4,261
Views
166
CrossRef citations to date
0
Altmetric
Review Article

Are platelet volume indices of clinical use? A multidisciplinary review

, &
Pages 805-816 | Received 01 Mar 2011, Accepted 13 Dec 2011, Published online: 13 Mar 2012

References

  • van der Loo B, Martin JF. A role for changes in platelet production in the cause of acute coronary syndromes. Arterioscler Thromb Vasc Biol. 1999;19:672–9.
  • Thompson CB, Eaton KA, Princiotta SM, Rushin CA, Valeri CR. Size dependent platelet subpopulations: relationship of platelet volume to ultrastructure, enzymatic activity, and function. Br J Haematol. 1982;50:509–19.
  • Jakubowski JA, Thompson CB, Vaillancourt R, Valeri CR, Deykin D. Arachidonic acid metabolism by platelets of differing size. Br J Haematol. 1983;53:503–11.
  • Martin JF, Trowbridge EA, Salmon G, Plumb J. The biological significance of platelet volume: its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration. Thromb Res. 1983;32:443–60.
  • Tschoepe D, Roesen P, Kaufmann L, Schauseil S, Kehrel B, Ostermann H, . Evidence for abnormal platelet glycoprotein expression in diabetes mellitus. Eur J Clin Invest. 1990;20:166–70.
  • Giles H, Smith RE, Martin JF. Platelet glycoprotein IIb-IIIa and size are increased in acute myocardial infarction. Eur J Clin Invest. 1994;24: 69–72.
  • Briggs C. Quality counts: new parameters in blood cell counting. Int J Lab Hematol. 2009;31:277–97.
  • Kaito K, Otsubo H, Usui N, Yoshida M, Tanno J, Kurihara E, . Platelet size deviation width, platelet large cell ratio, and mean platelet volume have sufficient sensitivity and specificity in the diagnosis of immune thrombocytopenia. Br J Haematol. 2005;128:698–702.
  • Farias MG, Schunck EG, Dal Bo S, de Castro SM. Definition of reference ranges for the platelet distribution width (PDW): a local need. Clin Chem Lab Med. 2010;48:255–7.
  • Bowles KM, Cooke LJ, Richards EM, Baglin TP. Platelet size has diagnostic predictive value in patients with thrombocytopenia. Clin Lab Haematol. 2005;27:370–3.
  • Ntaios G, Papadopoulos A, Chatzinikolaou A, Saouli Z, Karalazou P, Kaiafa G, . Increased values of mean platelet volume and platelet size deviation width may provide a safe positive diagnosis of idiopathic thrombocytopenic purpura. Acta Haematol. 2008;119:173–7.
  • Numbenjapon T, Mahapo N, Pornvipavee R, Sriswasdi C, Mongkonsritragoon W, Leelasiri A, . A prospective evaluation of normal mean platelet volume in discriminating hyperdestructive thrombocytopenia from hypoproductive thrombocytopenia. Int J Lab Hematol. 2008;30:408–14.
  • Lee WS, Kim TY. Mean platelet volume and platelet distribution width are useful in the differential diagnosis of aplastic anemia and idiopathic thrombocytopenic purpura. Clin Chem Lab Med. 2010; 48:1675–6.
  • ten Berg MJ, Huisman A, van den Bemt PM, den Breeijen H, Egberts TC, van Solinge WW. Discriminative value of platelet size indices for the identification of the mechanism of chemotherapy- induced thrombocytopenia. Biomarkers. 2011;16:51–7.
  • Chandra H, Chandra S, Rawat A, Verma SK. Role of mean platelet volume as discriminating guide for bone marrow disease in patients with thrombocytopenia. Int J Lab Hematol. 2010;32:498–505.
  • Tomita E, Akatsuka JI, Kokubun Y. Differential diagnosis of various thrombocytopenias in childhood by analysis of platelet volume. Pediatr Res. 1980;14:133–7.
  • Niethammer AG, Forman EN. Use of the platelet histogram maximum in evaluating thrombocytopenia. Am J Hematol. 1999;60:19–23.
  • Noris P, Klersy C, Zecca M, Arcaini L, Pecci A, Melazzini F, . Platelet size distinguishes between inherited macrothrombocytopenias and immune thrombocytopenia. J Thromb Haemost. 2009; 7:2131–6.
