Licorice-induced hypertension and common variants of genes regulating renal sodium reabsorption

References

• Lifton RP, Gharavi AG, Geller DS. Molecular mechanisms of human hypertension. Cell. 2001;104:545–56.
   PubMed Web of Science ®Google Scholar
• Liddle GW, Bledsoe T, Coppage WSJ. A familial renal disorder simulating primary aldosteronism but with negligible aldosterone secretion. Trans Assoc Am Physicians. 1963;76: 199–213.
   Web of Science ®Google Scholar
• New MI, Levine LS, Biglieri EG, Pareira J, Ulick S. Evidence for an unidentified steroid in a child with apparent mineralocorticoid hypertension. J Clin Endocrinol Metab. 1977;44:924–33.
   PubMed Web of Science ®Google Scholar
• Ulick S, Levine LS, Gunczler P, Zanconato G, Ramirez LC, Rauh W, . A syndrome of apparent mineralocorticoid excess associated with defects in the peripheral metabolism of cortisol. J Clin Endocrinol Metab. 1979;49:757–64.
   PubMed Web of Science ®Google Scholar
• Shimkets RA, Warnock DG, Bositis CM, Nelson-Williams C, Hansson JH, Schambelan M, . Liddle's syndrome: heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel. Cell. 1994;79:407–14.
   PubMed Web of Science ®Google Scholar
• Hansson JH, Nelson-Williams C, Suzuki H, Schild L, Shimkets R, Lu Y, . Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndrome. Nat Genet. 1995;11:76–82.
   PubMed Web of Science ®Google Scholar
• Baker EH, Dong YB, Sagnella GA, Rothwell M, Onipinla AK, Markandu ND, . Association of hypertension with T594M mutation in beta subunit of epithelial sodium channels in black people resident in London. Lancet. 1998;351:1388–92.
   PubMed Web of Science ®Google Scholar
• Ambrosius WT, Bloem LJ, Zhou L, Rebhun JF, Snyder PM, Wagner MA, . Genetic variants in the epithelial sodium channel in relation to aldosterone and potassium excretion and risk for hypertension. Hypertension. 1999;34:631–7.
   PubMed Web of Science ®Google Scholar
• Rayner BL, Owen EP, King JA, Soule SG, Vreede H, Opie LH, . A new mutation, R563Q, of the beta subunit of the epithelial sodium channel associated with low-renin, low-aldosterone hypertension. J Hypertens. 2003;21:921–6.
   PubMed Web of Science ®Google Scholar
• Wong ZY, Stebbing M, Ellis JA, Lamantia A, Harrap SB. Genetic linkage of beta and gamma subunits of epithelial sodium channel to systolic blood pressure. Lancet. 1999;353:1222–5.
   PubMed Web of Science ®Google Scholar
• Hannila-Handelberg T, Kontula K, Tikkanen I, Tikkanen T, Fyhrquist F, Helin K, . Common variants of the beta and gamma subunits of the epithelial sodium channel and their relation to plasma renin and aldosterone levels in essential hypertension. BMC Med Genet. 2005;6:4.
   PubMed Web of Science ®Google Scholar
• Mune T, Rogerson FM, Nikkila H, Agarwal AK, White PC. Human hypertension caused by mutations in the kidney isozyme of 11 beta-hydroxysteroid dehydrogenase. Nat Genet. 1995;10:394–9.
   PubMed Web of Science ®Google Scholar
• van Uum SH, Hermus AR, Smits P, Thien T, Lenders JW. The role of 11 beta-hydroxysteroid dehydrogenase in the pathogenesis of hypertension. Cardiovasc Res. 1998;38:16–24.
   PubMed Web of Science ®Google Scholar
• Dave-Sharma S, Wilson RC, Harbison MD, Newfield R, Azar MR, Krozowski ZS, . Examination of genotype and phenotype relationships in 14 patients with apparent mineralocorticoid excess. J Clin Endocrinol Metab. 1998;83:2244–54.
