A, Lucas W E, Yon J L, Green M. Intraperitoneal cisplatin with systemic thiosulfate protection. Ann Intern Med 1982; 97: 845–851
   PubMed Web of Science ®Google Scholar
• Markman M., Howell S B, Lucas W E, Pfeifle C E, Green M R. Combination intraperitoneal chemotherapy with cisplatin, cytarabine, and doxorubicin for refractory ovarian carcinoma and other malignancies confined to the peritoneal cavity. J Clin Oncol 1984; 2: 1321–1326
   PubMed Web of Science ®Google Scholar
• Gonias S L, Oakley A C, Walther P J, Pizzo S V. Effects of diethyldithiocarbamate and nine other nucleophiles on the intersubunit protein cross-linking and inactivation of purified human β2-macroglobulin by cis,-diamminedichloroplatinum (II). Cancer Res 1984; 44: 5764–5770
   PubMed Web of Science ®Google Scholar
• Reedijk J., den Hartog J H J., Fichtinger-Schepman A M J., Marcelis A T M. Specific binding of cis-platinum compounds to DNA and DNA fragments. Platinum Coordination Complexes in Cancer Chemotherapy, M P Hacker, E B Douple, I H Krakoff. Martinus Nijhoff Publishers, Boston 1984; 45–50
   Google Scholar
• Ozols R F, Corden B J, Collins J., Young R C. Renal effects and clinical pharmacokinetics of high-dose (HD) cis,-platinum (P) (40 mg/m2 QD 5) in hypertonic saline. 4th International Symposium Platinum Coordination Complexes Cancer Chemotherapy. 1983. C11: 75
   Google Scholar
• Hrushesky W J M. Circadian timing of cancer chemotherapy. Science 1985; 228: 73–75
   PubMed Web of Science ®Google Scholar
• Hrushesky W J M., Roemeling R., Wood P A, Langevin T R, Lange P., Fraley E. Potentially curative chemotherapy for bladder cancer, Submitted for publication
   Google Scholar
• Roemeling R., Christiansen N. P., Hrushesky W J M. Lack of anti-emetic effect of high-dose metaclopramide. J Clin Oncol 1985; 3: 1273–1276
   PubMed Web of Science ®Google Scholar