  • Naina HV, Harris S. Platelet and red blood cell indices in Harris platelet syndrome. Platelets. 2010;21:303–6.
  • Chandra H, Chandra S, Rawat A, Verma SK. Megaloblastic pancytopenia vis-a-vis non-megaloblastic pancytopenia: is mean platelet volume useful discriminating indicator. Int J Lab Hematol. 2011; 33:409–13.
  • Parker LS. Thrombocytopenia caused by immunologic platelet destruction. In: Lee R, Forrester J, Lukens J, Paraskevas F, Greer J, Rodgers G, editors. Wintrobe's clinical haematology. Baltimore, MD: Williams & Wilkins; 1999. p. 1589.
  • Mannucci PM, Sharp AA. Platelet volume and shape in relation to aggregation and adhesion. Br J Haematol. 1967;13:604–17.
  • Hirsh J, Glynn MF, Mustard JF. The effect of platelet age on platelet adherence to collagen. J Clin Invest. 1968;47:466–73.
  • Shulman NR, Watkins SP Jr, Itscoitz SB, Students AB. Evidence that the spleen retains the youngest and hemostatically most effective platelets. Trans Assoc Am Physicians. 1968;81:302–13.
  • Karpatkin S. Heterogeneity of human platelets. I. Metabolic and kinetic evidence suggestive of young and old platelets. J Clin Invest. 1969;48: 1073–82.
  • Karpatkin S. Heterogeneity of human platelets. II. Functional evidence suggestive of young and old platelets. J Clin Invest. 1969;48: 1083–87.
  • Harker LA, Slichter SJ. The bleeding time as a screening test for evaluation of platelet function. N Engl J Med. 1972;287:155–9.
  • Kraytman M. Platelet size in thrombocytopenias and thrombocytosis of various origin. Blood. 1973;41:587–98.
  • Karpatkin S. Heterogeneity of human platelets. VI. Correlation of platelet function with platelet volume. Blood. 1978;51:307–16.
  • Haver VM, Gear AR. Functional fractionation of platelets. J Lab Clin Med. 1981;97:187–204.
  • Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis. 1996;7:157–61.
  • Martin JF, Bath PM. Platelets and megakaryocytes in vascular disease. In: Herman AG, editor. Antithrombotics: pathophysiological rationale for pharmacological inventions. Boston, MA: Kluwer Academic Publishers; 2001. p. 49–62.
  • Rand ML, Dean JA. Platelet function in autoimmune (idiopathic) thrombocytopenic purpura. Acta Paediatr Suppl. 1998;424:57–60.
  • Eldor A, Avitzour M, Or R, Hanna R, Penchas S. Prediction of haemorrhagic diathesis in thrombocytopenia by mean platelet volume. Br Med J (Clin Res Ed). 1982;285:397–400.
  • Klimiuk PS, Holt PJ, Clague RB, Herod E, Dyer PA. Predictive value of mean platelet volume in gold induced thrombocytopenia. Ann Rheum Dis. 1987;46:38–41.
  • Makay B, Turkyilmaz Z, Duman M, Unsal E. Mean platelet volume in Henoch-Schonlein purpura: relationship to gastrointestinal bleeding. Clin Rheumatol. 2009;28:1225–8.
  • Van der Lelie J, Von dem Borne AK. Platelet volume analysis for differential diagnosis of thrombocytosis. J Clin Pathol. 1986;39: 129–33.
  • Baynes RD, Lamparelli RD, Bezwoda WR, Gear AJ, Chetty N, Atkinson P. Platelet parameters. Part II. Platelet volume-number relationships in various normal and disease states. S Afr Med J. 1988;73:39–43.
  • Osselaer JC, Jamart J, Scheiff JM. Platelet distribution width for differential diagnosis of thrombocytosis. Clin Chem. 1997;43 (Pt 1):1072–6.
  • Syed NN, Usman M, Khurshid M. Thrombocytosis: age dependent aetiology and analysis of platelet indices for differential diagnosis. Indian J Pathol Microbiol. 2007;50:628–33.
  • Sehayek E, Ben-Yosef N, Modan M, Chetrit A, Meytes D. Platelet parameters and aggregation in essential and reactive thrombocytosis. Am J Clin Pathol. 1988;90:431–6.