   PubMed Web of Science ®Google Scholar
• White PC, Agarwal AK, Nunez BS, Giacchetti G, Mantero F, Stewart PM. Genotype-phenotype correlations of mutations and polymorphisms in HSD11B2, the gene encoding the kidney isozyme of 11beta-hydroxysteroid dehydrogenase. Endocr Res. 2000;26:771–80.
   PubMed Web of Science ®Google Scholar
• Watson B Jr, Bergman SM, Myracle A, Callen DF, Acton RT, Warnock DG. Genetic association of 11 beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) flanking microsatellites with essential hypertension in blacks. Hypertension. 1996;28:478–82.
   PubMed Web of Science ®Google Scholar
• Lovati E, Ferrari P, Dick B, Jostarndt K, Frey BM, Frey FJ, . Molecular basis of human salt sensitivity: the role of the 11beta-hydroxysteroid dehydrogenase type 2. J Clin Endocrinol Metab. 1999;84:3745–9.
   PubMed Web of Science ®Google Scholar
• Agarwal AK, Giacchetti G, Lavery G, Nikkila H, Palermo M, Ricketts M, . CA-Repeat polymorphism in intron 1 of HSD11B2: effects on gene expression and salt sensitivity. Hypertension. 2000;36:187–94.
   PubMed Web of Science ®Google Scholar
• Stewart PM, Wallace AM, Valentino R, Burt D, Shackleton CH, Edwards CR. Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age. Lancet. 1987;2:821–4.
   PubMed Web of Science ®Google Scholar
• Whorwood CB, Sheppard MC, Stewart PM. Licorice inhibits 11 beta-hydroxysteroid dehydrogenase messenger ribonucleic acid levels and potentiates glucocorticoid hormone action. Endocrinology. 1993;132:2287–92.
   PubMed Web of Science ®Google Scholar
• Tanahashi T, Mune T, Morita H, Tanahashi H, Isomura Y, Suwa T, . Glycyrrhizic acid suppresses type 2 11 beta-hydroxysteroid dehydrogenase expression in vivo. J Steroid Biochem Mol Biol. 2002;80:441–7.
   PubMed Web of Science ®Google Scholar
• Epstein MT, Espiner EA, Donald RA, Hughes H. Effect of eating liquorice on the renin-angiotensin aldosterone axis in normal subjects. BMJ. 1977;1:488–90.
   PubMed Web of Science ®Google Scholar
• Forslund T, Fyhrquist F, Froseth B, Tikkanen I. Effects of licorice on plasma atrial natriuretic peptide in healthy volunteers. J Intern Med. 1989;225:95–9.
   PubMed Web of Science ®Google Scholar
• Ferrari P, Sansonnens A, Dick B, Frey FJ. In vivo 11beta-HSD-2 activity: variability, salt-sensitivity, and effect of licorice. Hypertension. 2001;38:1330–6.
   PubMed Web of Science ®Google Scholar
• Smolenicka Z, Bach E, Schaer A, Liechti-Gallati S, Frey BM, Frey FJ, . A new polymorphic restriction site in the human 11 beta-hydroxysteroid dehydrogenase type 2 gene. J Clin Endocrinol Metab. 1998;8383:1814–7.
   Google Scholar
• Melander O, Orho M, Fagerudd J, Bengtsson K, Groop PH, Mattiasson I, . Mutations and variants of the epithelial sodium channel gene in Liddle's syndrome and primary hypertension. Hypertension. 1998;31:1118–24.
   PubMed Web of Science ®Google Scholar
• Persu A, Barbry P, Bassilana F, Houot AM, Mengual R, Lazdunski M, . Genetic analysis of the beta subunit of the epithelial Na+ channel in essential hypertension. Hypertension. 1998;32:129–37.
   PubMed Web of Science ®Google Scholar
• Blomberg K, Hallikainen A. Suomessa kaupan olevien lakritsivalmisteiden glykyrritsiinipitoisuudet. Helsinki: Elintarvikeviraston julkaisuja; 1993.
   Google Scholar
• Conn J, Rovner JR, Cohen EL. Licorice-induced pseudoaldosteronism. Hypertension, hypokalemia, aldosteronopenia, and suppressed plasma renin activity. JAMA. 1968;205:80–4.
