Drug Burden Index associated with function in community-dwelling older people in Finland: A cross-sectional study

References

• Haider SI, Johnell K, Thorslund M, Fastbom J. Trends in polypharmacy and potential drug-drug interactions across educational groups in elderly patients in Sweden for the period 1992–2002. Int J Clin Pharmacol Ther. 2007;45: 643–53.
   PubMed Web of Science ®Google Scholar
• Kuijpers MA, van Marum RJ, Egberts AC, Jansen PA. Relationship between polypharmacy and underprescribing. Br J Clin Pharmacol. 2008;65:130–3.
   PubMed Web of Science ®Google Scholar
• Hilmer SN, Gnjidic D. The effects of polypharmacy in older adults. Clin Pharmacol Ther. 2009;85:86–8.
   PubMed Web of Science ®Google Scholar
• Fick DM, Cooper JW, Wade WE, Waller JL, Maclean JR, Beers MH. Updating the Beers criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of experts. Arch Intern Med. 2003;163: 2716–24.
   PubMed Web of Science ®Google Scholar
• Jano E, Aparasu RR. Healthcare outcomes associated with beers’ criteria: a systematic review. Ann Pharmacother. 2007;41:438–47.
   PubMed Web of Science ®Google Scholar
• Steinman MA, Rosenthal GE, Landefeld CS, Bertenthal D, Kaboli PJ. Agreement between drugs-to-avoid criteria and expert assessments of problematic prescribing. Arch Intern Med. 2009;169:1326–32.
   PubMed Web of Science ®Google Scholar
• O'Mahony D, Gallagher PF. Inappropriate prescribing in the older population: need for new criteria. Age Ageing. 2008; 37:138–41.
   PubMed Web of Science ®Google Scholar
• Aizenberg D, Sigler M, Weizman A, Barak Y. Anticholinergic burden and the risk of falls among elderly psychiatric inpatients: a 4-year case-control study. Int Psychogeriatr. 2002; 14:307–10.
   PubMed Web of Science ®Google Scholar
• Landi F, Russo A, Liperoti R, Cesari M, Barillaro C, Pahor M, . Anticholinergic drugs and physical function among frail elderly population. Clin Pharmacol Ther. 2007;81: 235–41.
   PubMed Web of Science ®Google Scholar
• Carriere I, Fourrier-Reglat A, Dartigues JF, Rouaud O, Pasquier F, Ritchie K, . Drugs with anticholinergic properties, cognitive decline, and dementia in an elderly general population: the 3-city study. Arch Intern Med. 2009;169:1317–24.
   PubMed Web of Science ®Google Scholar
• Tinetti ME, Speechley M, Ginter SF. Risk factors for falls among elderly persons living in the community. N Engl J Med. 1988;319:1701–7.
   PubMed Web of Science ®Google Scholar
• Gray SL, LaCroix AZ, Hanlon JT, Penninx BW, Blough DK, Leveille SG, . Benzodiazepine use and physical disability in community-dwelling older adults. J Am Geriatr Soc. 2006;54:224–30.
   PubMed Web of Science ®Google Scholar
• Hanlon JT, Horner RD, Schmader KE, Fillenbaum GG, Lewis IK, Wall WE Jr, . Benzodiazepine use and cognitive function among community-dwelling elderly. Clin Pharmacol Ther. 1998;64:684–92.
   PubMed Web of Science ®Google Scholar
• Hilmer SN, Mager DE, Simonsick EM, Cao Y, Ling SM, Windham BG, . A drug burden index to define the functional burden of medications in older people. Arch Intern Med. 2007;167:781–7.
   PubMed Web of Science ®Google Scholar
• Gnjidic D, Cumming RG, Le Couteur DG, Handelsman DJ, Naganathan V, Abernethy DR, . Drug Burden Index and physical function in older Australian men. Br J Clin Pharmacol. 2009;68:97–105.
   PubMed Web of Science ®Google Scholar
• Cao YJ, Mager DE, Simonsick EM, Hilmer SN, Ling SM, Windham BG, . Physical and cognitive performance and burden of anticholinergics, sedatives, and ACE inhibitors in older women. Clin Pharmacol Ther. 2008;83: 422–9.
