1,147
Views
55
CrossRef citations to date
0
Altmetric
Review Article

Antihypertensive effects of bioactive tripeptides—a random effects meta-analysis

, , , &
Pages 51-56 | Received 19 Jul 2011, Accepted 23 Jan 2012, Published online: 09 Mar 2012

References

  • Miller ED Jr, Samuel AI, Haber E, Barger AC. Inhibition of angiotensin conversion in experimental renovascular hypertension. Science. 1972;177:1106–9.
  • Jäkälä P, Vapaatalo H. Antihypertensive peptides from milk protein. Pharmaceuticals. 2010;3:251–72.
  • Nakamura Y, Yamamoto N, Sakai K, Okubo A, Yamazaki S, Takano T. Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk. J Dairy Sci. 1995;78:777–83.
  • Masuda O, Nakamura Y, Takano T. Antihypertensive peptides are present in aorta after oral administration of sour milk containing these peptides in spontaneously hypertensive rats. J Nutr. 1996;126:3063–8.
  • Luhtala S, Vaajanen A, Oksala O, Valjakka J, Vapaatalo H. Activities of angiotensin-converting enzymes ACE1 and ACE2 and inhibition by bioactive peptides in porcine tissues. J Ocul Pharmacol Ther. 2009;25:23–8.
  • Leo FD, Panarese S, Gallerani R, Ceci LR. Angiotensin converting enzyme (ACE) inhibitory peptides: production and implementation of functional food. Curr Pharmaceut Des. 2009;15:3622–43.
  • Ehlers PI, Kivimäki AS, Turpeinen AM, Korpela R, Vapaatalo H. High blood pressure lowering and vasoprotective effects of milk products in experimental hypertension. Br J Nutr. 2011;106:1353–63.
  • Engberink MF, Schouten EG, Kok FJ, van Mierlo LAJ, Brouwer IA, Geleijnse JM. Lactotripeptides show no effect in human blood pressure. Hypertension. 2008;51:399–405.
  • van Mierlo LAJ, Koning MMG, van der Zander K, Draijer R. Lactotripeptides do not lower blood pressure in untreated whites: Results from 2 controlled multicenter crossover studies. Am J Clin Nutr. 2009;89:617–23.
  • van der Zander K, Bots ML, Bak AAA, Koning MMG, de Leeuw PW. Enzymatically hydrolyzed lactotripeptides do not lower blood pressure in mildly hypertensive subjects. Am J Clin Nutr. 2008;88:1697–702.
  • Xu J-Y, Qin L-Q, Wang P-Y, Li W, Chang C. Effects of milk tripeptides on blood pressure: A meta-analysis of randomized controlled trials. Nutrition. 2008;24:933–40.
  • Cicero AFG, Gerocarni B, Laghi L, Borghi C. Blood pressure lowering effect of lactotripeptides assumed as functional foods: a meta-analysis of current available clinical trials. J Hum Hypertens. 2010;25:1–12.
  • Pripp AH. Effect of peptides derived from food proteins on blood pressure: a meta-analysis of randomized controlled trials. Food Nutr Res. 2008;52. doi: 10.3402/fnr.v25i0.1641.
  • Hata Y, Yamamoto M, Ohni M, Nakajima K, Nakamura Y, Takano T. A placebo-controlled study of the effect of sour milk on blood pressure in hypertensive subjects. Am J Clin Nutr. 1996;64:767–71.
  • Kajimoto O, Aihara K, Hirata H, Takahashi R, Nakamura Y. Hypotensive effects of tablets containing “lactotripeptides (VPP, IPP)”. J Nutr Food. 2001;4:51–61.
  • Kajimoto O, Nakamura Y, Yada H, Moriguchi S, Hirata H, Takahashi T. Hypotensive effects of sour milk in subjects with mild or moderate hypertension. J Jpn Soc Nutr Food Sci. 2001;54:347–54.
  • Kajimoto O, Kurosaki T, Mizutani J, Nagisa I, Kaneko K, Aihara K, . Antihypertensive effects of liquid yoghurts containing “lactotripeptides (VPP, IPP)” in mild hypertensive subjects. J Nutr Food. 2002;5: 55–66.
  • Hirata H, Nakamura Y, Yada H, Moriguchi S, Kajimoto O, Takahashi T. Clinical effects of new sour milk drink on mild or moderate hypertensive subjects. J New Rem Clin. 2002;51:61–9.
  • Seppo L, Kerojoki O, Suomalainen T, Korpela R. The effect of a Lactobacillus helveticus LBK-16H fermented milk on hypertension—a pilot study on humans. Milchwissenschaft. 2002;57:124–7.