  • Small BM, Bettigole RE. Diagnosis of myeloproliferative disease by analysis of the platelet volume distribution. Am J Clin Pathol. 1981;76:685–91.
  • Babu E, Basu D. Platelet large cell ratio in the differential diagnosis of abnormal platelet counts. Indian J Pathol Microbiol. 2004; 47:202–5.
  • Slavka G, Perkmann T, Haslacher H, Greisenegger S, Marsik C, Wagner OF, . Mean platelet volume may represent a predictive parameter for overall vascular mortality and ischemic heart disease. Arterioscler Thromb Vasc Biol. 2011;31:1215–8.
  • Muscari A, De Pascalis S, Cenni A, Ludovico C, Castaldini N, Antonelli S, . Determinants of mean platelet volume (MPV) in an elderly population: relevance of body fat, blood glucose and ischaemic electrocardiographic changes. Thromb Haemost. 2008;99: 1079–84.
  • Hekimsoy Z, Payzin B, Ornek T, Kandogan G. Mean platelet volume in type 2 diabetic patients. J Diabetes Complications. 2004;18: 173–6.
  • Coban E, Bostan F, Ozdogan M. The mean platelet volume in subjects with impaired fasting glucose. Platelets. 2006;17:67–9.
  • Varol E, Akcay S, Ozaydin M, Erdogan D, Dogan A, Altinbas A. Mean platelet volume is associated with insulin resistance in non-obese, non-diabetic patients with coronary artery disease. J Cardiol. 2010; 56:154–8.
  • Nadar SK, Blann AD, Kamath S, Beevers DG, Lip GY. Platelet indexes in relation to target organ damage in high-risk hypertensive patients: a substudy of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT). J Am Coll Cardiol. 2004;44:415–22.
  • Coban E, Yazicioglu G, Berkant Avci A, Akcit F. The mean platelet volume in patients with essential and white coat hypertension. Platelets. 2005;16:435–8.
  • Boos CJ, Beevers GD, Lip GY. Assessment of platelet activation indices using the ADVIATM 120 amongst ‘high-risk’ patients with hypertension. Ann Med. 2007;39:72–8.
  • Varol E, Akcay S, Icli A, Yucel H, Ozkan E, Erdogan D, . Mean platelet volume in patients with prehypertension and hypertension. Clin Hemorheol Microcirc. 2010;45:67–72.
  • Coban E, Afacan B. The effect of rosuvastatin treatment on the mean platelet volume in patients with uncontrolled primary dyslipidemia with hypolipidemic diet treatment. Platelets. 2008;19:111–4.
  • Demirtunc R, Duman D, Basar M. Effects of doxazosin and amlodipine on mean platelet volume and serum serotonin level in patients with metabolic syndrome: a randomised, controlled study. Clin Drug Investig. 2007;27:435–41.
  • Kario K, Matsuo T, Nakao K. Cigarette smoking increases the mean platelet volume in elderly patients with risk factors for atherosclerosis. Clin Lab Haematol. 1992;14:281–7.
  • Papanas N, Symeonidis G, Maltezos E, Mavridis G, Karavageli E, Vosnakidis T, . Mean platelet volume in patients with type 2 diabetes mellitus. Platelets. 2004;15:475–8.
  • Demirtunc R, Duman D, Basar M, Bilgi M, Teomete M, Garip T. The relationship between glycemic control and platelet activity in type 2 diabetes mellitus. J Diabetes Complications. 2009;23:89–94.
  • Jindal S, Gupta S, Gupta R, Kakkar A, Singh HV, Gupta K, . Platelet indices in diabetes mellitus: indicators of diabetic microvascular complications. Hematology. 2011;16:86–9.
  • Inanc T, Kaya MG, Yarlioglues M, Ardic I, Ozdogru I, Dogan A, . The mean platelet volume in patients with non-dipper hypertension compared to dippers and normotensives. Blood Press. 2010; 19:81–5.
  • Yarlioglues M, Kaya MG, Ardic I, Dogdu O, Kasapkara HA, Gunturk E, . Relationship between mean platelet volume levels and subclinical target organ damage in newly diagnosed hypertensive patients. Blood Press. 2011;20:92–7.