   PubMed Web of Science ®Google Scholar
• Wilson NM, Hilmer SN, March LM, Cameron ID, Lord SR, Seibel MJ, . Associations between drug burden index and physical function in older people in residential aged care facilities. Age Ageing. 2010;39:503–7.
   PubMed Web of Science ®Google Scholar
• Gnjidic D, Le Couteur DG, Abernethy DR, Hilmer SN. Drug Burden Index and Beers criteria: Impact on functional outcomes in older people living in self-care retirement villages. J Clin Pharm. 2011 Feb 2 (Epub ahead of print).
   Web of Science ®Google Scholar
• Perera S, Mody SH, Woodman RC, Studenski SA. Meaningful change and responsiveness in common physical performance measures in older adults. J Am Geriatr Soc. 2006;54:743–9.
   PubMed Web of Science ®Google Scholar
• Hilmer SN, Mager DE, Simonsick EM, Ling SM, Windham BG, Harris TB, . Drug burden index score and functional decline in older people. Am J Med. 2009; 122:1142–9.e1–2.
   PubMed Web of Science ®Google Scholar
• Pokela N, Bell JS, Lihavainen K, Sulkava R, Hartikainen S. Analgesic use among community-dwelling people aged 75 years and older: A population-based interview study. Am J Geriatr Pharmacother. 2010;8:233–44.
   PubMed Web of Science ®Google Scholar
• Lampela P, Hartikainen S, Sulkava R, Huupponen R. Adverse drug effects in elderly people—a disparity between clinical examination and adverse effects self-reported by the patient. Eur J Clin Pharmacol. 2007;63:509–15.
   PubMed Web of Science ®Google Scholar
• Rikala M, Hartikainen S, Sulkava R, Korhonen MJ. Validity of the Finnish Prescription Register for measuring psychotropic drug exposures among elderly Finns: a population-based intervention study. Drugs Aging. 2010; 27:337–49.
   PubMed Web of Science ®Google Scholar
• Rigler SK, Perera S, Jachna C, Shireman TI, Eng M. Comparison of the association between disease burden and inappropriate medication use across three cohorts of older adults. Am J Geriatr Pharmacother. 2004;2:239–47.
   PubMedGoogle Scholar
• Van Rensbergen G, Nawrot T. Medical conditions of nursing home admissions. BMC Geriatr. 2010;10:46.
   PubMed Web of Science ®Google Scholar
• WHO Collaborating Centre for Drug Statistics Methodology. The Anatomical Therapeutic Chemical Classification System. Norwegian Institute of Public Health. Available at: http://www.whocc.no/atcddd/ (accessed 14 April 2010).
   Google Scholar
• Pharmaca Fennica 2010. Available at: http://www.laaketie tokeskus.fi/page.php?page_id=493 (accessed 28 October 2010).
   Google Scholar
• Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, . Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56: M146–56.
   PubMed Web of Science ®Google Scholar
• Guralnik JM, Ferrucci L, Pieper CF, Leveille SG, Markides KS, Ostir GV, . Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery. J Gerontol A Biol Sci Med Sci. 2000;55:M221–31.
   PubMed Web of Science ®Google Scholar
• Roubenoff R. Sarcopenia: a major modifiable cause of frailty in the elderly. J Nutr Health Aging. 2000;4:140–2.
   PubMedGoogle Scholar
• Bohannon RW. Hand-grip dynamometry predicts future outcomes in aging adults. J Geriatr Phys Ther. 2008;31: 3–10.
   PubMedGoogle Scholar
• Podsiadlo D, Richardson S. The timed ‘Up & Go’: a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc. 1991;39:142–8.
   PubMed Web of Science ®Google Scholar
• Shumway-Cook A, Brauer S, Woollacott M. Predicting the probability for falls in community-dwelling older adults using the Timed Up & Go Test. Phys Ther. 2000;80: 896–903.
   PubMed Web of Science ®Google Scholar
• Lawton MP, Brody EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist. 1969;9:179–86.