  • Seppo L, Jauhiainen T, Poussa T, Korpela R. A fermented milk high in bioactive peptides has a blood pressure-lowering effect in hypertensive subjects. Am J Clin Nutr. 2003;77:326–30.
  • Mizushima S, Oshige K, Watanabe J, Kimura M, Kadowaki T, Nakamura Y, . Randomized controlled trial of sour milk on blood pressure in borderline hypertensive men. Am J Hypertens. 2004;17: 701–6.
  • Nakamura Y, Kajimoto O, Kaneko K, Aihara K, Mizutani J, Ikeda N, . Effects of the liquid yogurts containing “lactotripeptide (VPP, IPP)” on high normal blood pressure. J Nutr Food. 2004;7:123–37.
  • Tuomilehto J, Lindström J, Hyyrynen J, Korpela R, Karhunen M-L, Mikkola L, . Effect of ingesting sour milk fermented using Lactobacillus helveticus bacteria producing peptides on blood pressure in subjects with mild hypertension. J Hum Hypertens. 2004;18:795–802.
  • Mizuno S, Matsuura K, Gotou T, Nishimura S, Kajimoto O, Yabune M, . Antihypertensive effect of casein hydrolysate in a placebo-controlled study in subjects with high-normal blood pressure and mild hypertension. Br J Nutr. 2005;94:84–91.
  • Sano J, Ohki K, Higuchi T, Aihara K, Mizuno S, Kajimoto O, . Effect of casein hydrolysate, prepared with protease derived from Aspergillus oruzae on subjects with high-normal blood pressure or mild hypertension. J Med Food. 2005;8:423–30.
  • van der Zander K, Jäkel M, Bianco V, Koning MMG. Fermented lactotripeptides-containing milk lowers daytime blood pressure in high normal-to-mild hypertensive subjects. J Hum Hypertens. 2008;22: 804–6.
  • de Leeuw PW, van der Zander K, Kroon AA, Rennenberg RMW, Koning MMG. Dose-dependent lowering of blood pressure by dairy peptides in mildly hypertensive subjects. Blood Press. 2009;18:44–50.
  • Turpeinen AM, Kumpu M, Rönnback M, Seppo L, Kautiainen H, Jauhiainen T, . Antihypertensive and cholesterol-lowering effects of a spread containing bioactive peptides Ile-Pro-Pro and Val-Pro-Pro and plant sterols. J Funct Foods. 2009;1:260–5.
  • Jauhiainen T, Rönnback M, Vapaatalo H, Wuolle K, Kautiainen H, Groop P-H, . Long-term intervention with Lactobacillus helveticus fermented milk reduces augmentation index in hypertensive subjects. Eur J Clin Nutr. 2010;64:424–31.
  • Collins R, MacMahon S. Blood pressure, antihypertensive drug treatment and the risks of stroke and coronary heart disease. Br Med Bull. 1994:365:272–98.
  • Krousel-Wood MA, Muntner P, He J, Whelton PK. Primary prevention of essential hypertension. Med Clin North Am. 2004:88: 223–38.
  • Jauhiainen T, Wuolle K, Vapaatalo H, Kerojoki O, Nurmela K, Lowrie C, . Oral absorption, tissue distribution and excretion of radiolabelled analog of milk-derived antihypertensive peptide, Ile-Pro-Pro in rats. Int Dairy J. 2007;17:1216–23.
  • Jauhiainen T, Rönnback M, Vapaatalo H, Wuolle K, Kautiainen H, Korpela R. Lactobacillus helveticus fermented milk reduces arterial stiffness in hypertensive subjects. Int Dairy J. 2007;17:1209–11.
  • van Mierlo LAJ, Arends LR, Streppel MT, Zeegers MPA, Kok FJ, Grobbee DE, . Blood pressure response to calcium supplementation: a meta-analysis of randomized controlled trials. J Hum Hypertens. 2006;20:571–80.
  • Whelton PK, He J, Cutler JA, Brancati FL, Appel LJ, Follmann D, . Effect of oral potassium on blood pressure. Meta-analysis of randomized controled clinical trials. JAMA. 1997;277:1624–32.
  • Dickinson HO, Nicolson D, Campbell F, Beyer FR, Mason J. Potassium supplementation for the management of primary hypertension in adults. Cochrane Database Syst Rev. 2006;3:CD004641.
  • Cicero AFG, Rosticci M, Veronesi M, Bacchelli S, Strocchi E, Melegari C, . Hemodynamic effects of lactotripeptides from casein hydrolysate in Mediterranean normotensive subjects and patients with high-normal blood pressure: a randomized, double-blind, crossover clinical trial. J Med Food. 2010;13:1363–8.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.