  • Gupta RK, Kjeldsen SE, Motley E, Weder AB, Zweifler AJ, Julius S. Platelet function during antihypertensive treatment with quinapril, a novel angiotensin converting enzyme inhibitor. J Cardiovasc Pharmacol. 1991;17:13–19.
  • Pathansali R, Smith NM, Bath PM. Prothrombotic megakaryocyte and platelet changes in hypertension are reversed following treatment: a pilot study. Platelets. 2001;12:144–9.
  • Bath P, Algert C, Chapman N, Neal B; PROGRESS Collaborative Group. Association of mean platelet volume with risk of stroke among 3134 individuals with history of cerebrovascular disease. Stroke. 2004;35:622–6.
  • Yazici M, Kaya A, Kaya Y, Albayrak S, Cinemre H, Ozhan H. Lifestyle modification decreases the mean platelet volume in prehypertensive patients. Platelets. 2009;20:58–63.
  • Ozhan H, Aydin M, Yazici M, Yazgan O, Basar C, Gungor A, . Mean platelet volume in patients with non-alcoholic fatty liver disease. Platelets. 2010;21:29–32.
  • Shin WY, Jung DH, Shim JY, Lee HR. The association between non-alcoholic hepatic steatosis and mean platelet volume in an obese Korean population. Platelets. 2011;22:442–6.
  • Lattimore JD, Celermajer DS, Wilcox I. Obstructive sleep apnea and cardiovascular disease. J Am Coll Cardiol. 2003;41:1429–37.
  • Varol E, Ozturk O, Gonca T, Has M, Ozaydin M, Erdogan D, . Mean platelet volume is increased in patients with severe obstructive sleep apnea. Scand J Clin Lab Invest. 2010;70:49–502.
  • Varol E, Ozturk O, Yucel H, Gonca T, Has M, Dogan A, . The effects of continuous positive airway pressure therapy on mean platelet volume in patients with obstructive sleep apnea. Platelets. 2011; 22:552–6.
  • Berger JS, Eraso LH, Xie D, Sha D, Mohler ER 3rd. Mean platelet volume and prevalence of peripheral artery disease, the National Health and Nutrition Examination Survey, 1999–2004. Atherosclerosis. 2010;213:58–91.
  • Wang RT, Li Y, Zhu XY, Zhang YN. Increased mean platelet volume is associated with arterial stiffness. Platelets. 2011;22:447–51.
  • Jung DH, Lee HR, Lee YJ, Kim JK, Park BJ, Shim JY. The association between coronary artery calcification and mean platelet volume in the general population. Platelets. 2011;22:567–71.
  • Haberl R, Becker A, Leber A, Knez A, Becker C, Lang C, . Correlation of coronary calcification and angiographically documented stenoses in patients with suspected coronary artery disease: results of 1,764 patients. J Am Coll Cardiol. 2001;37:451–7.
  • Budoff MJ, Gul KM. Expert review on coronary calcium. Vasc Health Risk Manag. 2008;4:315–24.
  • De Luca G, Santagostino M, Secco GG, Cassetti E, Giuliani L, Franchi E, . Mean platelet volume and the extent of coronary artery disease: results from a large prospective study. Atherosclerosis. 2009; 206:292–7.
  • Kilciler G, Genc H, Tapan S, Ors F, Kara M, Karadurmus N, . Mean platelet volume and its relationship with carotid atherosclerosis in subjects with non-alcoholic fatty liver disease. Ups J Med Sci. 2010;115:253–9.
  • Endler G, Klimesch A, Sunder-Plassmann H, Schillinger M, Exner M, Mannhalter C, . Mean platelet volume is an independent risk factor for myocardial infarction but not for coronary artery disease. Br J Haematol. 2002;117:399–404.
  • De Luca G, Venegoni L, Iorio S, Secco GG, Cassetti E, Verdoia M, . Platelet distribution width and the extent of coronary artery disease: results from a large prospective study. Platelets. 2010;21:508–14.
  • Choi CU, Seo HS, Kim YK, Na JO, Lim HE, Kim JW, . Can mean platelet volume predict coronary vasospasm? Platelets. 2011; 22:173–8.
  • Chu H, Chen WL, Huang CC, Chang HY, Kuo HY, Gau CM, . Diagnostic performance of mean platelet volume for patients with acute coronary syndrome visiting an emergency department with acute chest pain: the Chinese scenario. Emerg Med J. 2011;28: 569–74.