   PubMed Web of Science ®Google Scholar
• van der Putten JJ, Hobart JC, Freeman JA, Thompson AJ. Measuring change in disability after inpatient rehabilitation: comparison of the responsiveness of the Barthel index and the Functional Independence Measure. J Neurol Neurosurg Psychiatry. 1999;66:480–4.
   PubMed Web of Science ®Google Scholar
• Groll DL, To T, Bombardier C, Wright JG. The development of a comorbidity index with physical function as the outcome. J Clin Epidemiol. 2005;58:595–602.
   PubMed Web of Science ®Google Scholar
• Furu K, Wettermark B, Andersen M, Martikainen JE, Almarsdottir AB, Sorensen HT. The Nordic countries as a cohort for pharmacoepidemiological research. Basic Clin Pharmacol Toxicol. 2010;106:86–94.
   PubMed Web of Science ®Google Scholar
• Yesavage JA, Brink TL, Rose TL, Lum O, Huang V, Adey M, . Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res. 1982; 17:37–49.
   PubMed Web of Science ®Google Scholar
• Folstein MF, Folstein SE, McHugh PR. ‘Mini-mental state’. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189–98.
   PubMed Web of Science ®Google Scholar
• Crum RM, Anthony JC, Bassett SS, Folstein MF. Population-based norms for the Mini-Mental State Examination by age and educational level. JAMA. 1993;269:2386–91.
   PubMed Web of Science ®Google Scholar
• Hartl K, Janni W, Kastner R, Sommer H, Strobl B, Rack B, . Impact of medical and demographic factors on long-term quality of life and body image of breast cancer patients. Ann Oncol. 2003;14:1064–71.
   PubMed Web of Science ®Google Scholar
• Cooper R, Kuh D, Hardy R. Objectively measured physical capability levels and mortality: systematic review and meta-analysis. BMJ. 2010;341:c4467.
   PubMed Web of Science ®Google Scholar
• Cesari M, Kritchevsky SB, Newman AB, Simonsick EM, Harris TB, Penninx BW, . Added value of physical performance measures in predicting adverse health-related events: results from the Health, Aging And Body Composition Study. J Am Geriatr Soc. 2009;57:251–9.
   PubMed Web of Science ®Google Scholar
• Gaugler JE, Duval S, Anderson KA, Kane RL. Predicting nursing home admission in the US: a meta-analysis. BMC Geriatr. 2007;7:13.
   PubMedGoogle Scholar
• Gnjidic D, Le Couteur DG, Abernethy DR, Hilmer SN. A pilot randomized clinical trial utilizing the drug burden index to reduce exposure to anticholinergic and sedative medications in older people. Ann Pharmacother. 2010;44: 1725–32.
   PubMed Web of Science ®Google Scholar
• Alanen HM, Finne-Soveri H, Fialova D, Topinkova E, Jonsson PV, Soerbye LW, . Use of antipsychotic medications in older home-care patients. Report from nine European countries. Aging Clin Exp Res. 2008;20:260–5.
   PubMed Web of Science ®Google Scholar
• Fialova D, Topinkova E, Gambassi G, Finne-Soveri H, Jonsson PV, Carpenter I, . Potentially inappropriate medication use among elderly home care patients in Europe. JAMA. 2005;293:1348–58.
   PubMed Web of Science ®Google Scholar
• Curtis LH, Ostbye T, Sendersky V, Hutchison S, Dans PE, Wright A, . Inappropriate prescribing for elderly Americans in a large outpatient population. Arch Intern Med. 2004;164:1621–5.
   PubMed Web of Science ®Google Scholar
• Draper B, Brodaty H, Low LF, Saab D, Lie D, Richards V, . Use of psychotropics in Sydney nursing homes: associations with depression, psychosis, and behavioral disturbances. Int Psychogeriatr. 2001;13:107–20.
   PubMed Web of Science ®Google Scholar
• Gill TM. Assessment of function and disability in longitudinal studies. J Am Geriatr Soc. 2010;58 Suppl 2: S308–12.
   PubMedGoogle Scholar