   Web of Science ®Google Scholar
• Stormer FC, Reistad R, Alexander J. Glycyrrhizic acid in liquorice—evaluation of health hazard. Food Chem Toxicol. 1993;31:303–12.
   PubMed Web of Science ®Google Scholar
• Sigurjonsdottir HA, Franzson L, Manhem K, Ragnarsson J, Sigurdsson G, Wallerstedt S. Liquorice-induced rise in blood pressure: a linear dose-response relationship. J Hum Hypertens. 2001;15:549–52.
   PubMed Web of Science ®Google Scholar
• Sigurjonsdottir HA, Manhem K, Axelson M, Wallerstedt S. Subjects with essential hypertension are more sensitive to the inhibition of 11 beta-HSD by liquorice. J Hum Hypertens. 2003;17:125–31.
   PubMed Web of Science ®Google Scholar
• Ploeger B, Mensinga T, Sips A, Seinen W, Meulenbelt J, DeJongh J. The pharmacokinetics of glycyrrhizic acid evaluated by physiologically based pharmacokinetic modeling. Drug Metab Rev. 2001;33:125–47.
   PubMed Web of Science ®Google Scholar
• Iwai N, Baba S, Mannami T, Ogihara T, Ogata J. Association of a sodium channel alpha subunit promoter variant with blood pressure. J Am Soc Nephrol. 2002;13:80–5.
   PubMed Web of Science ®Google Scholar
• Samaha FF, Rubenstein RC, Yan W, Ramkumar M, Levy DI, Ahn YJ, . Functional polymorphism in the carboxyl terminus of the alpha-subunit of the human epithelial sodium channel. J Biol Chem. 2004;279:23900–7.
   PubMed Web of Science ®Google Scholar
• Tong Q, Menon AG, Stockand JD. Functional polymorphisms in the alpha-subunit of the human epithelial Na+ channel increase activity. Am J Physiol Renal Physiol. 2006;290:F821–7.
   PubMed Web of Science ®Google Scholar
• Hiltunen TP, Hannila-Handelberg T, Petajaniemi N, Kantola I, Tikkanen I, Virtamo J, . Liddle's syndrome associated with a point mutation in the extracellular domain of the epithelial sodium channel gamma subunit. J Hypertens. 2002;20:2383–90.
   PubMed Web of Science ®Google Scholar
• Shi H, Asher C, Yung Y, Kligman L, Reuveny E, Seger R, . Casein kinase 2 specifically binds to and phosphorylates the carboxy termini of ENaC subunits. Eur J Biochem. 2002;269:4551–8.
   PubMedGoogle Scholar
• Shimkets RA, Lifton R, Canessa CM. In vivo phosphorylation of the epithelial sodium channel. Proc Natl Acad Sci U S A. 1998;95:3301–5.
   PubMed Web of Science ®Google Scholar
• Findling JW, Raff H, Hansson JH, Lifton RP. Liddle's syndrome: prospective genetic screening and suppressed aldosterone secretion in an extended kindred. J Clin Endocrinol Metab. 1997;82:1071–4.
   PubMed Web of Science ®Google Scholar
• Poch E, Gonzalez D, Giner V, Bragulat E, Coca A, de La Sierra A. Molecular basis of salt sensitivity in human hypertension. Evaluation of renin-angiotensin-aldosterone system gene polymorphisms. Hypertension. 2001;38:1204–9.
   PubMed Web of Science ®Google Scholar
• Ji W, Foo JN, O'Roak BJ, Zhao H, Larson MG, Simon DB, . Rare independent mutations in renal salt handling genes contribute to blood pressure variation. Nat Genet. 2008;40:592–9.
   PubMed Web of Science ®Google Scholar
• Doi M, Takahashi Y, Komatsu R, Yamazaki F, Yamada H, Haraguchi S, . Salt-sensitive hypertension in circadian clock–deficient Cry-null mice involves dysregulated adrenal Hsd3b6. Nat Med. 2010;16:67–75.
   PubMed Web of Science ®Google Scholar