  • Yilmaz MB, Cihan G, Guray Y, Guray U, Kisacik HL, Sasmaz H, . Role of mean platelet volume in triagging acute coronary syndromes. J Thromb Thrombolysis. 2008;26:49–54.
  • Chu SG, Becker RC, Berger PB, Bhatt DL, Eikelboom JW, Konkle B, . Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost. 2010;8: 148–56.
  • Klovaite J, Benn M, Yazdanyar S, Nordestgaard BG. High platelet volume and increased risk of myocardial infarction: 39,531 participants from the general population. J Thromb Haemost. 2011;9:49–56.
  • Cameron HA, Phillips R, Ibbotson RM, Carson PH. Platelet size in myocardial infarction. Br Med J (Clin Res Ed). 1983;287:449–51.
  • Pizzulli L, Yang A, Martin JF, Luderitz B. Changes in platelet size and count in unstable angina compared to stable angina or non-cardiac chest pain. Eur Heart J. 1998;19:80–4.
  • Martin JF, Bath PM, Burr ML. Influence of platelet size on outcome after myocardial infarction. Lancet. 1991;338:1409–11.
  • Huczek Z, Kochman J, Filipiak KJ, Horszczaruk GJ, Grabowski M, Piatkowski R, . Mean platelet volume on admission predicts impaired reperfusion and long-term mortality in acute myocardial infarction treated with primary percutaneous coronary intervention. J Am Coll Cardiol. 2005;46:284–90.
  • Estevez-Loureiro R, Salgado-Fernandez J, Marzoa-Rivas R, Barge-Caballero E, Perez-Perez A, Noriega-Concepcion V, . Mean platelet volume predicts patency of the infarct-related artery before mechanical reperfusion and short-term mortality in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Thromb Res. 2009;124:536–40.
  • Maden O, Kacmaz F, Selcuk H, Selcuk MT, Aksu T, Tufekcioglu O, . Relationship of admission hematological indexes with myocardial reperfusion abnormalities in acute ST segment elevation myocardial infarction patients treated with primary percutaneous coronary interventions. Can J Cardiol. 2009;25:e164–8.
  • Pereg D, Berlin T, Mosseri M. Mean platelet volume on admission correlates with impaired response to thrombolysis in patients with ST-elevation myocardial infarction. Platelets. 2010;21:117–21.
  • Taglieri N, Saia F, Rapezzi C, Marrozzini C, Bacchi Reggiani ML, Palmerini T, . Prognostic significance of mean platelet volume on admission in an unselected cohort of patients with non ST-segment elevation acute coronary syndrome. Thromb Haemost. 2011;106: 132–40.
  • Lopez-Cuenca AA, Tello-Montoliu A, Roldan V, Perez-Berbel P, Valdes M, Marin F. Prognostic value of mean platelet volume in patients with non-ST-elevation acute coronary syndrome. Angiology. 2011 Jul 6. [Epub ahead of print].
  • Bessman JD, Williams LJ, Gilmer PR Jr. Mean platelet volume. The inverse relation of platelet size and count in normal subjects, and an artifact of other particles. Am J Clin Pathol. 1981;76:289–93.
  • Lamparelli RD, Baynes RD, Atkinson P, Bezwoda WR, Mendelow BV. Platelet parameters. Part I. Platelet counts and mean platelet volume in normal and pregnant subjects. S Afr Med J. 1988;73:36–9.
  • Azab B, Torbey E, Singh J, Akerman M, Khoueiry G, McGinn JT, . Mean platelet volume/platelet count ratio as a predictor of long-term mortality after non-ST-elevation myocardial infarction. Platelets. 2011;22:557–66.
  • Goncalves SC, Labinaz M, Le May M, Glover C, Froeschl M, Marquis JF, . Usefulness of mean platelet volume as a biomarker for long-term outcomes after percutaneous coronary intervention. Am J Cardiol. 2011;107:204–9.
  • Duygu H, Turkoglu C, Kirilmaz B, Turk U. Effect of mean platelet volume on postintervention coronary blood flow in patients with chronic stable angina pectoris. J Invasive Cardiol. 2008;20:120–4.
