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ORIGINAL ARTICLE

Central nervous system-related symptoms and findings are common in acute Puumala hantavirus infection

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Pages 344-351 | Received 30 Sep 2009, Accepted 16 Mar 2010, Published online: 14 Jun 2010

References

  • Vapalahti O, Mustonen J, Lundkvist A, Henttonen H, Plyusnin A, Vaheri A. Hantavirus infections in Europe. Lancet Infect Dis. 2003;3:653–61.
  • Kariwa H, Yoshimatsu K, Arikawa J. Hantavirus infection in East Asia. Comp Immunol Microbiol Infect Dis. 2007;30: 341–56.
  • Mustonen J, Partanen J, Kanerva M, Pietila K, Vapalahti O, Pasternack A, . Association of HLA B27 with benign clinical course of nephropathia epidemica caused by Puumala hantavirus. Scand J Immunol. 1998;47:277–9.
  • Ahlm C, Linden C, Linderholm M, Alexeyev OA, Billheden J, Elgh F, . Central nervous system and ophthalmic involvement in nephropathia epidemica (European type of haemorrhagic fever with renal syndrome). J Infect. 1998; 36:149–55.
  • Alexeyev OA, Morozov VG. Neurological manifestations of hemorrhagic fever with renal syndrome caused by Puumala virus: review of 811 cases. Clin Infect Dis. 1995;20:255–8.
  • Hautala T, Sironen T, Vapalahti O, Pääkko E, Sarkioja T, Salmela PI, . Hypophyseal hemorrhage and panhypopituitarism during Puumala virus infection: magnetic resonance imaging and detection of viral antigen in the hypophysis. Clin Infect Dis. 2002;35:96–101.
  • Mähonen SM, Sironen T, Vapalahti O, Pääkko E, Hautala N, Ilonen J, . Puumala virus RNA in cerebrospinal fluid in a patient with uncomplicated nephropathia epidemica. J Clin Virol. 2007;40:248–51.
  • Lim TH, Chang KH, Han MC, Chang YB, Lim SM, Yu YS, . Pituitary atrophy in Korean (epidemic) hemorrhagic fever: CT correlation with pituitary function and visual field. Am J Neuroradiol. 1986;7:633–7.
  • Pekic S, Cvijovic G, Stojanovic M, Kendereski A, Micic D, Popovic V. Hypopituitarism as a late complication of hemorrhagic fever. Endocrine. 2005;26:79–82.
  • Settergren B, Boman J, Linderholm M, Wistrom J, Hägg E, Arvidsson PA. A case of nephropathia epidemica associated with panhypopituitarism and nephrotic syndrome. Nephron. 1992;61:234–5.
  • Forslund T, Saltevo J, Anttinen J, Auvinen S, Brummer-Korvenkontio M, Korhonen A, . Complications of nephropathia epidemica: three cases. J Intern Med. 1992;232: 87–90.
  • Suh DC, Park JS, Park SK, Lee HK, Chang KH. Pituitary hemorrhage as a complication of hantaviral disease. Am J Neuroradiol. 1995;16:175–8.
  • Park JE, Pyo HJ. Delayed onset of diuresis in a patient with acute renal failure due to hemorrhagic fever with renal syndrome who also developed anterior hypopituitarism. Clin Nephrol. 1996;46:141–5.
  • Stojanovic M, Pekic S, Cvijovic G, Miljic D, Doknic M, Nikolic-Djurovic M, . High risk of hypopituitarism in patients who recovered from hemorrhagic fever with renal syndrome. J Clin Endocrinol Metab. 2008;93:2722–8.
  • Brummer-Korvenkontio M, Vapalahti O, Henttonen H, Koskela P, Kuusisto P, Vaheri A. Epidemiological study of nephropathia epidemica in Finland 1989–96. Scand J Infect Dis. 1999;31:427–35.
  • Ahlm C, Thelin A, Elgh F, Juto P, Stiernstrom EL, Holmberg S, . Prevalence of antibodies specific to Puumala virus among farmers in Sweden. Scand J Work Environ Health. 1998;24:104–8.
  • Piechotowski I, Brockmann SO, Schwarz C, Winter CH, Ranft U, Pfaff G. Emergence of hantavirus in South Germany: rodents, climate and human infections. Parasitol Res. 2008;103 Suppl 1:S131–7.
  • Tersago K, Verhagen R, Servais A, Heyman P, Ducoffre G, Leirs H. Hantavirus disease (nephropathia epidemica) in Belgium: effects of tree seed production and climate. Epidemiol Infect. 2009;137:250–6.
  • Vaheri A, Vapalahti O, Plyusnin A. How to diagnose hantavirus infections and detect them in rodents and insectivores. Rev Med Virol. 2008;18:277–88.
  • Vapalahti O, Lundkvist A, Kallio-Kokko H, Paukku K, Julkunen I, Lankinen H, . Antigenic properties and diagnostic potential of puumala virus nucleocapsid protein expressed in insect cells. J Clin Microbiol. 1996;34:119–25.
  • Vapalahti O, Kallio-Kokko H, Narvanen A, Julkunen I, Lundkvist A, Plyusnin A, . Human B-cell epitopes of Puumala virus nucleocapsid protein, the major antigen in early serological response. J Med Virol. 1995;46:293–303.
  • Hedman K, Vaheri A, Brummer-Korvenkontio M. Rapid diagnosis of hantavirus disease with an IgG-avidity assay. Lancet. 1991;338:1353–6.
  • Plyusnin A, Horling J, Kanerva M, Mustonen J, Cheng Y, Partanen J, . Puumala hantavirus genome in patients with nephropathia epidemica: correlation of PCR positivity with HLA haplotype and link to viral sequences in local rodents. J Clin Microbiol. 1997;35:1090–6.
  • Hermann R, Turpeinen H, Laine AP, Veijola R, Knip M, Simell O, . HLA DR-DQ-encoded genetic determinants of childhood-onset type 1 diabetes in Finland: an analysis of 622 nuclear families. Tissue Antigens. 2003;62: 162–9.
  • Kiviniemi M, Ilonen J, Lovgren T. A homogeneous HLA-B*27 genotyping assay using dried reagent mixtures. Dis Markers. 2009;27:85–91.
  • Sindic CJ, Cambiaso CL, Depre A, Laterre EC, Masson PL. The concentration of IgM in the cerebrospinal fluid of neurological patients. J Neurol Sci. 1982;55:339–50.
  • Kontkanen M, Puustjarvi T, Kauppi P, Lähdevirta J. Ocular characteristics in nephropathia epidemica or Puumala virus infection. Acta Ophthalmol Scand. 1996; 74:621–5.
  • Siren MK, Sareneva H, Lokki ML, Koskimies S. Unique HLA antigen frequencies in the Finnish population. Tissue Antigens. 1996;48:703–7.
  • Mustonen J, Partanen J, Kanerva M, Pietilä K, Vapalahti O, Pasternack A, . Genetic susceptibility to severe course of nephropathia epidemica caused by Puumala hantavirus. Kidney Int. 1996;49:217–21.
  • Schaefer S, Boegershausen N, Meyer S, Ivan D, Schepelmann K, Kann PH. Hypothalamic-pituitary insufficiency following infectious diseases of the central nervous system. Eur J Endocrinol. 2008;158:3–9.

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