  • Huczek Z, Filipiak KJ, Kochman J, Michalak M, Roik M, Piatkowski R, . Baseline platelet size is increased in patients with acute coronary syndromes developing early stent thrombosis and predicts future residual platelet reactivity. A case-control study. Thromb Res. 2010; 125:406–12.
  • Yang A, Pizzulli L, Luderitz B. Mean platelet volume as marker of restenosis after percutaneous transluminal coronary angioplasty in patients with stable and unstable angina pectoris. Thromb Res. 2006;117:371–7.
  • Kandis H, Ozhan H, Ordu S, Erden I, Caglar O, Basar C, . The prognostic value of mean platelet volume in decompensated heart failure. Emerg Med J. 2011;28:575–8.
  • Yilmaz MB, Ozeke O, Akin Y, Guray U, Biyikoglu SF, Kisacik HL, . Platelet aggregation in left ventricular thrombus formation after acute anterior myocardial infarction: mean platelet volume. Int J Cardiol. 2003;90:123–5.
  • Yilmaz MB, Akin Y, Biyikoglu SF, Guray U, Kisacik HL, Korkmaz S. Left ventricular thrombosis is associated with increased mean platelet volume in patients with dilated cardiomyopathy and sinus rhythm. Acta Cardiol. 2004;59:41–5.
  • Ha SI, Choi DH, Ki YJ, Yang JS, Park G, Chung JW, . Stroke prediction using mean platelet volume in patients with atrial fibrillation. Platelets. 2011;22:408–14.
  • Yuce M, Cakici M, Davutoglu V, Ozer O, Sari I, Ercan S, . Relationship between mean platelet volume and atrial thrombus in patients with atrial fibrillation. Blood Coagul Fibrinolysis. 2010;21:722–5.
  • Varol E, Ozaydin M, Turker Y, Alaca S. Mean platelet volume, an indicator of platelet activation, is increased in patients with mitral stenosis and sinus rhythm. Scand J Clin Lab Invest. 2009;69:708–12.
  • Yavuz B, Ertugrul DT, Yalcin AA, Kucukazman M, Ata N, Dal K. Increased mean platelet volume in rheumatic mitral stenosis: a possible factor for thromboembolic events. J Cardiol. 2009;53:204–7.
  • Varol E, Arslan A, Yucel H, Ozaydin M, Erdogan D, Dogan A. Increased mean platelet volume in patients with aortic stenosis. Clin Appl Thromb Hemost. 2010 Aug 3. [Epub ahead of print].
  • Mayda-Domac F, Misirli H, Yilmaz M. Prognostic role of mean platelet volume and platelet count in ischemic and hemorrhagic stroke. J Stroke Cerebrovasc Dis. 2010;19:66–72.
  • McCabe DJ, Harrison P, Sidhu PS, Brown MM, Machin SJ. Circulating reticulated platelets in the early and late phases after ischaemic stroke and transient ischaemic attack. Br J Haematol. 2004;126:861–9.
  • Tohgi H, Suzuki H, Tamura K, Kimura B. Platelet volume, aggregation, and adenosine triphosphate release in cerebral thrombosis. Stroke. 1991;22:17–21.
  • Nadar SK, Lip GY, Blann AD. Platelet morphology, soluble P selectin and platelet P-selectin in acute ischaemic stroke. The West Birmingham Stroke Project. Thromb Haemost. 2004;92:1342–8.
  • Butterworth RJ, Bath PM. The relationship between mean platelet volume, stroke subtype and clinical outcome. Platelets. 1998;9:359–64.
  • Muscari A, Puddu GM, Cenni A, Silvestri MG, Giuzio R, Rosati M, . Mean platelet volume (MPV) increase during acute non-lacunar ischemic strokes. Thromb Res. 2009;123:587–91.
  • Pikija S, Cvetko D, Hajduk M, Trkulja V. Higher mean platelet volume determined shortly after the symptom onset in acute ischemic stroke patients is associated with a larger infarct volume on CT brain scans and with worse clinical outcome. Clin Neurol Neurosurg. 2009; 111:568–73.
  • Ntaios G, Gurer O, Faouzi M, Aubert C, Michel P. Mean platelet volume in the early phase of acute ischemic stroke is not associated with severity or functional outcome. Cerebrovasc Dis. 2010;29:484–9.
  • Braekkan SK, Mathiesen EB, Njolstad I, Wilsgaard T, Stormer J, Hansen JB. Mean platelet volume is a risk factor for venous thromboembolism: the Tromso Study, Tromso, Norway. J Thromb Haemost. 2010;8:157–62.
  • Kostrubiec M, Labyk A, Pedowska-Wloszek J, Hrynkiewicz- Szymanska A, Pacho S, Jankowski K, . Mean platelet volume predicts early death in acute pulmonary embolism. Heart. 2010;96:460–5.
  • Varol E, Icli A, Uysal BA, Ozaydin M. Platelet indices in patients with acute pulmonary embolism. Scand J Clin Lab Invest. 2011;71:163–7.
  • Acikgoz N, Karincaoglu Y, Ermis N, Yagmur J, Atas H, Kurtoglu E, . Increased mean platelet volume in Behcet's disease with thrombotic tendency. Tohoku J Exp Med. 2010;221:119–23.
  • Sharpe PC, Desai ZR, Morris TC. Increase in mean platelet volume in patients with chronic renal failure treated with erythropoietin. J Clin Pathol. 1994;47:159–61.
  • Jagroop IA, Tsiara S, Mikhailidis DP. Mean platelet volume as an indicator of platelet activation: methodological issues. Platelets. 2003;14:335–6.
  • Jagroop IA, Mikhailidis DP. Mean platelet volume is an independent risk factor for myocardial infarction but not for coronary artery disease. Br J Haematol. 2003;120:169–70.
  • Bozkurt N, Yilmaz E, Biri A, Taner Z, Himmetoglu O. The mean platelet volume in gestational diabetes. J Thromb Thrombolysis. 2006; 22:51–4.
  • Erikci AA, Muhcu M, Dundar O, Ozturk A. Could mean platelet volume be a predictive marker for gestational diabetes mellitus? Hematology. 2008;13:46–8.
  • Hutt R, Ogunniyi SO, Sullivan MH, Elder MG. Increased platelet volume and aggregation precede the onset of preeclampsia. Obstet Gynecol. 1994;83:146–9.
  • Dundar O, Yoruk P, Tutuncu L, Erikci AA, Muhcu M, Ergur AR, . Longitudinal study of platelet size changes in gestation and predictive power of elevated MPV in development of pre-eclampsia. Prenat Diagn. 2008;28:1052–6.
  • Ceyhan T, Beyan C, Baser I, Kaptan K, Gungor S, Ifran A. The effect of pre-eclampsia on complete blood count, platelet count and mean platelet volume. Ann Hematol. 2006;85:320–2.
  • Gioia S, Piazze J, Anceschi MM, Cerekja A, Alberini A, Giancotti A, . Mean platelet volume: association with adverse neonatal outcome. Platelets. 2007;18:284–8.
  • Milovanovic M, Nilsson E, Jaremo P. Relationships between platelets and inflammatory markers in rheumatoid arthritis. Clin Chim Acta. 2004;343:237–40.
  • Kayahan H, Akarsu M, Ozcan MA, Demir S, Ates H, Unsal B, . Reticulated platelet levels in patients with ulcerative colitis. Int J Colorectal Dis. 2007;22:1429–35.
  • Canpolat F, Akpinar H, Eskioglu F. Mean platelet volume in psoriasis and psoriatic arthritis. Clin Rheumatol. 2010;29:325–8.
  • Magen E, Mishal J, Zeldin Y, Feldman V, Kidon M, Schlesinger M, . Increased mean platelet volume and C-reactive protein levels in patients with chronic urticaria with a positive autologous serum skin test. Am J Med Sci. 2010;339:504–8.
  • Yazici S, Yazici M, Erer B, Erer B, Calik Y, Bulur S, . The platelet functions in patients with ankylosing spondylitis: anti-TNF-alpha therapy decreases the mean platelet volume and platelet mass. Platelets. 2010;21:126–31.
  • Yazici S, Yazici M, Erer B, Erer B, Calik Y, Ozhan H, . The platelet indices in patients with rheumatoid arthritis: mean platelet volume reflects disease activity. Platelets. 2010;21:122–5.
  • Kim DA, Kim TY. Controversies over the interpretation of changes of mean platelet volume in rheumatoid arthritis. Platelets. 2011; 22:77–8.
  • Kisacik B, Tufan A, Kalyoncu U, Karadag O, Akdogan A, Ozturk MA, . Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis. Joint Bone Spine. 2008;75:291–4.
  • Gunebakmaz O, Kaya MG, Kaya EG, Ardic I, Yarlioglues M, Dogdu O, . Mean platelet volume predicts embolic complications and prognosis in infective endocarditis. Int J Infect Dis. 2010;14:e982–5.
  • Makay B, Turkyilmaz Z, Unsal E. Mean platelet volume in children with familial Mediterranean fever. Clin Rheumatol. 2009;28:975–8.
  • Yuksel O, Helvaci K, Basar O, Koklu S, Caner S, Helvaci N, . An overlooked indicator of disease activity in ulcerative colitis: mean platelet volume. Platelets. 2009;20:277–81.
  • Biljak VR, Pancirov D, Cepelak I, Popovic-Grle S, Stjepanovic G, Grubisic TZ. Platelet count, mean platelet volume and smoking status in stable chronic obstructive pulmonary disease. Platelets. 2011;22: 466–70.
  • Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des. 2011;17:47–58.
  • Varol E, Uysal BA, Ozaydin M. Platelet indices in patients with pulmonary arterial hypertension. Clin Appl Thromb Hemost. 2011 Mar 14. [Epub ahead of print].
  • Yilmaz H, Ertugrul O, Ertugrul B, Ertugrul D. Mean platelet volume in patients with subclinical hypothyroidism. Platelets. 2011;22: 143–7.
  • Purnak T, Efe C, Yuksel O, Beyazit Y, Ozaslan E, Altiparmak E. Mean platelet volume could be a promising biomarker to monitor dietary compliance in celiac disease. Ups J Med Sci. 2011;116:208–11.
  • Bowles KM, Bloxham DM, Perry DJ, Baglin TP. Discrepancy between impedance and immunofluorescence platelet counting has implications for clinical decision making in patients with idiopathic thrombocytopenia purpura. Br J Haematol. 2006;134:320–2.
  • Diquattro M, Gagliano F, Calabro GM, Tommasi M, Scott CS, Mancuso G, . Relationships between platelet counts, platelet volumes and reticulated platelets in patients with ITP: evidence for significant platelet count inaccuracies with conventional instrument methods. Int J Lab Hematol. 2009;31:199–206.
  • Patterson K. Platelet parameters generated by automated blood counters. CME Bull Haematol. 1997;1:13–16.
  • Dastjerdi MS, Emami T, Najafian A, Amini M. Mean platelet volume measurement, EDTA or citrate? Hematology. 2006;11:317–9.
  • Diaz-Ricart M, Brunso L, Pino M, Navalon F, Jou JM, Heras M, . Preanalytical treatment of EDTA-anticoagulated blood to ensure stabilization of the mean platelet volume and component measured with the ADVIA counters. Thromb Res. 2010;126:e30–5.
  • Lance MD, van Oerle R, Henskens YM, Marcus MA. Do we need time adjusted mean platelet volume measurements? Lab Hematol. 2010; 16:28–31.
  • Demirin H, Ozhan H, Ucgun T, Celer A, Bulur S, Cil H, . Normal range of mean platelet volume in healthy subjects: Insight from a large epidemiologic study. Thromb Res. 2011;128:358–60.
  • Briggs C, Harrison P, Machin SJ. Continuing developments with the automated platelet count. Int J Lab Hematol. 2007;29:77–91.
  • Vizioli L, Muscari S, Muscari A. The relationship of mean platelet volume with the risk and prognosis of cardiovascular diseases. Int J Clin Pract. 2009;63:1509–15.
  • Kuwana M, Kurata Y, Fujimura K, Fujisawa K, Wada H, Nagasawa T, . Preliminary laboratory based diagnostic criteria for immune thrombocytopenic purpura: evaluation by multi-center prospective study. J Thromb Haemost. 2006;4:1936–43.
  • Soranzo N, Rendon A, Gieger C, Jones CI, Watkins NA, Menzel S, . A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts, and function. Blood. 2009;113:3831–7.
  • Lippi G, Filippozzi L, Salvagno GL, Montagnana M, Franchini M, Guidi GC, . Increased mean platelet volume in patients with acute coronary syndromes. Arch Pathol Lab Med. 2009;133:1441–3.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.